SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3ip3'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWJ_B_BAXB1723_2
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 3ip3 OXIDOREDUCTASE,
PUTATIVE
(Thermotoga
maritima) 		3 / 3 ILE A 312
ASP A 305
PHE A 126
 None
 0.65A 1uwjB-3ip3A:
undetectable		 1uwjB-3ip3A:
23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HA4_A_ACHA546_0
(ACETYLCHOLINESTERASE)		 3ip3 OXIDOREDUCTASE,
PUTATIVE
(Thermotoga
maritima) 		4 / 8 TYR A 236
GLU A  96
HIS A  12
GLY A  11
 None
 1.13A 2ha4A-3ip3A:
undetectable		 2ha4A-3ip3A:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HA4_B_ACHB603_0
(ACETYLCHOLINESTERASE)		 3ip3 OXIDOREDUCTASE,
PUTATIVE
(Thermotoga
maritima) 		4 / 7 TYR A 236
GLU A  96
HIS A  12
GLY A  11
 None
 1.15A 2ha4B-3ip3A:
2.4		 2ha4B-3ip3A:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PNC_A_CLUA808_1
(COPPER AMINE
OXIDASE, LIVER
ISOZYME)		 3ip3 OXIDOREDUCTASE,
PUTATIVE
(Thermotoga
maritima) 		4 / 7 TYR A  15
ASP A 246
TYR A 158
HIS A 183
 None
 1.37A 2pncA-3ip3A:
undetectable		 2pncA-3ip3A:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2UZ2_A_ACTA1123_0
(XENAVIDIN)		 3ip3 OXIDOREDUCTASE,
PUTATIVE
(Thermotoga
maritima) 		4 / 7 LEU A  78
SER A  77
THR A 172
VAL A  75
 None
 1.10A 2uz2A-3ip3A:
undetectable		 2uz2A-3ip3A:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JZ0_B_CLYB900_1
(LINCOSAMIDE
NUCLEOTIDYLTRANSFERA
SE)		 3ip3 OXIDOREDUCTASE,
PUTATIVE
(Thermotoga
maritima) 		4 / 8 TYR A 173
TYR A 167
TYR A 158
PHE A  76
 None
 1.02A 3jz0B-3ip3A:
undetectable		 3jz0B-3ip3A:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_K_TFPK202_1
(PROTEIN S100-A4)		 3ip3 OXIDOREDUCTASE,
PUTATIVE
(Thermotoga
maritima) 		5 / 12 SER A 111
ILE A 307
GLU A 107
LEU A 106
ASP A 105
 None
 1.18A 3ko0K-3ip3A:
undetectable
3ko0L-3ip3A:
undetectable
3ko0S-3ip3A:
undetectable
3ko0T-3ip3A:
undetectable		 3ko0K-3ip3A:
16.94
3ko0L-3ip3A:
16.94
3ko0S-3ip3A:
16.94
3ko0T-3ip3A:
16.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_L_TFPL202_1
(PROTEIN S100-A4)		 3ip3 OXIDOREDUCTASE,
PUTATIVE
(Thermotoga
maritima) 		5 / 12 GLU A 107
LEU A 106
ASP A 105
SER A 111
ILE A 307
 None
 1.21A 3ko0K-3ip3A:
undetectable
3ko0L-3ip3A:
undetectable
3ko0M-3ip3A:
undetectable
3ko0N-3ip3A:
undetectable		 3ko0K-3ip3A:
16.94
3ko0L-3ip3A:
16.94
3ko0M-3ip3A:
16.94
3ko0N-3ip3A:
16.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MYU_A_VIBA500_1
(HIGH AFFINITY
TRANSPORT SYSTEM
PROTEIN P37)		 3ip3 OXIDOREDUCTASE,
PUTATIVE
(Thermotoga
maritima) 		5 / 10 ASP A 186
ASP A 248
TRP A 187
ILE A 182
GLY A 181
 None
 1.48A 3myuA-3ip3A:
0.2		 3myuA-3ip3A:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MYU_B_VIBB500_1
(HIGH AFFINITY
TRANSPORT SYSTEM
PROTEIN P37)		 3ip3 OXIDOREDUCTASE,
PUTATIVE
(Thermotoga
maritima) 		5 / 10 ASP A 186
ASP A 248
TRP A 187
ILE A 182
GLY A 181
 None
 1.48A 3myuB-3ip3A:
0.2		 3myuB-3ip3A:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SNF_A_ACTA110_0
(PROTEIN P-30)		 3ip3 OXIDOREDUCTASE,
PUTATIVE
(Thermotoga
maritima) 		4 / 5 ILE A 182
THR A 309
SER A 306
PHE A 126
 None
 1.18A 3snfA-3ip3A:
undetectable		 3snfA-3ip3A:
17.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZOF_A_HQEA200_1
(FLAVOREDOXIN)		 3ip3 OXIDOREDUCTASE,
PUTATIVE
(Thermotoga
maritima) 		4 / 5 TYR A 236
VAL A 180
TRP A 179
HIS A  12
 None
 1.29A 3zofA-3ip3A:
0.0		 3zofA-3ip3A:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZOF_B_HQEB200_1
(FLAVOREDOXIN)		 3ip3 OXIDOREDUCTASE,
PUTATIVE
(Thermotoga
maritima) 		4 / 5 TYR A 236
VAL A 180
TRP A 179
HIS A  12
 None
 1.27A 3zofB-3ip3A:
0.0		 3zofB-3ip3A:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FIA_A_0U9A601_1
(CHOLESTEROL
24-HYDROXYLASE)		 3ip3 OXIDOREDUCTASE,
PUTATIVE
(Thermotoga
maritima) 		5 / 12 VAL A 301
ARG A 110
ALA A 124
GLU A 311
THR A 310
 None
 1.27A 4fiaA-3ip3A:
undetectable		 4fiaA-3ip3A:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FIA_A_198A602_1
(CHOLESTEROL
24-HYDROXYLASE)		 3ip3 OXIDOREDUCTASE,
PUTATIVE
(Thermotoga
maritima) 		5 / 12 VAL A 301
ARG A 110
ALA A 124
GLU A 311
THR A 310
 None
 1.27A 4fiaA-3ip3A:
undetectable		 4fiaA-3ip3A:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G19_D_ACTD302_0
(GLUTATHIONE
TRANSFERASE GTE1)		 3ip3 OXIDOREDUCTASE,
PUTATIVE
(Thermotoga
maritima) 		3 / 3 TYR A 236
PHE A  76
ARG A 163
 None
 1.10A 4g19D-3ip3A:
undetectable		 4g19D-3ip3A:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PD9_A_ADNA501_2
(NUPC FAMILY PROTEIN)		 3ip3 OXIDOREDUCTASE,
PUTATIVE
(Thermotoga
maritima) 		3 / 3 THR A 309
ASN A  79
PHE A  76
 None
 0.79A 4pd9A-3ip3A:
undetectable		 4pd9A-3ip3A:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RYA_A_MTLA501_1
(ABC TRANSPORTER
SUBSTRATE BINDING
PROTEIN (SORBITOL))		 3ip3 OXIDOREDUCTASE,
PUTATIVE
(Thermotoga
maritima) 		3 / 3 GLU A 292
TYR A 113
GLU A 304
 None
 0.59A 4ryaA-3ip3A:
undetectable		 4ryaA-3ip3A:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4USW_A_ACTA1470_0
(ADENYLATE CYCLASE
TYPE 10)		 3ip3 OXIDOREDUCTASE,
PUTATIVE
(Thermotoga
maritima) 		4 / 6 LEU A 224
LEU A 151
VAL A 152
PHE A 229
 None
 0.88A 4uswA-3ip3A:
undetectable		 4uswA-3ip3A:
22.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EML_A_SAMA701_1
(PROTEIN ARGININE
N-METHYLTRANSFERASE
5)		 3ip3 OXIDOREDUCTASE,
PUTATIVE
(Thermotoga
maritima) 		4 / 6 LYS A 156
TYR A 158
GLY A 127
ASP A 288
 None
 1.31A 5emlA-3ip3A:
2.3		 5emlA-3ip3A:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IWU_A_ERYA404_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 3ip3 OXIDOREDUCTASE,
PUTATIVE
(Thermotoga
maritima) 		4 / 6 GLY A  11
ASP A 248
ILE A 234
TYR A 236
 None
 0.90A 5iwuA-3ip3A:
undetectable		 5iwuA-3ip3A:
23.55