SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3ipw'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DTL_A_BEPA206_1
(CARDIAC TROPONIN C)		 3ipw HYDROLASE TATD
FAMILY PROTEIN
(Entamoeba
histolytica) 		4 / 8 PRO A 264
GLU A 263
GLU A  29
ASP A  32
 None
 1.17A 1dtlA-3ipwA:
undetectable		 1dtlA-3ipwA:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FKO_A_EFZA999_1
(HIV-1 RT, A-CHAIN)		 3ipw HYDROLASE TATD
FAMILY PROTEIN
(Entamoeba
histolytica) 		5 / 10 LEU A  53
VAL A  80
TYR A  93
GLY A  79
LEU A 100
 None
 1.41A 1fkoA-3ipwA:
undetectable		 1fkoA-3ipwA:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_B_TRPB81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 3ipw HYDROLASE TATD
FAMILY PROTEIN
(Entamoeba
histolytica) 		4 / 8 GLY A   9
ALA A 110
THR A  49
ILE A  47
 None
 0.81A 1gtnA-3ipwA:
undetectable
1gtnB-3ipwA:
undetectable		 1gtnA-3ipwA:
13.78
1gtnB-3ipwA:
13.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N2X_A_SAMA401_0
(S-ADENOSYL-METHYLTRA
NSFERASE MRAW)		 3ipw HYDROLASE TATD
FAMILY PROTEIN
(Entamoeba
histolytica) 		5 / 12 GLY A 112
GLU A 113
GLY A 115
VAL A 108
TYR A 143
 None
 1.31A 1n2xA-3ipwA:
undetectable		 1n2xA-3ipwA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TD7_A_NFLA2001_1
(PHOSPHOLIPASE A2
ISOFORM 3)		 3ipw HYDROLASE TATD
FAMILY PROTEIN
(Entamoeba
histolytica) 		5 / 9 LEU A  88
ILE A 138
GLY A  79
CYH A 101
TYR A  93
 None
 1.31A 1td7A-3ipwA:
undetectable		 1td7A-3ipwA:
16.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2B25_B_SAMB602_1
(HYPOTHETICAL PROTEIN)		 3ipw HYDROLASE TATD
FAMILY PROTEIN
(Entamoeba
histolytica) 		3 / 3 GLY A 180
GLU A 184
ASP A 179
 None
 0.65A 2b25B-3ipwA:
undetectable		 2b25B-3ipwA:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DTT_A_H4BA1003_1
(HYPOTHETICAL PROTEIN
PH0634)		 3ipw HYDROLASE TATD
FAMILY PROTEIN
(Entamoeba
histolytica) 		5 / 10 HIS A 176
HIS A 151
THR A  49
GLU A 113
ASP A  14
 None
 1.30A 2dttA-3ipwA:
undetectable
2dttC-3ipwA:
undetectable		 2dttA-3ipwA:
20.33
2dttC-3ipwA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XRL_A_DXTA1211_1
(TETRACYCLINE
REPRESSOR PROTEIN
CLASS D)		 3ipw HYDROLASE TATD
FAMILY PROTEIN
(Entamoeba
histolytica) 		5 / 12 SER A  50
THR A  76
VAL A 108
LEU A 146
ILE A 111
 None
 1.39A 2xrlA-3ipwA:
undetectable		 2xrlA-3ipwA:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YJA_B_ESTB1550_1
(ESTROGEN RECEPTOR)		 3ipw HYDROLASE TATD
FAMILY PROTEIN
(Entamoeba
histolytica) 		5 / 12 ALA A 271
ILE A   8
GLY A 196
HIS A 220
LEU A 219
 None
 1.16A 2yjaB-3ipwA:
undetectable		 2yjaB-3ipwA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B2R_B_VDNB1_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 3ipw HYDROLASE TATD
FAMILY PROTEIN
(Entamoeba
histolytica) 		5 / 11 ILE A 214
ALA A 271
ILE A 270
VAL A 289
ILE A   8
 None
 0.97A 3b2rB-3ipwA:
undetectable		 3b2rB-3ipwA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BXO_A_SAMA238_1
(N,N-DIMETHYLTRANSFER
ASE)		 3ipw HYDROLASE TATD
FAMILY PROTEIN
(Entamoeba
histolytica) 		3 / 3 TYR A  66
GLU A 263
ASP A 244
 None
 0.81A 3bxoA-3ipwA:
undetectable		 3bxoA-3ipwA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BXO_B_SAMB238_1
(N,N-DIMETHYLTRANSFER
ASE)		 3ipw HYDROLASE TATD
FAMILY PROTEIN
(Entamoeba
histolytica) 		3 / 3 TYR A  66
GLU A 263
ASP A 244
 None
 0.87A 3bxoB-3ipwA:
undetectable		 3bxoB-3ipwA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ETE_A_H3PA552_1
(GLUTAMATE
DEHYDROGENASE)		 3ipw HYDROLASE TATD
FAMILY PROTEIN
(Entamoeba
histolytica) 		4 / 6 ILE A 221
MET A 211
ILE A 195
HIS A 176
 None
 1.04A 3eteA-3ipwA:
undetectable
3eteE-3ipwA:
undetectable		 3eteA-3ipwA:
19.92
3eteE-3ipwA:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K4V_B_ROCB201_1
(HIV-1 PROTEASE)		 3ipw HYDROLASE TATD
FAMILY PROTEIN
(Entamoeba
histolytica) 		6 / 12 LEU A  43
ASP A   7
GLY A   9
ALA A  10
ILE A  62
ILE A  46
 None
 1.45A 3k4vA-3ipwA:
undetectable		 3k4vA-3ipwA:
14.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K4V_B_ROCB201_3
(HIV-1 PROTEASE)		 3ipw HYDROLASE TATD
FAMILY PROTEIN
(Entamoeba
histolytica) 		6 / 12 LEU A  43
ASP A   7
GLY A   9
ALA A  10
ILE A  62
ILE A  46
 None
 1.48A 3k4vB-3ipwA:
undetectable		 3k4vB-3ipwA:
14.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDT_A_ROCA101_3
(PROTEASE)		 3ipw HYDROLASE TATD
FAMILY PROTEIN
(Entamoeba
histolytica) 		6 / 12 LEU A  43
ASP A   7
GLY A   9
ALA A  10
ILE A  62
ILE A  46
 None
 1.49A 3ndtB-3ipwA:
undetectable		 3ndtB-3ipwA:
14.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDT_D_ROCD100_1
(PROTEASE)		 3ipw HYDROLASE TATD
FAMILY PROTEIN
(Entamoeba
histolytica) 		6 / 12 LEU A  43
ASP A   7
GLY A   9
ALA A  10
ILE A  62
ILE A  46
 None
 1.48A 3ndtC-3ipwA:
undetectable		 3ndtC-3ipwA:
14.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDU_A_ROCA101_1
(PROTEASE)		 3ipw HYDROLASE TATD
FAMILY PROTEIN
(Entamoeba
histolytica) 		6 / 12 LEU A  43
ASP A   7
GLY A   9
ALA A  10
ILE A  62
ILE A  46
 None
 1.49A 3nduA-3ipwA:
undetectable		 3nduA-3ipwA:
14.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDU_A_ROCA101_2
(PROTEASE)		 3ipw HYDROLASE TATD
FAMILY PROTEIN
(Entamoeba
histolytica) 		6 / 12 LEU A  43
ASP A   7
GLY A   9
ALA A  10
ILE A  62
ILE A  46
 None
 1.49A 3nduB-3ipwA:
undetectable		 3nduB-3ipwA:
14.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QFX_A_CP6A602_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3ipw HYDROLASE TATD
FAMILY PROTEIN
(Entamoeba
histolytica) 		5 / 12 VAL A 289
ILE A 195
SER A 201
LEU A 202
ILE A 221
 None
 1.21A 3qfxA-3ipwA:
undetectable		 3qfxA-3ipwA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WSJ_A_MK1A201_2
(PROTEASE)		 3ipw HYDROLASE TATD
FAMILY PROTEIN
(Entamoeba
histolytica) 		4 / 7 LEU A  43
ASP A   7
ALA A  10
ILE A  46
 None
 0.96A 3wsjB-3ipwA:
undetectable		 3wsjB-3ipwA:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACA_B_DXCB1473_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 3ipw HYDROLASE TATD
FAMILY PROTEIN
(Entamoeba
histolytica) 		5 / 9 ASP A   7
ILE A  47
GLY A   9
THR A  77
GLY A 112
 None
 1.16A 4acaB-3ipwA:
2.5
4acaC-3ipwA:
2.1		 4acaB-3ipwA:
22.65
4acaC-3ipwA:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGL_D_CLQD303_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 3ipw HYDROLASE TATD
FAMILY PROTEIN
(Entamoeba
histolytica) 		4 / 6 GLY A 180
ASN A 200
GLU A 184
ILE A 188
 None
 0.99A 4fglD-3ipwA:
undetectable		 4fglD-3ipwA:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKI_D_KAND301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 3ipw HYDROLASE TATD
FAMILY PROTEIN
(Entamoeba
histolytica) 		5 / 11 HIS A 176
ASP A  55
ARG A 261
GLU A 113
ASP A  14
 None
 1.35A 4gkiC-3ipwA:
0.0
4gkiD-3ipwA:
0.0		 4gkiC-3ipwA:
20.35
4gkiD-3ipwA:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PXM_B_ESTB2000_1
(ESTROGEN RECEPTOR)		 3ipw HYDROLASE TATD
FAMILY PROTEIN
(Entamoeba
histolytica) 		5 / 11 ALA A 271
ILE A   8
GLY A 196
HIS A 220
LEU A 219
 None
 1.20A 4pxmB-3ipwA:
undetectable		 4pxmB-3ipwA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X61_A_SAMA701_1
(PROTEIN ARGININE
N-METHYLTRANSFERASE
5)		 3ipw HYDROLASE TATD
FAMILY PROTEIN
(Entamoeba
histolytica) 		4 / 5 TYR A  17
TYR A  66
GLU A 263
ASP A 244
 None
 1.42A 4x61A-3ipwA:
7.3		 4x61A-3ipwA:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZJ8_A_SUVA2001_2
(HUMAN OX1R FUSION
PROTEIN TO P.ABYSII
GLYCOGEN SYNTHASE)		 3ipw HYDROLASE TATD
FAMILY PROTEIN
(Entamoeba
histolytica) 		4 / 6 PRO A 299
HIS A 220
ILE A  47
VAL A  75
 None
 0.83A 4zj8A-3ipwA:
undetectable		 4zj8A-3ipwA:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZXI_A_GLYA1402_0
(TYROCIDINE
SYNTHETASE 3)		 3ipw HYDROLASE TATD
FAMILY PROTEIN
(Entamoeba
histolytica) 		4 / 7 ASP A   7
ILE A   8
GLY A 196
THR A 223
 None
 1.16A 4zxiA-3ipwA:
undetectable		 4zxiA-3ipwA:
12.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DXB_B_ESTB601_1
(ESTROGEN RECEPTOR)		 3ipw HYDROLASE TATD
FAMILY PROTEIN
(Entamoeba
histolytica) 		5 / 11 ALA A 271
ILE A   8
GLY A 196
HIS A 220
LEU A 219
 None
 1.15A 5dxbB-3ipwA:
undetectable		 5dxbB-3ipwA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ENT_C_MIYC901_1
(MULTIDRUG EFFLUX
PUMP SUBUNIT
ACRB,MULTIDRUG
EFFLUX PUMP SUBUNIT
ACRB)		 3ipw HYDROLASE TATD
FAMILY PROTEIN
(Entamoeba
histolytica) 		5 / 9 SER A 265
GLU A 263
ASN A 262
ILE A 270
ALA A 271
 None
 1.31A 5entC-3ipwA:
undetectable		 5entC-3ipwA:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KKZ_E_ASCE1004_0
(CYTOCHROME B
UBIQUINOL-CYTOCHROME
C REDUCTASE
IRON-SULFUR SUBUNIT)		 3ipw HYDROLASE TATD
FAMILY PROTEIN
(Entamoeba
histolytica) 		4 / 7 HIS A  81
ILE A 114
VAL A  80
GLN A 129
 None
 1.25A 5kkzC-3ipwA:
undetectable
5kkzE-3ipwA:
undetectable		 5kkzC-3ipwA:
19.76
5kkzE-3ipwA:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KKZ_K_ASCK1004_0
(CYTOCHROME B
UBIQUINOL-CYTOCHROME
C REDUCTASE
IRON-SULFUR SUBUNIT)		 3ipw HYDROLASE TATD
FAMILY PROTEIN
(Entamoeba
histolytica) 		4 / 7 HIS A  81
ILE A 114
VAL A  80
GLN A 129
 None
 1.20A 5kkzK-3ipwA:
undetectable
5kkzQ-3ipwA:
undetectable		 5kkzK-3ipwA:
19.15
5kkzQ-3ipwA:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0T_B_SAMB501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 3ipw HYDROLASE TATD
FAMILY PROTEIN
(Entamoeba
histolytica) 		5 / 12 ILE A 273
GLY A 236
ILE A 221
MET A 274
VAL A 197
 None
 1.07A 5n0tB-3ipwA:
undetectable		 5n0tB-3ipwA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0W_B_SAMB501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 3ipw HYDROLASE TATD
FAMILY PROTEIN
(Entamoeba
histolytica) 		5 / 12 ILE A 273
GLY A 236
ILE A 221
MET A 274
VAL A 197
 None
 1.05A 5n0wB-3ipwA:
undetectable		 5n0wB-3ipwA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N4I_A_SAMA501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 3ipw HYDROLASE TATD
FAMILY PROTEIN
(Entamoeba
histolytica) 		5 / 12 ILE A 273
GLY A 236
ILE A 221
MET A 274
VAL A 197
 None
 1.04A 5n4iA-3ipwA:
undetectable		 5n4iA-3ipwA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DJ1_B_AB1B201_1
(HIV-1 PROTEASE)		 3ipw HYDROLASE TATD
FAMILY PROTEIN
(Entamoeba
histolytica) 		5 / 12 GLY A 112
ASP A  55
GLY A   9
ILE A   8
VAL A  75
 None
 0.79A 6dj1B-3ipwA:
undetectable		 6dj1B-3ipwA:
14.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DJ2_B_AB1B201_1
(HIV-1 PROTEASE)		 3ipw HYDROLASE TATD
FAMILY PROTEIN
(Entamoeba
histolytica) 		5 / 12 GLY A 112
ASP A  55
GLY A   9
ILE A   8
VAL A  75
 None
 0.80A 6dj2B-3ipwA:
undetectable		 6dj2B-3ipwA:
14.75