SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3in6'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PKV_A_RBFA100_1
(RIBOFLAVIN SYNTHASE
ALPHA CHAIN)		 3in6 FMN-BINDING PROTEIN
(Syntrophomonas
wolfei) 		5 / 11 SER A  91
LEU A  85
THR A  86
ILE A  25
ILE A  95
 None
 1.16A 1pkvA-3in6A:
2.5
1pkvB-3in6A:
2.3		 1pkvA-3in6A:
18.44
1pkvB-3in6A:
18.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PKV_B_RBFB101_1
(RIBOFLAVIN SYNTHASE
ALPHA CHAIN)		 3in6 FMN-BINDING PROTEIN
(Syntrophomonas
wolfei) 		5 / 11 ILE A  95
SER A  91
LEU A  85
THR A  86
ILE A  25
 None
 1.16A 1pkvA-3in6A:
2.5
1pkvB-3in6A:
2.3		 1pkvA-3in6A:
18.44
1pkvB-3in6A:
18.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S9Q_A_CHDA459_0
(ESTROGEN-RELATED
RECEPTOR GAMMA)		 3in6 FMN-BINDING PROTEIN
(Syntrophomonas
wolfei) 		4 / 6 ASP A 104
LEU A 132
VAL A 133
ILE A  60
 None
 0.81A 1s9qA-3in6A:
undetectable		 1s9qA-3in6A:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP6_A_SALA3005_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 3in6 FMN-BINDING PROTEIN
(Syntrophomonas
wolfei) 		4 / 8 ASN A  44
THR A  36
LEU A  73
ALA A  71
 FMN  A 148 (-2.9A)
None
None
None
 0.95A 3kp6A-3in6A:
undetectable		 3kp6A-3in6A:
25.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8X_A_NIMA701_2
(PROSTAGLANDIN G/H
SYNTHASE 1)		 3in6 FMN-BINDING PROTEIN
(Syntrophomonas
wolfei) 		3 / 3 VAL A  83
SER A  31
LEU A  85
 None
 0.59A 3n8xA-3in6A:
undetectable		 3n8xA-3in6A:
14.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UFN_A_ROCA401_2
(HIV-1 PROTEASE)		 3in6 FMN-BINDING PROTEIN
(Syntrophomonas
wolfei) 		4 / 7 GLY A  55
ILE A  54
VAL A  99
VAL A  97
 None
 0.72A 3ufnB-3in6A:
undetectable		 3ufnB-3in6A:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WRI_A_CAMA502_0
(CAMPHOR
5-MONOOXYGENASE)		 3in6 FMN-BINDING PROTEIN
(Syntrophomonas
wolfei) 		4 / 5 LEU A  34
GLY A  79
ILE A 136
VAL A 137
 None
None
MPD  A 149 (-4.4A)
None
 0.81A 3wriA-3in6A:
undetectable		 3wriA-3in6A:
17.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WRI_B_CAMB502_0
(CAMPHOR
5-MONOOXYGENASE)		 3in6 FMN-BINDING PROTEIN
(Syntrophomonas
wolfei) 		4 / 5 LEU A  34
GLY A  79
ILE A 136
VAL A 137
 None
None
MPD  A 149 (-4.4A)
None
 0.80A 3wriB-3in6A:
undetectable		 3wriB-3in6A:
17.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WRK_A_CAMA502_0
(CAMPHOR
5-MONOOXYGENASE)		 3in6 FMN-BINDING PROTEIN
(Syntrophomonas
wolfei) 		4 / 5 LEU A  34
GLY A  79
ILE A 136
VAL A 137
 None
None
MPD  A 149 (-4.4A)
None
 0.84A 3wrkA-3in6A:
undetectable		 3wrkA-3in6A:
17.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J5J_B_478B401_2
(PROTEASE)		 3in6 FMN-BINDING PROTEIN
(Syntrophomonas
wolfei) 		5 / 10 ILE A 139
GLY A  55
ILE A  54
VAL A  99
VAL A  97
 MPD  A 149 (-4.0A)
None
None
None
None
 1.09A 4j5jB-3in6A:
undetectable		 4j5jB-3in6A:
18.54