SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3it7'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBI_C_SAMC2293_0
(GLYCINE
N-METHYLTRANSFERASE)		 3it7 PROTEASE LASA
(Pseudomonas
aeruginosa) 		5 / 12 GLY A  57
THR A  58
ALA A  95
SER A  94
GLY A  74
 None
 1.05A 1nbiC-3it7A:
undetectable		 1nbiC-3it7A:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBI_D_SAMD3293_0
(GLYCINE
N-METHYLTRANSFERASE)		 3it7 PROTEASE LASA
(Pseudomonas
aeruginosa) 		5 / 12 GLY A  57
THR A  58
ALA A  95
SER A  94
GLY A  74
 None
 1.06A 1nbiD-3it7A:
undetectable		 1nbiD-3it7A:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P6K_B_MTLB871_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 3it7 PROTEASE LASA
(Pseudomonas
aeruginosa) 		4 / 8 SER A  34
ASN A  78
PHE A 123
ASP A  36
 None
None
None
ZN  A 183 ( 2.1A)
 1.30A 1p6kB-3it7A:
undetectable		 1p6kB-3it7A:
18.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RS6_B_MTLB871_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 3it7 PROTEASE LASA
(Pseudomonas
aeruginosa) 		4 / 8 SER A  34
ASN A  78
PHE A 123
ASP A  36
 None
None
None
ZN  A 183 ( 2.1A)
 1.29A 1rs6B-3it7A:
undetectable		 1rs6B-3it7A:
18.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZU_B_MTLB871_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 3it7 PROTEASE LASA
(Pseudomonas
aeruginosa) 		4 / 8 SER A  34
ASN A  78
PHE A 123
ASP A  36
 None
None
None
ZN  A 183 ( 2.1A)
 1.30A 1zzuB-3it7A:
undetectable		 1zzuB-3it7A:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PRG_B_BRLB2_1
(PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
GAMMA)		 3it7 PROTEASE LASA
(Pseudomonas
aeruginosa) 		5 / 12 LEU A  99
VAL A  87
HIS A  55
LEU A   6
LEU A 180
 None
 1.45A 2prgB-3it7A:
undetectable		 2prgB-3it7A:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A51_B_VDYB6178_1
(VITAMIN D
HYDROXYLASE)		 3it7 PROTEASE LASA
(Pseudomonas
aeruginosa) 		5 / 12 ASN A 177
ILE A 144
VAL A 132
PRO A   2
LEU A 125
 None
 1.39A 3a51B-3it7A:
undetectable		 3a51B-3it7A:
17.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C0Z_A_SHHA301_1
(HISTONE DEACETYLASE
7A)		 3it7 PROTEASE LASA
(Pseudomonas
aeruginosa) 		4 / 5 HIS A 120
HIS A  81
ASP A  36
HIS A 122
 TLA  A 300 (-3.9A)
TLA  A 300 (-4.2A)
ZN  A 183 ( 2.1A)
ZN  A 183 ( 3.0A)
 1.03A 3c0zA-3it7A:
undetectable		 3c0zA-3it7A:
16.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C0Z_C_SHHC301_1
(HISTONE DEACETYLASE
7A)		 3it7 PROTEASE LASA
(Pseudomonas
aeruginosa) 		4 / 6 HIS A 120
HIS A  81
ASP A  36
HIS A 122
 TLA  A 300 (-3.9A)
TLA  A 300 (-4.2A)
ZN  A 183 ( 2.1A)
ZN  A 183 ( 3.0A)
 1.04A 3c0zC-3it7A:
undetectable		 3c0zC-3it7A:
16.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3M7R_A_VDXA425_1
(VITAMIN D3 RECEPTOR)		 3it7 PROTEASE LASA
(Pseudomonas
aeruginosa) 		5 / 12 LEU A  99
VAL A  52
SER A  94
VAL A  87
GLN A  86
 None
 1.32A 3m7rA-3it7A:
undetectable		 3m7rA-3it7A:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUD_D_SUED1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 3it7 PROTEASE LASA
(Pseudomonas
aeruginosa) 		5 / 12 HIS A  55
GLY A  57
VAL A  52
GLY A  74
ALA A  76
 None
 1.02A 3sudD-3it7A:
undetectable		 3sudD-3it7A:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUG_A_SUEA1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 3it7 PROTEASE LASA
(Pseudomonas
aeruginosa) 		5 / 12 HIS A  55
GLY A  57
VAL A  52
GLY A  74
ALA A  76
 None
 1.07A 3sugA-3it7A:
undetectable		 3sugA-3it7A:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3THR_A_C2FA1100_0
(GLYCINE
N-METHYLTRANSFERASE)		 3it7 PROTEASE LASA
(Pseudomonas
aeruginosa) 		4 / 6 SER A   4
LEU A   6
HIS A  55
MET A   7
 None
 1.07A 3thrB-3it7A:
undetectable		 3thrB-3it7A:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YB6_C_HISC302_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE)		 3it7 PROTEASE LASA
(Pseudomonas
aeruginosa) 		5 / 10 GLY A  57
VAL A  93
THR A  77
VAL A  59
LEU A  99
 None
 1.32A 4yb6C-3it7A:
undetectable
4yb6F-3it7A:
undetectable		 4yb6C-3it7A:
18.69
4yb6F-3it7A:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YB6_D_HISD302_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE)		 3it7 PROTEASE LASA
(Pseudomonas
aeruginosa) 		5 / 10 LEU A  99
GLY A  57
VAL A  93
THR A  77
VAL A  59
 None
 1.30A 4yb6A-3it7A:
undetectable
4yb6D-3it7A:
undetectable		 4yb6A-3it7A:
18.69
4yb6D-3it7A:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YB6_E_HISE302_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE)		 3it7 PROTEASE LASA
(Pseudomonas
aeruginosa) 		5 / 10 LEU A  99
GLY A  57
VAL A  93
THR A  77
VAL A  59
 None
 1.33A 4yb6D-3it7A:
undetectable
4yb6E-3it7A:
undetectable		 4yb6D-3it7A:
18.69
4yb6E-3it7A:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H5F_A_SAMA301_1
(PROTEIN ARGININE
N-METHYLTRANSFERASE
SFM1)		 3it7 PROTEASE LASA
(Pseudomonas
aeruginosa) 		4 / 5 GLY A 104
THR A  48
GLN A  84
THR A 108
 None
 1.04A 5h5fA-3it7A:
undetectable		 5h5fA-3it7A:
17.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KI6_A_IPHA901_0
(PROTEIN ARGONAUTE-2)		 3it7 PROTEASE LASA
(Pseudomonas
aeruginosa) 		4 / 5 LEU A 175
TYR A 176
LEU A   9
TYR A 142
 None
 1.25A 5ki6A-3it7A:
undetectable		 5ki6A-3it7A:
11.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UMD_A_YMZA3801_1
(60S RIBOSOMAL
PROTEIN L28
28S RIBOSOMAL RNA
60S RIBOSOMAL
PROTEIN L4)		 3it7 PROTEASE LASA
(Pseudomonas
aeruginosa) 		4 / 6 ASN A 153
PRO A  19
ASP A 152
TYR A 158
 None
 1.14A 5umd2-3it7A:
undetectable
5umdF-3it7A:
undetectable		 5umd2-3it7A:
18.93
5umdF-3it7A:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A7J_A_TESA502_0
(CYTOCHROME P450)		 3it7 PROTEASE LASA
(Pseudomonas
aeruginosa) 		4 / 7 LEU A 180
ALA A  53
ALA A  54
THR A  77
 None
 0.83A 6a7jA-3it7A:
undetectable		 6a7jA-3it7A:
17.88