SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3iup'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HRK_B_CHDB2503_0
(FERROCHELATASE)		 3iup PUTATIVE
NADPH:QUINONE
OXIDOREDUCTASE
(Cupriavidus
pinatubonensis) 		4 / 4 LEU A 157
PRO A 156
LEU A 160
ARG A 321
 None
None
ACT  A 383 (-4.0A)
ACT  A 383 (-4.4A)
 1.43A 1hrkB-3iupA:
2.7		 1hrkB-3iupA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YMX_B_CFXB1002_2
(BETA-LACTAMASE
CTX-M-9)		 3iup PUTATIVE
NADPH:QUINONE
OXIDOREDUCTASE
(Cupriavidus
pinatubonensis) 		4 / 5 CYH A 220
PRO A 225
THR A 247
THR A 177
 None
None
NDP  A 401 (-4.5A)
None
 1.11A 1ymxB-3iupA:
undetectable		 1ymxB-3iupA:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HRC_B_CHDB1604_0
(FERROCHELATASE)		 3iup PUTATIVE
NADPH:QUINONE
OXIDOREDUCTASE
(Cupriavidus
pinatubonensis) 		4 / 4 LEU A 157
PRO A 156
LEU A 160
ARG A 321
 None
None
ACT  A 383 (-4.0A)
ACT  A 383 (-4.4A)
 1.40A 2hrcB-3iupA:
2.8		 2hrcB-3iupA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU6_C_SAMC300_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 3iup PUTATIVE
NADPH:QUINONE
OXIDOREDUCTASE
(Cupriavidus
pinatubonensis) 		5 / 12 LEU A 284
TYR A 285
GLY A 248
LEU A 252
ALA A 180
 None
NDP  A 401 (-4.0A)
None
None
NDP  A 401 ( 4.1A)
 1.29A 3ou6C-3iupA:
2.9		 3ou6C-3iupA:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU7_C_SAMC300_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 3iup PUTATIVE
NADPH:QUINONE
OXIDOREDUCTASE
(Cupriavidus
pinatubonensis) 		5 / 12 LEU A 284
TYR A 285
GLY A 248
LEU A 252
HIS A 176
 None
NDP  A 401 (-4.0A)
None
None
None
 1.25A 3ou7C-3iupA:
4.2		 3ou7C-3iupA:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU7_C_SAMC300_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 3iup PUTATIVE
NADPH:QUINONE
OXIDOREDUCTASE
(Cupriavidus
pinatubonensis) 		5 / 12 TYR A 285
GLY A 248
LEU A 252
ALA A 180
HIS A 176
 NDP  A 401 (-4.0A)
None
None
NDP  A 401 ( 4.1A)
None
 1.35A 3ou7C-3iupA:
4.2		 3ou7C-3iupA:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P73_A_ACTA275_0
(MHC RFP-Y CLASS I
ALPHA CHAIN)		 3iup PUTATIVE
NADPH:QUINONE
OXIDOREDUCTASE
(Cupriavidus
pinatubonensis) 		3 / 3 ILE A 196
VAL A 163
ARG A 167
 None
ACT  A 383 (-4.5A)
ACT  A 384 ( 2.7A)
 0.66A 3p73A-3iupA:
undetectable		 3p73A-3iupA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AX8_A_SAMA1474_1
(WBDD)		 3iup PUTATIVE
NADPH:QUINONE
OXIDOREDUCTASE
(Cupriavidus
pinatubonensis) 		4 / 6 ARG A  68
ASP A  25
GLU A 103
LEU A   5
 None
EDO  A 381 (-3.3A)
None
None
 1.27A 4ax8A-3iupA:
5.5		 4ax8A-3iupA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FO4_B_MOAB502_1
(INOSINE
5'-MONOPHOSPHATE
DEHYDROGENASE)		 3iup PUTATIVE
NADPH:QUINONE
OXIDOREDUCTASE
(Cupriavidus
pinatubonensis) 		4 / 8 GLY A 254
THR A 258
MET A 301
GLY A 300
 None
 0.81A 4fo4B-3iupA:
undetectable		 4fo4B-3iupA:
23.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WW7_A_ACTA303_0
(EKC/KEOPS COMPLEX
SUBUNIT BUD32)		 3iup PUTATIVE
NADPH:QUINONE
OXIDOREDUCTASE
(Cupriavidus
pinatubonensis) 		4 / 4 LEU A 160
VAL A 163
GLU A 164
ARG A 167
 ACT  A 383 (-4.0A)
ACT  A 383 (-4.5A)
ACT  A 383 (-3.8A)
ACT  A 384 ( 2.7A)
 1.20A 4ww7A-3iupA:
0.1		 4ww7A-3iupA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YGF_G_AZMG303_1
(ALPHA-CARBONIC
ANHYDRASE)		 3iup PUTATIVE
NADPH:QUINONE
OXIDOREDUCTASE
(Cupriavidus
pinatubonensis) 		5 / 12 ASN A 155
HIS A 176
LYS A 367
LEU A 288
ALA A 246
 NDP  A 401 (-3.3A)
None
NDP  A 401 (-2.6A)
NDP  A 401 (-3.8A)
NDP  A 401 ( 3.8A)
 1.48A 4ygfG-3iupA:
undetectable		 4ygfG-3iupA:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YV5_B_SVRB207_1
(BASIC PHOSPHOLIPASE
A2 HOMOLOG 2)		 3iup PUTATIVE
NADPH:QUINONE
OXIDOREDUCTASE
(Cupriavidus
pinatubonensis) 		4 / 6 LEU A  48
ASN A  44
PRO A  45
ARG A 203
 None
NDP  A 401 ( 4.8A)
NDP  A 401 (-4.3A)
NDP  A 401 (-3.4A)
 1.38A 4yv5A-3iupA:
undetectable		 4yv5A-3iupA:
15.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZBR_A_NPSA603_1
(SERUM ALBUMIN)		 3iup PUTATIVE
NADPH:QUINONE
OXIDOREDUCTASE
(Cupriavidus
pinatubonensis) 		5 / 10 ALA A 240
LEU A 235
ALA A 234
LEU A 264
ALA A 263
 None
 1.12A 4zbrA-3iupA:
undetectable		 4zbrA-3iupA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MFX_A_ACTA701_0
(GENOME POLYPROTEIN)		 3iup PUTATIVE
NADPH:QUINONE
OXIDOREDUCTASE
(Cupriavidus
pinatubonensis) 		4 / 5 THR A 177
HIS A 176
ALA A 178
ASP A 245
 None
None
NDP  A 401 ( 3.8A)
None
 1.44A 5mfxA-3iupA:
3.8		 5mfxA-3iupA:
23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MFX_A_ACTA701_0
(GENOME POLYPROTEIN)		 3iup PUTATIVE
NADPH:QUINONE
OXIDOREDUCTASE
(Cupriavidus
pinatubonensis) 		4 / 5 THR A 177
HIS A 176
ALA A 246
ASP A 245
 None
None
NDP  A 401 ( 3.8A)
None
 1.27A 5mfxA-3iupA:
3.8		 5mfxA-3iupA:
23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VW4_A_NCAA403_0
(FERREDOXIN--NADP
REDUCTASE)		 3iup PUTATIVE
NADPH:QUINONE
OXIDOREDUCTASE
(Cupriavidus
pinatubonensis) 		5 / 9 SER A 291
THR A 247
GLY A 248
LEU A 252
GLU A 294
 None
NDP  A 401 (-4.5A)
None
None
None
 1.20A 5vw4A-3iupA:
3.8		 5vw4A-3iupA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7P_A_ACRA1421_1
(GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE)		 3iup PUTATIVE
NADPH:QUINONE
OXIDOREDUCTASE
(Cupriavidus
pinatubonensis) 		4 / 5 TYR A 283
TYR A 285
GLY A 307
GLY A 306
 None
NDP  A 401 (-4.0A)
None
None
 1.17A 5x7pA-3iupA:
4.0		 5x7pA-3iupA:
15.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y2T_A_8LXA501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 3iup PUTATIVE
NADPH:QUINONE
OXIDOREDUCTASE
(Cupriavidus
pinatubonensis) 		3 / 3 SER A 181
HIS A 176
TYR A 285
 NDP  A 401 (-3.5A)
None
NDP  A 401 (-4.0A)
 0.87A 5y2tA-3iupA:
undetectable		 5y2tA-3iupA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YCP_A_BRLA501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 3iup PUTATIVE
NADPH:QUINONE
OXIDOREDUCTASE
(Cupriavidus
pinatubonensis) 		3 / 3 GLY A 249
VAL A 282
MET A 305
 None
 0.58A 5ycpA-3iupA:
undetectable		 5ycpA-3iupA:
13.75