SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3iom'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HBP_A_RTLA184_0
(RETINOL BINDING
PROTEIN)		 3iom PURINE NUCLEOSIDE
PHOSPHORYLASE
(Mycobacterium
tuberculosis) 		5 / 11 LEU A 224
ALA A  43
ALA A  41
VAL A 226
LEU A 260
 None
 1.14A 1hbpA-3iomA:
undetectable		 1hbpA-3iomA:
18.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1PWY_E_AC2E290_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 3iom PURINE NUCLEOSIDE
PHOSPHORYLASE
(Mycobacterium
tuberculosis) 		7 / 10 GLY A 122
GLU A 189
VAL A 205
GLY A 206
MET A 207
THR A 230
ASN A 231
 GNG  A 800 (-3.6A)
GNG  A 800 (-2.9A)
GNG  A 800 (-4.4A)
GNG  A 800 (-3.6A)
GNG  A 800 (-3.4A)
GNG  A 800 (-3.9A)
GNG  A 800 (-2.8A)
 0.52A 1pwyE-3iomA:
34.0		 1pwyE-3iomA:
38.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1PWY_E_AC2E290_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 3iom PURINE NUCLEOSIDE
PHOSPHORYLASE
(Mycobacterium
tuberculosis) 		7 / 10 GLY A 122
GLU A 189
VAL A 205
GLY A 206
THR A 230
ASN A 231
HIS A 243
 GNG  A 800 (-3.6A)
GNG  A 800 (-2.9A)
GNG  A 800 (-4.4A)
GNG  A 800 (-3.6A)
GNG  A 800 (-3.9A)
GNG  A 800 (-2.8A)
GNG  A 800 (-3.3A)
 0.73A 1pwyE-3iomA:
34.0		 1pwyE-3iomA:
38.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_C_FUAC701_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 3iom PURINE NUCLEOSIDE
PHOSPHORYLASE
(Mycobacterium
tuberculosis) 		4 / 4 ALA A  31
VAL A 104
ALA A 107
HIS A  28
 None
 1.20A 1q23A-3iomA:
undetectable		 1q23A-3iomA:
20.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1V3Q_E_2DIE290_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 3iom PURINE NUCLEOSIDE
PHOSPHORYLASE
(Mycobacterium
tuberculosis) 		7 / 10 GLY A 122
GLU A 189
VAL A 205
GLY A 206
MET A 207
THR A 230
ASN A 231
 GNG  A 800 (-3.6A)
GNG  A 800 (-2.9A)
GNG  A 800 (-4.4A)
GNG  A 800 (-3.6A)
GNG  A 800 (-3.4A)
GNG  A 800 (-3.9A)
GNG  A 800 (-2.8A)
 0.37A 1v3qE-3iomA:
33.3		 1v3qE-3iomA:
38.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1V3Q_E_2DIE290_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 3iom PURINE NUCLEOSIDE
PHOSPHORYLASE
(Mycobacterium
tuberculosis) 		7 / 10 GLY A 122
GLU A 189
VAL A 205
GLY A 206
THR A 230
ASN A 231
HIS A 243
 GNG  A 800 (-3.6A)
GNG  A 800 (-2.9A)
GNG  A 800 (-4.4A)
GNG  A 800 (-3.6A)
GNG  A 800 (-3.9A)
GNG  A 800 (-2.8A)
GNG  A 800 (-3.3A)
 0.59A 1v3qE-3iomA:
33.3		 1v3qE-3iomA:
38.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJF_A_ADNA2001_1
(235AA LONG
HYPOTHETICAL
BIOTIN--[ACETYL-COA-
CARBOXYLASE] LIGASE)		 3iom PURINE NUCLEOSIDE
PHOSPHORYLASE
(Mycobacterium
tuberculosis) 		4 / 7 ARG A 217
GLU A 212
ALA A 112
ALA A  31
 None
 1.07A 2ejfA-3iomA:
undetectable		 2ejfA-3iomA:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q9R_A_BEZA203_0
(PROTEIN OF UNKNOWN
FUNCTION)		 3iom PURINE NUCLEOSIDE
PHOSPHORYLASE
(Mycobacterium
tuberculosis) 		4 / 5 LEU A 232
GLY A 122
ILE A 194
ILE A 236
 None
GNG  A 800 (-3.6A)
None
None
 0.75A 2q9rA-3iomA:
undetectable		 2q9rA-3iomA:
23.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3E9R_A_ACTA700_0
(PURINE-NUCLEOSIDE
PHOSPHORYLASE)		 3iom PURINE NUCLEOSIDE
PHOSPHORYLASE
(Mycobacterium
tuberculosis) 		6 / 6 GLY A 122
TYR A 188
GLU A 189
GLY A 206
MET A 207
ASN A 231
 GNG  A 800 (-3.6A)
GNG  A 800 (-4.6A)
GNG  A 800 (-2.9A)
GNG  A 800 (-3.6A)
GNG  A 800 (-3.4A)
GNG  A 800 (-2.8A)
 0.65A 3e9rA-3iomA:
32.3		 3e9rA-3iomA:
34.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3E9R_C_ACTC700_0
(PURINE-NUCLEOSIDE
PHOSPHORYLASE)		 3iom PURINE NUCLEOSIDE
PHOSPHORYLASE
(Mycobacterium
tuberculosis) 		6 / 6 GLY A 122
TYR A 188
GLU A 189
GLY A 206
MET A 207
ASN A 231
 GNG  A 800 (-3.6A)
GNG  A 800 (-4.6A)
GNG  A 800 (-2.9A)
GNG  A 800 (-3.6A)
GNG  A 800 (-3.4A)
GNG  A 800 (-2.8A)
 0.65A 3e9rC-3iomA:
32.7		 3e9rC-3iomA:
34.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3F8W_A_ADNA300_1
(PURINE-NUCLEOSIDE
PHOSPHORYLASE)		 3iom PURINE NUCLEOSIDE
PHOSPHORYLASE
(Mycobacterium
tuberculosis) 		12 / 12 SER A  36
TYR A  92
ALA A 120
GLY A 122
TYR A 188
GLU A 189
VAL A 205
GLY A 206
MET A 207
ASN A 231
HIS A 243
VAL A 246
 SO4  A 301 ( 2.2A)
None
GNG  A 800 (-3.3A)
GNG  A 800 (-3.6A)
GNG  A 800 (-4.6A)
GNG  A 800 (-2.9A)
GNG  A 800 (-4.4A)
GNG  A 800 (-3.6A)
GNG  A 800 (-3.4A)
GNG  A 800 (-2.8A)
GNG  A 800 (-3.3A)
GNG  A 800 (-4.2A)
 0.53A 3f8wA-3iomA:
33.6		 3f8wA-3iomA:
34.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3F8W_B_ADNB301_1
(PURINE-NUCLEOSIDE
PHOSPHORYLASE)		 3iom PURINE NUCLEOSIDE
PHOSPHORYLASE
(Mycobacterium
tuberculosis) 		5 / 12 GLY A 206
TYR A 188
GLU A 189
GLY A 185
HIS A 243
 GNG  A 800 (-3.6A)
GNG  A 800 (-4.6A)
GNG  A 800 (-2.9A)
None
GNG  A 800 (-3.3A)
 1.30A 3f8wB-3iomA:
33.1		 3f8wB-3iomA:
34.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3F8W_B_ADNB301_1
(PURINE-NUCLEOSIDE
PHOSPHORYLASE)		 3iom PURINE NUCLEOSIDE
PHOSPHORYLASE
(Mycobacterium
tuberculosis) 		12 / 12 SER A  36
HIS A  90
TYR A  92
GLY A 122
TYR A 188
GLU A 189
VAL A 205
GLY A 206
MET A 207
ASN A 231
HIS A 243
VAL A 246
 SO4  A 301 ( 2.2A)
SO4  A 301 (-3.3A)
None
GNG  A 800 (-3.6A)
GNG  A 800 (-4.6A)
GNG  A 800 (-2.9A)
GNG  A 800 (-4.4A)
GNG  A 800 (-3.6A)
GNG  A 800 (-3.4A)
GNG  A 800 (-2.8A)
GNG  A 800 (-3.3A)
GNG  A 800 (-4.2A)
 0.52A 3f8wB-3iomA:
33.1		 3f8wB-3iomA:
34.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3F8W_C_ADNC302_1
(PURINE-NUCLEOSIDE
PHOSPHORYLASE)		 3iom PURINE NUCLEOSIDE
PHOSPHORYLASE
(Mycobacterium
tuberculosis) 		5 / 12 HIS A 139
TYR A 160
ALA A 215
GLY A 220
VAL A 104
 None
 1.06A 3f8wC-3iomA:
33.5		 3f8wC-3iomA:
34.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3F8W_C_ADNC302_1
(PURINE-NUCLEOSIDE
PHOSPHORYLASE)		 3iom PURINE NUCLEOSIDE
PHOSPHORYLASE
(Mycobacterium
tuberculosis) 		12 / 12 SER A  36
HIS A  90
TYR A  92
ALA A 120
GLY A 122
TYR A 188
GLU A 189
VAL A 205
GLY A 206
MET A 207
ASN A 231
VAL A 246
 SO4  A 301 ( 2.2A)
SO4  A 301 (-3.3A)
None
GNG  A 800 (-3.3A)
GNG  A 800 (-3.6A)
GNG  A 800 (-4.6A)
GNG  A 800 (-2.9A)
GNG  A 800 (-4.4A)
GNG  A 800 (-3.6A)
GNG  A 800 (-3.4A)
GNG  A 800 (-2.8A)
GNG  A 800 (-4.2A)
 0.49A 3f8wC-3iomA:
33.5		 3f8wC-3iomA:
34.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KM6_B_EAAB222_1
(GLUTATHIONE
S-TRANSFERASE P)		 3iom PURINE NUCLEOSIDE
PHOSPHORYLASE
(Mycobacterium
tuberculosis) 		5 / 9 TYR A 180
VAL A 205
GLN A 132
VAL A 246
GLY A 122
 None
GNG  A 800 (-4.4A)
None
GNG  A 800 (-4.2A)
GNG  A 800 (-3.6A)
 1.45A 3km6B-3iomA:
undetectable		 3km6B-3iomA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDV_A_CL6A506_1
(CHOLESTEROL
24-HYDROXYLASE)		 3iom PURINE NUCLEOSIDE
PHOSPHORYLASE
(Mycobacterium
tuberculosis) 		5 / 9 LEU A 117
VAL A 104
LEU A 164
ILE A 114
GLU A 222
 None
 1.02A 3mdvA-3iomA:
undetectable		 3mdvA-3iomA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PHN_A_ACTA108_0
(PROTEIN P-30)		 3iom PURINE NUCLEOSIDE
PHOSPHORYLASE
(Mycobacterium
tuberculosis) 		3 / 3 THR A  49
SER A  74
ARG A  81
 None
 0.78A 3phnA-3iomA:
undetectable		 3phnA-3iomA:
16.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ODO_B_FK5B203_2
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
SLYD)		 3iom PURINE NUCLEOSIDE
PHOSPHORYLASE
(Mycobacterium
tuberculosis) 		3 / 3 ALA A 110
GLN A  54
GLY A  70
 None
 0.47A 4odoC-3iomA:
undetectable		 4odoC-3iomA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UUU_A_SAMA1546_0
(CYSTATHIONINE
BETA-SYNTHASE)		 3iom PURINE NUCLEOSIDE
PHOSPHORYLASE
(Mycobacterium
tuberculosis) 		5 / 11 LEU A 142
ASP A 138
ALA A 181
VAL A 210
THR A 213
 None
 1.22A 4uuuA-3iomA:
undetectable
4uuuB-3iomA:
undetectable		 4uuuA-3iomA:
22.91
4uuuB-3iomA:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UUU_B_SAMB1548_0
(CYSTATHIONINE
BETA-SYNTHASE)		 3iom PURINE NUCLEOSIDE
PHOSPHORYLASE
(Mycobacterium
tuberculosis) 		5 / 11 LEU A 142
ASP A 138
ALA A 181
VAL A 210
THR A 213
 None
 1.16A 4uuuB-3iomA:
undetectable		 4uuuB-3iomA:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WNW_A_RTZA602_1
(CYTOCHROME P450 2D6)		 3iom PURINE NUCLEOSIDE
PHOSPHORYLASE
(Mycobacterium
tuberculosis) 		5 / 12 PHE A 268
GLY A 258
LEU A 261
VAL A 226
VAL A  30
 None
 1.22A 4wnwA-3iomA:
undetectable		 4wnwA-3iomA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L6E_B_ACTB401_0
(N6-ADENOSINE-METHYLT
RANSFERASE 70 KDA
SUBUNIT
N6-ADENOSINE-METHYLT
RANSFERASE SUBUNIT
METTL14)		 3iom PURINE NUCLEOSIDE
PHOSPHORYLASE
(Mycobacterium
tuberculosis) 		4 / 6 GLU A 222
ARG A 217
ARG A 165
ARG A 163
 None
 1.24A 5l6eA-3iomA:
1.6
5l6eB-3iomA:
undetectable		 5l6eA-3iomA:
24.06
5l6eB-3iomA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X6Y_A_SAMA901_0
(MRNA CAPPING ENZYME
P5)		 3iom PURINE NUCLEOSIDE
PHOSPHORYLASE
(Mycobacterium
tuberculosis) 		5 / 11 GLY A 206
SER A 227
ASP A 203
ALA A 202
LEU A 140
 GNG  A 800 (-3.6A)
None
None
None
None
 1.24A 5x6yA-3iomA:
undetectable		 5x6yA-3iomA:
16.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIO_A_HFGA801_0
(PROLINE-TRNA
SYNTHETASE CLASS II
AARS (YBAK RNA
BINDING DOMAIN PLUS
TRNA SYNTHETASE))		 3iom PURINE NUCLEOSIDE
PHOSPHORYLASE
(Mycobacterium
tuberculosis) 		5 / 12 GLU A  93
PRO A 186
GLU A 189
THR A 230
GLY A 122
 None
None
GNG  A 800 (-2.9A)
GNG  A 800 (-3.9A)
GNG  A 800 (-3.6A)
 1.30A 5xioA-3iomA:
undetectable		 5xioA-3iomA:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XOO_B_ADNB503_1
(GLYCOSAMINOGLYCAN
XYLOSYLKINASE)		 3iom PURINE NUCLEOSIDE
PHOSPHORYLASE
(Mycobacterium
tuberculosis) 		4 / 5 TRP A  38
LEU A  34
VAL A  32
LEU A  45
 None
 0.74A 5xooB-3iomA:
undetectable		 5xooB-3iomA:
14.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XXI_A_LSNA503_1
(CYTOCHROME P450 2C9)		 3iom PURINE NUCLEOSIDE
PHOSPHORYLASE
(Mycobacterium
tuberculosis) 		5 / 12 ILE A  77
LEU A 117
LEU A  39
PRO A  40
LEU A  45
 None
 1.23A 5xxiA-3iomA:
undetectable		 5xxiA-3iomA:
19.51