SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3iox'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P93_A_DEXA1999_1
(GLUCOCORTICOID
RECEPTOR)		 3iox AGI/II
(Streptococcus
mutans) 		5 / 12 LEU A 599
LEU A 600
GLY A 525
GLN A 604
GLN A 563
 None
 1.50A 1p93A-3ioxA:
undetectable		 1p93A-3ioxA:
18.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RL8_A_RITA9001_2
(PROTEASE RETROPEPSIN)		 3iox AGI/II
(Streptococcus
mutans) 		5 / 12 LEU A 645
GLY A 654
ASP A 650
ALA A 606
ILE A 647
 None
 0.83A 1rl8B-3ioxA:
undetectable		 1rl8B-3ioxA:
11.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ROX_B_T44B128_1
(TRANSTHYRETIN)		 3iox AGI/II
(Streptococcus
mutans) 		5 / 6 LYS A 642
LEU A 599
GLU A 601
LEU A 561
THR A 661
 None
 1.41A 2roxB-3ioxA:
undetectable		 2roxB-3ioxA:
14.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEU_D_KAND301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 3iox AGI/II
(Streptococcus
mutans) 		4 / 8 ASP A 760
ASP A 554
ASP A 555
ASN A 699
 PMS  A 900 (-3.6A)
None
None
CA  A 903 (-3.1A)
 1.09A 4feuD-3ioxA:
undetectable		 4feuD-3ioxA:
16.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GRQ_C_AVLC203_1
(MACROPHAGE MIGRATION
INHIBITORY FACTOR)		 3iox AGI/II
(Streptococcus
mutans) 		4 / 7 TYR A 392
PRO A 871
GLN A 400
TYR A 399
 None
 1.46A 4grqA-3ioxA:
undetectable
4grqC-3ioxA:
undetectable		 4grqA-3ioxA:
13.09
4grqC-3ioxA:
13.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QOI_B_ML1B303_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 3iox AGI/II
(Streptococcus
mutans) 		5 / 11 GLY A 821
GLY A 620
ILE A 623
PHE A 678
PHE A 688
 None
 1.00A 4qoiA-3ioxA:
undetectable
4qoiB-3ioxA:
undetectable		 4qoiA-3ioxA:
17.76
4qoiB-3ioxA:
17.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZDY_A_1YNA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 3iox AGI/II
(Streptococcus
mutans) 		5 / 12 GLY A 662
GLY A 575
THR A 585
LEU A 553
THR A 541
 None
 1.22A 4zdyA-3ioxA:
undetectable		 4zdyA-3ioxA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BKL_G_EU7G101_0
(MATRIX PROTEIN 2)		 3iox AGI/II
(Streptococcus
mutans) 		5 / 9 ALA A 696
GLY A 772
ALA A 732
SER A 722
GLY A 724
 PMS  A 900 ( 4.8A)
None
None
None
None
 1.07A 6bklE-3ioxA:
undetectable
6bklF-3ioxA:
undetectable
6bklG-3ioxA:
undetectable
6bklH-3ioxA:
undetectable		 6bklE-3ioxA:
3.67
6bklF-3ioxA:
3.67
6bklG-3ioxA:
3.67
6bklH-3ioxA:
3.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6E8Q_A_X2NA602_0
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 3iox AGI/II
(Streptococcus
mutans) 		5 / 12 GLY A 662
GLY A 575
THR A 585
LEU A 553
THR A 541
 None
 1.18A 6e8qA-3ioxA:
undetectable		 6e8qA-3ioxA:
11.32