SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3ing'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7C_A_HLTA4001_1
(SERUM ALBUMIN)		 3ing HOMOSERINE
DEHYDROGENASE
(Thermoplasma
acidophilum) 		4 / 5 ARG A 215
LYS A 216
ALA A 214
GLY A 210
 None
NDP  A 326 ( 4.5A)
None
None
 1.22A 1e7cA-3ingA:
undetectable		 1e7cA-3ingA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EII_A_RTLA135_0
(CELLULAR
RETINOL-BINDING
PROTEIN II)		 3ing HOMOSERINE
DEHYDROGENASE
(Thermoplasma
acidophilum) 		5 / 12 ALA A 142
ILE A   7
PHE A 151
LEU A 101
LEU A 120
 NDP  A 326 (-4.8A)
None
None
None
None
 1.37A 1eiiA-3ingA:
undetectable		 1eiiA-3ingA:
16.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MEI_A_MOAA600_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE)		 3ing HOMOSERINE
DEHYDROGENASE
(Thermoplasma
acidophilum) 		4 / 8 SER A 171
SER A 172
ASN A 175
GLY A 146
 None
None
None
NDP  A 326 (-3.9A)
 1.01A 1meiA-3ingA:
undetectable		 1meiA-3ingA:
23.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2KUH_A_HLTA150_1
(CALMODULIN)		 3ing HOMOSERINE
DEHYDROGENASE
(Thermoplasma
acidophilum) 		4 / 6 LEU A  77
MET A   9
LEU A  85
MET A  78
 None
 1.20A 2kuhA-3ingA:
undetectable		 2kuhA-3ingA:
12.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PYN_A_1UNA1001_3
(PROTEASE RETROPEPSIN)		 3ing HOMOSERINE
DEHYDROGENASE
(Thermoplasma
acidophilum) 		3 / 3 ASP A  76
THR A  89
PRO A  90
 None
NDP  A 326 (-4.6A)
NDP  A 326 (-4.0A)
 0.56A 2pynB-3ingA:
undetectable		 2pynB-3ingA:
16.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q64_B_1UNB1001_4
(PROTEASE RETROPEPSIN)		 3ing HOMOSERINE
DEHYDROGENASE
(Thermoplasma
acidophilum) 		3 / 3 ASP A  76
THR A  89
PRO A  90
 None
NDP  A 326 (-4.6A)
NDP  A 326 (-4.0A)
 0.54A 2q64B-3ingA:
undetectable		 2q64B-3ingA:
16.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QAK_A_1UNA1001_4
(PROTEASE RETROPEPSIN)		 3ing HOMOSERINE
DEHYDROGENASE
(Thermoplasma
acidophilum) 		3 / 3 ASP A  76
THR A  89
PRO A  90
 None
NDP  A 326 (-4.6A)
NDP  A 326 (-4.0A)
 0.56A 2qakB-3ingA:
undetectable		 2qakB-3ingA:
15.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXW_B_017B200_2
(HIV-1 PROTEASE)		 3ing HOMOSERINE
DEHYDROGENASE
(Thermoplasma
acidophilum) 		5 / 10 LEU A  84
VAL A  36
GLY A  15
VAL A  14
ILE A   6
 None
None
None
NDP  A 326 (-3.8A)
None
 1.03A 3oxwB-3ingA:
undetectable		 3oxwB-3ingA:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SM2_A_478A126_2
(GAG-PRO-POL
POLYPROTEIN)		 3ing HOMOSERINE
DEHYDROGENASE
(Thermoplasma
acidophilum) 		5 / 11 ALA A 115
VAL A  86
VAL A  18
GLY A 310
LEU A   8
 NDP  A 326 (-3.5A)
None
None
None
None
 0.98A 3sm2B-3ingA:
undetectable		 3sm2B-3ingA:
17.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TKG_C_ROCC901_3
(PROTEASE)		 3ing HOMOSERINE
DEHYDROGENASE
(Thermoplasma
acidophilum) 		3 / 3 ASP A  76
THR A  89
PRO A  90
 None
NDP  A 326 (-4.6A)
NDP  A 326 (-4.0A)
 0.56A 3tkgD-3ingA:
undetectable		 3tkgD-3ingA:
17.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TWP_A_SALA404_1
(ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE)		 3ing HOMOSERINE
DEHYDROGENASE
(Thermoplasma
acidophilum) 		4 / 7 ASN A 122
ALA A 121
ALA A  91
ARG A  93
 None
None
NDP  A 326 ( 4.9A)
None
 0.89A 3twpA-3ingA:
4.1		 3twpA-3ingA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TWP_B_SALB404_1
(ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE)		 3ing HOMOSERINE
DEHYDROGENASE
(Thermoplasma
acidophilum) 		4 / 7 ASN A 122
ALA A 121
ALA A  91
ARG A  93
 None
None
NDP  A 326 ( 4.9A)
None
 0.88A 3twpB-3ingA:
2.9		 3twpB-3ingA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TWP_C_SALC404_1
(ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE)		 3ing HOMOSERINE
DEHYDROGENASE
(Thermoplasma
acidophilum) 		4 / 7 ASN A 122
ALA A 121
ALA A  91
ARG A  93
 None
None
NDP  A 326 ( 4.9A)
None
 0.88A 3twpC-3ingA:
3.2		 3twpC-3ingA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AF0_A_MOAA1526_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE)		 3ing HOMOSERINE
DEHYDROGENASE
(Thermoplasma
acidophilum) 		4 / 8 SER A 171
SER A 172
ASN A 175
GLY A 147
 None
 1.01A 4af0A-3ingA:
undetectable		 4af0A-3ingA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KRH_B_SAMB900_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE
2)		 3ing HOMOSERINE
DEHYDROGENASE
(Thermoplasma
acidophilum) 		5 / 12 PHE A 106
GLY A 119
GLY A  95
SER A 100
ILE A 138
 None
 1.09A 4krhB-3ingA:
undetectable		 4krhB-3ingA:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKV_A_AERA601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 3ing HOMOSERINE
DEHYDROGENASE
(Thermoplasma
acidophilum) 		5 / 12 LEU A 154
PHE A 151
ILE A 288
THR A 252
VAL A 170
 None
 1.16A 4nkvA-3ingA:
undetectable		 4nkvA-3ingA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKV_C_AERC601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 3ing HOMOSERINE
DEHYDROGENASE
(Thermoplasma
acidophilum) 		5 / 12 LEU A 154
PHE A 151
ILE A 288
THR A 252
VAL A 170
 None
 1.15A 4nkvC-3ingA:
undetectable		 4nkvC-3ingA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O5F_B_PAUB302_0
(TYPE III
PANTOTHENATE KINASE)		 3ing HOMOSERINE
DEHYDROGENASE
(Thermoplasma
acidophilum) 		5 / 12 VAL A  36
LEU A  77
GLY A  38
THR A  11
ILE A  66
 None
None
None
NDP  A 326 (-4.5A)
None
 1.17A 4o5fA-3ingA:
undetectable
4o5fB-3ingA:
undetectable		 4o5fA-3ingA:
23.03
4o5fB-3ingA:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UW0_A_SAMA1506_0
(WBDD)		 3ing HOMOSERINE
DEHYDROGENASE
(Thermoplasma
acidophilum) 		5 / 12 TYR A 102
ALA A 105
ILE A   6
VAL A  86
ILE A 316
 None
 1.12A 4uw0A-3ingA:
2.0		 4uw0A-3ingA:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B8H_A_PAUA302_0
(TYPE III
PANTOTHENATE KINASE)		 3ing HOMOSERINE
DEHYDROGENASE
(Thermoplasma
acidophilum) 		5 / 12 VAL A  36
LEU A  77
GLY A  38
THR A  11
ILE A  66
 None
None
None
NDP  A 326 (-4.5A)
None
 1.20A 5b8hA-3ingA:
undetectable
5b8hB-3ingA:
undetectable		 5b8hA-3ingA:
22.28
5b8hB-3ingA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B8H_B_PAUB302_0
(TYPE III
PANTOTHENATE KINASE)		 3ing HOMOSERINE
DEHYDROGENASE
(Thermoplasma
acidophilum) 		5 / 12 VAL A  36
LEU A  77
GLY A  38
THR A  11
ILE A  66
 None
None
None
NDP  A 326 (-4.5A)
None
 1.21A 5b8hA-3ingA:
undetectable
5b8hB-3ingA:
undetectable		 5b8hA-3ingA:
22.28
5b8hB-3ingA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G5G_C_ACTC1740_0
(PUTATIVE XANTHINE
DEHYDROGENASE YAGS
FAD-BINDING SUBUNIT)		 3ing HOMOSERINE
DEHYDROGENASE
(Thermoplasma
acidophilum) 		4 / 4 VAL A 251
GLU A 253
GLY A 168
LEU A 276
 None
 1.36A 5g5gC-3ingA:
undetectable		 5g5gC-3ingA:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_B_SAMB301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))		 3ing HOMOSERINE
DEHYDROGENASE
(Thermoplasma
acidophilum) 		5 / 12 ALA A 213
ASP A 303
GLY A 285
SER A 299
TYR A 286
 None
 1.29A 5hfjB-3ingA:
undetectable		 5hfjB-3ingA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_F_SAMF301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))		 3ing HOMOSERINE
DEHYDROGENASE
(Thermoplasma
acidophilum) 		5 / 12 ALA A 213
ASP A 303
GLY A 285
SER A 299
TYR A 286
 None
 1.28A 5hfjF-3ingA:
undetectable		 5hfjF-3ingA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HWA_A_GCSA302_1
(CHITOSANASE)		 3ing HOMOSERINE
DEHYDROGENASE
(Thermoplasma
acidophilum) 		4 / 7 THR A  89
ASP A  87
TYR A 102
GLY A 119
 NDP  A 326 (-4.6A)
None
None
None
 0.97A 5hwaA-3ingA:
undetectable		 5hwaA-3ingA:
23.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNE_A_ACRA602_2
(-)		 3ing HOMOSERINE
DEHYDROGENASE
(Thermoplasma
acidophilum) 		4 / 6 TYR A 302
ASN A  17
TYR A 306
GLU A  61
 None
 1.49A 6gneA-3ingA:
3.3		 6gneA-3ingA:
22.38