SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3ira'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX1_D_THAD4_2
(LIVER
CARBOXYLESTERASE I)		 3ira CONSERVED PROTEIN
(Methanosarcina
mazei) 		3 / 3 PHE A 118
LEU A 137
MET A  70
 None
 0.87A 1mx1D-3iraA:
undetectable		 1mx1D-3iraA:
14.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N4F_A_ASRA140_0
(LYSOZYME C)		 3ira CONSERVED PROTEIN
(Methanosarcina
mazei) 		3 / 3 ASN A  19
ALA A  67
ASN A  71
 None
 0.74A 1n4fA-3iraA:
undetectable		 1n4fA-3iraA:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RV7_B_AB1B1001_1
(PROTEASE)		 3ira CONSERVED PROTEIN
(Methanosarcina
mazei) 		5 / 11 ASN A  38
LEU A 153
PRO A 116
ALA A 156
VAL A 152
 None
 1.16A 1rv7A-3iraA:
undetectable
1rv7B-3iraA:
undetectable		 1rv7A-3iraA:
21.02
1rv7B-3iraA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOQ_A_ROFA502_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 3ira CONSERVED PROTEIN
(Methanosarcina
mazei) 		3 / 3 ASN A  19
TRP A  23
GLN A  15
 None
 1.42A 1xoqA-3iraA:
undetectable		 1xoqA-3iraA:
17.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VN0_A_TDZA501_1
(CYTOCHROME P450 2C8)		 3ira CONSERVED PROTEIN
(Methanosarcina
mazei) 		5 / 12 ILE A 163
PHE A  42
ASN A 107
VAL A 152
ILE A 123
 None
 1.20A 2vn0A-3iraA:
undetectable		 2vn0A-3iraA:
16.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG4_W_CHDW1059_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)		 3ira CONSERVED PROTEIN
(Methanosarcina
mazei) 		4 / 7 ILE A 109
PHE A  74
ARG A 140
MET A 134
 None
 1.06A 3ag4N-3iraA:
undetectable
3ag4W-3iraA:
undetectable		 3ag4N-3iraA:
14.40
3ag4W-3iraA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GBO_B_CUB301_0
(E7)		 3ira CONSERVED PROTEIN
(Methanosarcina
mazei) 		4 / 5 HIS A  54
ALA A  57
HIS A  16
GLN A  15
 None
 1.47A 4gboB-3iraA:
undetectable		 4gboB-3iraA:
17.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TRQ_B_ACTB306_0
(WELO5)		 3ira CONSERVED PROTEIN
(Methanosarcina
mazei) 		3 / 3 GLU A  29
ARG A   4
TYR A  24
 None
 0.64A 5trqB-3iraA:
undetectable		 5trqB-3iraA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_ACTA817_0
(GEPHYRIN)		 3ira CONSERVED PROTEIN
(Methanosarcina
mazei) 		3 / 3 THR A 111
ALA A 156
LYS A 158
 None
 0.77A 6fgdA-3iraA:
undetectable		 6fgdA-3iraA:
17.42