SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3is5'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PXX_A_DIFA701_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3is5 CALCIUM-DEPENDENT
PROTEIN KINASE
(Toxoplasma
gondii) 		5 / 10 LEU A 374
GLY A 323
ALA A 322
SER A 321
LEU A 261
 None
 0.98A 1pxxA-3is5A:
undetectable		 1pxxA-3is5A:
18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PXX_C_DIFC2701_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3is5 CALCIUM-DEPENDENT
PROTEIN KINASE
(Toxoplasma
gondii) 		5 / 12 LEU A 374
GLY A 323
ALA A 322
SER A 321
LEU A 261
 None
 0.97A 1pxxC-3is5A:
undetectable		 1pxxC-3is5A:
18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SA1_B_PODB700_1
(TUBULIN ALPHA CHAIN
TUBULIN BETA CHAIN)		 3is5 CALCIUM-DEPENDENT
PROTEIN KINASE
(Toxoplasma
gondii) 		6 / 12 LEU A 362
ALA A 366
LEU A 370
MET A 373
VAL A 237
ALA A 238
 None
 1.06A 1sa1A-3is5A:
undetectable
1sa1B-3is5A:
undetectable		 1sa1A-3is5A:
20.87
1sa1B-3is5A:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SA1_D_PODD701_1
(TUBULIN ALPHA CHAIN
TUBULIN BETA CHAIN)		 3is5 CALCIUM-DEPENDENT
PROTEIN KINASE
(Toxoplasma
gondii) 		6 / 12 LEU A 362
ALA A 366
LEU A 370
MET A 373
VAL A 237
ALA A 238
 None
 1.07A 1sa1C-3is5A:
undetectable
1sa1D-3is5A:
undetectable		 1sa1C-3is5A:
20.87
1sa1D-3is5A:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_A_SC2A1290_1
(FICOLIN-2)		 3is5 CALCIUM-DEPENDENT
PROTEIN KINASE
(Toxoplasma
gondii) 		4 / 5 ASP A 270
SER A 275
LEU A 267
GLY A 215
 None
GOL  A 400 ( 4.7A)
None
None
 0.96A 2j2pA-3is5A:
undetectable
2j2pB-3is5A:
undetectable		 2j2pA-3is5A:
18.40
2j2pB-3is5A:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_C_SC2C1289_1
(FICOLIN-2)		 3is5 CALCIUM-DEPENDENT
PROTEIN KINASE
(Toxoplasma
gondii) 		4 / 6 ASP A 270
SER A 275
LEU A 267
GLY A 215
 None
GOL  A 400 ( 4.7A)
None
None
 0.98A 2j2pA-3is5A:
undetectable
2j2pC-3is5A:
undetectable		 2j2pA-3is5A:
18.40
2j2pC-3is5A:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_F_SC2F1289_1
(FICOLIN-2)		 3is5 CALCIUM-DEPENDENT
PROTEIN KINASE
(Toxoplasma
gondii) 		4 / 6 ASP A 270
SER A 275
LEU A 267
GLY A 215
 None
GOL  A 400 ( 4.7A)
None
None
 0.99A 2j2pD-3is5A:
undetectable
2j2pF-3is5A:
undetectable		 2j2pD-3is5A:
18.40
2j2pF-3is5A:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QB4_A_DSMA801_1
(TRANSPORTER)		 3is5 CALCIUM-DEPENDENT
PROTEIN KINASE
(Toxoplasma
gondii) 		5 / 12 LEU A 185
LEU A 188
ALA A 247
PHE A 251
LEU A 261
 GOL  A 398 ( 4.6A)
None
None
None
None
 0.99A 2qb4A-3is5A:
undetectable		 2qb4A-3is5A:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QJU_A_DSMA801_1
(TRANSPORTER)		 3is5 CALCIUM-DEPENDENT
PROTEIN KINASE
(Toxoplasma
gondii) 		5 / 11 LEU A 185
LEU A 188
ALA A 247
PHE A 251
LEU A 261
 GOL  A 398 ( 4.6A)
None
None
None
None
 1.05A 2qjuA-3is5A:
undetectable		 2qjuA-3is5A:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W8Y_A_486A1000_2
(PROGESTERONE
RECEPTOR)		 3is5 CALCIUM-DEPENDENT
PROTEIN KINASE
(Toxoplasma
gondii) 		4 / 7 LEU A 261
ASN A 265
GLU A 217
LEU A 219
 None
MG  A 399 (-3.0A)
ANP  A   1 (-4.4A)
None
 1.21A 2w8yA-3is5A:
undetectable		 2w8yA-3is5A:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y05_A_RALA802_1
(PROSTAGLANDIN
REDUCTASE 1)		 3is5 CALCIUM-DEPENDENT
PROTEIN KINASE
(Toxoplasma
gondii) 		4 / 7 VAL A 308
GLY A 283
VAL A 257
ASP A 281
 None
None
None
MG  A 399 ( 3.0A)
 0.83A 2y05A-3is5A:
undetectable
2y05B-3is5A:
undetectable		 2y05A-3is5A:
20.66
2y05B-3is5A:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CS9_B_NILB600_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 3is5 CALCIUM-DEPENDENT
PROTEIN KINASE
(Toxoplasma
gondii) 		5 / 9 LEU A 141
VAL A 149
LYS A 164
ILE A 208
LEU A 267
 ANP  A   1 (-3.9A)
ANP  A   1 (-4.9A)
GOL  A 398 ( 3.1A)
None
None
 0.89A 3cs9B-3is5A:
18.3		 3cs9B-3is5A:
27.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CS9_D_NILD600_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 3is5 CALCIUM-DEPENDENT
PROTEIN KINASE
(Toxoplasma
gondii) 		4 / 6 LEU A 141
VAL A 149
LYS A 164
LEU A 267
 ANP  A   1 (-3.9A)
ANP  A   1 (-4.9A)
GOL  A 398 ( 3.1A)
None
 0.84A 3cs9D-3is5A:
17.4		 3cs9D-3is5A:
27.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WAR_A_NIOA401_1
(CASEIN KINASE II
SUBUNIT ALPHA)		 3is5 CALCIUM-DEPENDENT
PROTEIN KINASE
(Toxoplasma
gondii) 		5 / 8 VAL A 149
VAL A 162
LYS A 164
ILE A 194
ILE A 280
 ANP  A   1 (-4.9A)
ANP  A   1 (-4.4A)
GOL  A 398 ( 3.1A)
ANP  A   1 (-4.8A)
ANP  A   1 (-4.2A)
 0.46A 3warA-3is5A:
23.7		 3warA-3is5A:
24.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AN2_A_EUIA1382_1
(DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1)		 3is5 CALCIUM-DEPENDENT
PROTEIN KINASE
(Toxoplasma
gondii) 		6 / 12 LYS A 164
ILE A 208
MET A 210
ASP A 260
ASN A 265
ASP A 281
 GOL  A 398 ( 3.1A)
None
GOL  A 398 ( 3.6A)
None
MG  A 399 (-3.0A)
MG  A 399 ( 3.0A)
 0.93A 4an2A-3is5A:
19.1		 4an2A-3is5A:
27.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4COX_A_IMNA701_1
(CYCLOOXYGENASE-2)		 3is5 CALCIUM-DEPENDENT
PROTEIN KINASE
(Toxoplasma
gondii) 		5 / 12 LEU A 374
GLY A 323
ALA A 322
SER A 321
LEU A 261
 None
 1.01A 4coxA-3is5A:
undetectable		 4coxA-3is5A:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4COX_B_IMNB701_1
(CYCLOOXYGENASE-2)		 3is5 CALCIUM-DEPENDENT
PROTEIN KINASE
(Toxoplasma
gondii) 		5 / 12 LEU A 374
GLY A 323
ALA A 322
SER A 321
LEU A 261
 None
 1.01A 4coxB-3is5A:
undetectable		 4coxB-3is5A:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4COX_D_IMND701_1
(CYCLOOXYGENASE-2)		 3is5 CALCIUM-DEPENDENT
PROTEIN KINASE
(Toxoplasma
gondii) 		5 / 12 LEU A 374
GLY A 323
ALA A 322
SER A 321
LEU A 261
 None
 1.00A 4coxD-3is5A:
undetectable		 4coxD-3is5A:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1G_B_LNLB701_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3is5 CALCIUM-DEPENDENT
PROTEIN KINASE
(Toxoplasma
gondii) 		4 / 7 TYR A 236
VAL A 237
LEU A 240
VAL A 325
 GOL  A 400 (-4.7A)
None
None
None
 0.94A 4e1gB-3is5A:
undetectable		 4e1gB-3is5A:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I41_A_MIXA500_1
(SERINE/THREONINE-PRO
TEIN KINASE PIM-1)		 3is5 CALCIUM-DEPENDENT
PROTEIN KINASE
(Toxoplasma
gondii) 		7 / 12 VAL A 149
ILE A 194
ASP A 260
LYS A 262
ASN A 265
LEU A 267
ILE A 280
 ANP  A   1 (-4.9A)
ANP  A   1 (-4.8A)
None
None
MG  A 399 (-3.0A)
None
ANP  A   1 (-4.2A)
 0.68A 4i41A-3is5A:
19.6		 4i41A-3is5A:
27.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OTY_A_LURA705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3is5 CALCIUM-DEPENDENT
PROTEIN KINASE
(Toxoplasma
gondii) 		5 / 12 LEU A 374
GLY A 323
ALA A 322
SER A 321
LEU A 261
 None
 1.02A 4otyA-3is5A:
undetectable		 4otyA-3is5A:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OTY_B_LURB705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3is5 CALCIUM-DEPENDENT
PROTEIN KINASE
(Toxoplasma
gondii) 		5 / 12 LEU A 374
GLY A 323
ALA A 322
SER A 321
LEU A 261
 None
 1.01A 4otyB-3is5A:
undetectable		 4otyB-3is5A:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OU1_A_BEZA302_0
(RETRO-ALDOLASE,
DESIGN RA114)		 3is5 CALCIUM-DEPENDENT
PROTEIN KINASE
(Toxoplasma
gondii) 		4 / 8 ILE A 266
ILE A 279
ASN A 192
ALA A 247
 None
 0.64A 4ou1A-3is5A:
undetectable		 4ou1A-3is5A:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRW_C_LURC705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3is5 CALCIUM-DEPENDENT
PROTEIN KINASE
(Toxoplasma
gondii) 		5 / 12 LEU A 374
GLY A 323
ALA A 322
SER A 321
LEU A 261
 None
 0.99A 4rrwC-3is5A:
undetectable		 4rrwC-3is5A:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRW_D_LURD705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3is5 CALCIUM-DEPENDENT
PROTEIN KINASE
(Toxoplasma
gondii) 		5 / 12 LEU A 374
GLY A 323
ALA A 322
SER A 321
LEU A 261
 None
 1.00A 4rrwD-3is5A:
undetectable		 4rrwD-3is5A:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRZ_C_LURC705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3is5 CALCIUM-DEPENDENT
PROTEIN KINASE
(Toxoplasma
gondii) 		5 / 12 LEU A 374
GLY A 323
ALA A 322
SER A 321
LEU A 261
 None
 0.99A 4rrzC-3is5A:
undetectable		 4rrzC-3is5A:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRZ_D_LURD705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3is5 CALCIUM-DEPENDENT
PROTEIN KINASE
(Toxoplasma
gondii) 		5 / 12 LEU A 374
GLY A 323
ALA A 322
SER A 321
LEU A 261
 None
 1.00A 4rrzD-3is5A:
undetectable		 4rrzD-3is5A:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TYJ_A_0LIA801_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 4)		 3is5 CALCIUM-DEPENDENT
PROTEIN KINASE
(Toxoplasma
gondii) 		4 / 6 LEU A 141
VAL A 149
ILE A 193
ILE A 279
 ANP  A   1 (-3.9A)
ANP  A   1 (-4.9A)
None
None
 0.60A 4tyjA-3is5A:
18.1		 4tyjA-3is5A:
26.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V01_B_0LIB1770_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 3is5 CALCIUM-DEPENDENT
PROTEIN KINASE
(Toxoplasma
gondii) 		6 / 9 LEU A 141
VAL A 149
LYS A 164
ILE A 194
LEU A 267
ILE A 279
 ANP  A   1 (-3.9A)
ANP  A   1 (-4.9A)
GOL  A 398 ( 3.1A)
ANP  A   1 (-4.8A)
None
None
 0.84A 4v01B-3is5A:
18.3		 4v01B-3is5A:
28.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XUE_A_SAMA303_0
(CATECHOL
O-METHYLTRANSFERASE)		 3is5 CALCIUM-DEPENDENT
PROTEIN KINASE
(Toxoplasma
gondii) 		5 / 12 VAL A 324
ILE A 280
ILE A 193
ASN A 192
HIS A 258
 None
ANP  A   1 (-4.2A)
None
None
None
 1.30A 4xueA-3is5A:
undetectable		 4xueA-3is5A:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FSE_C_HQEC1583_1
(UREASE SUBUNIT ALPHA)		 3is5 CALCIUM-DEPENDENT
PROTEIN KINASE
(Toxoplasma
gondii) 		4 / 5 ILE A 194
GLN A 269
CYH A 213
GLU A 214
 ANP  A   1 (-4.8A)
None
ANP  A   1 (-4.3A)
None
 1.47A 5fseC-3is5A:
undetectable		 5fseC-3is5A:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIE_B_P06B801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 3is5 CALCIUM-DEPENDENT
PROTEIN KINASE
(Toxoplasma
gondii) 		4 / 7 GLY A 142
CYH A 213
ASP A 281
PHE A 282
 ANP  A   1 (-3.5A)
ANP  A   1 (-4.3A)
MG  A 399 ( 3.0A)
GOL  A 398 (-4.5A)
 0.89A 5hieB-3is5A:
25.0		 5hieB-3is5A:
29.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIE_D_P06D801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 3is5 CALCIUM-DEPENDENT
PROTEIN KINASE
(Toxoplasma
gondii) 		4 / 8 GLY A 142
CYH A 213
ASP A 281
PHE A 282
 ANP  A   1 (-3.5A)
ANP  A   1 (-4.3A)
MG  A 399 ( 3.0A)
GOL  A 398 (-4.5A)
 0.87A 5hieD-3is5A:
19.4		 5hieD-3is5A:
29.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IZF_E_AZ1E2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
6J9-ZEU-DAR-ACA-DAR-
NH2)		 3is5 CALCIUM-DEPENDENT
PROTEIN KINASE
(Toxoplasma
gondii) 		4 / 7 GLY A 142
GLY A 144
PHE A 146
LYS A 164
 ANP  A   1 (-3.5A)
ANP  A   1 (-3.4A)
None
GOL  A 398 ( 3.1A)
 0.71A 5izfA-3is5A:
19.0		 5izfA-3is5A:
25.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IZJ_F_AZ1F2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
47P-AZ1-DAR-DAR-DAR)		 3is5 CALCIUM-DEPENDENT
PROTEIN KINASE
(Toxoplasma
gondii) 		5 / 7 GLY A 142
GLY A 144
PHE A 146
GLY A 147
VAL A 149
 ANP  A   1 (-3.5A)
ANP  A   1 (-3.4A)
None
None
ANP  A   1 (-4.9A)
 0.81A 5izjB-3is5A:
19.5		 5izjB-3is5A:
25.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LJC_A_RTLA201_1
(RETINOL-BINDING
PROTEIN 1)		 3is5 CALCIUM-DEPENDENT
PROTEIN KINASE
(Toxoplasma
gondii) 		4 / 7 LEU A 218
ILE A 319
MET A 373
MET A 244
 None
 1.31A 5ljcA-3is5A:
undetectable		 5ljcA-3is5A:
17.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TE0_A_XINA401_2
(AP2-ASSOCIATED
PROTEIN KINASE 1)		 3is5 CALCIUM-DEPENDENT
PROTEIN KINASE
(Toxoplasma
gondii) 		4 / 5 LEU A 141
VAL A 149
MET A 210
CYH A 213
 ANP  A   1 (-3.9A)
ANP  A   1 (-4.9A)
GOL  A 398 ( 3.6A)
ANP  A   1 (-4.3A)
 0.45A 5te0A-3is5A:
24.8		 5te0A-3is5A:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y9M_A_NIOA401_1
(CASEIN KINASE II
SUBUNIT ALPHA')		 3is5 CALCIUM-DEPENDENT
PROTEIN KINASE
(Toxoplasma
gondii) 		5 / 8 LEU A 141
VAL A 149
VAL A 162
LYS A 164
ILE A 280
 ANP  A   1 (-3.9A)
ANP  A   1 (-4.9A)
ANP  A   1 (-4.4A)
GOL  A 398 ( 3.1A)
ANP  A   1 (-4.2A)
 0.87A 5y9mA-3is5A:
17.4		 5y9mA-3is5A:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YF9_B_NIOB401_1
(CASEIN KINASE II
SUBUNIT ALPHA')		 3is5 CALCIUM-DEPENDENT
PROTEIN KINASE
(Toxoplasma
gondii) 		4 / 7 VAL A 149
VAL A 162
LYS A 164
ILE A 280
 ANP  A   1 (-4.9A)
ANP  A   1 (-4.4A)
GOL  A 398 ( 3.1A)
ANP  A   1 (-4.2A)
 0.60A 5yf9B-3is5A:
22.9		 5yf9B-3is5A:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YF9_X_NIOX401_1
(CASEIN KINASE II
SUBUNIT ALPHA')		 3is5 CALCIUM-DEPENDENT
PROTEIN KINASE
(Toxoplasma
gondii) 		6 / 9 LEU A 141
VAL A 149
LYS A 164
ILE A 194
ILE A 280
ASP A 281
 ANP  A   1 (-3.9A)
ANP  A   1 (-4.9A)
GOL  A 398 ( 3.1A)
ANP  A   1 (-4.8A)
ANP  A   1 (-4.2A)
MG  A 399 ( 3.0A)
 1.00A 5yf9X-3is5A:
23.6		 5yf9X-3is5A:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YF9_X_NIOX401_1
(CASEIN KINASE II
SUBUNIT ALPHA')		 3is5 CALCIUM-DEPENDENT
PROTEIN KINASE
(Toxoplasma
gondii) 		6 / 9 LEU A 141
VAL A 149
VAL A 162
LYS A 164
ILE A 194
ILE A 280
 ANP  A   1 (-3.9A)
ANP  A   1 (-4.9A)
ANP  A   1 (-4.4A)
GOL  A 398 ( 3.1A)
ANP  A   1 (-4.8A)
ANP  A   1 (-4.2A)
 0.77A 5yf9X-3is5A:
23.6		 5yf9X-3is5A:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YWM_X_NIOX403_0
(CASEIN KINASE II
SUBUNIT ALPHA')		 3is5 CALCIUM-DEPENDENT
PROTEIN KINASE
(Toxoplasma
gondii) 		5 / 7 VAL A 149
VAL A 162
LYS A 164
ILE A 194
ILE A 280
 ANP  A   1 (-4.9A)
ANP  A   1 (-4.4A)
GOL  A 398 ( 3.1A)
ANP  A   1 (-4.8A)
ANP  A   1 (-4.2A)
 0.56A 5ywmX-3is5A:
18.0		 5ywmX-3is5A:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C2M_B_SUEB1202_1
(NS3 PROTEASE)		 3is5 CALCIUM-DEPENDENT
PROTEIN KINASE
(Toxoplasma
gondii) 		5 / 9 VAL A 387
HIS A 389
LEU A 330
ALA A 366
ASP A 368
 None
 1.39A 6c2mB-3is5A:
undetectable		 6c2mB-3is5A:
13.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EU9_D_READ601_1
(RETINOIC ACID
RECEPTOR)		 3is5 CALCIUM-DEPENDENT
PROTEIN KINASE
(Toxoplasma
gondii) 		4 / 7 LEU A 374
PHE A 309
LEU A 341
GLY A 299
 None
 0.68A 6eu9D-3is5A:
undetectable		 6eu9D-3is5A:
15.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_D8ZA831_0
(GEPHYRIN)		 3is5 CALCIUM-DEPENDENT
PROTEIN KINASE
(Toxoplasma
gondii) 		5 / 11 MET A 326
LEU A 369
ARG A 381
PRO A 382
MET A 245
 None
 1.28A 6fgdA-3is5A:
undetectable		 6fgdA-3is5A:
14.39