SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3iuo'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YC5_A_NCAA2001_0
(NAD-DEPENDENT
DEACETYLASE)		 3iuo ATP-DEPENDENT DNA
HELICASE RECQ
(Porphyromonas
gingivalis) 		4 / 7 ALA A 637
ILE A 641
ASP A 639
ILE A 668
 None
 0.91A 1yc5A-3iuoA:
undetectable		 1yc5A-3iuoA:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P68_A_MTXA201_1
(DIHYDROFOLATE
REDUCTASE)		 3iuo ATP-DEPENDENT DNA
HELICASE RECQ
(Porphyromonas
gingivalis) 		5 / 11 ILE A 641
LYS A 625
SER A 721
ILE A 632
TYR A 670
 None
 1.50A 4p68A-3iuoA:
undetectable		 4p68A-3iuoA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UIH_A_8CVA201_1
(DIHYDROFOLATE
REDUCTASE)		 3iuo ATP-DEPENDENT DNA
HELICASE RECQ
(Porphyromonas
gingivalis) 		4 / 8 ILE A 628
ALA A 642
LEU A 653
ILE A 632
 None
 0.77A 5uihA-3iuoA:
undetectable		 5uihA-3iuoA:
18.49