SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3iu4'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4EM2_A_SALA501_1 (UNCHARACTERIZED HTH-TYPE TRANSCRIPTIONAL REGULATOR SAR2349)	3iu4	CHP3 FAB HEAVY CHAIN (Homo sapiens; Mus musculus)	4 / 5	TYR H 90 LEU H 80 LEU H 82 ARG H 66	None	1.17A	4em2A-3iu4H: undetectable	4em2A-3iu4H: 18.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4FU8_A_ACTA302_0 (UROKINASE-TYPE PLASMINOGEN ACTIVATOR)	3iu4	CHP3 FAB HEAVY CHAIN (Homo sapiens; Mus musculus)	4 / 5	HIS H 35 GLN H 100 GLY H 96 SER H 95	None None SO4 H 257 (-3.1A) None	1.18A	4fu8A-3iu4H: undetectable	4fu8A-3iu4H: 26.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	5MTH_A_ACTA302_0 (ANTIBODY FAB HEAVY CHAIN)	3iu4	CHP3 FAB HEAVY CHAIN (Homo sapiens; Mus musculus)	4 / 5	SER H 112 ALA H 114 PHE H 146 LEU H 170	None	0.31A	5mthA-3iu4H: 27.0	5mthA-3iu4H: 46.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6DRZ_A_H8JA1206_0 (5HT2B RECEPTOR, BRIL CHIMERA)	3iu4	CHP3 FAB HEAVY CHAIN (Homo sapiens; Mus musculus)	5 / 12	VAL H 207 THR H 205 VAL H 211 GLY H 118 VAL H 152	None	1.05A	6drzA-3iu4H: undetectable	6drzA-3iu4H: 18.42

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["4EM2_A_SALA501_1","UNCHARACTERIZED HTH-TYPE TRANSCRIPTIONAL REGULATOR SAR2349","3iu4","CHP3 FAB HEAVY CHAIN","Homo sapiens;Mus musculus",4,"TYR H  90;LEU H  80;LEU H  82;ARG H  66","None","1.17A","4em2A-3iu4H:undetectable","4em2A-3iu4H:18.25"],["4FU8_A_ACTA302_0","UROKINASE-TYPE PLASMINOGEN ACTIVATOR","3iu4","CHP3 FAB HEAVY CHAIN","Homo sapiens;Mus musculus",4,"HIS H  35;GLN H 100;GLY H  96;SER H  95","None;None;SO4 H 257 (-3.1A);None","1.18A","4fu8A-3iu4H:undetectable","4fu8A-3iu4H:26.99"],["5MTH_A_ACTA302_0","ANTIBODY FAB HEAVY CHAIN","3iu4","CHP3 FAB HEAVY CHAIN","Homo sapiens;Mus musculus",4,"SER H 112;ALA H 114;PHE H 146;LEU H 170","None","0.31A","5mthA-3iu4H:27.0","5mthA-3iu4H:46.51"],["6DRZ_A_H8JA1206_0","5HT2B RECEPTOR, BRIL CHIMERA","3iu4","CHP3 FAB HEAVY CHAIN","Homo sapiens;Mus musculus",5,"VAL H 207;THR H 205;VAL H 211;GLY H 118;VAL H 152","None","1.05A","6drzA-3iu4H:undetectable","6drzA-3iu4H:18.42"]]