SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3ilv'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C4D_D_DVAD6_0
(GRAMICIDIN A)		 3ilv GLUTAMINE-DEPENDENT
NAD(+) SYNTHETASE
(Cytophaga
hutchinsonii) 		3 / 3 TRP A 605
ALA A 115
VAL A 119
 None
 0.89A 1c4dC-3ilvA:
undetectable
1c4dD-3ilvA:
undetectable		 1c4dC-3ilvA:
3.45
1c4dD-3ilvA:
3.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_J_TRPJ81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 3ilv GLUTAMINE-DEPENDENT
NAD(+) SYNTHETASE
(Cytophaga
hutchinsonii) 		4 / 8 THR A 371
ALA A 318
GLY A 395
THR A 365
 None
 0.75A 1gtnI-3ilvA:
undetectable
1gtnJ-3ilvA:
undetectable		 1gtnI-3ilvA:
9.03
1gtnJ-3ilvA:
9.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V55_C_CHDC3271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE III
CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART)		 3ilv GLUTAMINE-DEPENDENT
NAD(+) SYNTHETASE
(Cytophaga
hutchinsonii) 		4 / 7 LEU A 221
GLN A  13
LEU A 290
PHE A 251
 None
 1.11A 1v55C-3ilvA:
undetectable
1v55J-3ilvA:
undetectable		 1v55C-3ilvA:
16.67
1v55J-3ilvA:
6.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HA6_A_SCKA902_1
(ACETYLCHOLINESTERASE)		 3ilv GLUTAMINE-DEPENDENT
NAD(+) SYNTHETASE
(Cytophaga
hutchinsonii) 		5 / 10 GLU A 408
GLU A 405
GLU A 415
LEU A 422
LEU A 431
 None
 1.40A 2ha6A-3ilvA:
undetectable		 2ha6A-3ilvA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HA6_B_SCKB952_1
(ACETYLCHOLINESTERASE)		 3ilv GLUTAMINE-DEPENDENT
NAD(+) SYNTHETASE
(Cytophaga
hutchinsonii) 		5 / 10 GLU A 408
GLU A 405
GLU A 415
LEU A 422
LEU A 431
 None
 1.42A 2ha6B-3ilvA:
undetectable		 2ha6B-3ilvA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HRE_B_CHDB701_0
(FERROCHELATASE)		 3ilv GLUTAMINE-DEPENDENT
NAD(+) SYNTHETASE
(Cytophaga
hutchinsonii) 		3 / 3 LYS A 542
GLY A 561
PRO A 562
 None
 0.83A 2hreB-3ilvA:
undetectable		 2hreB-3ilvA:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2KUG_A_HLTA149_1
(CALMODULIN)		 3ilv GLUTAMINE-DEPENDENT
NAD(+) SYNTHETASE
(Cytophaga
hutchinsonii) 		4 / 5 MET A 343
LEU A 346
MET A 296
LYS A 450
 None
 1.36A 2kugA-3ilvA:
1.4		 2kugA-3ilvA:
7.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_B_HSMB1162_1
(ALLERGEN ARG R 1)		 3ilv GLUTAMINE-DEPENDENT
NAD(+) SYNTHETASE
(Cytophaga
hutchinsonii) 		3 / 3 GLU A  44
HIS A 120
GLU A 122
 None
 0.80A 2x45B-3ilvA:
undetectable		 2x45B-3ilvA:
11.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_C_HSMC1162_1
(ALLERGEN ARG R 1)		 3ilv GLUTAMINE-DEPENDENT
NAD(+) SYNTHETASE
(Cytophaga
hutchinsonii) 		3 / 3 GLU A  44
HIS A 120
GLU A 122
 None
 0.78A 2x45C-3ilvA:
undetectable		 2x45C-3ilvA:
11.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AF3_A_PAUA314_0
(PANTOTHENATE KINASE)		 3ilv GLUTAMINE-DEPENDENT
NAD(+) SYNTHETASE
(Cytophaga
hutchinsonii) 		4 / 6 TYR A 606
ARG A 586
PHE A 575
PHE A 576
 None
 1.22A 3af3A-3ilvA:
undetectable		 3af3A-3ilvA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D41_A_FCNA4001_1
(FOMA PROTEIN)		 3ilv GLUTAMINE-DEPENDENT
NAD(+) SYNTHETASE
(Cytophaga
hutchinsonii) 		4 / 8 GLY A 477
GLY A 476
ILE A 443
THR A 447
 None
 0.58A 3d41A-3ilvA:
undetectable		 3d41A-3ilvA:
17.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KU9_B_SPMB700_1
(POLYAMINE OXIDASE)		 3ilv GLUTAMINE-DEPENDENT
NAD(+) SYNTHETASE
(Cytophaga
hutchinsonii) 		4 / 7 GLU A 164
TYR A 230
GLU A  44
TYR A 217
 None
 1.13A 3ku9B-3ilvA:
undetectable		 3ku9B-3ilvA:
23.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q95_A_ESLA700_1
(ESTROGEN RECEPTOR)		 3ilv GLUTAMINE-DEPENDENT
NAD(+) SYNTHETASE
(Cytophaga
hutchinsonii) 		5 / 12 GLU A  53
ARG A 603
ILE A 229
GLY A 222
LEU A 220
 None
 1.07A 3q95A-3ilvA:
undetectable		 3q95A-3ilvA:
17.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q95_B_ESLB700_1
(ESTROGEN RECEPTOR)		 3ilv GLUTAMINE-DEPENDENT
NAD(+) SYNTHETASE
(Cytophaga
hutchinsonii) 		5 / 12 GLU A  53
ARG A 603
ILE A 229
GLY A 222
LEU A 220
 None
 1.07A 3q95B-3ilvA:
undetectable		 3q95B-3ilvA:
17.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3Z_D_9PLD501_1
(CYTOCHROME P450 2E1)		 3ilv GLUTAMINE-DEPENDENT
NAD(+) SYNTHETASE
(Cytophaga
hutchinsonii) 		4 / 6 LEU A 306
ALA A 322
THR A 365
LEU A 390
 None
 0.98A 3t3zD-3ilvA:
undetectable		 3t3zD-3ilvA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TAJ_A_NBOA700_1
(LACTOTRANSFERRIN)		 3ilv GLUTAMINE-DEPENDENT
NAD(+) SYNTHETASE
(Cytophaga
hutchinsonii) 		4 / 7 GLY A 226
ASN A 223
GLY A  49
THR A  48
 None
 0.81A 3tajA-3ilvA:
undetectable		 3tajA-3ilvA:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AN2_A_EUIA1382_2
(DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1)		 3ilv GLUTAMINE-DEPENDENT
NAD(+) SYNTHETASE
(Cytophaga
hutchinsonii) 		4 / 4 ASN A  12
SER A  82
LEU A  42
THR A  14
 None
 1.34A 4an2A-3ilvA:
undetectable		 4an2A-3ilvA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QB9_D_PARD500_1
(ENHANCED
INTRACELLULAR
SURVIVAL PROTEIN)		 3ilv GLUTAMINE-DEPENDENT
NAD(+) SYNTHETASE
(Cytophaga
hutchinsonii) 		4 / 8 SER A  82
SER A 109
GLU A 164
ASP A 165
 None
 1.34A 4qb9D-3ilvA:
undetectable		 4qb9D-3ilvA:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QCK_A_ASDA404_1
(3-KETOSTEROID-9-ALPH
A-MONOOXYGENASE
OXYGENASE SUBUNIT)		 3ilv GLUTAMINE-DEPENDENT
NAD(+) SYNTHETASE
(Cytophaga
hutchinsonii) 		5 / 12 ASN A 219
VAL A 234
LEU A  83
ALA A   9
GLY A  49
 None
 1.33A 4qckA-3ilvA:
undetectable		 4qckA-3ilvA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_D_SORD1341_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 3ilv GLUTAMINE-DEPENDENT
NAD(+) SYNTHETASE
(Cytophaga
hutchinsonii) 		4 / 6 CYH A  98
LYS A 106
GLU A 101
GLY A 103
 None
 0.90A 5a06D-3ilvA:
undetectable		 5a06D-3ilvA:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DBY_A_ACTA617_0
(SERUM ALBUMIN)		 3ilv GLUTAMINE-DEPENDENT
NAD(+) SYNTHETASE
(Cytophaga
hutchinsonii) 		3 / 3 TRP A 495
ARG A 500
LEU A 505
 None
 0.85A 5dbyA-3ilvA:
1.4		 5dbyA-3ilvA:
23.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KVA_A_SAMA301_1
(CAFFEOYL-COA
O-METHYLTRANSFERASE)		 3ilv GLUTAMINE-DEPENDENT
NAD(+) SYNTHETASE
(Cytophaga
hutchinsonii) 		3 / 3 THR A 456
SER A 458
ASP A 601
 None
 0.81A 5kvaA-3ilvA:
2.8		 5kvaA-3ilvA:
18.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KVA_B_SAMB301_1
(CAFFEOYL-COA
O-METHYLTRANSFERASE)		 3ilv GLUTAMINE-DEPENDENT
NAD(+) SYNTHETASE
(Cytophaga
hutchinsonii) 		3 / 3 THR A 456
SER A 458
ASP A 601
 None
 0.83A 5kvaB-3ilvA:
3.0		 5kvaB-3ilvA:
18.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MVS_B_ADNB401_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-79
SPECIFIC)		 3ilv GLUTAMINE-DEPENDENT
NAD(+) SYNTHETASE
(Cytophaga
hutchinsonii) 		4 / 8 GLY A  49
GLU A 224
ALA A 225
PHE A  56
 None
 0.80A 5mvsB-3ilvA:
undetectable		 5mvsB-3ilvA:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AZ3_1_PAR11802_1
(RRNA ALPHA
RIBOSOMAL PROTEIN
UL4
RIBOSOMAL PROTEIN
UL15
RIBOSOMAL PROTEIN
EL15)		 3ilv GLUTAMINE-DEPENDENT
NAD(+) SYNTHETASE
(Cytophaga
hutchinsonii) 		3 / 3 ARG A 248
LYS A 327
ARG A 200
 None
 1.32A 6az3C-3ilvA:
undetectable
6az3L-3ilvA:
undetectable
6az3M-3ilvA:
undetectable		 6az3C-3ilvA:
7.94
6az3L-3ilvA:
7.96
6az3M-3ilvA:
7.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_ACTA817_0
(GEPHYRIN)		 3ilv GLUTAMINE-DEPENDENT
NAD(+) SYNTHETASE
(Cytophaga
hutchinsonii) 		3 / 3 THR A 371
ALA A 396
LYS A 362
 None
 0.75A 6fgdA-3ilvA:
2.7		 6fgdA-3ilvA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G31_C_ZOLC401_0
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE)		 3ilv GLUTAMINE-DEPENDENT
NAD(+) SYNTHETASE
(Cytophaga
hutchinsonii) 		4 / 5 ASP A 596
ASP A 597
ARG A 460
LYS A 280
 None
 1.35A 6g31C-3ilvA:
undetectable		 6g31C-3ilvA:
9.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN5_F_LLLF301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 3ilv GLUTAMINE-DEPENDENT
NAD(+) SYNTHETASE
(Cytophaga
hutchinsonii) 		4 / 5 TYR A 467
GLU A 462
ASP A 313
CYH A 317
 None
 1.34A 6mn5F-3ilvA:
0.0		 6mn5F-3ilvA:
9.11