SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3ism'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_F_ACTF3008_0
(BETA-CARBONIC
ANHYDRASE)		 3ism CG4930
(Drosophila
melanogaster) 		4 / 8 GLN C 135
PHE C 167
TYR C 158
GLY C 137
 None
 0.86A 1ekjE-3ismC:
undetectable
1ekjF-3ismC:
undetectable		 1ekjE-3ismC:
19.62
1ekjF-3ismC:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MCN_P_DHIP1_0
(IMMUNOGLOBULIN
LAMBDA DIMER MCG
(LIGHT CHAIN)
PEPTIDE
N-ACETYL-D-HIS-L-PRO
-NH2)		 3ism CG4930
(Drosophila
melanogaster) 		3 / 3 PHE C 157
TYR C 107
PRO C 138
 None
 0.87A 1mcnA-3ismC:
undetectable
1mcnB-3ismC:
undetectable
1mcnP-3ismC:
undetectable		 1mcnA-3ismC:
20.77
1mcnB-3ismC:
20.77
1mcnP-3ismC:
1.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GJ5_A_VD3A164_1
(BETA-LACTOGLOBULIN)		 3ism CG4930
(Drosophila
melanogaster) 		4 / 5 ASP C 116
LEU C 119
LYS C 120
ARG C 115
 None
 1.28A 2gj5A-3ismC:
undetectable		 2gj5A-3ismC:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NMZ_B_ROCB401_2
(PROTEASE)		 3ism CG4930
CG8862
(Drosophila
melanogaster) 		3 / 3 ARG A 153
VAL C  50
THR C  55
 None
 0.77A 2nmzA-3ismA:
undetectable		 2nmzA-3ismA:
15.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNK_A_ROCA401_2
(PROTEASE)		 3ism CG4930
CG8862
(Drosophila
melanogaster) 		3 / 3 ARG A 153
VAL C  50
THR C  55
 None
 0.78A 2nnkA-3ismA:
undetectable		 2nnkA-3ismA:
15.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q6H_A_CXXA801_1
(TRANSPORTER)		 3ism CG4930
(Drosophila
melanogaster) 		5 / 11 LEU C  39
VAL C  44
GLN C  45
ILE C  27
LEU C  91
 None
 1.19A 2q6hA-3ismC:
1.2		 2q6hA-3ismC:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEI_A_CXXA801_1
(TRANSPORTER)		 3ism CG4930
(Drosophila
melanogaster) 		5 / 11 LEU C  39
VAL C  44
GLN C  45
ILE C  27
LEU C  91
 None
 1.19A 2qeiA-3ismC:
undetectable		 2qeiA-3ismC:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZM9_A_ACAA502_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 3ism CG8862
(Drosophila
melanogaster) 		4 / 8 MET A  77
TRP A 106
GLY A  74
ILE A  73
 None
 0.89A 2zm9A-3ismA:
undetectable		 2zm9A-3ismA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H5G_A_LEIA16_0
(COIL SER L16D-PEN)		 3ism CG4930
(Drosophila
melanogaster) 		5 / 6 GLN C  90
LEU C  92
GLU C  93
LYS C 134
LEU C 136
 None
 0.70A 3h5gA-3ismC:
undetectable
3h5gC-3ismC:
undetectable		 3h5gA-3ismC:
6.19
3h5gC-3ismC:
6.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H5G_C_LEIC16_0
(COIL SER L16D-PEN)		 3ism CG4930
(Drosophila
melanogaster) 		4 / 6 LYS C 134
GLN C  90
LEU C  92
GLU C  93
 None
 1.02A 3h5gB-3ismC:
undetectable
3h5gC-3ismC:
undetectable		 3h5gB-3ismC:
6.19
3h5gC-3ismC:
6.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H5G_C_LEIC16_0
(COIL SER L16D-PEN)		 3ism CG4930
(Drosophila
melanogaster) 		4 / 6 LYS C 134
LEU C 136
GLN C  90
GLU C  93
 None
 0.79A 3h5gB-3ismC:
undetectable
3h5gC-3ismC:
undetectable		 3h5gB-3ismC:
6.19
3h5gC-3ismC:
6.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K4V_B_ROCB201_2
(HIV-1 PROTEASE)		 3ism CG4930
CG8862
(Drosophila
melanogaster) 		3 / 3 ARG A 153
VAL C  50
THR C  55
 None
 0.77A 3k4vA-3ismA:
undetectable		 3k4vA-3ismA:
15.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDT_A_ROCA101_2
(PROTEASE)		 3ism CG4930
CG8862
(Drosophila
melanogaster) 		3 / 3 ARG A 153
VAL C  50
THR C  55
 None
 0.81A 3ndtA-3ismA:
undetectable		 3ndtA-3ismA:
15.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDU_D_ROCD100_3
(PROTEASE)		 3ism CG4930
CG8862
(Drosophila
melanogaster) 		3 / 3 ARG A 153
VAL C  50
THR C  55
 None
 0.84A 3nduD-3ismA:
undetectable		 3nduD-3ismA:
15.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PWR_A_ROCA401_2
(PROTEASE)		 3ism CG4930
CG8862
(Drosophila
melanogaster) 		3 / 3 ARG A 153
VAL C  50
THR C  55
 None
 0.83A 3pwrA-3ismA:
undetectable		 3pwrA-3ismA:
15.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TL9_A_ROCA401_2
(PROTEASE)		 3ism CG4930
CG8862
(Drosophila
melanogaster) 		3 / 3 ARG A 153
VAL C  50
THR C  55
 None
 0.79A 3tl9A-3ismA:
undetectable		 3tl9A-3ismA:
14.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KCN_A_MTLA804_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3ism CG4930
(Drosophila
melanogaster) 		4 / 6 GLU C  93
ARG C  96
ASP C 143
ARG C 142
 None
 1.38A 4kcnA-3ismC:
undetectable		 4kcnA-3ismC:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KCN_B_MTLB805_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3ism CG4930
(Drosophila
melanogaster) 		4 / 6 GLU C  93
ARG C  96
ASP C 143
ARG C 142
 None
 1.38A 4kcnB-3ismC:
undetectable		 4kcnB-3ismC:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKX_B_STRB601_2
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 3ism CG8862
(Drosophila
melanogaster) 		4 / 5 ILE A 305
LEU A 302
GLU A 260
VAL A 208
 None
 0.95A 4nkxB-3ismA:
undetectable		 4nkxB-3ismA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YMG_A_SAMA1001_1
(PUTATIVE
SAM-DEPENDENT
O-METHYLTRANFERASE)		 3ism CG8862
CG4930
(Drosophila
melanogaster;
Drosophila
melanogaster) 		4 / 4 SER C 141
SER C 149
GLU A 195
ASP A 189
 None
None
MG  A   1 ( 3.9A)
None
 1.24A 4ymgA-3ismC:
undetectable		 4ymgA-3ismC:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ECM_D_LEUD602_0
(JASMONIC ACID-AMIDO
SYNTHETASE JAR1)		 3ism CG4930
(Drosophila
melanogaster) 		4 / 7 ALA C  63
THR C  62
TYR C  25
VAL C  44
 None
 0.76A 5ecmD-3ismC:
1.7		 5ecmD-3ismC:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ECN_D_LEUD602_0
(JASMONIC ACID-AMIDO
SYNTHETASE JAR1)		 3ism CG4930
(Drosophila
melanogaster) 		4 / 8 ALA C  63
THR C  62
TYR C  25
VAL C  44
 None
 0.66A 5ecnD-3ismC:
undetectable		 5ecnD-3ismC:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JS5_A_ASCA202_0
(CYTOCHROME C')		 3ism CG8862
(Drosophila
melanogaster) 		3 / 3 CYH A 169
LYS A 167
HIS A 168
 None
 1.26A 5js5A-3ismA:
undetectable		 5js5A-3ismA:
16.48