SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3imh'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4Y_A_TPVA501_1
(PROTEIN (HIV-1
PROTEASE))		 3imh GALACTOSE-1-EPIMERAS
E
(Lactobacillus
acidophilus) 		5 / 10 LEU A 127
ASP A 129
ILE A  72
GLY A 102
ILE A 103
 None
 1.07A 1d4yA-3imhA:
undetectable		 1d4yA-3imhA:
15.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MT1_B_AG2B7001_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN)		 3imh GALACTOSE-1-EPIMERAS
E
(Lactobacillus
acidophilus) 		4 / 6 ILE A  49
GLU A  18
LEU A  32
LEU A  65
 None
 1.00A 1mt1B-3imhA:
undetectable
1mt1C-3imhA:
undetectable		 1mt1B-3imhA:
12.81
1mt1C-3imhA:
10.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S9A_A_BEZA306_0
(CHLOROCATECHOL
1,2-DIOXYGENASE)		 3imh GALACTOSE-1-EPIMERAS
E
(Lactobacillus
acidophilus) 		5 / 11 ASP A 292
ILE A 288
GLY A 289
TYR A 274
HIS A 278
 MG  A 337 ( 4.0A)
None
CL  A 344 (-3.6A)
GOL  A 340 (-3.8A)
GOL  A 340 (-4.2A)
 1.36A 1s9aA-3imhA:
undetectable		 1s9aA-3imhA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S9A_B_BEZB307_0
(CHLOROCATECHOL
1,2-DIOXYGENASE)		 3imh GALACTOSE-1-EPIMERAS
E
(Lactobacillus
acidophilus) 		5 / 12 ASP A 292
ILE A 288
GLY A 289
TYR A 274
HIS A 278
 MG  A 337 ( 4.0A)
None
CL  A 344 (-3.6A)
GOL  A 340 (-3.8A)
GOL  A 340 (-4.2A)
 1.39A 1s9aB-3imhA:
undetectable		 1s9aB-3imhA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_A_SAMA301_1
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 3imh GALACTOSE-1-EPIMERAS
E
(Lactobacillus
acidophilus) 		3 / 3 LYS A  14
ASP A 129
ASP A 131
 None
 1.01A 2br4A-3imhA:
undetectable		 2br4A-3imhA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O4P_A_TPVA300_1
(PROTEASE)		 3imh GALACTOSE-1-EPIMERAS
E
(Lactobacillus
acidophilus) 		5 / 11 LEU A 127
ASP A 129
ILE A  72
GLY A 102
ILE A 103
 None
 1.04A 2o4pA-3imhA:
undetectable		 2o4pA-3imhA:
15.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QX6_B_ML1B233_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 3imh GALACTOSE-1-EPIMERAS
E
(Lactobacillus
acidophilus) 		4 / 6 GLY A 239
GLY A 224
PHE A 217
PHE A 244
 None
 1.00A 2qx6A-3imhA:
undetectable
2qx6B-3imhA:
undetectable		 2qx6A-3imhA:
22.16
2qx6B-3imhA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZAW_A_CAMA422_0
(CYTOCHROME P450-CAM)		 3imh GALACTOSE-1-EPIMERAS
E
(Lactobacillus
acidophilus) 		4 / 6 PHE A 215
TYR A 194
VAL A 197
ASP A 231
 None
 1.07A 2zawA-3imhA:
undetectable		 2zawA-3imhA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJ8_C_SPMC500_1
(DIAMINE
ACETYLTRANSFERASE 1)		 3imh GALACTOSE-1-EPIMERAS
E
(Lactobacillus
acidophilus) 		4 / 6 ASP A 184
LEU A 227
ASP A 292
LEU A  50
 None
None
MG  A 337 ( 4.0A)
None
 1.05A 3bj8C-3imhA:
0.1
3bj8D-3imhA:
undetectable		 3bj8C-3imhA:
20.06
3bj8D-3imhA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DL9_B_V2HB602_0
(CYTOCHROME P450 2R1)		 3imh GALACTOSE-1-EPIMERAS
E
(Lactobacillus
acidophilus) 		5 / 12 VAL A 264
ALA A 253
ALA A 268
GLU A 297
ILE A 294
 None
None
None
GOL  A 341 (-2.6A)
None
 1.22A 3dl9B-3imhA:
undetectable		 3dl9B-3imhA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM0_B_CHDB152_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 3imh GALACTOSE-1-EPIMERAS
E
(Lactobacillus
acidophilus) 		4 / 8 ILE A 311
TYR A 136
PRO A 137
GLY A  70
 None
 0.92A 3em0B-3imhA:
1.9		 3em0B-3imhA:
17.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM3_B_478B200_1
(PROTEASE)		 3imh GALACTOSE-1-EPIMERAS
E
(Lactobacillus
acidophilus) 		5 / 10 GLY A 293
ALA A 182
ASP A 184
LEU A 262
ILE A 223
 None
 0.92A 3em3A-3imhA:
undetectable		 3em3A-3imhA:
16.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3F8W_B_ADNB301_1
(PURINE-NUCLEOSIDE
PHOSPHORYLASE)		 3imh GALACTOSE-1-EPIMERAS
E
(Lactobacillus
acidophilus) 		5 / 12 HIS A 173
TYR A 175
GLY A 239
ASN A 238
HIS A 278
 GOL  A 340 (-3.8A)
None
None
None
GOL  A 340 (-4.2A)
 1.36A 3f8wB-3imhA:
undetectable		 3f8wB-3imhA:
23.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GN0_A_DMOA551_1
(ARGINASE-1)		 3imh GALACTOSE-1-EPIMERAS
E
(Lactobacillus
acidophilus) 		5 / 9 ASP A 131
ASN A 133
GLY A 132
ASP A 129
THR A 166
 None
 1.34A 3gn0A-3imhA:
undetectable		 3gn0A-3imhA:
23.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GN0_B_DMOB552_1
(ARGINASE-1)		 3imh GALACTOSE-1-EPIMERAS
E
(Lactobacillus
acidophilus) 		5 / 9 ASP A 131
ASN A 133
GLY A 132
ASP A 129
THR A 166
 None
 1.33A 3gn0B-3imhA:
undetectable		 3gn0B-3imhA:
23.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HGI_A_BEZA284_0
(CATECHOL
1,2-DIOXYGENASE)		 3imh GALACTOSE-1-EPIMERAS
E
(Lactobacillus
acidophilus) 		5 / 12 ASP A 292
ILE A 288
GLY A 289
TYR A 274
HIS A 278
 MG  A 337 ( 4.0A)
None
CL  A 344 (-3.6A)
GOL  A 340 (-3.8A)
GOL  A 340 (-4.2A)
 1.34A 3hgiA-3imhA:
undetectable		 3hgiA-3imhA:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q1E_C_T44C128_1
(5-HYDROXYISOURATE
HYDROLASE)		 3imh GALACTOSE-1-EPIMERAS
E
(Lactobacillus
acidophilus) 		4 / 6 LEU A 185
LEU A 255
LEU A 240
LEU A 273
 None
 1.07A 3q1eA-3imhA:
undetectable
3q1eC-3imhA:
undetectable		 3q1eA-3imhA:
14.54
3q1eC-3imhA:
14.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BZF_B_ACTB502_0
(ALDOSE 1-EPIMERASE)		 3imh GALACTOSE-1-EPIMERAS
E
(Lactobacillus
acidophilus) 		4 / 4 HIS A 100
HIS A 173
ASP A 241
TYR A 274
 GOL  A 340 (-4.2A)
GOL  A 340 (-3.8A)
GOL  A 341 (-2.8A)
GOL  A 340 (-3.8A)
 0.57A 4bzfB-3imhA:
31.5		 4bzfB-3imhA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJU_A_TPVA500_1
(PROTEASE)		 3imh GALACTOSE-1-EPIMERAS
E
(Lactobacillus
acidophilus) 		5 / 12 LEU A 127
ASP A 129
ILE A  72
GLY A 102
ILE A 103
 None
 1.05A 4njuA-3imhA:
undetectable		 4njuA-3imhA:
15.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJU_C_TPVC500_1
(PROTEASE)		 3imh GALACTOSE-1-EPIMERAS
E
(Lactobacillus
acidophilus) 		5 / 12 LEU A 127
ASP A 129
ILE A  72
GLY A 102
ILE A 103
 None
 1.04A 4njuC-3imhA:
undetectable		 4njuC-3imhA:
15.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OBW_A_SAMA602_1
(2-METHOXY-6-POLYPREN
YL-1,4-BENZOQUINOL
METHYLASE,
MITOCHONDRIAL)		 3imh GALACTOSE-1-EPIMERAS
E
(Lactobacillus
acidophilus) 		3 / 3 ASP A 292
ASN A 280
SER A  51
 MG  A 337 ( 4.0A)
None
None
 0.83A 4obwA-3imhA:
undetectable		 4obwA-3imhA:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XI3_B_29SB601_2
(ESTROGEN RECEPTOR)		 3imh GALACTOSE-1-EPIMERAS
E
(Lactobacillus
acidophilus) 		4 / 5 LEU A 165
GLU A 317
LEU A 308
HIS A  88
 None
 1.31A 4xi3B-3imhA:
undetectable		 4xi3B-3imhA:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FSA_A_X2NA590_1
(CYP51 VARIANT1)		 3imh GALACTOSE-1-EPIMERAS
E
(Lactobacillus
acidophilus) 		5 / 12 ALA A 211
LEU A 273
PHE A 244
GLY A 293
LEU A 227
 None
 1.08A 5fsaA-3imhA:
undetectable		 5fsaA-3imhA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CNJ_D_NCTD402_1
(NEURONAL
ACETYLCHOLINE
RECEPTOR SUBUNIT
ALPHA-4
NEURONAL
ACETYLCHOLINE
RECEPTOR SUBUNIT
BETA-2)		 3imh GALACTOSE-1-EPIMERAS
E
(Lactobacillus
acidophilus) 		4 / 8 TYR A   8
THR A  37
TYR A  34
LEU A  52
 None
None
GOL  A 343 (-4.9A)
None
 1.40A 6cnjD-3imhA:
undetectable
6cnjE-3imhA:
undetectable		 6cnjD-3imhA:
12.33
6cnjE-3imhA:
11.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_ACTA826_0
(GEPHYRIN)		 3imh GALACTOSE-1-EPIMERAS
E
(Lactobacillus
acidophilus) 		3 / 3 HIS A 100
ARG A  75
ILE A  99
 GOL  A 340 (-4.2A)
GOL  A 341 ( 3.2A)
None
 0.87A 6fgdA-3imhA:
undetectable		 6fgdA-3imhA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GP2_B_DAHB126_0
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
BETA CHAIN)		 3imh GALACTOSE-1-EPIMERAS
E
(Lactobacillus
acidophilus) 		5 / 11 LEU A 273
THR A 295
GLY A 276
PHE A 217
ILE A 223
 None
 1.08A 6gp2B-3imhA:
undetectable		 6gp2B-3imhA:
13.40