SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3im7'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RLB_F_REAF177_1
(RETINOL BINDING
PROTEIN)		 3im7 CARDIAC CA2+ RELEASE
CHANNEL
(Mus
musculus) 		5 / 11 PHE A  67
LEU A  22
ALA A 205
VAL A 214
LEU A  14
 None
 1.09A 1rlbF-3im7A:
undetectable		 1rlbF-3im7A:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AZX_A_TRPA602_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 3im7 CARDIAC CA2+ RELEASE
CHANNEL
(Mus
musculus) 		4 / 8 ILE A 119
LEU A 181
ILE A 182
HIS A 163
 None
 0.77A 2azxA-3im7A:
undetectable		 2azxA-3im7A:
15.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NPN_A_SAMA4633_0
(PUTATIVE COBALAMIN
SYNTHESIS RELATED
PROTEIN)		 3im7 CARDIAC CA2+ RELEASE
CHANNEL
(Mus
musculus) 		5 / 9 GLY A 116
THR A 161
ALA A 118
LEU A  69
LEU A  78
 None
 1.19A 2npnA-3im7A:
undetectable		 2npnA-3im7A:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CE6_B_ADNB500_2
(ADENOSYLHOMOCYSTEINA
SE)		 3im7 CARDIAC CA2+ RELEASE
CHANNEL
(Mus
musculus) 		4 / 5 GLN A  33
THR A  27
THR A 210
HIS A 193
 None
 1.32A 3ce6B-3im7A:
undetectable		 3ce6B-3im7A:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CE6_C_ADNC500_2
(ADENOSYLHOMOCYSTEINA
SE)		 3im7 CARDIAC CA2+ RELEASE
CHANNEL
(Mus
musculus) 		4 / 5 GLN A  33
THR A  27
THR A 210
HIS A 193
 None
 1.34A 3ce6C-3im7A:
undetectable		 3ce6C-3im7A:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKV_B_AERB601_2
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 3im7 CARDIAC CA2+ RELEASE
CHANNEL
(Mus
musculus) 		4 / 5 TYR A 129
ARG A 122
ASP A  17
VAL A 175
 None
 1.47A 4nkvB-3im7A:
undetectable		 4nkvB-3im7A:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HPU_C_IPHC101_0
(INSULIN, CHAIN A
INSULIN, CHAIN B)		 3im7 CARDIAC CA2+ RELEASE
CHANNEL
(Mus
musculus) 		4 / 6 CYH A  47
LEU A  37
HIS A 193
LEU A 192
 None
 0.89A 5hpuC-3im7A:
undetectable
5hpuD-3im7A:
undetectable		 5hpuC-3im7A:
8.76
5hpuD-3im7A:
9.30