SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3inp'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A58_B_RBFB301_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 3inp D-RIBULOSE-PHOSPHATE
3-EPIMERASE
(Francisella
tularensis) 		5 / 12 ILE A  10
LEU A  11
HIS A  68
GLY A  49
LEU A  46
 None
 1.30A 2a58A-3inpA:
undetectable
2a58B-3inpA:
undetectable		 2a58A-3inpA:
21.60
2a58B-3inpA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A58_C_RBFC302_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 3inp D-RIBULOSE-PHOSPHATE
3-EPIMERASE
(Francisella
tularensis) 		5 / 12 ILE A  10
LEU A  11
HIS A  68
GLY A  49
LEU A  46
 None
 1.30A 2a58B-3inpA:
undetectable
2a58C-3inpA:
undetectable		 2a58B-3inpA:
21.60
2a58C-3inpA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A58_E_RBFE304_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 3inp D-RIBULOSE-PHOSPHATE
3-EPIMERASE
(Francisella
tularensis) 		5 / 12 ILE A  10
LEU A  11
HIS A  68
GLY A  49
LEU A  46
 None
 1.30A 2a58D-3inpA:
undetectable
2a58E-3inpA:
undetectable		 2a58D-3inpA:
21.60
2a58E-3inpA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J5M_A_ACTA1321_0
(CHLOROPEROXIDASE)		 3inp D-RIBULOSE-PHOSPHATE
3-EPIMERASE
(Francisella
tularensis) 		4 / 6 LEU A 174
PHE A 196
ILE A 188
ALA A 158
 None
 0.91A 2j5mA-3inpA:
undetectable		 2j5mA-3inpA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MIH_A_CUA358_0
(PEPTIDYL-GLYCINE
ALPHA-AMIDATING
MONOOXYGENASE)		 3inp D-RIBULOSE-PHOSPHATE
3-EPIMERASE
(Francisella
tularensis) 		3 / 3 HIS A  68
HIS A  92
MET A  70
 None
 0.72A 3mihA-3inpA:
undetectable		 3mihA-3inpA:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q95_A_ESLA700_1
(ESTROGEN RECEPTOR)		 3inp D-RIBULOSE-PHOSPHATE
3-EPIMERASE
(Francisella
tularensis) 		5 / 12 LEU A 174
ALA A 195
ILE A 133
GLY A 114
LEU A 137
 None
 1.12A 3q95A-3inpA:
undetectable		 3q95A-3inpA:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QGT_A_CP6A609_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3inp D-RIBULOSE-PHOSPHATE
3-EPIMERASE
(Francisella
tularensis) 		5 / 10 ILE A 185
PHE A 196
SER A 140
ILE A 138
ILE A 188
 None
 1.28A 3qgtA-3inpA:
undetectable		 3qgtA-3inpA:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLT_A_GCSA301_1
(CHITOSANASE)		 3inp D-RIBULOSE-PHOSPHATE
3-EPIMERASE
(Francisella
tularensis) 		4 / 4 ASP A  36
GLY A 144
PRO A 143
GLN A 148
 None
 1.44A 4oltA-3inpA:
0.0		 4oltA-3inpA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_2_BEZ2801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
BEZ-LEU-LEU)		 3inp D-RIBULOSE-PHOSPHATE
3-EPIMERASE
(Francisella
tularensis) 		4 / 4 LEU A 173
ARG A 170
ILE A 172
ILE A 133
 None
 1.32A 5dzk2-3inpA:
undetectable
5dzkM-3inpA:
undetectable
5dzkN-3inpA:
undetectable		 5dzk2-3inpA:
1.01
5dzkM-3inpA:
22.40
5dzkN-3inpA:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VCY_A_DB8A401_2
(MEMBRANE-ASSOCIATED
TYROSINE- AND
THREONINE-SPECIFIC
CDC2-INHIBITORY
KINASE)		 3inp D-RIBULOSE-PHOSPHATE
3-EPIMERASE
(Francisella
tularensis) 		4 / 4 VAL A 197
LEU A  11
ASN A  32
ASP A  66
 None
 1.38A 5vcyA-3inpA:
undetectable		 5vcyA-3inpA:
26.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GIQ_T_PCFT101_0
(CYTOCHROME B-C1
COMPLEX SUBUNIT 1,
MITOCHONDRIAL
CYTOCHROME B-C1
COMPLEX SUBUNIT 9
CYTOCHROME B-C1
COMPLEX SUBUNIT
RIESKE,
MITOCHONDRIAL)		 3inp D-RIBULOSE-PHOSPHATE
3-EPIMERASE
(Francisella
tularensis) 		4 / 8 ASP A  21
GLY A 179
SER A 140
VAL A 197
 None
SO4  A 226 (-3.8A)
None
None
 0.98A 6giqL-3inpA:
undetectable
6giqP-3inpA:
undetectable
6giqT-3inpA:
undetectable		 6giqL-3inpA:
19.96
6giqP-3inpA:
22.81
6giqT-3inpA:
14.29