SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3ipc'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AEG_A_4APA296_1
(CYTOCHROME C
PEROXIDASE)
3ipc ABC TRANSPORTER,
SUBSTRATE BINDING
PROTEIN (AMINO ACID)

(Agrobacterium
fabrum)
4 / 8 GLY A 249
THR A 247
LEU A 154
ASP A 121
None
0.86A 1aegA-3ipcA:
undetectable
1aegA-3ipcA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FBY_A_9CRA500_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)
3ipc ABC TRANSPORTER,
SUBSTRATE BINDING
PROTEIN (AMINO ACID)

(Agrobacterium
fabrum)
5 / 12 ILE A 286
ALA A 289
ALA A 290
LEU A 305
ALA A 304
None
0.71A 1fbyA-3ipcA:
undetectable
1fbyA-3ipcA:
23.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FBY_B_9CRB1500_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)
3ipc ABC TRANSPORTER,
SUBSTRATE BINDING
PROTEIN (AMINO ACID)

(Agrobacterium
fabrum)
5 / 12 ILE A 286
ALA A 289
ALA A 290
LEU A 305
ALA A 304
None
0.72A 1fbyB-3ipcA:
undetectable
1fbyB-3ipcA:
23.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FM6_A_9CRA501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)
3ipc ABC TRANSPORTER,
SUBSTRATE BINDING
PROTEIN (AMINO ACID)

(Agrobacterium
fabrum)
6 / 12 ILE A 286
ALA A 289
ALA A 290
LEU A 305
ALA A 304
VAL A  74
None
1.08A 1fm6A-3ipcA:
undetectable
1fm6A-3ipcA:
23.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FM9_A_9CRA201_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)
3ipc ABC TRANSPORTER,
SUBSTRATE BINDING
PROTEIN (AMINO ACID)

(Agrobacterium
fabrum)
5 / 12 ILE A 286
ALA A 289
ALA A 290
LEU A 305
ALA A 304
None
0.77A 1fm9A-3ipcA:
undetectable
1fm9A-3ipcA:
23.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JR1_B_MOAB1333_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE 2)
3ipc ABC TRANSPORTER,
SUBSTRATE BINDING
PROTEIN (AMINO ACID)

(Agrobacterium
fabrum)
4 / 8 ASN A 103
GLY A 151
GLY A 125
GLN A 124
None
0.83A 1jr1B-3ipcA:
undetectable
1jr1B-3ipcA:
24.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1K74_A_9CRA463_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)
3ipc ABC TRANSPORTER,
SUBSTRATE BINDING
PROTEIN (AMINO ACID)

(Agrobacterium
fabrum)
5 / 12 ILE A 286
ALA A 289
ALA A 290
LEU A 305
ALA A 304
None
0.80A 1k74A-3ipcA:
undetectable
1k74A-3ipcA:
23.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OHR_A_1UNA201_1
(ASPARTYLPROTEASE)
3ipc ABC TRANSPORTER,
SUBSTRATE BINDING
PROTEIN (AMINO ACID)

(Agrobacterium
fabrum)
6 / 11 GLY A 200
ALA A 155
ASP A 156
GLY A 125
VAL A 141
ILE A 143
None
1.34A 1ohrA-3ipcA:
undetectable
1ohrA-3ipcA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q13_A_TESA501_1
(PROSTAGLANDIN-E2
9-REDUCTASE)
3ipc ABC TRANSPORTER,
SUBSTRATE BINDING
PROTEIN (AMINO ACID)

(Agrobacterium
fabrum)
4 / 6 TYR A 345
TYR A 333
GLU A 273
PRO A 272
None
1.30A 1q13A-3ipcA:
undetectable
1q13A-3ipcA:
24.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XDK_E_9CRE1500_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)
3ipc ABC TRANSPORTER,
SUBSTRATE BINDING
PROTEIN (AMINO ACID)

(Agrobacterium
fabrum)
5 / 12 ILE A 286
ALA A 289
ALA A 290
LEU A 305
ALA A 304
None
0.69A 1xdkE-3ipcA:
undetectable
1xdkE-3ipcA:
23.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XIU_A_9CRA201_1
(RXR-LIKE PROTEIN)
3ipc ABC TRANSPORTER,
SUBSTRATE BINDING
PROTEIN (AMINO ACID)

(Agrobacterium
fabrum)
5 / 12 ILE A 286
ALA A 289
ALA A 290
LEU A 305
ALA A 304
None
0.83A 1xiuA-3ipcA:
undetectable
1xiuA-3ipcA:
23.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XLS_A_9CRA801_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)
3ipc ABC TRANSPORTER,
SUBSTRATE BINDING
PROTEIN (AMINO ACID)

(Agrobacterium
fabrum)
5 / 12 ALA A 289
ALA A 290
LEU A 305
ALA A 304
VAL A  74
None
0.83A 1xlsA-3ipcA:
undetectable
1xlsA-3ipcA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XLS_B_9CRB802_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)
3ipc ABC TRANSPORTER,
SUBSTRATE BINDING
PROTEIN (AMINO ACID)

(Agrobacterium
fabrum)
5 / 12 ALA A 289
ALA A 290
LEU A 305
ALA A 304
VAL A  74
None
0.83A 1xlsB-3ipcA:
undetectable
1xlsB-3ipcA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XLS_C_9CRC803_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)
3ipc ABC TRANSPORTER,
SUBSTRATE BINDING
PROTEIN (AMINO ACID)

(Agrobacterium
fabrum)
5 / 12 ALA A 289
ALA A 290
LEU A 305
ALA A 304
VAL A  74
None
0.83A 1xlsC-3ipcA:
undetectable
1xlsC-3ipcA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XLS_D_9CRD804_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)
3ipc ABC TRANSPORTER,
SUBSTRATE BINDING
PROTEIN (AMINO ACID)

(Agrobacterium
fabrum)
5 / 12 ALA A 289
ALA A 290
LEU A 305
ALA A 304
VAL A  74
None
0.83A 1xlsD-3ipcA:
undetectable
1xlsD-3ipcA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2B60_B_RITB100_1
(GAG-POL POLYPROTEIN)
3ipc ABC TRANSPORTER,
SUBSTRATE BINDING
PROTEIN (AMINO ACID)

(Agrobacterium
fabrum)
5 / 12 GLY A 288
ALA A 287
ILE A  44
ILE A   5
ILE A  33
None
0.90A 2b60A-3ipcA:
undetectable
2b60A-3ipcA:
14.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GLU_A_SAMA301_0
(YCGJ)
3ipc ABC TRANSPORTER,
SUBSTRATE BINDING
PROTEIN (AMINO ACID)

(Agrobacterium
fabrum)
5 / 12 GLY A 225
GLY A 227
HIS A 203
ASP A 226
ALA A 128
None
LEU  A 500 (-3.3A)
None
LEU  A 500 (-3.0A)
None
0.76A 2gluA-3ipcA:
undetectable
2gluA-3ipcA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GLU_A_SAMA301_0
(YCGJ)
3ipc ABC TRANSPORTER,
SUBSTRATE BINDING
PROTEIN (AMINO ACID)

(Agrobacterium
fabrum)
5 / 12 GLY A 225
GLY A 227
HIS A 203
ASP A 226
THR A 102
None
LEU  A 500 (-3.3A)
None
LEU  A 500 (-3.0A)
LEU  A 500 (-3.0A)
0.90A 2gluA-3ipcA:
undetectable
2gluA-3ipcA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HS1_A_017A201_2
(HIV-1 PROTEASE)
3ipc ABC TRANSPORTER,
SUBSTRATE BINDING
PROTEIN (AMINO ACID)

(Agrobacterium
fabrum)
5 / 12 GLY A 288
ALA A 287
ILE A  44
ILE A   5
ILE A  33
None
0.83A 2hs1B-3ipcA:
undetectable
2hs1B-3ipcA:
13.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PKK_A_2FAA501_1
(ADENOSINE KINASE)
3ipc ABC TRANSPORTER,
SUBSTRATE BINDING
PROTEIN (AMINO ACID)

(Agrobacterium
fabrum)
5 / 12 ASP A 146
GLY A 201
ALA A 101
GLY A 153
ASP A 121
None
None
LEU  A 500 (-4.0A)
None
None
1.01A 2pkkA-3ipcA:
undetectable
2pkkA-3ipcA:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQC_E_AG2E671_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))
3ipc ABC TRANSPORTER,
SUBSTRATE BINDING
PROTEIN (AMINO ACID)

(Agrobacterium
fabrum)
4 / 7 ILE A 127
GLN A 348
LEU A 132
GLY A 129
None
0.98A 2qqcD-3ipcA:
undetectable
2qqcE-3ipcA:
undetectable
2qqcD-3ipcA:
17.80
2qqcE-3ipcA:
13.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_B_KLNB1498_1
(CYTOCHROME P450 3A4)
3ipc ABC TRANSPORTER,
SUBSTRATE BINDING
PROTEIN (AMINO ACID)

(Agrobacterium
fabrum)
5 / 9 LEU A 222
ILE A 144
ALA A 142
GLY A 217
LEU A 218
None
1.06A 2v0mB-3ipcA:
undetectable
2v0mB-3ipcA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_A_QPSA1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)
3ipc ABC TRANSPORTER,
SUBSTRATE BINDING
PROTEIN (AMINO ACID)

(Agrobacterium
fabrum)
5 / 12 VAL A  73
ASN A  78
VAL A  81
GLY A  58
ALA A  85
None
1.18A 2x2iA-3ipcA:
undetectable
2x2iA-3ipcA:
16.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_C_QPSC1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)
3ipc ABC TRANSPORTER,
SUBSTRATE BINDING
PROTEIN (AMINO ACID)

(Agrobacterium
fabrum)
5 / 12 VAL A  73
ASN A  78
VAL A  81
GLY A  58
ALA A  85
None
1.19A 2x2iC-3ipcA:
undetectable
2x2iC-3ipcA:
16.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XF3_A_J01A500_1
(ORF12)
3ipc ABC TRANSPORTER,
SUBSTRATE BINDING
PROTEIN (AMINO ACID)

(Agrobacterium
fabrum)
5 / 10 VAL A   3
ILE A  44
LEU A 305
GLY A 288
ALA A 289
None
1.15A 2xf3A-3ipcA:
undetectable
2xf3A-3ipcA:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XF3_B_J01B500_1
(ORF12)
3ipc ABC TRANSPORTER,
SUBSTRATE BINDING
PROTEIN (AMINO ACID)

(Agrobacterium
fabrum)
5 / 9 VAL A   3
ILE A  44
LEU A 305
GLY A 288
ALA A 289
None
1.15A 2xf3B-3ipcA:
undetectable
2xf3B-3ipcA:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XFS_B_J01B500_1
(ORF12)
3ipc ABC TRANSPORTER,
SUBSTRATE BINDING
PROTEIN (AMINO ACID)

(Agrobacterium
fabrum)
5 / 9 VAL A   3
ILE A  44
LEU A 305
GLY A 288
ALA A 289
None
1.14A 2xfsB-3ipcA:
undetectable
2xfsB-3ipcA:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XH9_B_J01B1436_1
(ORF12)
3ipc ABC TRANSPORTER,
SUBSTRATE BINDING
PROTEIN (AMINO ACID)

(Agrobacterium
fabrum)
5 / 9 VAL A   3
ILE A  44
LEU A 305
GLY A 288
ALA A 289
None
1.16A 2xh9B-3ipcA:
undetectable
2xh9B-3ipcA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D1Y_A_ROCA201_1
(HIV-1 PROTEASE)
3ipc ABC TRANSPORTER,
SUBSTRATE BINDING
PROTEIN (AMINO ACID)

(Agrobacterium
fabrum)
6 / 12 GLY A 200
ALA A 155
ASP A 156
GLY A 125
VAL A 141
ILE A 143
None
1.33A 3d1yA-3ipcA:
undetectable
3d1yA-3ipcA:
15.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_C_SAMC300_1
(PUTATIVE RRNA
METHYLASE)
3ipc ABC TRANSPORTER,
SUBSTRATE BINDING
PROTEIN (AMINO ACID)

(Agrobacterium
fabrum)
3 / 3 ASN A  78
ASP A 121
GLN A 124
None
0.79A 3eeyC-3ipcA:
2.1
3eeyC-3ipcA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_D_SAMD300_1
(PUTATIVE RRNA
METHYLASE)
3ipc ABC TRANSPORTER,
SUBSTRATE BINDING
PROTEIN (AMINO ACID)

(Agrobacterium
fabrum)
3 / 3 ASN A  78
ASP A 121
GLN A 124
None
0.81A 3eeyD-3ipcA:
2.8
3eeyD-3ipcA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_E_SAME300_1
(PUTATIVE RRNA
METHYLASE)
3ipc ABC TRANSPORTER,
SUBSTRATE BINDING
PROTEIN (AMINO ACID)

(Agrobacterium
fabrum)
3 / 3 ASN A  78
ASP A 121
GLN A 124
None
0.78A 3eeyE-3ipcA:
3.0
3eeyE-3ipcA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FAL_C_REAC501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)
3ipc ABC TRANSPORTER,
SUBSTRATE BINDING
PROTEIN (AMINO ACID)

(Agrobacterium
fabrum)
5 / 10 ILE A 286
ALA A 289
ALA A 290
LEU A 305
ALA A 304
None
0.73A 3falC-3ipcA:
undetectable
3falC-3ipcA:
23.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FC6_A_REAA501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)
3ipc ABC TRANSPORTER,
SUBSTRATE BINDING
PROTEIN (AMINO ACID)

(Agrobacterium
fabrum)
5 / 11 ILE A 286
ALA A 289
ALA A 290
LEU A 305
ALA A 304
None
0.66A 3fc6A-3ipcA:
undetectable
3fc6A-3ipcA:
23.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G4L_C_ROFC903_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)
3ipc ABC TRANSPORTER,
SUBSTRATE BINDING
PROTEIN (AMINO ACID)

(Agrobacterium
fabrum)
3 / 3 SER A 183
GLN A 212
PHE A 182
None
0.78A 3g4lC-3ipcA:
undetectable
3g4lC-3ipcA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H0A_A_9RAA500_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)
3ipc ABC TRANSPORTER,
SUBSTRATE BINDING
PROTEIN (AMINO ACID)

(Agrobacterium
fabrum)
5 / 12 ALA A 289
ALA A 290
LEU A 305
ALA A 304
VAL A  74
None
0.69A 3h0aA-3ipcA:
undetectable
3h0aA-3ipcA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ID5_B_SAMB301_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)
3ipc ABC TRANSPORTER,
SUBSTRATE BINDING
PROTEIN (AMINO ACID)

(Agrobacterium
fabrum)
5 / 11 TYR A 150
GLY A 227
THR A 102
ALA A 206
ILE A 228
LEU  A 500 (-3.6A)
LEU  A 500 (-3.3A)
LEU  A 500 (-3.0A)
None
None
1.27A 3id5B-3ipcA:
2.6
3id5B-3ipcA:
23.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ID5_F_SAMF301_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)
3ipc ABC TRANSPORTER,
SUBSTRATE BINDING
PROTEIN (AMINO ACID)

(Agrobacterium
fabrum)
5 / 11 TYR A 150
GLY A 227
THR A 102
ALA A 206
ILE A 228
LEU  A 500 (-3.6A)
LEU  A 500 (-3.3A)
LEU  A 500 (-3.0A)
None
None
1.27A 3id5F-3ipcA:
undetectable
3id5F-3ipcA:
23.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LD6_A_KKKA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)
3ipc ABC TRANSPORTER,
SUBSTRATE BINDING
PROTEIN (AMINO ACID)

(Agrobacterium
fabrum)
5 / 12 PHE A  65
GLY A  58
ALA A  85
ILE A 286
MET A 283
None
1.20A 3ld6A-3ipcA:
undetectable
3ld6A-3ipcA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OAP_A_9CRA500_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)
3ipc ABC TRANSPORTER,
SUBSTRATE BINDING
PROTEIN (AMINO ACID)

(Agrobacterium
fabrum)
5 / 12 ILE A 286
ALA A 289
ALA A 290
LEU A 305
ALA A 304
None
0.81A 3oapA-3ipcA:
undetectable
3oapA-3ipcA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S54_B_017B201_1
(PROTEASE)
3ipc ABC TRANSPORTER,
SUBSTRATE BINDING
PROTEIN (AMINO ACID)

(Agrobacterium
fabrum)
5 / 12 GLY A 288
ALA A 290
ILE A  97
ILE A  44
ILE A  39
None
0.91A 3s54A-3ipcA:
undetectable
3s54A-3ipcA:
14.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LG1_A_SAMA301_0
(PROTEIN-LYSINE
METHYLTRANSFERASE
METTL21D)
3ipc ABC TRANSPORTER,
SUBSTRATE BINDING
PROTEIN (AMINO ACID)

(Agrobacterium
fabrum)
5 / 12 ALA A 206
GLY A 225
GLY A 227
ASP A 226
GLU A 157
None
None
LEU  A 500 (-3.3A)
LEU  A 500 (-3.0A)
None
0.80A 4lg1A-3ipcA:
2.3
4lg1A-3ipcA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZJO_D_ERYD1101_0
(MULTIDRUG EFFLUX
PUMP SUBUNIT ACRB)
3ipc ABC TRANSPORTER,
SUBSTRATE BINDING
PROTEIN (AMINO ACID)

(Agrobacterium
fabrum)
5 / 11 SER A 224
SER A 230
ALA A  77
GLU A 232
GLY A 207
None
None
LEU  A 500 (-4.0A)
None
None
1.38A 4zjoD-3ipcA:
undetectable
4zjoD-3ipcA:
17.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D0Y_A_FOLA201_0
(CONSERVED
HYPOTHETICAL
MEMBRANE PROTEIN)
3ipc ABC TRANSPORTER,
SUBSTRATE BINDING
PROTEIN (AMINO ACID)

(Agrobacterium
fabrum)
5 / 12 GLN A 124
GLY A 329
TYR A 333
ASN A 246
VAL A 223
None
1.46A 5d0yA-3ipcA:
undetectable
5d0yA-3ipcA:
18.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_B_SAMB301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))
3ipc ABC TRANSPORTER,
SUBSTRATE BINDING
PROTEIN (AMINO ACID)

(Agrobacterium
fabrum)
5 / 12 ASP A  50
PRO A  10
GLY A  58
SER A  60
SER A  82
None
1.21A 5hfjB-3ipcA:
3.5
5hfjB-3ipcA:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HWA_A_GCSA302_1
(CHITOSANASE)
3ipc ABC TRANSPORTER,
SUBSTRATE BINDING
PROTEIN (AMINO ACID)

(Agrobacterium
fabrum)
4 / 7 THR A 102
ASP A 226
ASP A 121
GLY A 200
LEU  A 500 (-3.0A)
LEU  A 500 (-3.0A)
None
None
1.08A 5hwaA-3ipcA:
undetectable
5hwaA-3ipcA:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A5Y_D_9CRD501_0
(RETINOIC ACID
RECEPTOR RXR-ALPHA)
3ipc ABC TRANSPORTER,
SUBSTRATE BINDING
PROTEIN (AMINO ACID)

(Agrobacterium
fabrum)
6 / 12 ILE A 286
ALA A 289
ALA A 290
LEU A 305
ALA A 304
ILE A  94
None
1.39A 6a5yD-3ipcA:
undetectable
6a5yD-3ipcA:
14.14