SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3iqt'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXF_B_DZPB2001_1
(SERUM ALBUMIN)		 3iqt SIGNAL TRANSDUCTION
HISTIDINE-PROTEIN
KINASE BARA
(Escherichia
coli) 		5 / 12 LEU A 878
ILE A 882
LEU A 837
VAL A 840
LEU A 863
 None
 1.08A 2bxfB-3iqtA:
2.9		 2bxfB-3iqtA:
13.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NV4_A_ACTA148_0
(UPF0066 PROTEIN
AF_0241)		 3iqt SIGNAL TRANSDUCTION
HISTIDINE-PROTEIN
KINASE BARA
(Escherichia
coli) 		3 / 3 VAL A 849
GLU A 845
GLU A 846
 None
 0.73A 2nv4A-3iqtA:
undetectable		 2nv4A-3iqtA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DQF_A_LCRA612_1
(SERUM ALBUMIN)		 3iqt SIGNAL TRANSDUCTION
HISTIDINE-PROTEIN
KINASE BARA
(Escherichia
coli) 		5 / 9 LEU A 848
ASP A 894
LEU A 895
LEU A 899
LEU A 856
 None
 1.13A 5dqfA-3iqtA:
2.4		 5dqfA-3iqtA:
12.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HPU_C_IPHC101_0
(INSULIN, CHAIN A
INSULIN, CHAIN B)		 3iqt SIGNAL TRANSDUCTION
HISTIDINE-PROTEIN
KINASE BARA
(Escherichia
coli) 		4 / 6 LEU A 902
CYH A 867
HIS A 864
LEU A 863
 None
 1.06A 5hpuC-3iqtA:
undetectable
5hpuD-3iqtA:
undetectable		 5hpuC-3iqtA:
10.62
5hpuD-3iqtA:
9.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5U4S_A_BEZA301_0
(PUTATIVE SHORT CHAIN
DEHYDROGENASE)		 3iqt SIGNAL TRANSDUCTION
HISTIDINE-PROTEIN
KINASE BARA
(Escherichia
coli) 		4 / 7 ILE A 882
LEU A 902
MET A 906
LEU A 903
 None
 1.01A 5u4sA-3iqtA:
undetectable		 5u4sA-3iqtA:
19.18