SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3is6'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
11GS_A_EAAA211_1
(GLUTATHIONE
S-TRANSFERASE)		 3is6 PUTATIVE PERMEASE
PROTEIN, ABC
TRANSPORTER
(Porphyromonas
gingivalis) 		4 / 7 TYR A 262
VAL A  84
ILE A 216
GLY A  82
 None
 0.93A 11gsA-3is6A:
undetectable		 11gsA-3is6A:
24.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A52_A_ESTA1_1
(ESTROGEN RECEPTOR)		 3is6 PUTATIVE PERMEASE
PROTEIN, ABC
TRANSPORTER
(Porphyromonas
gingivalis) 		5 / 10 ALA A 158
MET A 200
LEU A 152
ILE A 181
LEU A 111
 None
 1.25A 1a52A-3is6A:
undetectable		 1a52A-3is6A:
23.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A52_B_ESTB2_1
(ESTROGEN RECEPTOR)		 3is6 PUTATIVE PERMEASE
PROTEIN, ABC
TRANSPORTER
(Porphyromonas
gingivalis) 		5 / 10 ALA A 158
MET A 200
LEU A 152
ILE A 181
LEU A 111
 None
 1.23A 1a52B-3is6A:
undetectable		 1a52B-3is6A:
23.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NV8_B_SAMB301_0
(HEMK PROTEIN)		 3is6 PUTATIVE PERMEASE
PROTEIN, ABC
TRANSPORTER
(Porphyromonas
gingivalis) 		5 / 12 ILE A 153
GLY A 185
GLY A 139
ILE A 137
ALA A 144
 None
 1.05A 1nv8B-3is6A:
undetectable		 1nv8B-3is6A:
24.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SG9_B_SAMB302_0
(HEMK PROTEIN)		 3is6 PUTATIVE PERMEASE
PROTEIN, ABC
TRANSPORTER
(Porphyromonas
gingivalis) 		5 / 12 ILE A 153
GLY A 185
GLY A 139
ILE A 137
ALA A 144
 None
 0.99A 1sg9B-3is6A:
undetectable		 1sg9B-3is6A:
24.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VQ1_B_SAMB301_0
(N5-GLUTAMINE
METHYLTRANSFERASE,
HEMK)		 3is6 PUTATIVE PERMEASE
PROTEIN, ABC
TRANSPORTER
(Porphyromonas
gingivalis) 		5 / 12 ILE A 153
GLY A 185
GLY A 139
ILE A 137
ALA A 144
 None
 0.98A 1vq1B-3is6A:
undetectable		 1vq1B-3is6A:
23.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GSS_A_EAAA0_1
(GLUTATHIONE
S-TRANSFERASE P1-1)		 3is6 PUTATIVE PERMEASE
PROTEIN, ABC
TRANSPORTER
(Porphyromonas
gingivalis) 		4 / 8 TYR A 262
VAL A  84
ILE A 216
GLY A  82
 None
 0.94A 2gssA-3is6A:
undetectable		 2gssA-3is6A:
24.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GSS_B_EAAB0_1
(GLUTATHIONE
S-TRANSFERASE P1-1)		 3is6 PUTATIVE PERMEASE
PROTEIN, ABC
TRANSPORTER
(Porphyromonas
gingivalis) 		4 / 8 TYR A 262
VAL A  84
ILE A 216
GLY A  82
 None
 0.94A 2gssB-3is6A:
undetectable		 2gssB-3is6A:
24.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GSS_A_EAAA212_1
(GLUTATHIONE
S-TRANSFERASE P1-1)		 3is6 PUTATIVE PERMEASE
PROTEIN, ABC
TRANSPORTER
(Porphyromonas
gingivalis) 		4 / 7 TYR A 262
VAL A  84
ILE A 216
GLY A  82
 None
 0.94A 3gssA-3is6A:
undetectable		 3gssA-3is6A:
24.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GSS_B_EAAB211_1
(GLUTATHIONE
S-TRANSFERASE P1-1)		 3is6 PUTATIVE PERMEASE
PROTEIN, ABC
TRANSPORTER
(Porphyromonas
gingivalis) 		4 / 7 TYR A 262
VAL A  84
ILE A 216
GLY A  82
 None
 0.94A 3gssB-3is6A:
undetectable		 3gssB-3is6A:
24.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N9J_A_EAAA210_1
(GLUTATHIONE
S-TRANSFERASE P)		 3is6 PUTATIVE PERMEASE
PROTEIN, ABC
TRANSPORTER
(Porphyromonas
gingivalis) 		4 / 8 TYR A 262
VAL A  84
ILE A 216
GLY A  82
 None
 0.97A 3n9jA-3is6A:
undetectable		 3n9jA-3is6A:
24.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJG_A_NCTA501_1
(CYTOCHROME P450 2A13)		 3is6 PUTATIVE PERMEASE
PROTEIN, ABC
TRANSPORTER
(Porphyromonas
gingivalis) 		4 / 7 PHE A 187
ALA A 124
THR A 101
LEU A 190
 None
 1.00A 4ejgA-3is6A:
undetectable		 4ejgA-3is6A:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KOU_A_C04A207_1
(UNCHARACTERIZED
PROTEIN)		 3is6 PUTATIVE PERMEASE
PROTEIN, ABC
TRANSPORTER
(Porphyromonas
gingivalis) 		3 / 3 GLY A 105
GLU A 118
THR A 119
 TRS  A   1 (-3.4A)
None
None
 0.49A 4kouA-3is6A:
undetectable		 4kouA-3is6A:
24.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YDQ_B_HFGB802_0
(PROLINE--TRNA LIGASE)		 3is6 PUTATIVE PERMEASE
PROTEIN, ABC
TRANSPORTER
(Porphyromonas
gingivalis) 		5 / 12 GLU A  96
VAL A  95
THR A  99
GLU A 125
PHE A 132
 None
 0.96A 4ydqB-3is6A:
undetectable		 4ydqB-3is6A:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIO_B_HFGB802_0
(PROLINE-TRNA
SYNTHETASE CLASS II
AARS (YBAK RNA
BINDING DOMAIN PLUS
TRNA SYNTHETASE))		 3is6 PUTATIVE PERMEASE
PROTEIN, ABC
TRANSPORTER
(Porphyromonas
gingivalis) 		5 / 12 GLU A  96
VAL A  95
THR A  99
GLU A 125
PHE A 132
 None
 0.88A 5xioB-3is6A:
undetectable		 5xioB-3is6A:
18.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZWR_B_9KLB402_0
(EST-Y29)		 3is6 PUTATIVE PERMEASE
PROTEIN, ABC
TRANSPORTER
(Porphyromonas
gingivalis) 		5 / 12 TYR A 224
PHE A 132
ILE A 196
LEU A 190
ALA A 124
 None
 1.28A 5zwrB-3is6A:
undetectable		 5zwrB-3is6A:
22.91