SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3ipl'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BSX_A_T3A1_1
(PROTEIN (THYROID
HORMONE RECEPTOR
BETA))		 3ipl 2-SUCCINYLBENZOATE--
COA LIGASE
(Staphylococcus
aureus) 		5 / 12 ILE A 299
MET A 264
LEU A 255
LEU A 274
ILE A 245
 None
 1.10A 1bsxA-3iplA:
undetectable		 1bsxA-3iplA:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BSX_B_T3B2_1
(PROTEIN (THYROID
HORMONE RECEPTOR
BETA))		 3ipl 2-SUCCINYLBENZOATE--
COA LIGASE
(Staphylococcus
aureus) 		5 / 12 ILE A 299
MET A 264
LEU A 255
LEU A 274
ILE A 245
 None
 1.11A 1bsxB-3iplA:
undetectable		 1bsxB-3iplA:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EII_A_RTLA135_1
(CELLULAR
RETINOL-BINDING
PROTEIN II)		 3ipl 2-SUCCINYLBENZOATE--
COA LIGASE
(Staphylococcus
aureus) 		4 / 7 GLN A 311
THR A 314
SER A 302
TYR A 300
 None
 1.29A 1eiiA-3iplA:
undetectable		 1eiiA-3iplA:
15.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX8_A_RTLA135_0
(CELLULAR
RETINOL-BINDING
PROTEIN I, HOLO)		 3ipl 2-SUCCINYLBENZOATE--
COA LIGASE
(Staphylococcus
aureus) 		5 / 12 LEU A  30
ALA A  34
LEU A  37
THR A 100
ILE A  57
 None
 1.30A 1mx8A-3iplA:
undetectable		 1mx8A-3iplA:
14.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MXD_A_ACRA734_1
(ALPHA AMYLASE)		 3ipl 2-SUCCINYLBENZOATE--
COA LIGASE
(Staphylococcus
aureus) 		4 / 6 ASN A  55
HIS A 213
TYR A 212
GLY A 216
 None
 1.35A 1mxdA-3iplA:
undetectable		 1mxdA-3iplA:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MXG_A_ACRA444_1
(ALPHA AMYLASE)		 3ipl 2-SUCCINYLBENZOATE--
COA LIGASE
(Staphylococcus
aureus) 		4 / 7 ASN A  55
HIS A 213
TYR A 212
GLY A 216
 None
 1.37A 1mxgA-3iplA:
undetectable		 1mxgA-3iplA:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PK2_A_ACAA91_1
(TISSUE-TYPE
PLASMINOGEN
ACTIVATOR)		 3ipl 2-SUCCINYLBENZOATE--
COA LIGASE
(Staphylococcus
aureus) 		4 / 8 VAL A 224
TRP A  67
HIS A  64
LEU A  30
 None
 1.26A 1pk2A-3iplA:
undetectable		 1pk2A-3iplA:
9.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RK3_A_VDXA500_2
(VITAMIN D3 RECEPTOR)		 3ipl 2-SUCCINYLBENZOATE--
COA LIGASE
(Staphylococcus
aureus) 		4 / 4 LEU A 101
ILE A 232
ARG A 231
TYR A 212
 None
 1.03A 1rk3A-3iplA:
undetectable		 1rk3A-3iplA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YI4_A_ADNA306_1
(PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE PIM-1)		 3ipl 2-SUCCINYLBENZOATE--
COA LIGASE
(Staphylococcus
aureus) 		5 / 10 LEU A  41
ALA A  65
ILE A  63
LEU A  51
ILE A  73
 None
 1.10A 1yi4A-3iplA:
undetectable		 1yi4A-3iplA:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HS2_B_017B203_1
(PROTEASE)		 3ipl 2-SUCCINYLBENZOATE--
COA LIGASE
(Staphylococcus
aureus) 		4 / 6 PRO A 324
LEU A 284
ARG A 323
GLY A 328
 None
 1.07A 2hs2B-3iplA:
undetectable		 2hs2B-3iplA:
11.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2R5Q_B_1UNB900_1
(PROTEASE)		 3ipl 2-SUCCINYLBENZOATE--
COA LIGASE
(Staphylococcus
aureus) 		5 / 9 LEU A 349
ASP A 379
GLY A 280
VAL A 389
ILE A 391
 None
 1.04A 2r5qA-3iplA:
undetectable		 2r5qA-3iplA:
12.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2R5Q_B_1UNB900_1
(PROTEASE)		 3ipl 2-SUCCINYLBENZOATE--
COA LIGASE
(Staphylococcus
aureus) 		5 / 9 LEU A 349
ASP A 379
GLY A 281
VAL A 389
ILE A 391
 None
 1.05A 2r5qA-3iplA:
undetectable		 2r5qA-3iplA:
12.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2R5Q_D_1UND900_1
(PROTEASE)		 3ipl 2-SUCCINYLBENZOATE--
COA LIGASE
(Staphylococcus
aureus) 		5 / 9 LEU A 349
ASP A 379
GLY A 280
VAL A 389
ILE A 391
 None
 1.04A 2r5qC-3iplA:
undetectable		 2r5qC-3iplA:
12.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2R5Q_D_1UND900_1
(PROTEASE)		 3ipl 2-SUCCINYLBENZOATE--
COA LIGASE
(Staphylococcus
aureus) 		5 / 9 LEU A 349
ASP A 379
GLY A 281
VAL A 389
ILE A 391
 None
 1.05A 2r5qC-3iplA:
undetectable		 2r5qC-3iplA:
12.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WD9_A_IBPA1570_1
(ACYL-COENZYME A
SYNTHETASE ACSM2A,
MITOCHONDRIAL)		 3ipl 2-SUCCINYLBENZOATE--
COA LIGASE
(Staphylococcus
aureus) 		4 / 7 ILE A 214
GLY A 281
GLY A 304
THR A 306
 None
 0.65A 2wd9A-3iplA:
38.0		 2wd9A-3iplA:
27.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WD9_B_IBPB1570_1
(ACYL-COENZYME A
SYNTHETASE ACSM2A,
MITOCHONDRIAL)		 3ipl 2-SUCCINYLBENZOATE--
COA LIGASE
(Staphylococcus
aureus) 		4 / 8 ILE A 214
GLY A 281
GLY A 304
THR A 306
 None
 0.63A 2wd9B-3iplA:
38.4		 2wd9B-3iplA:
27.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZLC_A_VDXA500_1
(VITAMIN D3 RECEPTOR)		 3ipl 2-SUCCINYLBENZOATE--
COA LIGASE
(Staphylococcus
aureus) 		5 / 12 LEU A 278
SER A 302
SER A 215
SER A 218
LEU A 268
 None
 1.40A 2zlcA-3iplA:
undetectable		 2zlcA-3iplA:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZLC_A_VDXA500_2
(VITAMIN D3 RECEPTOR)		 3ipl 2-SUCCINYLBENZOATE--
COA LIGASE
(Staphylococcus
aureus) 		4 / 5 LEU A 101
ILE A 232
ARG A 231
TYR A 212
 None
 1.10A 2zlcA-3iplA:
undetectable		 2zlcA-3iplA:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A9E_B_REAB1_1
(RETINOIC ACID
RECEPTOR ALPHA)		 3ipl 2-SUCCINYLBENZOATE--
COA LIGASE
(Staphylococcus
aureus) 		5 / 11 SER A 189
LEU A 221
ILE A 225
PHE A 199
LEU A 278
 None
 1.33A 3a9eB-3iplA:
undetectable		 3a9eB-3iplA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W1W_A_CHDA1503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 3ipl 2-SUCCINYLBENZOATE--
COA LIGASE
(Staphylococcus
aureus) 		4 / 8 ILE A 338
LEU A 349
VAL A 327
GLY A 328
 None
 0.83A 3w1wA-3iplA:
undetectable		 3w1wA-3iplA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D1Y_A_RBFA1176_1
(PUTATIVE PROTEASE I)		 3ipl 2-SUCCINYLBENZOATE--
COA LIGASE
(Staphylococcus
aureus) 		4 / 8 GLN A 176
ASN A  87
ASN A  77
THR A  78
 None
 1.23A 4d1yA-3iplA:
undetectable
4d1yB-3iplA:
2.1		 4d1yA-3iplA:
18.28
4d1yB-3iplA:
18.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWP_B_GCSB307_1
(CHITOSANASE)		 3ipl 2-SUCCINYLBENZOATE--
COA LIGASE
(Staphylococcus
aureus) 		4 / 7 THR A 172
GLY A 171
THR A 173
HIS A 213
 None
 1.01A 4qwpB-3iplA:
undetectable		 4qwpB-3iplA:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_A_ACTA307_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 3ipl 2-SUCCINYLBENZOATE--
COA LIGASE
(Staphylococcus
aureus) 		4 / 4 LEU A 284
LEU A 320
SER A 302
ALA A 315
 None
 1.14A 5uunA-3iplA:
undetectable		 5uunA-3iplA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W4Z_B_RBFB502_1
(RIBOFLAVIN LYASE)		 3ipl 2-SUCCINYLBENZOATE--
COA LIGASE
(Staphylococcus
aureus) 		5 / 12 GLY A 280
GLY A 198
SER A 302
GLN A 311
THR A 203
 None
 0.97A 5w4zB-3iplA:
undetectable		 5w4zB-3iplA:
10.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BTX_A_EDTA503_0
(SOLUTE CARRIER
FAMILY 39
(IRON-REGULATED
TRANSPORTER))		 3ipl 2-SUCCINYLBENZOATE--
COA LIGASE
(Staphylococcus
aureus) 		4 / 7 SER A 310
SER A 218
GLY A 216
ARG A 222
 None
 1.12A 6btxA-3iplA:
undetectable		 6btxA-3iplA:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EKZ_A_SNPA414_0
(AROMATIC
PEROXYGENASE)		 3ipl 2-SUCCINYLBENZOATE--
COA LIGASE
(Staphylococcus
aureus) 		4 / 5 PHE A 375
VAL A 389
MET A 305
VAL A 356
 None
 1.41A 6ekzA-3iplA:
undetectable		 6ekzA-3iplA:
10.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN5_B_LLLB301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 3ipl 2-SUCCINYLBENZOATE--
COA LIGASE
(Staphylococcus
aureus) 		4 / 7 ASP A 325
TYR A 392
GLU A 382
ASP A 384
 None
 1.24A 6mn5B-3iplA:
undetectable		 6mn5B-3iplA:
9.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN5_C_LLLC301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 3ipl 2-SUCCINYLBENZOATE--
COA LIGASE
(Staphylococcus
aureus) 		4 / 6 ASP A 325
TYR A 392
ASP A 384
GLU A 386
 None
 1.36A 6mn5C-3iplA:
undetectable		 6mn5C-3iplA:
9.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN5_C_LLLC301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 3ipl 2-SUCCINYLBENZOATE--
COA LIGASE
(Staphylococcus
aureus) 		4 / 6 ASP A 325
TYR A 392
GLU A 382
ASP A 384
 None
 1.24A 6mn5C-3iplA:
undetectable		 6mn5C-3iplA:
9.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN5_D_LLLD301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 3ipl 2-SUCCINYLBENZOATE--
COA LIGASE
(Staphylococcus
aureus) 		4 / 6 ASP A 325
GLU A 382
ASP A 384
GLU A 386
 None
 1.24A 6mn5D-3iplA:
undetectable		 6mn5D-3iplA:
9.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
7DFR_A_FOLA161_1
(DIHYDROFOLATE
REDUCTASE)		 3ipl 2-SUCCINYLBENZOATE--
COA LIGASE
(Staphylococcus
aureus) 		3 / 3 ASP A 365
LEU A 366
ARG A 395
 None
 0.76A 7dfrA-3iplA:
undetectable		 7dfrA-3iplA:
16.63