SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3isr'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VPT_A_SAMA400_1
(VP39)		 3isr TRANSGLUTAMINASE-LIK
E ENZYMES, PUTATIVE
CYSTEINE PROTEASE
(Cytophaga
hutchinsonii) 		3 / 3 ASP A 172
ARG A 171
ASP A 161
 None
 0.62A 1vptA-3isrA:
undetectable		 1vptA-3isrA:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
209D_C_DVAC8_0
(N8-ACTINOMYCIN D)		 3isr TRANSGLUTAMINASE-LIK
E ENZYMES, PUTATIVE
CYSTEINE PROTEASE
(Cytophaga
hutchinsonii) 		3 / 3 THR A  64
THR A  17
PRO A  16
 None
 0.88A 209dC-3isrA:
undetectable		 209dC-3isrA:
7.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D4S_A_TIMA401_2
(BETA-2 ADRENERGIC
RECEPTOR/T4-LYSOZYME
CHIMERA)		 3isr TRANSGLUTAMINASE-LIK
E ENZYMES, PUTATIVE
CYSTEINE PROTEASE
(Cytophaga
hutchinsonii) 		3 / 3 THR A  55
SER A  53
PHE A  49
 None
 0.62A 3d4sA-3isrA:
undetectable		 3d4sA-3isrA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H52_C_486C4_2
(GLUCOCORTICOID
RECEPTOR)		 3isr TRANSGLUTAMINASE-LIK
E ENZYMES, PUTATIVE
CYSTEINE PROTEASE
(Cytophaga
hutchinsonii) 		3 / 3 MET A   1
CYH A 259
PRO A 225
 None
 1.33A 3h52C-3isrA:
undetectable		 3h52C-3isrA:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C49_A_HCYA1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		 3isr TRANSGLUTAMINASE-LIK
E ENZYMES, PUTATIVE
CYSTEINE PROTEASE
(Cytophaga
hutchinsonii) 		5 / 12 ALA A 242
ILE A   9
SER A   7
PHE A  21
HIS A  24
 None
 1.28A 4c49A-3isrA:
undetectable		 4c49A-3isrA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGZ_A_CQAA301_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 3isr TRANSGLUTAMINASE-LIK
E ENZYMES, PUTATIVE
CYSTEINE PROTEASE
(Cytophaga
hutchinsonii) 		4 / 8 GLY A 212
VAL A 131
GLU A  89
TYR A 132
 None
 0.80A 4fgzA-3isrA:
undetectable		 4fgzA-3isrA:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGZ_B_CQAB301_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 3isr TRANSGLUTAMINASE-LIK
E ENZYMES, PUTATIVE
CYSTEINE PROTEASE
(Cytophaga
hutchinsonii) 		4 / 8 GLY A 212
VAL A 131
GLU A  89
TYR A 132
 None
 0.81A 4fgzB-3isrA:
undetectable		 4fgzB-3isrA:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLB_A_TRPA901_0
(PROTEIN ARGONAUTE-2)		 3isr TRANSGLUTAMINASE-LIK
E ENZYMES, PUTATIVE
CYSTEINE PROTEASE
(Cytophaga
hutchinsonii) 		3 / 3 VAL A 169
ALA A 167
PHE A 173
 None
 0.91A 4olbA-3isrA:
undetectable		 4olbA-3isrA:
14.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5N_A_IPHA901_0
(PROTEIN ARGONAUTE-2)		 3isr TRANSGLUTAMINASE-LIK
E ENZYMES, PUTATIVE
CYSTEINE PROTEASE
(Cytophaga
hutchinsonii) 		3 / 3 VAL A 169
ALA A 167
PHE A 173
 None
 0.92A 4w5nA-3isrA:
undetectable		 4w5nA-3isrA:
14.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4I_A_IPHA903_0
(PROTEIN ARGONAUTE-2)		 3isr TRANSGLUTAMINASE-LIK
E ENZYMES, PUTATIVE
CYSTEINE PROTEASE
(Cytophaga
hutchinsonii) 		3 / 3 VAL A 169
ALA A 167
PHE A 173
 None
 0.93A 4z4iA-3isrA:
undetectable		 4z4iA-3isrA:
16.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IH0_A_ACTA402_0
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 3isr TRANSGLUTAMINASE-LIK
E ENZYMES, PUTATIVE
CYSTEINE PROTEASE
(Cytophaga
hutchinsonii) 		4 / 6 PHE A  69
PRO A  42
THR A  64
ILE A  44
 None
 1.14A 5ih0A-3isrA:
undetectable		 5ih0A-3isrA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JS1_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 3isr TRANSGLUTAMINASE-LIK
E ENZYMES, PUTATIVE
CYSTEINE PROTEASE
(Cytophaga
hutchinsonii) 		3 / 3 VAL A 169
ALA A 167
PHE A 173
 None
 0.91A 5js1A-3isrA:
undetectable		 5js1A-3isrA:
14.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WM2_A_ACTA605_0
(SALICYLATE-AMP
LIGASE)		 3isr TRANSGLUTAMINASE-LIK
E ENZYMES, PUTATIVE
CYSTEINE PROTEASE
(Cytophaga
hutchinsonii) 		3 / 3 THR A  55
THR A 234
ARG A 189
 None
 0.97A 5wm2A-3isrA:
undetectable		 5wm2A-3isrA:
18.87