SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3ipi'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DY4_A_SNPA437_1
(EXOGLUCANASE 1)
3ipi GERANYLTRANSTRANSFER
ASE

(Methanosarcina
mazei)
5 / 12 ASP A  90
SER A  86
THR A 175
ARG A  54
ASP A 215
None
None
None
MLA  A 305 (-4.0A)
None
1.43A 1dy4A-3ipiA:
undetectable
1dy4A-3ipiA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_A_VDYA1002_5
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)
3ipi GERANYLTRANSTRANSFER
ASE

(Methanosarcina
mazei)
4 / 4 LEU A 280
VAL A  61
CYH A  65
ALA A 192
None
None
MLA  A 309 (-4.4A)
None
1.14A 1mz9E-3ipiA:
undetectable
1mz9E-3ipiA:
10.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RQJ_A_RISA901_1
(GERANYLTRANSTRANSFER
ASE)
3ipi GERANYLTRANSTRANSFER
ASE

(Methanosarcina
mazei)
5 / 11 SER A  86
LEU A  87
THR A 175
GLN A 212
ASP A 215
None
0.98A 1rqjA-3ipiA:
28.2
1rqjA-3ipiA:
28.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RQJ_B_RISB903_1
(GERANYLTRANSTRANSFER
ASE)
3ipi GERANYLTRANSTRANSFER
ASE

(Methanosarcina
mazei)
5 / 11 SER A  86
LEU A  87
ASP A  90
THR A 175
GLN A 212
None
0.92A 1rqjB-3ipiA:
28.1
1rqjB-3ipiA:
28.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RQJ_B_RISB903_1
(GERANYLTRANSTRANSFER
ASE)
3ipi GERANYLTRANSTRANSFER
ASE

(Methanosarcina
mazei)
5 / 11 SER A  86
LEU A  87
THR A 175
GLN A 212
ASP A 215
None
0.97A 1rqjB-3ipiA:
28.1
1rqjB-3ipiA:
28.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C6N_B_LPRB705_2
(ANGIOTENSIN-CONVERTI
NG ENZYME, SOMATIC
ISOFORM)
3ipi GERANYLTRANSTRANSFER
ASE

(Methanosarcina
mazei)
3 / 3 ALA A  75
THR A 189
PHE A 140
None
0.78A 2c6nB-3ipiA:
1.4
2c6nB-3ipiA:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NOA_A_3TCA302_1
(DEOXYCYTIDINE KINASE)
3ipi GERANYLTRANSTRANSFER
ASE

(Methanosarcina
mazei)
5 / 12 ILE A  53
LEU A 280
PHE A 203
ALA A 264
PHE A 179
MLA  A 305 (-4.5A)
None
None
None
None
1.15A 2noaA-3ipiA:
undetectable
2noaA-3ipiA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G2O_B_SAMB600_0
(PCZA361.24)
3ipi GERANYLTRANSTRANSFER
ASE

(Methanosarcina
mazei)
5 / 12 ALA A 114
GLY A 110
LEU A 116
ASP A 119
GLY A  96
None
1.05A 3g2oB-3ipiA:
undetectable
3g2oB-3ipiA:
23.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IJX_H_HCZH800_1
(GLUTAMATE RECEPTOR 2)
3ipi GERANYLTRANSTRANSFER
ASE

(Methanosarcina
mazei)
4 / 5 LYS A 246
SER A 243
LEU A 250
SER A 253
None
1.49A 3ijxH-3ipiA:
undetectable
3ijxH-3ipiA:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HTF_A_ACTA303_0
(S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE)
3ipi GERANYLTRANSTRANSFER
ASE

(Methanosarcina
mazei)
3 / 3 TYR A 211
HIS A  83
ARG A  54
None
MLA  A 305 ( 4.7A)
MLA  A 305 (-4.0A)
1.02A 4htfA-3ipiA:
undetectable
4htfA-3ipiA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UMJ_B_BFQB1294_1
(GERANYLTRANSTRANSFER
ASE)
3ipi GERANYLTRANSTRANSFER
ASE

(Methanosarcina
mazei)
5 / 9 SER A  86
LEU A  87
ASP A  90
MET A 147
THR A 175
None
1.10A 4umjB-3ipiA:
27.3
4umjB-3ipiA:
29.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YOA_A_017A100_1
(HIV-1 PROTEASE)
3ipi GERANYLTRANSTRANSFER
ASE

(Methanosarcina
mazei)
4 / 6 ASP A 255
THR A 288
THR A 284
VAL A 261
None
1.15A 4yoaA-3ipiA:
undetectable
4yoaA-3ipiA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5K9D_A_CE9A402_0
(DIHYDROOROTATE
DEHYDROGENASE
(QUINONE),
MITOCHONDRIAL)
3ipi GERANYLTRANSTRANSFER
ASE

(Methanosarcina
mazei)
5 / 12 ALA A  76
LEU A  77
ALA A  78
PHE A 128
PHE A 140
None
1.10A 5k9dA-3ipiA:
undetectable
5k9dA-3ipiA:
21.46