SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3ioy'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CBS_A_REAA200_1
(CELLULAR RETINOIC
ACID BINDING PROTEIN
TYPE II)		 3ioy SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE SDR
(Novosphingobium
aromaticivorans) 		5 / 12 PHE A 127
LEU A  89
ALA A  76
VAL A  62
ARG A 130
 None
 1.11A 1cbsA-3ioyA:
undetectable		 1cbsA-3ioyA:
17.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UAY_A_ADNA1001_1
(TYPE II
3-HYDROXYACYL-COA
DEHYDROGENASE)		 3ioy SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE SDR
(Novosphingobium
aromaticivorans) 		8 / 11 GLY A  13
ALA A  15
ASP A  37
ASP A  65
VAL A  66
ALA A  93
VAL A  95
VAL A 115
 None
 0.56A 1uayA-3ioyA:
25.6		 1uayA-3ioyA:
28.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UAY_B_ADNB1002_1
(TYPE II
3-HYDROXYACYL-COA
DEHYDROGENASE)		 3ioy SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE SDR
(Novosphingobium
aromaticivorans) 		8 / 10 GLY A  13
ALA A  15
ASP A  37
ASP A  65
VAL A  66
ALA A  93
VAL A  95
VAL A 115
 None
 0.51A 1uayB-3ioyA:
25.9		 1uayB-3ioyA:
28.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V8B_A_ADNA502_2
(ADENOSYLHOMOCYSTEINA
SE)		 3ioy SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE SDR
(Novosphingobium
aromaticivorans) 		3 / 3 GLU A 274
GLU A 266
LEU A 155
 None
 0.57A 1v8bA-3ioyA:
6.6		 1v8bA-3ioyA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BM9_E_SAME301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 3ioy SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE SDR
(Novosphingobium
aromaticivorans) 		5 / 12 GLY A  13
ASP A  37
ASP A  65
ASN A  92
ALA A  93
 None
 0.95A 2bm9E-3ioyA:
6.1		 2bm9E-3ioyA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2H42_C_VIAC903_2
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 3ioy SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE SDR
(Novosphingobium
aromaticivorans) 		3 / 3 ASN A  91
ILE A 254
MET A 247
 None
 0.78A 2h42C-3ioyA:
undetectable		 2h42C-3ioyA:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YJA_B_ESTB1550_1
(ESTROGEN RECEPTOR)		 3ioy SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE SDR
(Novosphingobium
aromaticivorans) 		5 / 12 ALA A   9
LEU A  26
LEU A  27
ILE A  20
GLY A  19
 None
 1.14A 2yjaB-3ioyA:
undetectable		 2yjaB-3ioyA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AY0_A_ADNA401_1
(UNCHARACTERIZED
PROTEIN MJ0883)		 3ioy SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE SDR
(Novosphingobium
aromaticivorans) 		5 / 10 ASP A  37
ILE A  38
ALA A  15
ASP A  65
VAL A  66
 None
 1.07A 3ay0A-3ioyA:
7.8		 3ay0A-3ioyA:
23.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AY0_B_ADNB402_1
(UNCHARACTERIZED
PROTEIN MJ0883)		 3ioy SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE SDR
(Novosphingobium
aromaticivorans) 		5 / 10 GLY A  14
ASP A  37
ILE A  38
ASP A  65
VAL A  66
 None
 1.07A 3ay0B-3ioyA:
7.9		 3ay0B-3ioyA:
23.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_A_CHDA151_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 3ioy SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE SDR
(Novosphingobium
aromaticivorans) 		4 / 7 ILE A  43
GLY A  13
VAL A  79
LEU A  50
 None
 0.86A 3elzA-3ioyA:
undetectable		 3elzA-3ioyA:
18.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q1E_D_T44D328_1
(5-HYDROXYISOURATE
HYDROLASE)		 3ioy SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE SDR
(Novosphingobium
aromaticivorans) 		5 / 9 HIS A 253
LEU A 252
LEU A 173
LEU A 177
SER A 180
 None
 1.35A 3q1eB-3ioyA:
undetectable
3q1eD-3ioyA:
undetectable		 3q1eB-3ioyA:
16.50
3q1eD-3ioyA:
16.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q95_A_ESLA700_1
(ESTROGEN RECEPTOR)		 3ioy SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE SDR
(Novosphingobium
aromaticivorans) 		5 / 12 ALA A   9
LEU A  26
LEU A  27
ILE A  20
GLY A  19
 None
 1.11A 3q95A-3ioyA:
undetectable		 3q95A-3ioyA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGL_A_CLQA303_0
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 3ioy SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE SDR
(Novosphingobium
aromaticivorans) 		5 / 12 GLY A 187
MET A 131
VAL A 243
PHE A   4
ILE A  88
 None
 1.28A 4fglA-3ioyA:
6.4
4fglB-3ioyA:
5.9		 4fglA-3ioyA:
22.51
4fglB-3ioyA:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KLR_B_CHDB503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 3ioy SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE SDR
(Novosphingobium
aromaticivorans) 		4 / 8 PRO A 193
SER A 256
LYS A 167
VAL A 170
 None
 0.98A 4klrB-3ioyA:
3.3		 4klrB-3ioyA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AXD_A_RBVA502_2
(ADENOSYLHOMOCYSTEINA
SE)		 3ioy SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE SDR
(Novosphingobium
aromaticivorans) 		3 / 3 THR A 148
HIS A 230
LEU A 195
 None
 0.82A 5axdA-3ioyA:
7.2		 5axdA-3ioyA:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DXB_B_ESTB601_1
(ESTROGEN RECEPTOR)		 3ioy SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE SDR
(Novosphingobium
aromaticivorans) 		5 / 11 ALA A   9
LEU A  26
LEU A  27
ILE A  20
GLY A  19
 None
 1.16A 5dxbB-3ioyA:
undetectable		 5dxbB-3ioyA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_A_ID8A601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3ioy SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE SDR
(Novosphingobium
aromaticivorans) 		5 / 12 VAL A 170
LEU A 173
SER A 174
VAL A 124
GLY A 123
 None
 1.14A 5ikrA-3ioyA:
undetectable		 5ikrA-3ioyA:
18.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XXI_A_LSNA501_1
(CYTOCHROME P450 2C9)		 3ioy SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE SDR
(Novosphingobium
aromaticivorans) 		5 / 12 ALA A  75
GLY A  13
ALA A  15
LEU A  50
LEU A  47
 None
 1.06A 5xxiA-3ioyA:
undetectable		 5xxiA-3ioyA:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YBB_A_SAMA601_0
(TYPE I
RESTRICTION-MODIFICA
TION SYSTEM
METHYLTRANSFERASE
SUBUNIT)		 3ioy SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE SDR
(Novosphingobium
aromaticivorans) 		5 / 12 GLY A 240
GLY A  21
LEU A   1
ASN A  28
PHE A   4
 None
 1.07A 5ybbA-3ioyA:
5.3		 5ybbA-3ioyA:
23.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A94_A_ZOTA3001_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		 3ioy SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE SDR
(Novosphingobium
aromaticivorans) 		5 / 12 SER A 180
VAL A 170
GLY A 172
SER A 176
ASN A 147
 None
 1.35A 6a94A-3ioyA:
undetectable		 6a94A-3ioyA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWN_A_AQ4A602_0
(CYTOCHROME P450 1A1)		 3ioy SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE SDR
(Novosphingobium
aromaticivorans) 		5 / 12 SER A 256
ASN A  16
ASN A  92
GLY A 240
ASP A 237
 None
 1.36A 6dwnA-3ioyA:
undetectable		 6dwnA-3ioyA:
14.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NKN_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3ioy SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE SDR
(Novosphingobium
aromaticivorans) 		3 / 3 ARG A 134
PHE A  83
PHE A 127
 None
 0.91A 6nknC-3ioyA:
1.8
6nknJ-3ioyA:
undetectable		 6nknC-3ioyA:
19.94
6nknJ-3ioyA:
13.00