SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3iru'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MXD_A_ACRA733_1
(ALPHA AMYLASE)		 3iru PHOSHONOACETALDEHYDE
HYDROLASE LIKE
PROTEIN
(Oleispira
antarctica) 		4 / 6 SER A 155
THR A 156
LEU A  17
TRP A  19
 None
NA  A 301 (-4.7A)
None
None
 1.34A 1mxdA-3iruA:
undetectable		 1mxdA-3iruA:
19.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T3R_A_017A1200_1
(PROTEASE RETROPEPSIN)		 3iru PHOSHONOACETALDEHYDE
HYDROLASE LIKE
PROTEIN
(Oleispira
antarctica) 		5 / 10 LEU A  29
GLY A  21
ALA A  20
GLY A  56
VAL A  32
 None
 0.84A 1t3rA-3iruA:
undetectable		 1t3rA-3iruA:
16.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IEN_B_017B402_1
(PROTEASE)		 3iru PHOSHONOACETALDEHYDE
HYDROLASE LIKE
PROTEIN
(Oleispira
antarctica) 		5 / 12 LEU A  29
GLY A  21
ALA A  20
GLY A  56
VAL A  32
 None
 0.89A 2ienA-3iruA:
undetectable		 2ienA-3iruA:
16.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IEO_A_017A402_1
(PROTEASE)		 3iru PHOSHONOACETALDEHYDE
HYDROLASE LIKE
PROTEIN
(Oleispira
antarctica) 		5 / 12 LEU A  29
GLY A  21
ALA A  20
GLY A  56
VAL A  32
 None
 0.94A 2ieoA-3iruA:
undetectable		 2ieoA-3iruA:
16.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM3_B_478B200_1
(PROTEASE)		 3iru PHOSHONOACETALDEHYDE
HYDROLASE LIKE
PROTEIN
(Oleispira
antarctica) 		5 / 10 LEU A  29
GLY A  21
ALA A  20
GLY A  56
VAL A  32
 None
 0.88A 3em3A-3iruA:
undetectable		 3em3A-3iruA:
17.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G88_A_SAMA303_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE G)		 3iru PHOSHONOACETALDEHYDE
HYDROLASE LIKE
PROTEIN
(Oleispira
antarctica) 		5 / 11 GLY A 214
GLY A  21
ASP A 192
THR A 193
ALA A 239
 None
 1.06A 3g88A-3iruA:
undetectable		 3g88A-3iruA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G88_B_SAMB303_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE G)		 3iru PHOSHONOACETALDEHYDE
HYDROLASE LIKE
PROTEIN
(Oleispira
antarctica) 		5 / 11 GLY A 214
GLY A  21
ASP A 192
THR A 193
ALA A 239
 None
 1.07A 3g88B-3iruA:
undetectable		 3g88B-3iruA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G89_A_SAMA303_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE G)		 3iru PHOSHONOACETALDEHYDE
HYDROLASE LIKE
PROTEIN
(Oleispira
antarctica) 		5 / 12 GLY A 214
GLY A  21
ASP A 192
THR A 193
ALA A 239
 None
 1.09A 3g89A-3iruA:
undetectable		 3g89A-3iruA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G89_B_SAMB303_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE G)		 3iru PHOSHONOACETALDEHYDE
HYDROLASE LIKE
PROTEIN
(Oleispira
antarctica) 		5 / 11 GLY A 214
GLY A  21
ASP A 192
THR A 193
ALA A 239
 None
 1.10A 3g89B-3iruA:
undetectable		 3g89B-3iruA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G8B_A_SAMA303_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE G)		 3iru PHOSHONOACETALDEHYDE
HYDROLASE LIKE
PROTEIN
(Oleispira
antarctica) 		5 / 12 GLY A 214
GLY A  21
ASP A 192
THR A 193
ALA A 239
 None
 1.04A 3g8bA-3iruA:
undetectable		 3g8bA-3iruA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G8B_B_SAMB303_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE G)		 3iru PHOSHONOACETALDEHYDE
HYDROLASE LIKE
PROTEIN
(Oleispira
antarctica) 		5 / 12 GLY A 214
GLY A  21
ASP A 192
THR A 193
ALA A 239
 None
 1.03A 3g8bB-3iruA:
undetectable		 3g8bB-3iruA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JW2_A_017A401_1
(GAG-POL POLYPROTEIN)		 3iru PHOSHONOACETALDEHYDE
HYDROLASE LIKE
PROTEIN
(Oleispira
antarctica) 		5 / 12 LEU A  29
GLY A  21
ALA A  20
GLY A  56
VAL A  32
 None
 0.88A 3jw2A-3iruA:
undetectable		 3jw2A-3iruA:
16.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K13_C_THHC643_1
(5-METHYLTETRAHYDROFO
LATE-HOMOCYSTEINE
METHYLTRANSFERASE)		 3iru PHOSHONOACETALDEHYDE
HYDROLASE LIKE
PROTEIN
(Oleispira
antarctica) 		3 / 3 ASN A 131
ASP A 191
ARG A  64
 None
 0.95A 3k13C-3iruA:
undetectable		 3k13C-3iruA:
24.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LZU_A_017A200_2
(HIV-1 PROTEASE)		 3iru PHOSHONOACETALDEHYDE
HYDROLASE LIKE
PROTEIN
(Oleispira
antarctica) 		5 / 12 LEU A  29
GLY A  21
ALA A  20
GLY A  56
VAL A  32
 None
 0.76A 3lzuB-3iruA:
undetectable		 3lzuB-3iruA:
17.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXW_B_017B200_1
(HIV-1 PROTEASE)		 3iru PHOSHONOACETALDEHYDE
HYDROLASE LIKE
PROTEIN
(Oleispira
antarctica) 		5 / 10 LEU A  29
GLY A  21
ALA A  20
GLY A  56
VAL A  32
 None
 0.76A 3oxwA-3iruA:
undetectable		 3oxwA-3iruA:
17.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DQB_B_017B101_2
(ASPARTYL PROTEASE)		 3iru PHOSHONOACETALDEHYDE
HYDROLASE LIKE
PROTEIN
(Oleispira
antarctica) 		5 / 10 LEU A  29
GLY A  21
ALA A  20
GLY A  56
VAL A  32
 None
 0.67A 4dqbB-3iruA:
undetectable		 4dqbB-3iruA:
15.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DQE_B_017B101_2
(ASPARTYL PROTEASE)		 3iru PHOSHONOACETALDEHYDE
HYDROLASE LIKE
PROTEIN
(Oleispira
antarctica) 		5 / 10 LEU A  29
GLY A  21
ALA A  20
GLY A  56
VAL A  32
 None
 0.66A 4dqeB-3iruA:
undetectable		 4dqeB-3iruA:
15.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DQH_B_017B101_2
(WILD-TYPE HIV-1
PROTEASE DIMER)		 3iru PHOSHONOACETALDEHYDE
HYDROLASE LIKE
PROTEIN
(Oleispira
antarctica) 		5 / 10 LEU A  29
GLY A  21
ALA A  20
GLY A  56
VAL A  32
 None
 0.68A 4dqhB-3iruA:
undetectable		 4dqhB-3iruA:
15.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QN9_B_DXCB610_0
(N-ACYL-PHOSPHATIDYLE
THANOLAMINE-HYDROLYZ
ING PHOSPHOLIPASE D)		 3iru PHOSHONOACETALDEHYDE
HYDROLASE LIKE
PROTEIN
(Oleispira
antarctica) 		3 / 3 GLY A 137
PRO A 136
ALA A 159
 None
 0.40A 4qn9B-3iruA:
undetectable		 4qn9B-3iruA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XEY_A_1N1A601_2
(TYROSINE-PROTEIN
KINASE ABL1)		 3iru PHOSHONOACETALDEHYDE
HYDROLASE LIKE
PROTEIN
(Oleispira
antarctica) 		3 / 3 MET A  55
ASP A  25
PHE A  26
 None
 1.03A 4xeyA-3iruA:
undetectable		 4xeyA-3iruA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XEY_B_1N1B601_2
(TYROSINE-PROTEIN
KINASE ABL1)		 3iru PHOSHONOACETALDEHYDE
HYDROLASE LIKE
PROTEIN
(Oleispira
antarctica) 		3 / 3 MET A  55
ASP A  25
PHE A  26
 None
 1.07A 4xeyB-3iruA:
undetectable		 4xeyB-3iruA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FQD_E_LVYE1438_1
(PROTEIN CEREBLON
CASEIN KINASE I
ISOFORM ALPHA)		 3iru PHOSHONOACETALDEHYDE
HYDROLASE LIKE
PROTEIN
(Oleispira
antarctica) 		5 / 12 PRO A  54
HIS A  62
SER A  60
ILE A  72
GLY A  68
 None
 1.47A 5fqdE-3iruA:
0.0
5fqdF-3iruA:
0.0		 5fqdE-3iruA:
18.52
5fqdF-3iruA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_F_CVIF301_1
(REGULATORY PROTEIN
TETR)		 3iru PHOSHONOACETALDEHYDE
HYDROLASE LIKE
PROTEIN
(Oleispira
antarctica) 		4 / 8 ARG A 107
GLN A 100
TYR A 134
ASP A 223
 None
 1.16A 5vlmF-3iruA:
undetectable		 5vlmF-3iruA:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BXN_A_SAMA901_0
(DIPHTHAMIDE
BIOSYNTHESIS ENZYME
DPH2)		 3iru PHOSHONOACETALDEHYDE
HYDROLASE LIKE
PROTEIN
(Oleispira
antarctica) 		5 / 12 VAL A 261
ARG A 236
ILE A 252
ASP A 253
ASP A 257
 None
 1.11A 6bxnA-3iruA:
undetectable		 6bxnA-3iruA:
21.93