SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3iu6'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W8Y_A_486A1000_2
(PROGESTERONE
RECEPTOR)		 3iu6 PROTEIN POLYBROMO-1
(Homo
sapiens) 		4 / 7 LEU A 847
ASN A 850
GLU A 852
LEU A 854
 None
 1.24A 2w8yA-3iu6A:
undetectable		 2w8yA-3iu6A:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NBQ_B_URFB400_1
(URIDINE
PHOSPHORYLASE 1)		 3iu6 PROTEIN POLYBROMO-1
(Homo
sapiens) 		4 / 8 GLY A 851
LEU A 749
LEU A 745
ILE A 746
 None
 0.88A 3nbqB-3iu6A:
undetectable		 3nbqB-3iu6A:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NBQ_C_URFC400_1
(URIDINE
PHOSPHORYLASE 1)		 3iu6 PROTEIN POLYBROMO-1
(Homo
sapiens) 		4 / 8 GLY A 851
LEU A 749
LEU A 745
ILE A 746
 None
 0.86A 3nbqC-3iu6A:
undetectable		 3nbqC-3iu6A:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PGL_A_RZXA257_1
(CARBOXY-TERMINAL
DOMAIN RNA
POLYMERASE II
POLYPEPTIDE A SMALL
PHOSPHATASE 1)		 3iu6 PROTEIN POLYBROMO-1
(Homo
sapiens) 		4 / 7 PHE A 808
VAL A 797
ILE A 793
SER A 756
 None
 0.95A 3pglA-3iu6A:
undetectable		 3pglA-3iu6A:
24.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TPX_E_ACTE204_0
(E3 UBIQUITIN-PROTEIN
LIGASE MDM2)		 3iu6 PROTEIN POLYBROMO-1
(Homo
sapiens) 		3 / 3 LYS A 785
PRO A 786
LEU A 788
 None
 0.79A 3tpxE-3iu6A:
undetectable		 3tpxE-3iu6A:
18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VHU_A_SNLA1001_2
(MINERALOCORTICOID
RECEPTOR)		 3iu6 PROTEIN POLYBROMO-1
(Homo
sapiens) 		4 / 5 LEU A 855
LEU A 854
LEU A 859
SER A 860
 None
 1.03A 3vhuA-3iu6A:
undetectable		 3vhuA-3iu6A:
24.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IAR_A_ERMA2001_1
(CHIMERA PROTEIN OF
HUMAN
5-HYDROXYTRYPTAMINE
RECEPTOR 1B AND E.
COLI SOLUBLE
CYTOCHROME B562)		 3iu6 PROTEIN POLYBROMO-1
(Homo
sapiens) 		5 / 12 LEU A 788
VAL A 815
MET A 758
LEU A 753
PHE A 754
 None
 1.45A 4iarA-3iu6A:
2.7		 4iarA-3iu6A:
16.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IFX_A_ACTA404_0
(THIAMINE
BIOSYNTHESIS
LIPOPROTEIN APBE)		 3iu6 PROTEIN POLYBROMO-1
(Homo
sapiens) 		4 / 5 SER A 856
ARG A 844
LEU A 805
ASP A 806
 None
 1.43A 4ifxA-3iu6A:
undetectable		 4ifxA-3iu6A:
16.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IG1_A_ACTA504_0
(FAD:PROTEIN FMN
TRANSFERASE)		 3iu6 PROTEIN POLYBROMO-1
(Homo
sapiens) 		4 / 5 SER A 856
ARG A 844
LEU A 805
ASP A 806
 None
 1.47A 4ig1A-3iu6A:
undetectable		 4ig1A-3iu6A:
16.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VEU_A_RITA602_2
(CYTOCHROME P450 3A5)		 3iu6 PROTEIN POLYBROMO-1
(Homo
sapiens) 		3 / 3 ARG A 804
PHE A 754
LEU A 749
 None
 0.84A 5veuA-3iu6A:
undetectable		 5veuA-3iu6A:
16.95