SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3ius'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DIT_P_2PPP1_1
(ALPHA-THROMBIN
PEPTIDE INHIBITOR
CVS995)		 3ius UNCHARACTERIZED
CONSERVED PROTEIN
(Ruegeria
pomeroyi) 		4 / 6 LEU A  50
ILE A  41
ASP A  36
PRO A  35
 None
 1.04A 1ditH-3iusA:
undetectable
1ditP-3iusA:
undetectable		 1ditH-3iusA:
20.77
1ditP-3iusA:
5.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L7F_A_BCZA801_1
(NEURAMINIDASE)		 3ius UNCHARACTERIZED
CONSERVED PROTEIN
(Ruegeria
pomeroyi) 		3 / 3 ARG A 124
ARG A  33
ARG A 128
 None
 1.09A 1l7fA-3iusA:
undetectable		 1l7fA-3iusA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L7H_A_BCZA801_1
(NEURAMINIDASE)		 3ius UNCHARACTERIZED
CONSERVED PROTEIN
(Ruegeria
pomeroyi) 		3 / 3 ARG A 124
ARG A  33
ARG A 128
 None
 1.06A 1l7hA-3iusA:
undetectable		 1l7hA-3iusA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P93_D_DEXD4999_2
(GLUCOCORTICOID
RECEPTOR)		 3ius UNCHARACTERIZED
CONSERVED PROTEIN
(Ruegeria
pomeroyi) 		4 / 5 LEU A  64
TRP A  26
MET A 193
GLN A  91
 None
 1.14A 1p93D-3iusA:
undetectable		 1p93D-3iusA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T88_A_CAMA1422_0
(CYTOCHROME P450-CAM)		 3ius UNCHARACTERIZED
CONSERVED PROTEIN
(Ruegeria
pomeroyi) 		4 / 7 LEU A 143
VAL A  95
GLY A  96
VAL A  77
 None
 0.97A 1t88A-3iusA:
undetectable		 1t88A-3iusA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1X70_A_715A801_1
(DIPEPTIDYL PEPTIDASE
IV)		 3ius UNCHARACTERIZED
CONSERVED PROTEIN
(Ruegeria
pomeroyi) 		5 / 12 SER A 160
VAL A  16
TYR A  12
VAL A 182
HIS A 181
 None
EDO  A 286 (-3.7A)
None
None
None
 1.48A 1x70A-3iusA:
undetectable		 1x70A-3iusA:
17.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1X70_B_715B801_1
(DIPEPTIDYL PEPTIDASE
IV)		 3ius UNCHARACTERIZED
CONSERVED PROTEIN
(Ruegeria
pomeroyi) 		5 / 12 SER A 160
VAL A  16
TYR A  12
VAL A 182
HIS A 181
 None
EDO  A 286 (-3.7A)
None
None
None
 1.49A 1x70B-3iusA:
undetectable		 1x70B-3iusA:
17.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XIU_B_9CRB202_1
(RXR-LIKE PROTEIN)		 3ius UNCHARACTERIZED
CONSERVED PROTEIN
(Ruegeria
pomeroyi) 		5 / 12 ILE A 216
ALA A 219
ALA A 220
GLN A 223
LEU A 225
 None
 1.02A 1xiuB-3iusA:
undetectable		 1xiuB-3iusA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z2B_C_VLBC800_1
(TUBULIN BETA CHAIN
TUBULIN ALPHA CHAIN)		 3ius UNCHARACTERIZED
CONSERVED PROTEIN
(Ruegeria
pomeroyi) 		4 / 8 THR A 121
PRO A 120
TYR A 104
LEU A 118
 None
 0.96A 1z2bB-3iusA:
6.4		 1z2bB-3iusA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ACL_E_REAE504_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 3ius UNCHARACTERIZED
CONSERVED PROTEIN
(Ruegeria
pomeroyi) 		5 / 11 ILE A 216
ALA A 219
ALA A 220
GLN A 223
LEU A 225
 None
 1.02A 2aclE-3iusA:
undetectable		 2aclE-3iusA:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OKC_A_SAMA500_0
(TYPE I RESTRICTION
ENZYME STYSJI M
PROTEIN)		 3ius UNCHARACTERIZED
CONSERVED PROTEIN
(Ruegeria
pomeroyi) 		5 / 12 TYR A 270
ILE A 151
GLY A 150
VAL A 210
PRO A 268
 None
 1.01A 2okcA-3iusA:
4.1		 2okcA-3iusA:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OKC_B_SAMB500_0
(TYPE I RESTRICTION
ENZYME STYSJI M
PROTEIN)		 3ius UNCHARACTERIZED
CONSERVED PROTEIN
(Ruegeria
pomeroyi) 		5 / 12 TYR A 270
ILE A 151
GLY A 150
VAL A 210
PRO A 268
 None
 1.01A 2okcB-3iusA:
3.8		 2okcB-3iusA:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MNO_A_DEXA784_2
(GLUCOCORTICOID
RECEPTOR)		 3ius UNCHARACTERIZED
CONSERVED PROTEIN
(Ruegeria
pomeroyi) 		4 / 6 LEU A  64
TRP A  26
MET A 193
GLN A  91
 None
 1.19A 3mnoA-3iusA:
0.0		 3mnoA-3iusA:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MNP_A_DEXA784_2
(GLUCOCORTICOID
RECEPTOR)		 3ius UNCHARACTERIZED
CONSERVED PROTEIN
(Ruegeria
pomeroyi) 		4 / 6 LEU A  64
TRP A  26
MET A 193
GLN A  91
 None
 1.17A 3mnpA-3iusA:
0.0		 3mnpA-3iusA:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_H_ACTH503_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 3ius UNCHARACTERIZED
CONSERVED PROTEIN
(Ruegeria
pomeroyi) 		5 / 7 ALA A  40
ILE A  41
ARG A  19
HIS A  10
GLY A  11
 None
None
None
None
FMT  A 285 ( 4.0A)
 1.45A 3v4tH-3iusA:
undetectable		 3v4tH-3iusA:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PWD_C_NVPC901_1
(HIV-1 REVERSE
TRANSCRIPTASE, P66
SUBUNIT)		 3ius UNCHARACTERIZED
CONSERVED PROTEIN
(Ruegeria
pomeroyi) 		4 / 8 LEU A  98
VAL A 204
TRP A  94
LEU A 189
 None
 1.11A 4pwdC-3iusA:
undetectable		 4pwdC-3iusA:
18.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R21_B_STRB601_1
(CYTOCHROME P450
FAMILY 17
POLYPEPTIDE 2)		 3ius UNCHARACTERIZED
CONSERVED PROTEIN
(Ruegeria
pomeroyi) 		5 / 9 ILE A 185
VAL A 182
SER A  44
ILE A  28
VAL A  16
 None
None
None
None
EDO  A 286 (-3.7A)
 1.05A 4r21B-3iusA:
undetectable		 4r21B-3iusA:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTA_H_MFXH101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
GGTCATGAATGACTATGCAC
GTAA)		 3ius UNCHARACTERIZED
CONSERVED PROTEIN
(Ruegeria
pomeroyi) 		4 / 6 SER A 244
ARG A 156
GLY A 150
THR A  13
 None
 1.05A 5btaA-3iusA:
undetectable
5btaB-3iusA:
1.8
5btaC-3iusA:
undetectable		 5btaA-3iusA:
20.99
5btaB-3iusA:
24.83
5btaC-3iusA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTC_G_CPFG101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		 3ius UNCHARACTERIZED
CONSERVED PROTEIN
(Ruegeria
pomeroyi) 		4 / 6 SER A 244
ARG A 156
GLY A 150
THR A  13
 None
 1.07A 5btcA-3iusA:
undetectable
5btcC-3iusA:
undetectable
5btcD-3iusA:
undetectable		 5btcA-3iusA:
20.99
5btcC-3iusA:
20.99
5btcD-3iusA:
24.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTC_G_CPFG102_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		 3ius UNCHARACTERIZED
CONSERVED PROTEIN
(Ruegeria
pomeroyi) 		4 / 6 SER A 244
ARG A 156
GLY A 150
THR A  13
 None
 1.06A 5btcA-3iusA:
undetectable
5btcB-3iusA:
undetectable
5btcC-3iusA:
undetectable		 5btcA-3iusA:
20.99
5btcB-3iusA:
24.83
5btcC-3iusA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GS4_A_ESTA603_1
(ESTROGEN RECEPTOR)		 3ius UNCHARACTERIZED
CONSERVED PROTEIN
(Ruegeria
pomeroyi) 		5 / 12 THR A  13
ALA A  14
LEU A  21
GLY A  96
LEU A  98
 None
 1.16A 5gs4A-3iusA:
undetectable		 5gs4A-3iusA:
23.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OHH_A_ACTA307_0
(CARBONIC ANHYDRASE
13)		 3ius UNCHARACTERIZED
CONSERVED PROTEIN
(Ruegeria
pomeroyi) 		4 / 5 HIS A 107
VAL A 112
LEU A 118
THR A 119
 None
 1.36A 5ohhA-3iusA:
undetectable		 5ohhA-3iusA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y80_A_IREA402_0
(CYCLIN-G-ASSOCIATED
KINASE)		 3ius UNCHARACTERIZED
CONSERVED PROTEIN
(Ruegeria
pomeroyi) 		5 / 11 ALA A  46
VAL A  95
ILE A  66
THR A  68
ILE A  85
 None
 1.17A 5y80A-3iusA:
undetectable		 5y80A-3iusA:
13.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AG0_C_ACRC607_0
(ALPHA-AMYLASE)		 3ius UNCHARACTERIZED
CONSERVED PROTEIN
(Ruegeria
pomeroyi) 		4 / 6 GLY A 273
GLY A 153
PRO A 154
GLY A 157
 None
 0.66A 6ag0C-3iusA:
undetectable		 6ag0C-3iusA:
19.28