SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3itw'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QKN_A_RALA600_2
(ESTROGEN RECEPTOR
BETA)		 3itw PROTEIN TIOX
(Micromonospora
sp.
ML1) 		3 / 3 ASP A 108
LEU A 109
HIS A  37
 None
 0.54A 1qknA-3itwA:
undetectable		 1qknA-3itwA:
18.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B9M_A_SALA1200_1
(SERUM ALBUMIN)		 3itw PROTEIN TIOX
(Micromonospora
sp.
ML1) 		4 / 5 ILE A  46
HIS A   0
ARG A  24
GLY A  43
 None
 1.13A 3b9mA-3itwA:
undetectable		 3b9mA-3itwA:
11.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G0U_B_ASWB1301_1
(DNA TOPOISOMERASE
2-BETA)		 3itw PROTEIN TIOX
(Micromonospora
sp.
ML1) 		4 / 7 ILE A  35
PRO A  10
ARG A  51
GLY A  53
 None
 0.76A 4g0uB-3itwA:
undetectable		 4g0uB-3itwA:
9.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKX_C_STRC601_2
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 3itw PROTEIN TIOX
(Micromonospora
sp.
ML1) 		4 / 5 ILE A  70
ASP A 108
GLU A 115
VAL A  73
 None
 1.00A 4nkxC-3itwA:
undetectable		 4nkxC-3itwA:
12.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKX_D_STRD601_2
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 3itw PROTEIN TIOX
(Micromonospora
sp.
ML1) 		4 / 5 ILE A  70
ASP A 108
GLU A 115
VAL A  73
 None
 0.99A 4nkxD-3itwA:
undetectable		 4nkxD-3itwA:
12.74