SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3in5'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UOB_A_PNNA1311_1
(DEACETOXYCEPHALOSPOR
IN C SYNTHETASE)		 3in5 DNA POLYMERASE KAPPA
(Homo
sapiens) 		3 / 3 ARG A 339
ARG A  97
ILE A 335
 None
 0.69A 1uobA-3in5A:
undetectable		 1uobA-3in5A:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2N27_A_4DYA205_1
(CALMODULIN)		 3in5 DNA POLYMERASE KAPPA
(Homo
sapiens) 		5 / 11 LEU A 376
ILE A 357
LEU A  99
VAL A 342
MET A 343
 None
 1.33A 2n27A-3in5A:
undetectable		 2n27A-3in5A:
14.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNK_A_ROCA401_2
(PROTEASE)		 3in5 DNA POLYMERASE KAPPA
(Homo
sapiens) 		3 / 3 ARG A 298
VAL A 177
THR A 305
 None
 0.87A 2nnkA-3in5A:
undetectable		 2nnkA-3in5A:
11.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AQI_B_CHDB4_0
(FERROCHELATASE)		 3in5 DNA POLYMERASE KAPPA
(Homo
sapiens) 		4 / 6 MET A 343
PRO A 315
GLY A 403
MET A 318
 None
 1.43A 3aqiB-3in5A:
undetectable		 3aqiB-3in5A:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K4V_B_ROCB201_2
(HIV-1 PROTEASE)		 3in5 DNA POLYMERASE KAPPA
(Homo
sapiens) 		3 / 3 ARG A 298
VAL A 177
THR A 305
 None
 0.87A 3k4vA-3in5A:
undetectable		 3k4vA-3in5A:
11.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K4V_D_ROCD201_4
(HIV-1 PROTEASE)		 3in5 DNA POLYMERASE KAPPA
(Homo
sapiens) 		3 / 3 ARG A 298
VAL A 177
THR A 305
 None
 0.80A 3k4vD-3in5A:
undetectable		 3k4vD-3in5A:
11.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDU_D_ROCD100_3
(PROTEASE)		 3in5 DNA POLYMERASE KAPPA
(Homo
sapiens) 		3 / 3 ARG A 298
VAL A 177
THR A 305
 None
 0.76A 3nduD-3in5A:
undetectable		 3nduD-3in5A:
11.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TL9_A_ROCA401_2
(PROTEASE)		 3in5 DNA POLYMERASE KAPPA
(Homo
sapiens) 		3 / 3 ARG A 298
VAL A 177
THR A 305
 None
 0.87A 3tl9A-3in5A:
undetectable		 3tl9A-3in5A:
11.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QD3_A_5AEA201_1
(PEPTIDYL-TRNA
HYDROLASE)		 3in5 DNA POLYMERASE KAPPA
(Homo
sapiens) 		5 / 9 LEU A 349
GLY A 401
ASN A 316
VAL A 354
VAL A 322
 None
 0.99A 4qd3A-3in5A:
undetectable		 4qd3A-3in5A:
16.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_B_ID8B602_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3in5 DNA POLYMERASE KAPPA
(Homo
sapiens) 		3 / 3 SER A 423
LEU A 438
MET A 509
 None
 0.84A 5ikrB-3in5A:
undetectable		 5ikrB-3in5A:
20.93