SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3ilk'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

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	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1SQN_A_NDRA1001_0 (PROGESTERONE RECEPTOR)	3ilk	UNCHARACTERIZED TRNA/RRNA METHYLTRANSFERASE HI0380 (Haemophilus influenzae)	5 / 12	LEU A 223 LEU A 227 ASN A 224 MET A 203 TYR A 210	None	1.34A	1sqnA-3ilkA: undetectable	1sqnA-3ilkA: 22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1V2X_A_SAMA400_0 (TRNA (GM18) METHYLTRANSFERASE)	3ilk	UNCHARACTERIZED TRNA/RRNA METHYLTRANSFERASE HI0380 (Haemophilus influenzae)	7 / 12	PHE A 110 GLY A 111 GLY A 116 ILE A 131 SER A 139 LEU A 140 ALA A 145	None EDO A 242 (-4.6A) None EDO A 243 (-4.0A) None None EDO A 242 ( 3.7A)	0.75A	1v2xA-3ilkA: 16.8	1v2xA-3ilkA: 22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1X7P_A_SAMA301_0 (RRNA METHYLTRANSFERASE)	3ilk	UNCHARACTERIZED TRNA/RRNA METHYLTRANSFERASE HI0380 (Haemophilus influenzae)	7 / 11	THR A 78 GLY A 111 GLY A 116 ILE A 131 SER A 139 LEU A 140 ALA A 145	EDO A 242 (-3.4A) EDO A 242 (-4.6A) None EDO A 243 (-4.0A) None None EDO A 242 ( 3.7A)	0.93A	1x7pA-3ilkA: 17.1 1x7pB-3ilkA: 17.3	1x7pA-3ilkA: 22.15 1x7pB-3ilkA: 22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1X7P_B_SAMB302_0 (RRNA METHYLTRANSFERASE)	3ilk	UNCHARACTERIZED TRNA/RRNA METHYLTRANSFERASE HI0380 (Haemophilus influenzae)	6 / 10	THR A 78 GLY A 111 GLY A 116 ILE A 131 LEU A 140 ALA A 145	EDO A 242 (-3.4A) EDO A 242 (-4.6A) None EDO A 243 (-4.0A) None EDO A 242 ( 3.7A)	0.74A	1x7pA-3ilkA: 17.1 1x7pB-3ilkA: 17.3	1x7pA-3ilkA: 22.15 1x7pB-3ilkA: 22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2W3B_A_FOLA401_0 (DIHYDROFOLATE REDUCTASE)	3ilk	UNCHARACTERIZED TRNA/RRNA METHYLTRANSFERASE HI0380 (Haemophilus influenzae)	5 / 12	ILE A 7 ALA A 21 ARG A 112 PHE A 110 ILE A 131	None None None None EDO A 243 (-4.0A)	1.10A	2w3bA-3ilkA: undetectable	2w3bA-3ilkA: 24.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2W8Y_B_NDRB1000_0 (PROGESTERONE RECEPTOR)	3ilk	UNCHARACTERIZED TRNA/RRNA METHYLTRANSFERASE HI0380 (Haemophilus influenzae)	5 / 12	LEU A 223 LEU A 227 ASN A 224 MET A 203 TYR A 210	None	1.31A	2w8yB-3ilkA: undetectable	2w8yB-3ilkA: 23.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3D90_A_NOGA1001_1 (PROGESTERONE RECEPTOR)	3ilk	UNCHARACTERIZED TRNA/RRNA METHYLTRANSFERASE HI0380 (Haemophilus influenzae)	5 / 12	LEU A 223 LEU A 227 ASN A 224 MET A 203 TYR A 210	None	1.35A	3d90A-3ilkA: undetectable	3d90A-3ilkA: 22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3DCM_X_SAMX5452_0 (UNCHARACTERIZED PROTEIN TM_1570)	3ilk	UNCHARACTERIZED TRNA/RRNA METHYLTRANSFERASE HI0380 (Haemophilus influenzae)	6 / 11	THR A 78 GLY A 111 GLY A 116 ILE A 131 LEU A 140 ALA A 145	EDO A 242 (-3.4A) EDO A 242 (-4.6A) None EDO A 243 (-4.0A) None EDO A 242 ( 3.7A)	0.82A	3dcmX-3ilkA: 15.1	3dcmX-3ilkA: 21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3FPJ_A_SAMA301_1 (PUTATIVE UNCHARACTERIZED PROTEIN)	3ilk	UNCHARACTERIZED TRNA/RRNA METHYLTRANSFERASE HI0380 (Haemophilus influenzae)	4 / 6	TYR A 191 GLY A 225 THR A 187 GLU A 216	None	0.88A	3fpjA-3ilkA: undetectable	3fpjA-3ilkA: 21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3NK7_A_SAMA770_0 (23S RRNA METHYLTRANSFERASE)	3ilk	UNCHARACTERIZED TRNA/RRNA METHYLTRANSFERASE HI0380 (Haemophilus influenzae)	5 / 12	ASN A 17 GLY A 111 GLY A 116 ILE A 131 SER A 139	None EDO A 242 (-4.6A) None EDO A 243 (-4.0A) None	0.88A	3nk7A-3ilkA: 15.9	3nk7A-3ilkA: 21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3NK7_A_SAMA770_0 (23S RRNA METHYLTRANSFERASE)	3ilk	UNCHARACTERIZED TRNA/RRNA METHYLTRANSFERASE HI0380 (Haemophilus influenzae)	5 / 12	GLY A 111 GLY A 116 ILE A 131 SER A 139 ASN A 141	EDO A 242 (-4.6A) None EDO A 243 (-4.0A) None None	0.89A	3nk7A-3ilkA: 15.9	3nk7A-3ilkA: 21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3NK7_B_SAMB770_0 (23S RRNA METHYLTRANSFERASE)	3ilk	UNCHARACTERIZED TRNA/RRNA METHYLTRANSFERASE HI0380 (Haemophilus influenzae)	7 / 12	ASN A 17 PHE A 110 GLY A 111 GLY A 116 ILE A 131 SER A 139 LEU A 140	None None EDO A 242 (-4.6A) None EDO A 243 (-4.0A) None None	0.76A	3nk7B-3ilkA: 15.9	3nk7B-3ilkA: 21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5L0Z_A_SAMA304_0 (PROBABLE RNA METHYLTRANSFERASE, TRMH FAMILY)	3ilk	UNCHARACTERIZED TRNA/RRNA METHYLTRANSFERASE HI0380 (Haemophilus influenzae)	8 / 12	THR A 78 GLY A 111 GLY A 116 ILE A 131 SER A 139 LEU A 140 LEU A 142 ALA A 145	EDO A 242 (-3.4A) EDO A 242 (-4.6A) None EDO A 243 (-4.0A) None None EDO A 242 ( 4.5A) EDO A 242 ( 3.7A)	0.71A	5l0zA-3ilkA: 17.1	5l0zA-3ilkA: 24.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5L0Z_B_SAMB304_0 (PROBABLE RNA METHYLTRANSFERASE, TRMH FAMILY)	3ilk	UNCHARACTERIZED TRNA/RRNA METHYLTRANSFERASE HI0380 (Haemophilus influenzae)	8 / 10	THR A 78 GLY A 111 GLY A 116 ILE A 131 SER A 139 LEU A 140 LEU A 142 ALA A 145	EDO A 242 (-3.4A) EDO A 242 (-4.6A) None EDO A 243 (-4.0A) None None EDO A 242 ( 4.5A) EDO A 242 ( 3.7A)	0.80A	5l0zB-3ilkA: 7.2	5l0zB-3ilkA: 24.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6CDU_F_EY4F500_0 (CHIMERIC ALPHA1GABAA RECEPTOR)	3ilk	UNCHARACTERIZED TRNA/RRNA METHYLTRANSFERASE HI0380 (Haemophilus influenzae)	5 / 7	ALA A 24 THR A 27 ILE A 108 VAL A 146 PRO A 92	None	1.40A	6cduF-3ilkA: undetectable 6cduJ-3ilkA: undetectable	6cduF-3ilkA: 22.16 6cduJ-3ilkA: 22.16

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1SQN_A_NDRA1001_0","PROGESTERONE RECEPTOR","3ilk","UNCHARACTERIZED TRNA\/RRNA METHYLTRANSFERASE HI0380","Haemophilus influenzae",5,"LEU A 223;LEU A 227;ASN A 224;MET A 203;TYR A 210","None","1.34A","1sqnA-3ilkA:undetectable","1sqnA-3ilkA:22.91"],["1V2X_A_SAMA400_0","TRNA (GM18) METHYLTRANSFERASE","3ilk","UNCHARACTERIZED TRNA\/RRNA METHYLTRANSFERASE HI0380","Haemophilus influenzae",7,"PHE A 110;GLY A 111;GLY A 116;ILE A 131;SER A 139;LEU A 140;ALA A 145","None;EDO A 242 (-4.6A);None;EDO A 243 (-4.0A);None;None;EDO A 242 ( 3.7A)","0.75A","1v2xA-3ilkA:16.8","1v2xA-3ilkA:22.66"],["1X7P_A_SAMA301_0","RRNA METHYLTRANSFERASE","3ilk","UNCHARACTERIZED TRNA\/RRNA METHYLTRANSFERASE HI0380","Haemophilus influenzae",7,"THR A  78;GLY A 111;GLY A 116;ILE A 131;SER A 139;LEU A 140;ALA A 145","EDO A 242 (-3.4A);EDO A 242 (-4.6A);None;EDO A 243 (-4.0A);None;None;EDO A 242 ( 3.7A)","0.93A","1x7pA-3ilkA:17.1;1x7pB-3ilkA:17.3","1x7pA-3ilkA:22.15;1x7pB-3ilkA:22.15"],["1X7P_B_SAMB302_0","RRNA METHYLTRANSFERASE","3ilk","UNCHARACTERIZED TRNA\/RRNA METHYLTRANSFERASE HI0380","Haemophilus influenzae",6,"THR A  78;GLY A 111;GLY A 116;ILE A 131;LEU A 140;ALA A 145","EDO A 242 (-3.4A);EDO A 242 (-4.6A);None;EDO A 243 (-4.0A);None;EDO A 242 ( 3.7A)","0.74A","1x7pA-3ilkA:17.1;1x7pB-3ilkA:17.3","1x7pA-3ilkA:22.15;1x7pB-3ilkA:22.15"],["2W3B_A_FOLA401_0","DIHYDROFOLATE REDUCTASE","3ilk","UNCHARACTERIZED TRNA\/RRNA METHYLTRANSFERASE HI0380","Haemophilus influenzae",5,"ILE A   7;ALA A  21;ARG A 112;PHE A 110;ILE A 131","None;None;None;None;EDO A 243 (-4.0A)","1.10A","2w3bA-3ilkA:undetectable","2w3bA-3ilkA:24.14"],["2W8Y_B_NDRB1000_0","PROGESTERONE RECEPTOR","3ilk","UNCHARACTERIZED TRNA\/RRNA METHYLTRANSFERASE HI0380","Haemophilus influenzae",5,"LEU A 223;LEU A 227;ASN A 224;MET A 203;TYR A 210","None","1.31A","2w8yB-3ilkA:undetectable","2w8yB-3ilkA:23.47"],["3D90_A_NOGA1001_1","PROGESTERONE RECEPTOR","3ilk","UNCHARACTERIZED TRNA\/RRNA METHYLTRANSFERASE HI0380","Haemophilus influenzae",5,"LEU A 223;LEU A 227;ASN A 224;MET A 203;TYR A 210","None","1.35A","3d90A-3ilkA:undetectable","3d90A-3ilkA:22.91"],["3DCM_X_SAMX5452_0","UNCHARACTERIZED PROTEIN TM_1570","3ilk","UNCHARACTERIZED TRNA\/RRNA METHYLTRANSFERASE HI0380","Haemophilus influenzae",6,"THR A  78;GLY A 111;GLY A 116;ILE A 131;LEU A 140;ALA A 145","EDO A 242 (-3.4A);EDO A 242 (-4.6A);None;EDO A 243 (-4.0A);None;EDO A 242 ( 3.7A)","0.82A","3dcmX-3ilkA:15.1","3dcmX-3ilkA:21.67"],["3FPJ_A_SAMA301_1","PUTATIVE UNCHARACTERIZED PROTEIN","3ilk","UNCHARACTERIZED TRNA\/RRNA METHYLTRANSFERASE HI0380","Haemophilus influenzae",4,"TYR A 191;GLY A 225;THR A 187;GLU A 216","None","0.88A","3fpjA-3ilkA:undetectable","3fpjA-3ilkA:21.45"],["3NK7_A_SAMA770_0","23S RRNA METHYLTRANSFERASE","3ilk","UNCHARACTERIZED TRNA\/RRNA METHYLTRANSFERASE HI0380","Haemophilus influenzae",5,"ASN A  17;GLY A 111;GLY A 116;ILE A 131;SER A 139","None;EDO A 242 (-4.6A);None;EDO A 243 (-4.0A);None","0.88A","3nk7A-3ilkA:15.9","3nk7A-3ilkA:21.80"],["3NK7_A_SAMA770_0","23S RRNA METHYLTRANSFERASE","3ilk","UNCHARACTERIZED TRNA\/RRNA METHYLTRANSFERASE HI0380","Haemophilus influenzae",5,"GLY A 111;GLY A 116;ILE A 131;SER A 139;ASN A 141","EDO A 242 (-4.6A);None;EDO A 243 (-4.0A);None;None","0.89A","3nk7A-3ilkA:15.9","3nk7A-3ilkA:21.80"],["3NK7_B_SAMB770_0","23S RRNA METHYLTRANSFERASE","3ilk","UNCHARACTERIZED TRNA\/RRNA METHYLTRANSFERASE HI0380","Haemophilus influenzae",7,"ASN A  17;PHE A 110;GLY A 111;GLY A 116;ILE A 131;SER A 139;LEU A 140","None;None;EDO A 242 (-4.6A);None;EDO A 243 (-4.0A);None;None","0.76A","3nk7B-3ilkA:15.9","3nk7B-3ilkA:21.80"],["5L0Z_A_SAMA304_0","PROBABLE RNA METHYLTRANSFERASE, TRMH FAMILY","3ilk","UNCHARACTERIZED TRNA\/RRNA METHYLTRANSFERASE HI0380","Haemophilus influenzae",8,"THR A  78;GLY A 111;GLY A 116;ILE A 131;SER A 139;LEU A 140;LEU A 142;ALA A 145","EDO A 242 (-3.4A);EDO A 242 (-4.6A);None;EDO A 243 (-4.0A);None;None;EDO A 242 ( 4.5A);EDO A 242 ( 3.7A)","0.71A","5l0zA-3ilkA:17.1","5l0zA-3ilkA:24.34"],["5L0Z_B_SAMB304_0","PROBABLE RNA METHYLTRANSFERASE, TRMH FAMILY","3ilk","UNCHARACTERIZED TRNA\/RRNA METHYLTRANSFERASE HI0380","Haemophilus influenzae",8,"THR A  78;GLY A 111;GLY A 116;ILE A 131;SER A 139;LEU A 140;LEU A 142;ALA A 145","EDO A 242 (-3.4A);EDO A 242 (-4.6A);None;EDO A 243 (-4.0A);None;None;EDO A 242 ( 4.5A);EDO A 242 ( 3.7A)","0.80A","5l0zB-3ilkA:7.2","5l0zB-3ilkA:24.34"],["6CDU_F_EY4F500_0","CHIMERIC ALPHA1GABAA RECEPTOR","3ilk","UNCHARACTERIZED TRNA\/RRNA METHYLTRANSFERASE HI0380","Haemophilus influenzae",5,"ALA A  24;THR A  27;ILE A 108;VAL A 146;PRO A  92","None","1.40A","6cduF-3ilkA:undetectable;6cduJ-3ilkA:undetectable","6cduF-3ilkA:22.16;6cduJ-3ilkA:22.16"]]