SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3iu0'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIA_A_ACTA294_0
(GLYCINE
N-METHYLTRANSFERASE)		 3iu0 PROTEIN-GLUTAMINE
GAMMA-GLUTAMYLTRANSF
ERASE
(Streptomyces
mobaraensis) 		4 / 6 TYR A 348
ASN A 322
TYR A  12
TYR A 337
 None
 1.42A 1kiaA-3iu0A:
undetectable		 1kiaA-3iu0A:
23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIA_B_ACTB1294_0
(GLYCINE
N-METHYLTRANSFERASE)		 3iu0 PROTEIN-GLUTAMINE
GAMMA-GLUTAMYLTRANSF
ERASE
(Streptomyces
mobaraensis) 		4 / 6 TYR A 348
ASN A 322
TYR A  12
TYR A 337
 None
 1.41A 1kiaB-3iu0A:
undetectable		 1kiaB-3iu0A:
23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIA_C_ACTC2294_0
(GLYCINE
N-METHYLTRANSFERASE)		 3iu0 PROTEIN-GLUTAMINE
GAMMA-GLUTAMYLTRANSF
ERASE
(Streptomyces
mobaraensis) 		4 / 7 TYR A 348
ASN A 322
TYR A  12
TYR A 337
 None
 1.41A 1kiaC-3iu0A:
undetectable		 1kiaC-3iu0A:
23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIA_D_ACTD3294_0
(GLYCINE
N-METHYLTRANSFERASE)		 3iu0 PROTEIN-GLUTAMINE
GAMMA-GLUTAMYLTRANSF
ERASE
(Streptomyces
mobaraensis) 		4 / 7 TYR A 348
ASN A 322
TYR A  12
TYR A 337
 None
 1.40A 1kiaD-3iu0A:
undetectable		 1kiaD-3iu0A:
23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBH_A_ACTA294_0
(GLYCINE
N-METHYLTRANSFERASE)		 3iu0 PROTEIN-GLUTAMINE
GAMMA-GLUTAMYLTRANSF
ERASE
(Streptomyces
mobaraensis) 		4 / 6 TYR A 348
ASN A 322
TYR A  12
TYR A 337
 None
 1.42A 1nbhA-3iu0A:
0.0		 1nbhA-3iu0A:
23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBH_B_ACTB1294_0
(GLYCINE
N-METHYLTRANSFERASE)		 3iu0 PROTEIN-GLUTAMINE
GAMMA-GLUTAMYLTRANSF
ERASE
(Streptomyces
mobaraensis) 		4 / 7 TYR A 348
ASN A 322
TYR A  12
TYR A 337
 None
 1.41A 1nbhB-3iu0A:
undetectable		 1nbhB-3iu0A:
23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBH_C_ACTC2294_0
(GLYCINE
N-METHYLTRANSFERASE)		 3iu0 PROTEIN-GLUTAMINE
GAMMA-GLUTAMYLTRANSF
ERASE
(Streptomyces
mobaraensis) 		4 / 6 TYR A 348
ASN A 322
TYR A  12
TYR A 337
 None
 1.42A 1nbhC-3iu0A:
0.0		 1nbhC-3iu0A:
23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBH_D_ACTD3294_0
(GLYCINE
N-METHYLTRANSFERASE)		 3iu0 PROTEIN-GLUTAMINE
GAMMA-GLUTAMYLTRANSF
ERASE
(Streptomyces
mobaraensis) 		4 / 7 TYR A 348
ASN A 322
TYR A  12
TYR A 337
 None
 1.41A 1nbhD-3iu0A:
undetectable		 1nbhD-3iu0A:
23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J0D_A_ERYA1498_0
(CYTOCHROME P450 3A4)		 3iu0 PROTEIN-GLUTAMINE
GAMMA-GLUTAMYLTRANSF
ERASE
(Streptomyces
mobaraensis) 		5 / 12 PHE A 154
ARG A 135
ALA A 268
ARG A 157
GLU A 161
 None
 1.14A 2j0dA-3iu0A:
undetectable		 2j0dA-3iu0A:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RCT_A_RTLA140_1
(RETINOL-BINDING
PROTEIN II, CELLULAR)		 3iu0 PROTEIN-GLUTAMINE
GAMMA-GLUTAMYLTRANSF
ERASE
(Streptomyces
mobaraensis) 		3 / 3 GLN A 308
THR A 114
TRP A 344
 None
 1.15A 2rctA-3iu0A:
undetectable		 2rctA-3iu0A:
18.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_A_HSMA1160_1
(ALLERGEN ARG R 1)		 3iu0 PROTEIN-GLUTAMINE
GAMMA-GLUTAMYLTRANSF
ERASE
(Streptomyces
mobaraensis) 		4 / 6 SER A  32
TYR A 108
VAL A 111
TYR A 121
 None
 1.39A 2x45A-3iu0A:
undetectable		 2x45A-3iu0A:
16.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ARU_A_PNXA608_1
(CHITINASE A)		 3iu0 PROTEIN-GLUTAMINE
GAMMA-GLUTAMYLTRANSF
ERASE
(Streptomyces
mobaraensis) 		4 / 6 SER A 237
ALA A 186
HIS A 187
ASP A 188
 None
 1.36A 3aruA-3iu0A:
undetectable		 3aruA-3iu0A:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3F33_A_PFLA2001_1
(FERRITIN LIGHT CHAIN)		 3iu0 PROTEIN-GLUTAMINE
GAMMA-GLUTAMYLTRANSF
ERASE
(Streptomyces
mobaraensis) 		4 / 6 SER A 218
TYR A 217
ARG A 213
LEU A 193
 None
 1.04A 3f33A-3iu0A:
undetectable		 3f33A-3iu0A:
17.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JQA_A_DX4A270_0
(PTERIDINE REDUCTASE
1)		 3iu0 PROTEIN-GLUTAMINE
GAMMA-GLUTAMYLTRANSF
ERASE
(Streptomyces
mobaraensis) 		4 / 6 ARG A 353
SER A 162
PHE A 136
PRO A 266
 None
 1.40A 3jqaA-3iu0A:
undetectable		 3jqaA-3iu0A:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JQA_C_DX4C270_0
(PTERIDINE REDUCTASE
1)		 3iu0 PROTEIN-GLUTAMINE
GAMMA-GLUTAMYLTRANSF
ERASE
(Streptomyces
mobaraensis) 		4 / 6 ARG A 353
SER A 162
PHE A 136
PRO A 266
 None
 1.34A 3jqaC-3iu0A:
undetectable		 3jqaC-3iu0A:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JQA_D_DX4D270_0
(PTERIDINE REDUCTASE
1)		 3iu0 PROTEIN-GLUTAMINE
GAMMA-GLUTAMYLTRANSF
ERASE
(Streptomyces
mobaraensis) 		4 / 6 ARG A 353
SER A 162
PHE A 136
PRO A 266
 None
 1.36A 3jqaD-3iu0A:
undetectable		 3jqaD-3iu0A:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RAV_A_RAVA183_1
(FERRITIN LIGHT CHAIN)		 3iu0 PROTEIN-GLUTAMINE
GAMMA-GLUTAMYLTRANSF
ERASE
(Streptomyces
mobaraensis) 		4 / 6 SER A 218
TYR A 217
ARG A 213
LEU A 193
 None
 0.97A 3ravA-3iu0A:
undetectable		 3ravA-3iu0A:
17.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RD0_A_EDPA175_1
(FERRITIN LIGHT CHAIN)		 3iu0 PROTEIN-GLUTAMINE
GAMMA-GLUTAMYLTRANSF
ERASE
(Streptomyces
mobaraensis) 		4 / 6 SER A 218
TYR A 217
ARG A 213
LEU A 193
 None
 1.00A 3rd0A-3iu0A:
undetectable		 3rd0A-3iu0A:
17.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HYT_A_OBNA1104_2
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 3iu0 PROTEIN-GLUTAMINE
GAMMA-GLUTAMYLTRANSF
ERASE
(Streptomyces
mobaraensis) 		4 / 5 PRO A 287
ASN A 299
ILE A  26
VAL A 111
 None
 1.39A 4hytA-3iu0A:
undetectable		 4hytA-3iu0A:
16.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OAE_A_CLMA207_0
(GNAT SUPERFAMILY
ACETYLTRANSFERASE
PA4794)		 3iu0 PROTEIN-GLUTAMINE
GAMMA-GLUTAMYLTRANSF
ERASE
(Streptomyces
mobaraensis) 		5 / 12 PRO A 145
GLU A 149
ARG A 157
ALA A 159
GLY A 264
 None
 1.04A 4oaeA-3iu0A:
undetectable		 4oaeA-3iu0A:
16.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RV6_A_RPBA1103_1
(POLY [ADP-RIBOSE]
POLYMERASE 1)		 3iu0 PROTEIN-GLUTAMINE
GAMMA-GLUTAMYLTRANSF
ERASE
(Streptomyces
mobaraensis) 		5 / 11 GLN A 120
GLY A 303
TYR A 121
SER A 245
TYR A 244
 None
 1.38A 4rv6A-3iu0A:
undetectable		 4rv6A-3iu0A:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RV6_B_RPBB1103_1
(POLY [ADP-RIBOSE]
POLYMERASE 1)		 3iu0 PROTEIN-GLUTAMINE
GAMMA-GLUTAMYLTRANSF
ERASE
(Streptomyces
mobaraensis) 		5 / 11 GLN A 120
GLY A 303
TYR A 121
SER A 245
TYR A 244
 None
 1.36A 4rv6B-3iu0A:
undetectable		 4rv6B-3iu0A:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_C_377C401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 3iu0 PROTEIN-GLUTAMINE
GAMMA-GLUTAMYLTRANSF
ERASE
(Streptomyces
mobaraensis) 		4 / 6 TYR A  88
ASN A 117
GLU A 338
LEU A 106
 None
 1.15A 4twdB-3iu0A:
undetectable
4twdC-3iu0A:
undetectable		 4twdB-3iu0A:
21.68
4twdC-3iu0A:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_E_377E401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 3iu0 PROTEIN-GLUTAMINE
GAMMA-GLUTAMYLTRANSF
ERASE
(Streptomyces
mobaraensis) 		4 / 6 TYR A  88
ASN A 117
GLU A 338
LEU A 106
 None
 1.26A 4twdD-3iu0A:
undetectable
4twdE-3iu0A:
undetectable		 4twdD-3iu0A:
21.68
4twdE-3iu0A:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UAC_A_ACRA501_2
(CARBOHYDRATE ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN, CUT1 FAMILY
(TC 3.A.1.1.-))		 3iu0 PROTEIN-GLUTAMINE
GAMMA-GLUTAMYLTRANSF
ERASE
(Streptomyces
mobaraensis) 		4 / 7 PRO A 224
GLU A 228
GLU A 101
THR A  53
 None
 1.24A 4uacA-3iu0A:
undetectable		 4uacA-3iu0A:
23.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5C0O_G_SAMG301_1
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
TRMI)		 3iu0 PROTEIN-GLUTAMINE
GAMMA-GLUTAMYLTRANSF
ERASE
(Streptomyces
mobaraensis) 		3 / 3 GLU A  74
HIS A 335
ASP A  64
 None
 0.77A 5c0oG-3iu0A:
undetectable		 5c0oG-3iu0A:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TJY_A_BEZA304_0
(4-HYDROXY-TETRAHYDRO
DIPICOLINATE
REDUCTASE)		 3iu0 PROTEIN-GLUTAMINE
GAMMA-GLUTAMYLTRANSF
ERASE
(Streptomyces
mobaraensis) 		3 / 3 MET A  98
GLU A 104
ARG A 103
 None
 1.12A 5tjyA-3iu0A:
undetectable		 5tjyA-3iu0A:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TJZ_A_BEZA302_0
(4-HYDROXY-TETRAHYDRO
DIPICOLINATE
REDUCTASE)		 3iu0 PROTEIN-GLUTAMINE
GAMMA-GLUTAMYLTRANSF
ERASE
(Streptomyces
mobaraensis) 		3 / 3 MET A  98
GLU A 104
ARG A 103
 None
 1.04A 5tjzA-3iu0A:
undetectable		 5tjzA-3iu0A:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HU9_I_PCFI101_0
(CYTOCHROME B-C1
COMPLEX SUBUNIT 1,
MITOCHONDRIAL
CYTOCHROME B-C1
COMPLEX SUBUNIT 9
CYTOCHROME B-C1
COMPLEX SUBUNIT
RIESKE,
MITOCHONDRIAL)		 3iu0 PROTEIN-GLUTAMINE
GAMMA-GLUTAMYLTRANSF
ERASE
(Streptomyces
mobaraensis) 		5 / 11 ASP A 283
VAL A 111
GLY A 109
ALA A 326
ASN A 299
 None
 1.04A 6hu9A-3iu0A:
undetectable
6hu9E-3iu0A:
undetectable
6hu9I-3iu0A:
undetectable		 6hu9A-3iu0A:
21.91
6hu9E-3iu0A:
20.33
6hu9I-3iu0A:
9.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HU9_T_PCFT101_0
(CYTOCHROME B-C1
COMPLEX SUBUNIT 1,
MITOCHONDRIAL
CYTOCHROME B-C1
COMPLEX SUBUNIT 9
CYTOCHROME B-C1
COMPLEX SUBUNIT
RIESKE,
MITOCHONDRIAL)		 3iu0 PROTEIN-GLUTAMINE
GAMMA-GLUTAMYLTRANSF
ERASE
(Streptomyces
mobaraensis) 		5 / 10 ASP A 283
VAL A 111
GLY A 109
ALA A 326
ASN A 299
 None
 1.00A 6hu9L-3iu0A:
undetectable
6hu9P-3iu0A:
undetectable
6hu9T-3iu0A:
undetectable		 6hu9L-3iu0A:
21.91
6hu9P-3iu0A:
20.33
6hu9T-3iu0A:
9.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HUO_D_08HD501_0
(GAMMA-AMINOBUTYRIC
ACID RECEPTOR
SUBUNIT
ALPHA-1,GAMMA-AMINOB
UTYRIC ACID RECEPTOR
SUBUNIT ALPHA-1
GAMMA-AMINOBUTYRIC
ACID RECEPTOR
SUBUNIT GAMMA-2)		 3iu0 PROTEIN-GLUTAMINE
GAMMA-GLUTAMYLTRANSF
ERASE
(Streptomyces
mobaraensis) 		4 / 8 PHE A 248
VAL A 357
SER A 245
TYR A 356
 None
 1.19A 6huoC-3iu0A:
undetectable
6huoD-3iu0A:
undetectable		 6huoC-3iu0A:
12.43
6huoD-3iu0A:
11.39