SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3iq0'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX1_F_THAF6_1
(LIVER
CARBOXYLESTERASE I)		 3iq0 PUTATIVE RIBOKINASE
II
(Escherichia
coli) 		5 / 12 GLY A 136
VAL A 148
LEU A 182
LEU A 139
LEU A 186
 None
 1.04A 1mx1F-3iq0A:
undetectable		 1mx1F-3iq0A:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_B_FUAB703_2
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 3iq0 PUTATIVE RIBOKINASE
II
(Escherichia
coli) 		3 / 3 VAL A 148
ALA A 147
HIS A 120
 None
 0.61A 1q23C-3iq0A:
undetectable		 1q23C-3iq0A:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_G_FUAG708_2
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 3iq0 PUTATIVE RIBOKINASE
II
(Escherichia
coli) 		3 / 3 VAL A 148
ALA A 147
HIS A 120
 None
 0.56A 1q23H-3iq0A:
undetectable		 1q23H-3iq0A:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_I_FUAI707_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 3iq0 PUTATIVE RIBOKINASE
II
(Escherichia
coli) 		3 / 3 VAL A 148
ALA A 147
HIS A 120
 None
 0.62A 1q23G-3iq0A:
undetectable		 1q23G-3iq0A:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_K_FUAK712_2
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 3iq0 PUTATIVE RIBOKINASE
II
(Escherichia
coli) 		3 / 3 VAL A 148
ALA A 147
HIS A 120
 None
 0.72A 1q23L-3iq0A:
undetectable		 1q23L-3iq0A:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_L_FUAL710_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 3iq0 PUTATIVE RIBOKINASE
II
(Escherichia
coli) 		3 / 3 VAL A 148
ALA A 147
HIS A 120
 None
 0.54A 1q23J-3iq0A:
undetectable		 1q23J-3iq0A:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRL_A_TFPA204_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 3iq0 PUTATIVE RIBOKINASE
II
(Escherichia
coli) 		4 / 7 LEU A  84
PHE A 140
MET A 144
VAL A 145
 None
 0.98A 1wrlA-3iq0A:
undetectable
1wrlB-3iq0A:
undetectable		 1wrlA-3iq0A:
14.33
1wrlB-3iq0A:
14.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_B_CTXB2_1
(CES1 PROTEIN)		 3iq0 PUTATIVE RIBOKINASE
II
(Escherichia
coli) 		5 / 12 GLY A 136
VAL A 148
LEU A 182
LEU A 139
HIS A 133
 None
 1.30A 1ya4B-3iq0A:
undetectable		 1ya4B-3iq0A:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z95_A_198A501_1
(ANDROGEN RECEPTOR)		 3iq0 PUTATIVE RIBOKINASE
II
(Escherichia
coli) 		5 / 12 LEU A  11
GLY A  36
HIS A 133
THR A   6
ILE A  42
 None
 1.10A 1z95A-3iq0A:
undetectable		 1z95A-3iq0A:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A3A_A_TEPA1435_1
(CHITINASE)		 3iq0 PUTATIVE RIBOKINASE
II
(Escherichia
coli) 		3 / 3 TRP A 264
GLU A 222
TYR A 234
 None
 1.20A 2a3aA-3iq0A:
undetectable		 2a3aA-3iq0A:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2UXP_B_CLMB1211_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR TTGR)		 3iq0 PUTATIVE RIBOKINASE
II
(Escherichia
coli) 		5 / 11 HIS A 133
ALA A  37
GLU A   9
GLY A   8
VAL A  76
 None
 1.16A 2uxpB-3iq0A:
undetectable		 2uxpB-3iq0A:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MG0_K_BO2K1402_1
(PROTEASOME COMPONENT
PRE2
PROTEASOME COMPONENT
C5)		 3iq0 PUTATIVE RIBOKINASE
II
(Escherichia
coli) 		5 / 11 ALA A 232
VAL A 243
ALA A 286
GLY A 285
ALA A 281
 ATP  A 900 ( 4.0A)
None
ATP  A 900 (-3.6A)
ATP  A 900 (-3.4A)
None
 0.95A 3mg0K-3iq0A:
undetectable
3mg0L-3iq0A:
undetectable		 3mg0K-3iq0A:
18.92
3mg0L-3iq0A:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N23_A_OBNA1_1
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 3iq0 PUTATIVE RIBOKINASE
II
(Escherichia
coli) 		5 / 11 PRO A 166
ASP A 165
ALA A 263
PHE A 260
ARG A 227
 None
ATP  A 900 ( 4.3A)
None
ATP  A 900 (-4.2A)
None
 1.29A 3n23A-3iq0A:
3.7		 3n23A-3iq0A:
15.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N23_C_OBNC1_1
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 3iq0 PUTATIVE RIBOKINASE
II
(Escherichia
coli) 		5 / 11 PRO A 166
ASP A 165
ALA A 263
PHE A 260
ARG A 227
 None
ATP  A 900 ( 4.3A)
None
ATP  A 900 (-4.2A)
None
 1.29A 3n23C-3iq0A:
3.8		 3n23C-3iq0A:
15.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3THR_C_C2FC1410_0
(GLYCINE
N-METHYLTRANSFERASE)		 3iq0 PUTATIVE RIBOKINASE
II
(Escherichia
coli) 		3 / 3 ARG A 310
PRO A 247
PHE A 307
 None
 1.00A 3thrC-3iq0A:
undetectable		 3thrC-3iq0A:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_F_ACTF701_0
(RNA (33-MER)
RNA POLYMERASE
3D-POL)		 3iq0 PUTATIVE RIBOKINASE
II
(Escherichia
coli) 		4 / 4 PHE A 164
HIS A 133
GLY A 136
ILE A 134
 None
 1.03A 4k50E-3iq0A:
undetectable		 4k50E-3iq0A:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_M_ACTM503_0
(RNA POLYMERASE
3D-POL)		 3iq0 PUTATIVE RIBOKINASE
II
(Escherichia
coli) 		4 / 4 PHE A 164
HIS A 133
GLY A 136
ILE A 134
 None
 1.03A 4k50M-3iq0A:
undetectable		 4k50M-3iq0A:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KHP_A_PARA1606_1
(16S RIBOSOMAL RNA
30S RIBOSOMAL
PROTEIN S9
30S RIBOSOMAL
PROTEIN S10)		 3iq0 PUTATIVE RIBOKINASE
II
(Escherichia
coli) 		3 / 3 TYR A 235
ARG A 227
SER A 233
 None
 1.06A 4khpI-3iq0A:
undetectable
4khpJ-3iq0A:
undetectable		 4khpI-3iq0A:
18.55
4khpJ-3iq0A:
14.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KRH_B_SAMB900_1
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE
2)		 3iq0 PUTATIVE RIBOKINASE
II
(Escherichia
coli) 		4 / 4 ILE A  81
SER A  56
ASP A  77
ASP A 128
 None
 1.27A 4krhB-3iq0A:
3.5		 4krhB-3iq0A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OKW_A_198A1001_1
(ANDROGEN RECEPTOR)		 3iq0 PUTATIVE RIBOKINASE
II
(Escherichia
coli) 		5 / 12 LEU A  11
GLY A  36
HIS A 133
THR A   6
ILE A  42
 None
 1.09A 4okwA-3iq0A:
undetectable		 4okwA-3iq0A:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XT7_A_TOPA302_1
(RV2671)		 3iq0 PUTATIVE RIBOKINASE
II
(Escherichia
coli) 		5 / 11 ILE A  40
SER A  35
GLY A  36
ASP A 258
GLU A  13
 None
 1.30A 4xt7A-3iq0A:
2.9		 4xt7A-3iq0A:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XT8_A_TMQA302_1
(RV2671)		 3iq0 PUTATIVE RIBOKINASE
II
(Escherichia
coli) 		5 / 12 ILE A  40
SER A  35
GLY A  36
ALA A  37
ASP A 258
 None
 1.23A 4xt8A-3iq0A:
2.8		 4xt8A-3iq0A:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XTA_B_DIFB501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 3iq0 PUTATIVE RIBOKINASE
II
(Escherichia
coli) 		4 / 8 ILE A  42
SER A 138
LEU A 116
ILE A  10
 None
 0.99A 4xtaB-3iq0A:
undetectable		 4xtaB-3iq0A:
23.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ECK_D_ILED601_0
(JASMONIC ACID-AMIDO
SYNTHETASE JAR1)		 3iq0 PUTATIVE RIBOKINASE
II
(Escherichia
coli) 		4 / 6 ALA A 151
THR A 153
VAL A 155
VAL A 185
 None
 1.04A 5eckD-3iq0A:
undetectable		 5eckD-3iq0A:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NKN_A_LOCA201_2
(NEUTROPHIL
GELATINASE-ASSOCIATE
D LIPOCALIN)		 3iq0 PUTATIVE RIBOKINASE
II
(Escherichia
coli) 		3 / 3 VAL A  83
LYS A 115
MET A 144
 None
 1.10A 5nknA-3iq0A:
undetectable		 5nknA-3iq0A:
13.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZW4_A_SAMA302_0
(PUTATIVE
O-METHYLTRANSFERASE
YRRM)		 3iq0 PUTATIVE RIBOKINASE
II
(Escherichia
coli) 		6 / 12 ILE A 224
ALA A 232
TYR A 234
ALA A 283
ALA A 286
PHE A 307
 None
ATP  A 900 ( 4.0A)
None
None
ATP  A 900 (-3.6A)
None
 1.49A 5zw4A-3iq0A:
4.3		 5zw4A-3iq0A:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWN_B_AQ4B602_1
(CYTOCHROME P450 1A1)		 3iq0 PUTATIVE RIBOKINASE
II
(Escherichia
coli) 		4 / 7 SER A  56
ASN A 107
GLY A  36
ALA A  37
 None
 0.84A 6dwnB-3iq0A:
undetectable		 6dwnB-3iq0A:
14.42