SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3ir1'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A52_A_ESTA1_1
(ESTROGEN RECEPTOR)		 3ir1 OUTER MEMBRANE
LIPOPROTEIN GNA1946
(Neisseria
meningitidis) 		5 / 10 ALA A 241
LEU A  88
LEU A  93
ILE A  45
LEU A 252
 None
 1.37A 1a52A-3ir1A:
undetectable		 1a52A-3ir1A:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A52_B_ESTB2_1
(ESTROGEN RECEPTOR)		 3ir1 OUTER MEMBRANE
LIPOPROTEIN GNA1946
(Neisseria
meningitidis) 		5 / 10 ALA A 241
LEU A  88
LEU A  93
ILE A  45
LEU A 252
 None
 1.39A 1a52B-3ir1A:
undetectable		 1a52B-3ir1A:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERE_A_ESTA600_1
(ESTROGEN RECEPTOR)		 3ir1 OUTER MEMBRANE
LIPOPROTEIN GNA1946
(Neisseria
meningitidis) 		5 / 9 ALA A 241
LEU A  88
LEU A  93
ILE A  45
LEU A 252
 None
 1.45A 1ereA-3ir1A:
undetectable		 1ereA-3ir1A:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HA2_A_SCKA901_1
(ACETYLCHOLINESTERASE)		 3ir1 OUTER MEMBRANE
LIPOPROTEIN GNA1946
(Neisseria
meningitidis) 		4 / 8 ASP A  80
TYR A 216
TYR A 103
HIS A 100
 None
None
MET  A 600 (-3.6A)
MET  A 600 (-3.6A)
 1.42A 2ha2A-3ir1A:
undetectable		 2ha2A-3ir1A:
18.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HA2_B_SCKB951_1
(ACETYLCHOLINESTERASE)		 3ir1 OUTER MEMBRANE
LIPOPROTEIN GNA1946
(Neisseria
meningitidis) 		4 / 8 ASP A  80
TYR A 216
TYR A 103
HIS A 100
 None
None
MET  A 600 (-3.6A)
MET  A 600 (-3.6A)
 1.38A 2ha2B-3ir1A:
undetectable		 2ha2B-3ir1A:
18.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QBL_A_CAMA517_0
(CYTOCHROME P450-CAM)		 3ir1 OUTER MEMBRANE
LIPOPROTEIN GNA1946
(Neisseria
meningitidis) 		4 / 7 LEU A 252
VAL A 255
THR A 256
VAL A 121
 None
 0.94A 2qblA-3ir1A:
undetectable		 2qblA-3ir1A:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LTW_A_HLZA302_1
(ARYLAMINE
N-ACETYLTRANSFERASE
NAT)		 3ir1 OUTER MEMBRANE
LIPOPROTEIN GNA1946
(Neisseria
meningitidis) 		4 / 6 LEU A 126
GLU A 231
PRO A 232
ARG A 156
 None
None
None
MET  A 600 (-3.2A)
 1.13A 3ltwA-3ir1A:
undetectable		 3ltwA-3ir1A:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HOJ_A_ACTA303_0
(REGF PROTEIN)		 3ir1 OUTER MEMBRANE
LIPOPROTEIN GNA1946
(Neisseria
meningitidis) 		4 / 5 VAL A 157
ARG A 156
MET A 160
GLU A 231
 None
MET  A 600 (-3.2A)
None
None
 1.25A 4hojA-3ir1A:
undetectable		 4hojA-3ir1A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KOE_H_TR6H101_1
(DNA TOPOISOMERASE 4
SUBUNIT A
DNA TOPOISOMERASE 4
SUBUNIT B
E-SITE DNA4)		 3ir1 OUTER MEMBRANE
LIPOPROTEIN GNA1946
(Neisseria
meningitidis) 		4 / 7 SER A 203
GLY A 214
GLY A 127
GLU A 231
 None
 0.93A 4koeA-3ir1A:
undetectable
4koeB-3ir1A:
undetectable
4koeD-3ir1A:
undetectable		 4koeA-3ir1A:
19.64
4koeB-3ir1A:
19.64
4koeD-3ir1A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z53_H_TR6H101_1
(DNA TOPOISOMERASE 4
SUBUNIT B,DNA
TOPOISOMERASE 4
SUBUNIT A
E-SITE DNA)		 3ir1 OUTER MEMBRANE
LIPOPROTEIN GNA1946
(Neisseria
meningitidis) 		4 / 7 GLY A 214
GLY A 127
GLU A 231
SER A 203
 None
 0.89A 4z53A-3ir1A:
undetectable
4z53B-3ir1A:
undetectable		 4z53A-3ir1A:
16.60
4z53B-3ir1A:
16.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B8I_C_FK5C201_1
(SERINE/THREONINE-PRO
TEIN PHOSPHATASE
PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE)		 3ir1 OUTER MEMBRANE
LIPOPROTEIN GNA1946
(Neisseria
meningitidis) 		4 / 6 SER A 152
PRO A 151
PHE A 154
GLU A 194
 None
 1.28A 5b8iA-3ir1A:
undetectable		 5b8iA-3ir1A:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7P_E_CHDE401_0
(BILE SALT HYDROLASE)		 3ir1 OUTER MEMBRANE
LIPOPROTEIN GNA1946
(Neisseria
meningitidis) 		4 / 8 ILE A 192
ASN A 213
LEU A 158
LEU A 126
 None
MET  A 600 (-3.9A)
None
None
 0.80A 5y7pE-3ir1A:
undetectable		 5y7pE-3ir1A:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A93_B_8NUB3001_1
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		 3ir1 OUTER MEMBRANE
LIPOPROTEIN GNA1946
(Neisseria
meningitidis) 		4 / 5 ASP A  53
ILE A  62
PHE A 264
TYR A 275
 None
 1.21A 6a93B-3ir1A:
undetectable		 6a93B-3ir1A:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BEO_A_DHIA4_0
((DPR)PY(DHI)PKDL(DGN
))		 3ir1 OUTER MEMBRANE
LIPOPROTEIN GNA1946
(Neisseria
meningitidis) 		3 / 3 TYR A 129
PRO A 201
LEU A 200
 None
 0.95A 6beoA-3ir1A:
undetectable		 6beoA-3ir1A:
4.28