SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3irv'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AV2_D_DVAD8_0
(GRAMICIDIN A)		 3irv CYSTEINE HYDROLASE
(Pseudomonas
savastanoi) 		3 / 3 VAL A  41
VAL A 234
TRP A  43
 None
 0.65A 1av2C-3irvA:
undetectable
1av2D-3irvA:
undetectable		 1av2C-3irvA:
9.78
1av2D-3irvA:
9.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KQE_A_DVAA6_0
(MINI-GRAMICIDIN A)		 3irv CYSTEINE HYDROLASE
(Pseudomonas
savastanoi) 		3 / 3 ALA A 228
VAL A  41
TRP A  43
 None
 0.89A 1kqeA-3irvA:
undetectable
1kqeE-3irvA:
undetectable		 1kqeA-3irvA:
5.31
1kqeE-3irvA:
5.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W5U_D_DVAD8_0
(GRAMICIDIN D)		 3irv CYSTEINE HYDROLASE
(Pseudomonas
savastanoi) 		3 / 3 VAL A  41
VAL A 234
TRP A  43
 None
 0.57A 1w5uC-3irvA:
undetectable
1w5uD-3irvA:
undetectable		 1w5uC-3irvA:
9.78
1w5uD-3irvA:
9.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XVA_A_SAMA293_0
(GLYCINE
N-METHYLTRANSFERASE)		 3irv CYSTEINE HYDROLASE
(Pseudomonas
savastanoi) 		5 / 12 THR A 182
VAL A  55
ASP A  56
TYR A 206
TYR A 115
 None
 1.45A 1xvaA-3irvA:
3.1		 1xvaA-3irvA:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA3_B_STRB2001_1
(MINERALOCORTICOID
RECEPTOR)		 3irv CYSTEINE HYDROLASE
(Pseudomonas
savastanoi) 		5 / 12 LEU A 197
ASN A 201
ALA A 202
MET A  57
LEU A 135
 None
 1.34A 1ya3B-3irvA:
undetectable		 1ya3B-3irvA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IZQ_A_DVAA8_0
(GRAMICIDIN D)		 3irv CYSTEINE HYDROLASE
(Pseudomonas
savastanoi) 		3 / 3 VAL A 234
TRP A  43
VAL A  41
 None
 0.55A 2izqA-3irvA:
undetectable
2izqB-3irvA:
undetectable		 2izqA-3irvA:
9.78
2izqB-3irvA:
9.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NYU_B_SAMB201_0
(PUTATIVE RIBOSOMAL
RNA
METHYLTRANSFERASE 2)		 3irv CYSTEINE HYDROLASE
(Pseudomonas
savastanoi) 		5 / 12 GLY A 173
ALA A 200
LEU A 197
THR A 183
LEU A  97
 None
 1.06A 2nyuB-3irvA:
4.2		 2nyuB-3irvA:
24.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OAX_B_SNLB2001_1
(MINERALOCORTICOID
RECEPTOR)		 3irv CYSTEINE HYDROLASE
(Pseudomonas
savastanoi) 		5 / 12 LEU A 197
ASN A 201
ALA A 202
MET A  57
LEU A 135
 None
 1.34A 2oaxB-3irvA:
undetectable		 2oaxB-3irvA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OAX_C_SNLC3001_1
(MINERALOCORTICOID
RECEPTOR)		 3irv CYSTEINE HYDROLASE
(Pseudomonas
savastanoi) 		5 / 12 LEU A 197
ASN A 201
ALA A 202
MET A  57
LEU A 135
 None
 1.39A 2oaxC-3irvA:
undetectable		 2oaxC-3irvA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OAX_D_SNLD4001_1
(MINERALOCORTICOID
RECEPTOR)		 3irv CYSTEINE HYDROLASE
(Pseudomonas
savastanoi) 		5 / 12 LEU A 197
ASN A 201
ALA A 202
MET A  57
LEU A 135
 None
 1.36A 2oaxD-3irvA:
undetectable		 2oaxD-3irvA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WT9_A_NIOA1216_1
(NICOTINAMIDASE)		 3irv CYSTEINE HYDROLASE
(Pseudomonas
savastanoi) 		5 / 10 ASP A  56
PHE A  61
LEU A  68
TYR A 149
CYH A 179
 None
 0.63A 2wt9A-3irvA:
21.7		 2wt9A-3irvA:
24.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WT9_A_NIOA1216_1
(NICOTINAMIDASE)		 3irv CYSTEINE HYDROLASE
(Pseudomonas
savastanoi) 		5 / 10 PHE A  61
LEU A  68
ASP A  56
TYR A 149
CYH A 179
 None
 1.31A 2wt9A-3irvA:
21.7		 2wt9A-3irvA:
24.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EL0_A_1UNA201_2
(PROTEASE)		 3irv CYSTEINE HYDROLASE
(Pseudomonas
savastanoi) 		5 / 9 VAL A 171
ILE A 184
GLY A 187
ALA A  51
ILE A  53
 None
 0.81A 3el0B-3irvA:
undetectable		 3el0B-3irvA:
17.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_B_CHDB200_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 3irv CYSTEINE HYDROLASE
(Pseudomonas
savastanoi) 		4 / 5 PRO A 137
VAL A 131
THR A 183
GLY A 151
 None
 1.16A 3elzB-3irvA:
undetectable		 3elzB-3irvA:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IA4_D_MTXD164_2
(DIHYDROFOLATE
REDUCTASE)		 3irv CYSTEINE HYDROLASE
(Pseudomonas
savastanoi) 		3 / 3 ARG A  88
ILE A 170
THR A 183
 None
 0.62A 3ia4D-3irvA:
undetectable		 3ia4D-3irvA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L8L_B_DVAB8_0
(GRAMICIDIN D)		 3irv CYSTEINE HYDROLASE
(Pseudomonas
savastanoi) 		3 / 3 VAL A  41
VAL A 234
TRP A  43
 None
 0.73A 3l8lA-3irvA:
undetectable
3l8lB-3irvA:
undetectable		 3l8lA-3irvA:
9.78
3l8lB-3irvA:
7.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L8L_D_DVAD8_0
(GRAMICIDIN D)		 3irv CYSTEINE HYDROLASE
(Pseudomonas
savastanoi) 		3 / 3 VAL A  41
VAL A 234
TRP A  43
 None
 0.49A 3l8lC-3irvA:
undetectable
3l8lD-3irvA:
undetectable		 3l8lC-3irvA:
9.78
3l8lD-3irvA:
7.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P4W_A_DSFA319_1
(GLR4197 PROTEIN)		 3irv CYSTEINE HYDROLASE
(Pseudomonas
savastanoi) 		5 / 9 ILE A  53
ILE A 169
VAL A  55
THR A 183
ILE A 184
 None
 1.13A 3p4wA-3irvA:
undetectable		 3p4wA-3irvA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P4W_B_DSFB319_1
(GLR4197 PROTEIN)		 3irv CYSTEINE HYDROLASE
(Pseudomonas
savastanoi) 		5 / 9 ILE A  53
ILE A 169
VAL A  55
THR A 183
ILE A 184
 None
 1.12A 3p4wB-3irvA:
undetectable		 3p4wB-3irvA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P4W_D_DSFD319_1
(GLR4197 PROTEIN)		 3irv CYSTEINE HYDROLASE
(Pseudomonas
savastanoi) 		5 / 10 ILE A  53
ILE A 169
VAL A  55
THR A 183
ILE A 184
 None
 1.12A 3p4wD-3irvA:
undetectable		 3p4wD-3irvA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P4W_E_DSFE319_1
(GLR4197 PROTEIN)		 3irv CYSTEINE HYDROLASE
(Pseudomonas
savastanoi) 		5 / 10 ILE A  53
ILE A 169
VAL A  55
THR A 183
ILE A 184
 None
 1.13A 3p4wE-3irvA:
undetectable		 3p4wE-3irvA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R2J_B_NIOB311_1
(ALPHA/BETA-HYDROLASE
-LIKE PROTEIN)		 3irv CYSTEINE HYDROLASE
(Pseudomonas
savastanoi) 		5 / 11 ASP A  56
PHE A  61
LEU A  68
LYS A 146
TYR A 149
 None
 0.61A 3r2jB-3irvA:
23.0		 3r2jB-3irvA:
24.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R2J_C_NIOC311_1
(ALPHA/BETA-HYDROLASE
-LIKE PROTEIN)		 3irv CYSTEINE HYDROLASE
(Pseudomonas
savastanoi) 		5 / 12 ASP A  56
PHE A  61
LEU A  68
LYS A 146
TYR A 149
 None
 0.66A 3r2jC-3irvA:
23.3		 3r2jC-3irvA:
24.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R2J_D_NIOD311_1
(ALPHA/BETA-HYDROLASE
-LIKE PROTEIN)		 3irv CYSTEINE HYDROLASE
(Pseudomonas
savastanoi) 		5 / 11 ASP A  56
PHE A  61
LEU A  68
LYS A 146
TYR A 149
 None
 0.63A 3r2jD-3irvA:
23.0		 3r2jD-3irvA:
24.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RF4_A_FUNA201_1
(MACROPHAGE MIGRATION
INHIBITORY FACTOR)		 3irv CYSTEINE HYDROLASE
(Pseudomonas
savastanoi) 		5 / 11 ARG A 185
VAL A 194
PHE A 231
VAL A 188
ILE A 227
 None
 1.35A 3rf4A-3irvA:
undetectable
3rf4C-3irvA:
undetectable		 3rf4A-3irvA:
21.60
3rf4C-3irvA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RF4_B_FUNB202_1
(MACROPHAGE MIGRATION
INHIBITORY FACTOR)		 3irv CYSTEINE HYDROLASE
(Pseudomonas
savastanoi) 		5 / 11 ILE A 227
ARG A 185
VAL A 194
PHE A 231
VAL A 188
 None
 1.35A 3rf4A-3irvA:
undetectable
3rf4B-3irvA:
undetectable		 3rf4A-3irvA:
21.60
3rf4B-3irvA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RF4_C_FUNC203_1
(MACROPHAGE MIGRATION
INHIBITORY FACTOR)		 3irv CYSTEINE HYDROLASE
(Pseudomonas
savastanoi) 		5 / 11 ILE A 227
ARG A 185
VAL A 194
PHE A 231
VAL A 188
 None
 1.33A 3rf4B-3irvA:
undetectable
3rf4C-3irvA:
undetectable		 3rf4B-3irvA:
21.60
3rf4C-3irvA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VHU_A_SNLA1001_1
(MINERALOCORTICOID
RECEPTOR)		 3irv CYSTEINE HYDROLASE
(Pseudomonas
savastanoi) 		5 / 12 LEU A 197
ASN A 201
ALA A 202
MET A  57
LEU A 135
 None
 1.36A 3vhuA-3irvA:
undetectable		 3vhuA-3irvA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L1W_A_STRA402_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		 3irv CYSTEINE HYDROLASE
(Pseudomonas
savastanoi) 		4 / 7 VAL A 240
ILE A 241
LEU A 135
LEU A  84
 None
 1.00A 4l1wA-3irvA:
undetectable		 4l1wA-3irvA:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UDA_A_DEXA1985_1
(MINERALOCORTICOID
RECEPTOR)		 3irv CYSTEINE HYDROLASE
(Pseudomonas
savastanoi) 		5 / 12 LEU A 197
ASN A 201
ALA A 202
MET A  57
LEU A 135
 None
 1.34A 4udaA-3irvA:
undetectable		 4udaA-3irvA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MZR_A_PFLA412_1
(PROTON-GATED ION
CHANNEL)		 3irv CYSTEINE HYDROLASE
(Pseudomonas
savastanoi) 		5 / 10 ILE A  53
ILE A 169
VAL A  55
THR A 183
ILE A 184
 None
 1.16A 5mzrA-3irvA:
undetectable		 5mzrA-3irvA:
17.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MZR_C_PFLC409_1
(PROTON-GATED ION
CHANNEL)		 3irv CYSTEINE HYDROLASE
(Pseudomonas
savastanoi) 		5 / 10 ILE A  53
ILE A 169
VAL A  55
THR A 183
ILE A 184
 None
 1.16A 5mzrC-3irvA:
undetectable		 5mzrC-3irvA:
17.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MZR_D_PFLD410_1
(PROTON-GATED ION
CHANNEL)		 3irv CYSTEINE HYDROLASE
(Pseudomonas
savastanoi) 		5 / 9 ILE A  53
ILE A 169
VAL A  55
THR A 183
ILE A 184
 None
 1.12A 5mzrD-3irvA:
undetectable		 5mzrD-3irvA:
17.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ECE_C_DVAC3010_0
(VLM2
DODECADEPSIPEPTIDE)		 3irv CYSTEINE HYDROLASE
(Pseudomonas
savastanoi) 		3 / 3 ALA A  67
PHE A  61
GLN A  58
 None
 0.68A 6eceA-3irvA:
3.2		 6eceA-3irvA:
21.54