SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3iug'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZJ0_A_2FAA500_1
(ADENOSYLHOMOCYSTEINA
SE)		 3iug RHO/CDC42/RAC
GTPASE-ACTIVATING
PROTEIN RICS
(Homo
sapiens) 		5 / 12 LEU A 389
LEU A 378
GLY A 375
HIS A 493
PHE A 450
 None
 1.41A 2zj0A-3iugA:
undetectable		 2zj0A-3iugA:
16.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CE6_A_ADNA500_1
(ADENOSYLHOMOCYSTEINA
SE)		 3iug RHO/CDC42/RAC
GTPASE-ACTIVATING
PROTEIN RICS
(Homo
sapiens) 		5 / 12 LEU A 389
LEU A 378
GLY A 375
HIS A 493
PHE A 450
 None
 1.39A 3ce6A-3iugA:
undetectable		 3ce6A-3iugA:
16.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CE6_C_ADNC500_1
(ADENOSYLHOMOCYSTEINA
SE)		 3iug RHO/CDC42/RAC
GTPASE-ACTIVATING
PROTEIN RICS
(Homo
sapiens) 		5 / 12 LEU A 389
LEU A 378
GLY A 375
HIS A 493
PHE A 450
 None
 1.39A 3ce6C-3iugA:
undetectable		 3ce6C-3iugA:
16.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G1U_A_ADNA438_1
(ADENOSYLHOMOCYSTEINA
SE)		 3iug RHO/CDC42/RAC
GTPASE-ACTIVATING
PROTEIN RICS
(Homo
sapiens) 		5 / 12 LEU A 389
LEU A 378
GLY A 375
HIS A 493
PHE A 450
 None
 1.39A 3g1uA-3iugA:
undetectable		 3g1uA-3iugA:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKX_B_STRB601_2
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 3iug RHO/CDC42/RAC
GTPASE-ACTIVATING
PROTEIN RICS
(Homo
sapiens) 		4 / 5 ILE A 486
LEU A 489
GLU A 498
VAL A 385
 None
 0.69A 4nkxB-3iugA:
undetectable		 4nkxB-3iugA:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PFJ_A_ADNA502_1
(ADENOSYLHOMOCYSTEINA
SE)		 3iug RHO/CDC42/RAC
GTPASE-ACTIVATING
PROTEIN RICS
(Homo
sapiens) 		5 / 12 LEU A 389
LEU A 378
GLY A 375
HIS A 493
PHE A 450
 None
 1.46A 4pfjA-3iugA:
undetectable		 4pfjA-3iugA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RTB_A_SAMA501_1
(HYDG PROTEIN)		 3iug RHO/CDC42/RAC
GTPASE-ACTIVATING
PROTEIN RICS
(Homo
sapiens) 		3 / 3 GLU A 498
ARG A 502
GLN A 487
 None
 0.72A 4rtbA-3iugA:
undetectable		 4rtbA-3iugA:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SXQ_A_NIZA808_1
(CATALASE-PEROXIDASE)		 3iug RHO/CDC42/RAC
GTPASE-ACTIVATING
PROTEIN RICS
(Homo
sapiens) 		4 / 8 GLU A 425
VAL A 369
GLY A 382
LEU A 378
 None
 0.99A 5sxqA-3iugA:
undetectable		 5sxqA-3iugA:
15.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SXQ_B_NIZB808_1
(CATALASE-PEROXIDASE)		 3iug RHO/CDC42/RAC
GTPASE-ACTIVATING
PROTEIN RICS
(Homo
sapiens) 		4 / 8 GLU A 425
VAL A 369
GLY A 382
LEU A 378
 None
 0.96A 5sxqB-3iugA:
undetectable		 5sxqB-3iugA:
15.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SXT_A_NIZA807_1
(CATALASE-PEROXIDASE)		 3iug RHO/CDC42/RAC
GTPASE-ACTIVATING
PROTEIN RICS
(Homo
sapiens) 		4 / 8 GLU A 425
VAL A 369
GLY A 382
LEU A 378
 None
 1.00A 5sxtA-3iugA:
1.1		 5sxtA-3iugA:
15.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SXT_B_NIZB808_1
(CATALASE-PEROXIDASE)		 3iug RHO/CDC42/RAC
GTPASE-ACTIVATING
PROTEIN RICS
(Homo
sapiens) 		4 / 8 GLU A 425
VAL A 369
GLY A 382
LEU A 378
 None
 0.98A 5sxtB-3iugA:
1.1		 5sxtB-3iugA:
15.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SYJ_A_NIZA809_1
(CATALASE-PEROXIDASE)		 3iug RHO/CDC42/RAC
GTPASE-ACTIVATING
PROTEIN RICS
(Homo
sapiens) 		4 / 8 GLU A 425
VAL A 369
GLY A 382
LEU A 378
 None
 0.95A 5syjA-3iugA:
undetectable		 5syjA-3iugA:
15.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SYJ_B_NIZB809_1
(CATALASE-PEROXIDASE)		 3iug RHO/CDC42/RAC
GTPASE-ACTIVATING
PROTEIN RICS
(Homo
sapiens) 		4 / 8 GLU A 425
VAL A 369
GLY A 382
LEU A 378
 None
 0.96A 5syjB-3iugA:
undetectable		 5syjB-3iugA:
15.01