SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3iqd'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DLS_A_MTXA188_1
(DIHYDROFOLATE
REDUCTASE)		 3iqd OCTOPINE
DEHYDROGENASE
(Pecten
maximus) 		5 / 12 GLU B 122
PHE B 200
ILE B 260
ASN B 267
LEU B 269
 None
 1.16A 1dlsA-3iqdB:
undetectable		 1dlsA-3iqdB:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I9J_H_TESH1010_1
(RECOMBINANT
MONOCLONAL
ANTI-TESTOSTERONE
FAB FRAGMENT HEAVY
CHAIN
RECOMBINANT
MONOCLONAL
ANTI-TESTOSTERONE
FAB FRAGMENT LIGHT
CHAIN)		 3iqd OCTOPINE
DEHYDROGENASE
(Pecten
maximus) 		5 / 11 SER B  67
VAL B  65
GLY B 154
LEU B  46
VAL B  29
 None
 1.40A 1i9jH-3iqdB:
undetectable
1i9jL-3iqdB:
undetectable		 1i9jH-3iqdB:
20.90
1i9jL-3iqdB:
18.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OLT_A_SAMA501_0
(OXYGEN-INDEPENDENT
COPROPORPHYRINOGEN
III OXIDASE)		 3iqd OCTOPINE
DEHYDROGENASE
(Pecten
maximus) 		5 / 12 CYH B 382
THR B 379
ASP B 376
GLY B 374
ALA B 341
 None
 1.24A 1oltA-3iqdB:
undetectable		 1oltA-3iqdB:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WG8_A_SAMA3142_1
(PREDICTED
S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE)		 3iqd OCTOPINE
DEHYDROGENASE
(Pecten
maximus) 		4 / 4 HIS B 295
ASP B 244
ASN B 251
ASP B 292
 None
 1.31A 1wg8A-3iqdB:
3.8		 1wg8A-3iqdB:
24.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOQ_B_ROFB501_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 3iqd OCTOPINE
DEHYDROGENASE
(Pecten
maximus) 		5 / 12 PRO B 145
THR B  89
ILE B  87
SER B 117
PHE B 141
 None
 1.41A 1xoqB-3iqdB:
undetectable		 1xoqB-3iqdB:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YAJ_B_BEZB12_0
(CES1 PROTEIN)		 3iqd OCTOPINE
DEHYDROGENASE
(Pecten
maximus) 		4 / 4 GLY B  19
SER B  23
VAL B  29
LEU B  17
 None
 1.25A 1yajB-3iqdB:
undetectable		 1yajB-3iqdB:
23.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A1H_A_GBNA502_1
(BRANCHED CHAIN
AMINOTRANSFERASE)		 3iqd OCTOPINE
DEHYDROGENASE
(Pecten
maximus) 		4 / 8 GLY B 173
THR B 174
ALA B 175
VAL B 106
 None
 0.51A 2a1hA-3iqdB:
undetectable
2a1hB-3iqdB:
undetectable		 2a1hA-3iqdB:
22.58
2a1hB-3iqdB:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A1H_B_GBNB501_1
(BRANCHED CHAIN
AMINOTRANSFERASE)		 3iqd OCTOPINE
DEHYDROGENASE
(Pecten
maximus) 		4 / 8 VAL B 106
GLY B 173
THR B 174
ALA B 175
 None
 0.53A 2a1hA-3iqdB:
undetectable
2a1hB-3iqdB:
undetectable		 2a1hA-3iqdB:
22.58
2a1hB-3iqdB:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIK_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)		 3iqd OCTOPINE
DEHYDROGENASE
(Pecten
maximus) 		4 / 7 LEU B 184
PHE B 194
THR B  16
LEU B  17
 None
 0.92A 2eikA-3iqdB:
undetectable
2eikJ-3iqdB:
undetectable		 2eikA-3iqdB:
21.05
2eikJ-3iqdB:
9.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HC4_A_VDXA525_1
(VITAMIN D RECEPTOR)		 3iqd OCTOPINE
DEHYDROGENASE
(Pecten
maximus) 		5 / 12 PHE B  99
LEU B  88
CYH B 125
VAL B  85
HIS B 188
 None
 1.31A 2hc4A-3iqdB:
undetectable		 2hc4A-3iqdB:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IEO_A_017A402_2
(PROTEASE)		 3iqd OCTOPINE
DEHYDROGENASE
(Pecten
maximus) 		5 / 12 GLY B  13
ALA B  14
VAL B  31
VAL B   5
VAL B   7
 NAI  B 405 (-3.5A)
None
None
None
None
 0.76A 2ieoB-3iqdB:
undetectable		 2ieoB-3iqdB:
13.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZBU_D_ADND504_1
(UNCHARACTERIZED
CONSERVED PROTEIN)		 3iqd OCTOPINE
DEHYDROGENASE
(Pecten
maximus) 		3 / 3 PHE B 210
ASN B 351
PHE B 337
 None
 0.75A 2zbuD-3iqdB:
undetectable		 2zbuD-3iqdB:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABK_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)		 3iqd OCTOPINE
DEHYDROGENASE
(Pecten
maximus) 		4 / 8 LEU B 184
PHE B 194
THR B  16
LEU B  17
 None
 0.92A 3abkA-3iqdB:
undetectable
3abkJ-3iqdB:
undetectable		 3abkA-3iqdB:
21.05
3abkJ-3iqdB:
9.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG3_W_CHDW1059_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)		 3iqd OCTOPINE
DEHYDROGENASE
(Pecten
maximus) 		4 / 8 LEU B 184
PHE B 194
THR B  16
LEU B  17
 None
 0.91A 3ag3N-3iqdB:
undetectable
3ag3W-3iqdB:
undetectable		 3ag3N-3iqdB:
21.05
3ag3W-3iqdB:
9.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ASN_W_CHDW1059_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1)		 3iqd OCTOPINE
DEHYDROGENASE
(Pecten
maximus) 		4 / 8 LEU B 184
PHE B 194
THR B  16
LEU B  17
 None
 0.93A 3asnN-3iqdB:
undetectable
3asnW-3iqdB:
undetectable		 3asnN-3iqdB:
21.05
3asnW-3iqdB:
9.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ASO_W_CHDW1059_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1)		 3iqd OCTOPINE
DEHYDROGENASE
(Pecten
maximus) 		4 / 8 LEU B 184
PHE B 194
THR B  16
LEU B  17
 None
 0.92A 3asoN-3iqdB:
undetectable
3asoW-3iqdB:
undetectable		 3asoN-3iqdB:
21.05
3asoW-3iqdB:
9.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HJO_B_EAAB211_1
(GLUTATHIONE
S-TRANSFERASE P)		 3iqd OCTOPINE
DEHYDROGENASE
(Pecten
maximus) 		4 / 8 VAL B   7
VAL B 157
ASN B  12
GLY B  13
 None
None
NAI  B 405 (-3.7A)
NAI  B 405 (-3.5A)
 0.89A 3hjoB-3iqdB:
undetectable		 3hjoB-3iqdB:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LOQ_A_ACTA278_0
(UNIVERSAL STRESS
PROTEIN)		 3iqd OCTOPINE
DEHYDROGENASE
(Pecten
maximus) 		3 / 3 SER B 117
GLY B 114
SER B 169
 None
 0.66A 3loqA-3iqdB:
2.6		 3loqA-3iqdB:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LTW_A_486A302_1
(ANCESTRAL STEROID
RECEPTOR 2)		 3iqd OCTOPINE
DEHYDROGENASE
(Pecten
maximus) 		5 / 12 LEU B 269
ILE B 205
MET B 261
ILE B 260
ALA B 344
 None
 0.99A 4ltwA-3iqdB:
undetectable		 4ltwA-3iqdB:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RZV_A_032A801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 3iqd OCTOPINE
DEHYDROGENASE
(Pecten
maximus) 		4 / 5 ILE B  72
VAL B  71
CYH B   8
HIS B  15
 None
 1.35A 4rzvA-3iqdB:
0.9		 4rzvA-3iqdB:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XOY_A_DX4A401_0
(MITOGEN-ACTIVATED
PROTEIN KINASE 1)		 3iqd OCTOPINE
DEHYDROGENASE
(Pecten
maximus) 		4 / 6 ALA B 119
GLN B 118
LEU B 204
MET B 203
 None
 1.10A 4xoyA-3iqdB:
undetectable		 4xoyA-3iqdB:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_B_SAMB301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))		 3iqd OCTOPINE
DEHYDROGENASE
(Pecten
maximus) 		5 / 12 ALA B  36
HIS B  15
PHE B  35
GLY B  10
THR B  89
 None
None
NAI  B 405 (-3.7A)
NAI  B 405 (-3.2A)
None
 1.16A 5hfjB-3iqdB:
undetectable		 5hfjB-3iqdB:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KB6_B_ADNB401_1
(ADENOSINE KINASE)		 3iqd OCTOPINE
DEHYDROGENASE
(Pecten
maximus) 		5 / 12 GLY B 397
ILE B 171
ALA B 133
GLY B 130
ALA B 134
 None
 0.94A 5kb6B-3iqdB:
3.4		 5kb6B-3iqdB:
23.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MM4_B_TA1B501_1
(TUBULIN BETA CHAIN)		 3iqd OCTOPINE
DEHYDROGENASE
(Pecten
maximus) 		5 / 10 VAL B   5
LEU B 144
ALA B  21
PRO B  69
LEU B  51
 None
NAI  B 405 (-3.9A)
None
None
None
 1.42A 5mm4B-3iqdB:
undetectable		 5mm4B-3iqdB:
12.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDX_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT VIIA-HEART)		 3iqd OCTOPINE
DEHYDROGENASE
(Pecten
maximus) 		4 / 8 LEU B 184
PHE B 194
THR B  16
LEU B  17
 None
 0.92A 5xdxN-3iqdB:
undetectable
5xdxW-3iqdB:
undetectable		 5xdxN-3iqdB:
21.05
5xdxW-3iqdB:
9.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCO_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3iqd OCTOPINE
DEHYDROGENASE
(Pecten
maximus) 		4 / 8 LEU B 184
PHE B 194
THR B  16
LEU B  17
 None
 0.90A 5zcoA-3iqdB:
undetectable
5zcoJ-3iqdB:
undetectable		 5zcoA-3iqdB:
21.05
5zcoJ-3iqdB:
9.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCP_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3iqd OCTOPINE
DEHYDROGENASE
(Pecten
maximus) 		4 / 8 LEU B 184
PHE B 194
THR B  16
LEU B  17
 None
 0.94A 5zcpN-3iqdB:
undetectable
5zcpW-3iqdB:
undetectable		 5zcpN-3iqdB:
21.05
5zcpW-3iqdB:
9.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCQ_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3iqd OCTOPINE
DEHYDROGENASE
(Pecten
maximus) 		4 / 8 LEU B 184
PHE B 194
THR B  16
LEU B  17
 None
 0.92A 5zcqN-3iqdB:
undetectable
5zcqW-3iqdB:
undetectable		 5zcqN-3iqdB:
21.05
5zcqW-3iqdB:
9.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DM0_B_CYZB1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 3iqd OCTOPINE
DEHYDROGENASE
(Pecten
maximus) 		5 / 10 LEU B 391
LEU B 269
ASP B 272
PRO B 383
GLY B 339
 None
 1.24A 6dm0B-3iqdB:
5.0
6dm0C-3iqdB:
5.1		 6dm0B-3iqdB:
11.28
6dm0C-3iqdB:
11.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DM0_D_CYZD1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 3iqd OCTOPINE
DEHYDROGENASE
(Pecten
maximus) 		5 / 9 PRO B 383
GLY B 339
LEU B 391
LEU B 269
ASP B 272
 None
 1.24A 6dm0A-3iqdB:
5.1
6dm0D-3iqdB:
5.0		 6dm0A-3iqdB:
11.28
6dm0D-3iqdB:
11.28