SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3io0'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_J_TRPJ81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 3io0 ETUB PROTEIN
(Clostridium
kluyveri) 		4 / 8 ALA A 281
GLY A 221
ALA A 238
ILE A 267
 None
 0.63A 1gtnI-3io0A:
undetectable
1gtnJ-3io0A:
undetectable		 1gtnI-3io0A:
15.65
1gtnJ-3io0A:
15.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_O_TRPO81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 3io0 ETUB PROTEIN
(Clostridium
kluyveri) 		5 / 10 GLY A 122
HIS A 156
THR A 150
THR A 260
ALA A 226
 None
 1.16A 1gtnO-3io0A:
undetectable
1gtnP-3io0A:
undetectable		 1gtnO-3io0A:
15.65
1gtnP-3io0A:
15.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_Q_TRPQ81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 3io0 ETUB PROTEIN
(Clostridium
kluyveri) 		5 / 9 GLY A 122
HIS A 156
THR A 150
THR A 260
ALA A 226
 None
 1.24A 1gtnQ-3io0A:
undetectable
1gtnR-3io0A:
undetectable		 1gtnQ-3io0A:
15.65
1gtnR-3io0A:
15.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_S_TRPS81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 3io0 ETUB PROTEIN
(Clostridium
kluyveri) 		5 / 9 GLY A 155
HIS A 156
HIS A 224
ALA A 228
THR A 260
 None
 1.47A 1gtnS-3io0A:
undetectable
1gtnT-3io0A:
undetectable		 1gtnS-3io0A:
15.65
1gtnT-3io0A:
15.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PBC_A_BHAA396_0
(P-HYDROXYBENZOATE
HYDROXYLASE)		 3io0 ETUB PROTEIN
(Clostridium
kluyveri) 		5 / 10 GLY A 269
VAL A 244
LEU A 278
TYR A 200
ALA A 273
 None
 1.35A 1pbcA-3io0A:
undetectable		 1pbcA-3io0A:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PWY_E_AC2E290_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 3io0 ETUB PROTEIN
(Clostridium
kluyveri) 		5 / 10 GLY A  91
GLU A 175
VAL A  82
THR A  89
VAL A 174
 None
 1.17A 1pwyE-3io0A:
undetectable		 1pwyE-3io0A:
23.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T7I_A_017A200_2
(POL POLYPROTEIN)		 3io0 ETUB PROTEIN
(Clostridium
kluyveri) 		4 / 7 ALA A 202
GLY A 221
ILE A 222
THR A 303
 None
 0.82A 1t7iB-3io0A:
undetectable		 1t7iB-3io0A:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T7J_A_478A200_2
(POL POLYPROTEIN)		 3io0 ETUB PROTEIN
(Clostridium
kluyveri) 		4 / 7 ALA A 202
GLY A 221
ILE A 222
THR A 303
 None
 0.85A 1t7jB-3io0A:
undetectable		 1t7jB-3io0A:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V7Z_A_CRNA401_1
(CREATININE
AMIDOHYDROLASE)		 3io0 ETUB PROTEIN
(Clostridium
kluyveri) 		5 / 8 GLU A 262
HIS A 224
HIS A 156
HIS A 195
GLU A 197
 None
 1.37A 1v7zA-3io0A:
undetectable		 1v7zA-3io0A:
23.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V7Z_B_CRNB3401_1
(CREATININE
AMIDOHYDROLASE)		 3io0 ETUB PROTEIN
(Clostridium
kluyveri) 		5 / 8 GLU A 262
HIS A 224
HIS A 156
HIS A 195
GLU A 197
 None
 1.37A 1v7zB-3io0A:
undetectable		 1v7zB-3io0A:
23.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V7Z_C_CRNC4401_1
(CREATININE
AMIDOHYDROLASE)		 3io0 ETUB PROTEIN
(Clostridium
kluyveri) 		5 / 8 GLU A 262
HIS A 224
HIS A 156
HIS A 195
GLU A 197
 None
 1.37A 1v7zC-3io0A:
undetectable		 1v7zC-3io0A:
23.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V7Z_D_CRND5401_1
(CREATININE
AMIDOHYDROLASE)		 3io0 ETUB PROTEIN
(Clostridium
kluyveri) 		5 / 8 GLU A 262
HIS A 224
HIS A 156
HIS A 195
GLU A 197
 None
 1.38A 1v7zD-3io0A:
undetectable		 1v7zD-3io0A:
23.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V7Z_E_CRNE6401_1
(CREATININE
AMIDOHYDROLASE)		 3io0 ETUB PROTEIN
(Clostridium
kluyveri) 		5 / 8 GLU A 262
HIS A 224
HIS A 156
HIS A 195
GLU A 197
 None
 1.38A 1v7zE-3io0A:
undetectable		 1v7zE-3io0A:
23.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V7Z_F_CRNF7401_1
(CREATININE
AMIDOHYDROLASE)		 3io0 ETUB PROTEIN
(Clostridium
kluyveri) 		5 / 8 GLU A 262
HIS A 224
HIS A 156
HIS A 195
GLU A 197
 None
 1.38A 1v7zF-3io0A:
undetectable		 1v7zF-3io0A:
23.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DTT_A_H4BA1003_1
(HYPOTHETICAL PROTEIN
PH0634)		 3io0 ETUB PROTEIN
(Clostridium
kluyveri) 		5 / 10 HIS A 195
HIS A 224
THR A 260
GLU A 262
ASP A 149
 None
 1.42A 2dttA-3io0A:
undetectable
2dttC-3io0A:
undetectable		 2dttA-3io0A:
20.49
2dttC-3io0A:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FN1_A_SALA506_1
(SALICYLATE
SYNTHETASE, IRP9)		 3io0 ETUB PROTEIN
(Clostridium
kluyveri) 		5 / 11 ILE A 158
GLU A 197
GLY A 155
THR A 260
GLY A 157
 None
 1.09A 2fn1A-3io0A:
undetectable		 2fn1A-3io0A:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FN1_B_SALB503_1
(SALICYLATE
SYNTHETASE, IRP9)		 3io0 ETUB PROTEIN
(Clostridium
kluyveri) 		5 / 11 ILE A 158
GLU A 197
GLY A 155
THR A 260
GLY A 157
 None
 1.06A 2fn1B-3io0A:
undetectable		 2fn1B-3io0A:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WA2_B_SAMB1267_0
(NON-STRUCTURAL
PROTEIN 5)		 3io0 ETUB PROTEIN
(Clostridium
kluyveri) 		5 / 12 GLY A 157
GLY A 155
THR A 150
THR A  89
ILE A 158
 None
 0.95A 2wa2B-3io0A:
undetectable		 2wa2B-3io0A:
25.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y6R_C_CTCC1385_0
(TETX2 PROTEIN)		 3io0 ETUB PROTEIN
(Clostridium
kluyveri) 		5 / 12 ASN A 261
HIS A 224
GLY A 155
PRO A 252
GLY A 255
 None
 1.43A 2y6rC-3io0A:
undetectable		 2y6rC-3io0A:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A6J_A_CRNA303_1
(CREATININE
AMIDOHYDROLASE)		 3io0 ETUB PROTEIN
(Clostridium
kluyveri) 		5 / 8 GLU A 262
HIS A 224
HIS A 156
HIS A 195
GLU A 197
 None
 1.34A 3a6jA-3io0A:
undetectable		 3a6jA-3io0A:
23.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A6J_B_CRNB304_1
(CREATININE
AMIDOHYDROLASE)		 3io0 ETUB PROTEIN
(Clostridium
kluyveri) 		5 / 7 GLU A 262
HIS A 224
HIS A 156
HIS A 195
GLU A 197
 None
 1.35A 3a6jB-3io0A:
undetectable		 3a6jB-3io0A:
23.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A6J_C_CRNC305_1
(CREATININE
AMIDOHYDROLASE)		 3io0 ETUB PROTEIN
(Clostridium
kluyveri) 		5 / 8 GLU A 262
HIS A 224
HIS A 156
HIS A 195
GLU A 197
 None
 1.36A 3a6jC-3io0A:
undetectable		 3a6jC-3io0A:
23.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A6J_E_CRNE306_1
(CREATININE
AMIDOHYDROLASE)		 3io0 ETUB PROTEIN
(Clostridium
kluyveri) 		5 / 8 GLU A 262
HIS A 224
HIS A 156
HIS A 195
GLU A 197
 None
 1.35A 3a6jE-3io0A:
undetectable		 3a6jE-3io0A:
23.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A6J_F_CRNF307_1
(CREATININE
AMIDOHYDROLASE)		 3io0 ETUB PROTEIN
(Clostridium
kluyveri) 		5 / 8 GLU A 262
HIS A 224
HIS A 156
HIS A 195
GLU A 197
 None
 1.35A 3a6jF-3io0A:
undetectable		 3a6jF-3io0A:
23.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B0W_B_DGXB1_2
(NUCLEAR RECEPTOR
ROR-GAMMA)		 3io0 ETUB PROTEIN
(Clostridium
kluyveri) 		3 / 3 LEU A 278
VAL A 188
ARG A 282
 None
 0.73A 3b0wB-3io0A:
undetectable		 3b0wB-3io0A:
24.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACB_C_DXCC1478_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 3io0 ETUB PROTEIN
(Clostridium
kluyveri) 		4 / 6 SER A 268
THR A 248
ILE A 247
THR A 201
 None
 1.00A 4acbC-3io0A:
undetectable		 4acbC-3io0A:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMD_A_29EA603_1
(TRANSPORTER)		 3io0 ETUB PROTEIN
(Clostridium
kluyveri) 		5 / 10 PRO A 227
VAL A 230
ALA A 225
GLY A 293
GLY A 194
 None
 1.34A 4mmdA-3io0A:
undetectable		 4mmdA-3io0A:
17.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R1Z_A_AERA601_1
(CYP17A1 PROTEIN)		 3io0 ETUB PROTEIN
(Clostridium
kluyveri) 		5 / 9 ALA A 284
TYR A 249
ILE A 265
GLY A 231
ALA A 225
 None
 1.21A 4r1zA-3io0A:
undetectable		 4r1zA-3io0A:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M45_A_ACTA803_0
(ACETONE CARBOXYLASE
ALPHA SUBUNIT)		 3io0 ETUB PROTEIN
(Clostridium
kluyveri) 		4 / 4 GLU A 262
PRO A 252
ILE A 263
LEU A 264
 None
 1.18A 5m45A-3io0A:
undetectable		 5m45A-3io0A:
16.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M45_D_ACTD803_0
(ACETONE CARBOXYLASE
ALPHA SUBUNIT)		 3io0 ETUB PROTEIN
(Clostridium
kluyveri) 		4 / 4 GLU A 262
PRO A 252
ILE A 263
LEU A 264
 None
 1.20A 5m45D-3io0A:
undetectable		 5m45D-3io0A:
16.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M45_G_ACTG803_0
(ACETONE CARBOXYLASE
ALPHA SUBUNIT)		 3io0 ETUB PROTEIN
(Clostridium
kluyveri) 		4 / 4 GLU A 262
PRO A 252
ILE A 263
LEU A 264
 None
 1.16A 5m45G-3io0A:
undetectable		 5m45G-3io0A:
16.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M45_J_ACTJ803_0
(ACETONE CARBOXYLASE
ALPHA SUBUNIT)		 3io0 ETUB PROTEIN
(Clostridium
kluyveri) 		4 / 4 GLU A 262
PRO A 252
ILE A 263
LEU A 264
 None
 1.16A 5m45J-3io0A:
undetectable		 5m45J-3io0A:
16.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0X_B_SAMB501_1
(PEPTIDE
N-METHYLTRANSFERASE)		 3io0 ETUB PROTEIN
(Clostridium
kluyveri) 		3 / 3 SER A 287
ALA A 284
THR A 237
 None
 0.65A 5n0xB-3io0A:
undetectable		 5n0xB-3io0A:
18.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YW0_A_ACTA410_0
(UNCHARACTERIZED
PROTEIN KDOO)		 3io0 ETUB PROTEIN
(Clostridium
kluyveri) 		4 / 4 GLY A  91
LEU A 178
VAL A  82
GLU A 175
 None
 1.24A 5yw0A-3io0A:
undetectable		 5yw0A-3io0A:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWD_C_GLYC713_0
(DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1)		 3io0 ETUB PROTEIN
(Clostridium
kluyveri) 		3 / 3 GLN A 199
TYR A 184
ASN A 187
 None
 0.95A 6dwdC-3io0A:
undetectable		 6dwdC-3io0A:
19.24