SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3isl'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
11GS_A_EAAA211_1
(GLUTATHIONE
S-TRANSFERASE)		 3isl PURINE CATABOLISM
PROTEIN PUCG
(Bacillus
subtilis) 		4 / 7 PHE A  99
VAL A 145
ILE A 106
GLY A 100
 PLP  A 419 (-3.5A)
None
None
None
 0.89A 11gsA-3islA:
undetectable		 11gsA-3islA:
19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX1_D_THAD4_1
(LIVER
CARBOXYLESTERASE I)		 3isl PURINE CATABOLISM
PROTEIN PUCG
(Bacillus
subtilis) 		6 / 12 GLY A 181
GLY A 180
VAL A 282
LEU A 202
LEU A 290
LEU A  58
 None
 1.32A 1mx1D-3islA:
undetectable		 1mx1D-3islA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_A_BEZA502_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 3isl PURINE CATABOLISM
PROTEIN PUCG
(Bacillus
subtilis) 		4 / 6 ASN A  49
ARG A 264
ILE A  47
GLY A  46
 None
 1.09A 1oniA-3islA:
undetectable
1oniB-3islA:
undetectable		 1oniA-3islA:
16.59
1oniB-3islA:
16.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GSS_A_EAAA0_1
(GLUTATHIONE
S-TRANSFERASE P1-1)		 3isl PURINE CATABOLISM
PROTEIN PUCG
(Bacillus
subtilis) 		4 / 8 PHE A  99
VAL A 145
ILE A 106
GLY A 100
 PLP  A 419 (-3.5A)
None
None
None
 0.86A 2gssA-3islA:
undetectable		 2gssA-3islA:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GSS_B_EAAB0_1
(GLUTATHIONE
S-TRANSFERASE P1-1)		 3isl PURINE CATABOLISM
PROTEIN PUCG
(Bacillus
subtilis) 		4 / 8 PHE A  99
VAL A 145
ILE A 106
GLY A 100
 PLP  A 419 (-3.5A)
None
None
None
 0.85A 2gssB-3islA:
undetectable		 2gssB-3islA:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NXE_B_SAMB303_1
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)		 3isl PURINE CATABOLISM
PROTEIN PUCG
(Bacillus
subtilis) 		3 / 3 THR A 151
ASP A 174
SER A  73
 None
PLP  A 419 (-2.9A)
PLP  A 419 (-2.8A)
 0.85A 2nxeB-3islA:
5.8		 2nxeB-3islA:
23.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7P_A_SALA1001_1
(LYSR-TYPE REGULATORY
PROTEIN)		 3isl PURINE CATABOLISM
PROTEIN PUCG
(Bacillus
subtilis) 		4 / 6 MET A  17
SER A 372
PRO A  19
GLY A  20
 None
 1.49A 2y7pA-3islA:
undetectable		 2y7pA-3islA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A65_A_ACAA601_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 3isl PURINE CATABOLISM
PROTEIN PUCG
(Bacillus
subtilis) 		5 / 12 ALA A  79
VAL A 217
SER A  83
GLY A  76
ILE A 211
 None
 1.35A 3a65A-3islA:
undetectable		 3a65A-3islA:
23.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H52_C_486C4_2
(GLUCOCORTICOID
RECEPTOR)		 3isl PURINE CATABOLISM
PROTEIN PUCG
(Bacillus
subtilis) 		3 / 3 MET A 323
CYH A 201
PRO A  19
 None
 0.99A 3h52C-3islA:
undetectable		 3h52C-3islA:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HJO_A_EAAA211_1
(GLUTATHIONE
S-TRANSFERASE P)		 3isl PURINE CATABOLISM
PROTEIN PUCG
(Bacillus
subtilis) 		4 / 8 PHE A  99
VAL A 145
ILE A 106
GLY A 100
 PLP  A 419 (-3.5A)
None
None
None
 0.84A 3hjoA-3islA:
undetectable		 3hjoA-3islA:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HJO_B_EAAB211_1
(GLUTATHIONE
S-TRANSFERASE P)		 3isl PURINE CATABOLISM
PROTEIN PUCG
(Bacillus
subtilis) 		4 / 8 PHE A  99
VAL A 145
ILE A 106
GLY A 100
 PLP  A 419 (-3.5A)
None
None
None
 0.84A 3hjoB-3islA:
undetectable		 3hjoB-3islA:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KU1_A_SAMA226_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 3isl PURINE CATABOLISM
PROTEIN PUCG
(Bacillus
subtilis) 		5 / 12 GLY A 312
ALA A 383
GLY A 384
LEU A 389
ILE A 396
 None
 0.95A 3ku1A-3islA:
undetectable		 3ku1A-3islA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KU1_C_SAMC226_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 3isl PURINE CATABOLISM
PROTEIN PUCG
(Bacillus
subtilis) 		5 / 12 GLY A 312
ALA A 383
GLY A 384
LEU A 389
ILE A 396
 None
 0.90A 3ku1C-3islA:
3.7		 3ku1C-3islA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N9J_A_EAAA210_1
(GLUTATHIONE
S-TRANSFERASE P)		 3isl PURINE CATABOLISM
PROTEIN PUCG
(Bacillus
subtilis) 		4 / 8 PHE A  99
VAL A 145
ILE A 106
GLY A 100
 PLP  A 419 (-3.5A)
None
None
None
 0.87A 3n9jA-3islA:
undetectable		 3n9jA-3islA:
19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B17_A_SAMA1358_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE M)		 3isl PURINE CATABOLISM
PROTEIN PUCG
(Bacillus
subtilis) 		5 / 12 GLY A 337
GLY A 334
GLY A 333
ASP A 336
ASP A 342
 None
 0.98A 4b17A-3islA:
undetectable		 4b17A-3islA:
23.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N09_A_ADNA401_1
(ADENOSINE KINASE)		 3isl PURINE CATABOLISM
PROTEIN PUCG
(Bacillus
subtilis) 		5 / 12 CYH A 328
GLY A 152
CYH A 321
PHE A 316
GLY A  97
 None
 0.89A 4n09A-3islA:
5.5		 4n09A-3islA:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N09_B_ADNB401_1
(ADENOSINE KINASE)		 3isl PURINE CATABOLISM
PROTEIN PUCG
(Bacillus
subtilis) 		5 / 12 CYH A 328
GLY A 152
CYH A 321
PHE A 316
GLY A  97
 None
 0.92A 4n09B-3islA:
undetectable		 4n09B-3islA:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N09_C_ADNC401_1
(ADENOSINE KINASE)		 3isl PURINE CATABOLISM
PROTEIN PUCG
(Bacillus
subtilis) 		5 / 12 CYH A 328
GLY A 152
CYH A 321
PHE A 316
GLY A  97
 None
 0.91A 4n09C-3islA:
undetectable		 4n09C-3islA:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTG_E_LFXE101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
GGTCATGAATGACTATGCAC
GTAA)		 3isl PURINE CATABOLISM
PROTEIN PUCG
(Bacillus
subtilis) 		4 / 6 ALA A 387
ARG A 341
GLY A 337
GLU A 338
 None
 0.97A 5btgA-3islA:
2.2
5btgB-3islA:
undetectable
5btgC-3islA:
2.2		 5btgA-3islA:
22.73
5btgB-3islA:
21.55
5btgC-3islA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G48_A_1FLA1375_1
(DNA POLYMERASE III
SUBUNIT BETA)		 3isl PURINE CATABOLISM
PROTEIN PUCG
(Bacillus
subtilis) 		4 / 8 ILE A 134
PRO A  94
LEU A  92
MET A 144
 None
 0.91A 5g48A-3islA:
undetectable		 5g48A-3islA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GS4_A_ESTA603_1
(ESTROGEN RECEPTOR)		 3isl PURINE CATABOLISM
PROTEIN PUCG
(Bacillus
subtilis) 		5 / 12 MET A  32
THR A 273
LEU A 275
ALA A 271
GLU A 270
 None
 0.99A 5gs4A-3islA:
undetectable		 5gs4A-3islA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF7_B_6V8B304_0
(PROTEASOME SUBUNIT
BETA TYPE-6
PROTEASOME SUBUNIT
BETA TYPE-7)		 3isl PURINE CATABOLISM
PROTEIN PUCG
(Bacillus
subtilis) 		5 / 12 ALA A  79
SER A 206
GLY A 207
ALA A 209
THR A 198
 None
 1.20A 5lf7V-3islA:
undetectable
5lf7b-3islA:
undetectable		 5lf7V-3islA:
19.81
5lf7b-3islA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF7_N_6V8N305_0
(PROTEASOME SUBUNIT
BETA TYPE-6
PROTEASOME SUBUNIT
BETA TYPE-7)		 3isl PURINE CATABOLISM
PROTEIN PUCG
(Bacillus
subtilis) 		5 / 12 ALA A  79
SER A 206
GLY A 207
ALA A 209
THR A 198
 None
 1.20A 5lf7H-3islA:
undetectable
5lf7N-3islA:
undetectable		 5lf7H-3islA:
19.81
5lf7N-3islA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V0V_A_8QPA613_1
(SERUM ALBUMIN)		 3isl PURINE CATABOLISM
PROTEIN PUCG
(Bacillus
subtilis) 		4 / 8 ARG A  98
SER A 206
THR A  72
GLY A  20
 None
None
PLP  A 419 (-3.4A)
None
 0.86A 5v0vA-3islA:
undetectable		 5v0vA-3islA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VVD_B_H4BB502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 3isl PURINE CATABOLISM
PROTEIN PUCG
(Bacillus
subtilis) 		4 / 7 TRP A  65
TRP A 260
GLU A 257
ARG A  56
 None
 1.48A 5vvdA-3islA:
undetectable
5vvdB-3islA:
0.0		 5vvdA-3islA:
21.49
5vvdB-3islA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A93_A_8NUA3001_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		 3isl PURINE CATABOLISM
PROTEIN PUCG
(Bacillus
subtilis) 		5 / 12 TRP A 260
ILE A 172
LEU A 278
PHE A  59
LEU A  58
 None
 1.15A 6a93A-3islA:
undetectable		 6a93A-3islA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GBN_D_ADND501_2
(-)		 3isl PURINE CATABOLISM
PROTEIN PUCG
(Bacillus
subtilis) 		4 / 5 THR A 212
THR A 178
HIS A 146
LEU A 157
 None
 1.38A 6gbnD-3islA:
4.8		 6gbnD-3islA:
23.70