SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3io5'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LIN_A_TFPA154_1
(CALMODULIN)		 3io5 RECOMBINATION AND
REPAIR PROTEIN
(Escherichia
virus
T4) 		4 / 7 LEU A 242
MET A  39
LEU A  43
MET A  73
 None
 0.94A 1linA-3io5A:
undetectable		 1linA-3io5A:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRL_D_TFPD207_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 3io5 RECOMBINATION AND
REPAIR PROTEIN
(Escherichia
virus
T4) 		4 / 8 SER A  67
LEU A 100
PHE A  88
LEU A 148
 PO4  A   1 (-2.9A)
None
None
None
 1.01A 1wrlC-3io5A:
undetectable
1wrlD-3io5A:
undetectable		 1wrlC-3io5A:
15.84
1wrlD-3io5A:
15.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ACK_A_EDRA999_1
(ACETYLCHOLINESTERASE)		 3io5 RECOMBINATION AND
REPAIR PROTEIN
(Escherichia
virus
T4) 		4 / 7 GLY A 146
GLU A  92
SER A 144
HIS A 195
 None
None
None
PO4  A   1 (-4.1A)
 0.98A 2ackA-3io5A:
undetectable		 2ackA-3io5A:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XKW_B_P1BB1475_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 3io5 RECOMBINATION AND
REPAIR PROTEIN
(Escherichia
virus
T4) 		5 / 12 ILE A  41
GLU A  46
ALA A 218
LEU A  58
MET A  73
 None
 1.32A 2xkwB-3io5A:
undetectable		 2xkwB-3io5A:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IJD_B_C2FB314_0
(UNCHARACTERIZED
PROTEIN)		 3io5 RECOMBINATION AND
REPAIR PROTEIN
(Escherichia
virus
T4) 		5 / 12 LEU A 145
VAL A 115
ILE A 123
LEU A 175
ILE A 178
 None
 1.13A 3ijdB-3io5A:
undetectable		 3ijdB-3io5A:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BVA_B_T3B1314_1
(THIOMORPHOLINE-CARBO
XYLATE DEHYDROGENASE)		 3io5 RECOMBINATION AND
REPAIR PROTEIN
(Escherichia
virus
T4) 		5 / 12 VAL A 110
PHE A  88
VAL A 139
PHE A 141
PRO A  97
 None
 1.43A 4bvaB-3io5A:
undetectable		 4bvaB-3io5A:
25.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZVM_B_DM2B303_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 3io5 RECOMBINATION AND
REPAIR PROTEIN
(Escherichia
virus
T4) 		5 / 11 VAL A  31
PHE A 222
GLY A  45
GLU A  46
ILE A  47
 None
 1.28A 4zvmA-3io5A:
undetectable
4zvmB-3io5A:
undetectable		 4zvmA-3io5A:
19.22
4zvmB-3io5A:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_Z_BEZZ801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
BEZ-LEU-LEU)		 3io5 RECOMBINATION AND
REPAIR PROTEIN
(Escherichia
virus
T4) 		4 / 4 ILE A  41
GLY A  50
ILE A  47
LEU A  43
 None
 0.82A 5dzkl-3io5A:
undetectable
5dzkz-3io5A:
undetectable		 5dzkl-3io5A:
23.03
5dzkz-3io5A:
6.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6R2E_A_FFOA403_0
(THYMIDYLATE SYNTHASE)		 3io5 RECOMBINATION AND
REPAIR PROTEIN
(Escherichia
virus
T4) 		5 / 12 ILE A 193
ASN A 147
LEU A 148
ASP A  90
PHE A 141
 None
 1.23A 6r2eA-3io5A:
undetectable		 6r2eA-3io5A:
21.02