SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3iuu'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CBS_A_REAA200_1
(CELLULAR RETINOIC
ACID BINDING PROTEIN
TYPE II)		 3iuu PUTATIVE
METALLOPEPTIDASE
(Chelativorans
sp.
BNC1) 		5 / 12 LEU A 364
ILE A 314
ALA A 315
PRO A 323
VAL A 327
 None
 1.06A 1cbsA-3iuuA:
undetectable		 1cbsA-3iuuA:
15.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4F_A_ADNA601_2
(S-ADENOSYLHOMOCYSTEI
NE HYDROLASE)		 3iuu PUTATIVE
METALLOPEPTIDASE
(Chelativorans
sp.
BNC1) 		4 / 5 THR A 453
GLU A 202
THR A 160
HIS A 140
 None
None
None
ZN  A 495 ( 3.1A)
 1.46A 1d4fA-3iuuA:
undetectable		 1d4fA-3iuuA:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4F_D_ADND604_2
(S-ADENOSYLHOMOCYSTEI
NE HYDROLASE)		 3iuu PUTATIVE
METALLOPEPTIDASE
(Chelativorans
sp.
BNC1) 		4 / 5 THR A 453
GLU A 202
THR A 160
HIS A 140
 None
None
None
ZN  A 495 ( 3.1A)
 1.46A 1d4fD-3iuuA:
3.6		 1d4fD-3iuuA:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DRF_A_FOLA187_0
(DIHYDROFOLATE
REDUCTASE)		 3iuu PUTATIVE
METALLOPEPTIDASE
(Chelativorans
sp.
BNC1) 		5 / 12 ILE A  99
LEU A  47
ARG A  60
GLN A  94
ILE A  65
 None
 1.11A 1drfA-3iuuA:
undetectable		 1drfA-3iuuA:
18.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JG3_B_ADNB550_1
(PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE)		 3iuu PUTATIVE
METALLOPEPTIDASE
(Chelativorans
sp.
BNC1) 		5 / 11 GLY A 307
GLY A 309
ILE A  21
GLY A  15
THR A 460
 None
 1.12A 1jg3B-3iuuA:
undetectable		 1jg3B-3iuuA:
17.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OC3_A_BEZA201_0
(PEROXIREDOXIN 5)		 3iuu PUTATIVE
METALLOPEPTIDASE
(Chelativorans
sp.
BNC1) 		4 / 8 THR A  23
GLY A  73
PHE A  28
THR A 107
 None
 0.87A 1oc3A-3iuuA:
undetectable		 1oc3A-3iuuA:
17.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R55_A_097A518_1
(ADAM 33)		 3iuu PUTATIVE
METALLOPEPTIDASE
(Chelativorans
sp.
BNC1) 		5 / 10 ALA A 347
THR A 348
VAL A 349
ALA A 340
THR A 339
 None
 1.14A 1r55A-3iuuA:
3.3		 1r55A-3iuuA:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1USQ_B_CLMB1143_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 3iuu PUTATIVE
METALLOPEPTIDASE
(Chelativorans
sp.
BNC1) 		4 / 6 GLY A 307
PRO A 308
ILE A  21
GLY A  72
 None
 0.80A 1usqB-3iuuA:
undetectable		 1usqB-3iuuA:
14.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1USQ_C_CLMC1143_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 3iuu PUTATIVE
METALLOPEPTIDASE
(Chelativorans
sp.
BNC1) 		4 / 6 GLY A 307
PRO A 308
ILE A  21
GLY A  72
 None
 0.79A 1usqC-3iuuA:
undetectable		 1usqC-3iuuA:
14.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1USQ_D_CLMD1142_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 3iuu PUTATIVE
METALLOPEPTIDASE
(Chelativorans
sp.
BNC1) 		4 / 6 GLY A 307
PRO A 308
ILE A  21
GLY A  72
 None
 0.81A 1usqD-3iuuA:
undetectable		 1usqD-3iuuA:
14.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1USQ_E_CLME1143_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 3iuu PUTATIVE
METALLOPEPTIDASE
(Chelativorans
sp.
BNC1) 		4 / 6 GLY A 307
PRO A 308
ILE A  21
GLY A  72
 None
 0.81A 1usqE-3iuuA:
undetectable		 1usqE-3iuuA:
14.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1USQ_F_CLMF1144_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 3iuu PUTATIVE
METALLOPEPTIDASE
(Chelativorans
sp.
BNC1) 		4 / 7 GLY A 307
PRO A 308
ILE A  21
GLY A  72
 None
 0.82A 1usqF-3iuuA:
undetectable		 1usqF-3iuuA:
14.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YAJ_A_BEZA11_0
(CES1 PROTEIN)		 3iuu PUTATIVE
METALLOPEPTIDASE
(Chelativorans
sp.
BNC1) 		4 / 4 LEU A 119
SER A  64
LEU A 135
LEU A 103
 None
 1.10A 1yajA-3iuuA:
3.3		 1yajA-3iuuA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YAJ_D_BEZD2385_0
(CES1 PROTEIN)		 3iuu PUTATIVE
METALLOPEPTIDASE
(Chelativorans
sp.
BNC1) 		4 / 5 LEU A 119
SER A  64
LEU A 135
LEU A 103
 None
 1.16A 1yajD-3iuuA:
3.2		 1yajD-3iuuA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXE_A_1FLA2003_1
(SERUM ALBUMIN)		 3iuu PUTATIVE
METALLOPEPTIDASE
(Chelativorans
sp.
BNC1) 		5 / 9 LEU A 123
ARG A 124
LEU A 101
LEU A 103
ALA A 151
 None
 1.11A 2bxeA-3iuuA:
2.2		 2bxeA-3iuuA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXE_B_1FLB2003_1
(SERUM ALBUMIN)		 3iuu PUTATIVE
METALLOPEPTIDASE
(Chelativorans
sp.
BNC1) 		5 / 10 LEU A 123
ARG A 124
LEU A 101
LEU A 103
ALA A 151
 None
 1.10A 2bxeB-3iuuA:
2.1		 2bxeB-3iuuA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FR3_A_REAA300_1
(CELLULAR RETINOIC
ACID BINDING PROTEIN
2)		 3iuu PUTATIVE
METALLOPEPTIDASE
(Chelativorans
sp.
BNC1) 		5 / 12 LEU A 364
ILE A 314
ALA A 315
PRO A 323
VAL A 327
 None
 1.07A 2fr3A-3iuuA:
undetectable		 2fr3A-3iuuA:
15.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IGT_B_SAMB1002_1
(SAM DEPENDENT
METHYLTRANSFERASE)		 3iuu PUTATIVE
METALLOPEPTIDASE
(Chelativorans
sp.
BNC1) 		3 / 3 ASP A 391
ASP A  27
ASP A 394
 None
None
SO4  A 498 ( 4.6A)
 0.74A 2igtB-3iuuA:
2.2		 2igtB-3iuuA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKJ_A_CLMA1141_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 3iuu PUTATIVE
METALLOPEPTIDASE
(Chelativorans
sp.
BNC1) 		4 / 6 GLY A 307
PRO A 308
ILE A  21
GLY A  72
 None
 0.84A 2jkjA-3iuuA:
undetectable		 2jkjA-3iuuA:
14.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKJ_B_CLMB1141_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 3iuu PUTATIVE
METALLOPEPTIDASE
(Chelativorans
sp.
BNC1) 		4 / 6 GLY A 307
PRO A 308
ILE A  21
GLY A  72
 None
 0.84A 2jkjB-3iuuA:
undetectable		 2jkjB-3iuuA:
14.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKJ_C_CLMC1141_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 3iuu PUTATIVE
METALLOPEPTIDASE
(Chelativorans
sp.
BNC1) 		4 / 6 GLY A 307
PRO A 308
ILE A  21
GLY A  72
 None
 0.84A 2jkjC-3iuuA:
undetectable		 2jkjC-3iuuA:
14.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKJ_E_CLME1141_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 3iuu PUTATIVE
METALLOPEPTIDASE
(Chelativorans
sp.
BNC1) 		4 / 7 GLY A 307
PRO A 308
ILE A  21
GLY A  72
 None
 0.85A 2jkjE-3iuuA:
undetectable		 2jkjE-3iuuA:
14.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKL_B_CLMB1144_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 3iuu PUTATIVE
METALLOPEPTIDASE
(Chelativorans
sp.
BNC1) 		4 / 6 GLY A 307
PRO A 308
ILE A  21
GLY A  72
 None
 0.82A 2jklB-3iuuA:
undetectable		 2jklB-3iuuA:
14.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKL_E_CLME1143_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 3iuu PUTATIVE
METALLOPEPTIDASE
(Chelativorans
sp.
BNC1) 		4 / 7 GLY A 307
PRO A 308
ILE A  21
GLY A  72
 None
 0.83A 2jklE-3iuuA:
undetectable		 2jklE-3iuuA:
14.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNP_A_ROCA401_2
(PROTEASE)		 3iuu PUTATIVE
METALLOPEPTIDASE
(Chelativorans
sp.
BNC1) 		5 / 11 LEU A 398
VAL A 329
ILE A 314
VAL A 407
VAL A 405
 None
 1.02A 2nnpB-3iuuA:
undetectable		 2nnpB-3iuuA:
13.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PYN_A_1UNA1001_3
(PROTEASE RETROPEPSIN)		 3iuu PUTATIVE
METALLOPEPTIDASE
(Chelativorans
sp.
BNC1) 		3 / 3 ASP A 237
THR A 144
PRO A 145
 None
 0.51A 2pynB-3iuuA:
undetectable		 2pynB-3iuuA:
13.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q64_B_1UNB1001_4
(PROTEASE RETROPEPSIN)		 3iuu PUTATIVE
METALLOPEPTIDASE
(Chelativorans
sp.
BNC1) 		3 / 3 ASP A 237
THR A 144
PRO A 145
 None
 0.45A 2q64B-3iuuA:
undetectable		 2q64B-3iuuA:
13.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QAK_A_1UNA1001_4
(PROTEASE RETROPEPSIN)		 3iuu PUTATIVE
METALLOPEPTIDASE
(Chelativorans
sp.
BNC1) 		3 / 3 ASP A 237
THR A 144
PRO A 145
 None
 0.52A 2qakB-3iuuA:
undetectable		 2qakB-3iuuA:
14.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQT_A_AINA596_1
(LACTOPEROXIDASE)		 3iuu PUTATIVE
METALLOPEPTIDASE
(Chelativorans
sp.
BNC1) 		4 / 6 HIS A 233
PHE A 469
GLN A 466
PRO A 464
 None
 1.48A 2qqtA-3iuuA:
undetectable		 2qqtA-3iuuA:
23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_C_HSMC1161_1
(ALLERGEN ARG R 1)		 3iuu PUTATIVE
METALLOPEPTIDASE
(Chelativorans
sp.
BNC1) 		4 / 5 VAL A 232
VAL A 238
ASP A 237
SER A  17
 None
 1.33A 2x45C-3iuuA:
undetectable		 2x45C-3iuuA:
13.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZW9_B_SAMB801_1
(LEUCINE CARBOXYL
METHYLTRANSFERASE 2)		 3iuu PUTATIVE
METALLOPEPTIDASE
(Chelativorans
sp.
BNC1) 		4 / 8 ILE A 154
ASP A 226
TYR A 248
SER A 156
 None
 1.15A 2zw9B-3iuuA:
undetectable		 2zw9B-3iuuA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GCL_A_AINA609_1
(LACTOPEROXIDASE)		 3iuu PUTATIVE
METALLOPEPTIDASE
(Chelativorans
sp.
BNC1) 		4 / 6 HIS A 233
PHE A 469
GLN A 466
PRO A 464
 None
 1.37A 3gclA-3iuuA:
undetectable		 3gclA-3iuuA:
23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PHN_A_ACTA108_0
(PROTEIN P-30)		 3iuu PUTATIVE
METALLOPEPTIDASE
(Chelativorans
sp.
BNC1) 		3 / 3 THR A 155
SER A 156
ARG A 158
 None
 0.61A 3phnA-3iuuA:
undetectable		 3phnA-3iuuA:
12.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QX3_A_EVPA1_1
(DNA TOPOISOMERASE
2-BETA)		 3iuu PUTATIVE
METALLOPEPTIDASE
(Chelativorans
sp.
BNC1) 		4 / 5 GLY A 297
ASP A 298
ARG A 302
GLN A 276
 None
None
SO4  A 497 (-3.9A)
None
 1.19A 3qx3A-3iuuA:
undetectable		 3qx3A-3iuuA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RAE_F_LFXF101_1
(DNA TOPOISOMERASE 4
SUBUNIT A
DNA TOPOISOMERASE 4
SUBUNIT B)		 3iuu PUTATIVE
METALLOPEPTIDASE
(Chelativorans
sp.
BNC1) 		3 / 4 SER A  43
GLY A   9
GLU A  86
 None
 0.64A 3raeA-3iuuA:
undetectable
3raeC-3iuuA:
undetectable		 3raeA-3iuuA:
22.72
3raeC-3iuuA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TKG_C_ROCC901_3
(PROTEASE)		 3iuu PUTATIVE
METALLOPEPTIDASE
(Chelativorans
sp.
BNC1) 		3 / 3 ASP A 237
THR A 144
PRO A 145
 None
 0.44A 3tkgD-3iuuA:
undetectable		 3tkgD-3iuuA:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_A_W9TA1001_1
(HEMOLYTIC LECTIN
CEL-III)		 3iuu PUTATIVE
METALLOPEPTIDASE
(Chelativorans
sp.
BNC1) 		4 / 5 VAL A 303
GLY A 307
TYR A 332
ASP A 310
 None
 1.44A 3w9tA-3iuuA:
undetectable		 3w9tA-3iuuA:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_B_W9TB503_1
(HEMOLYTIC LECTIN
CEL-III)		 3iuu PUTATIVE
METALLOPEPTIDASE
(Chelativorans
sp.
BNC1) 		4 / 5 VAL A 303
GLY A 307
TYR A 332
ASP A 310
 None
 1.44A 3w9tB-3iuuA:
undetectable		 3w9tB-3iuuA:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_C_W9TC1001_1
(HEMOLYTIC LECTIN
CEL-III)		 3iuu PUTATIVE
METALLOPEPTIDASE
(Chelativorans
sp.
BNC1) 		4 / 5 VAL A 303
GLY A 307
TYR A 332
ASP A 310
 None
 1.44A 3w9tC-3iuuA:
undetectable		 3w9tC-3iuuA:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_D_W9TD502_1
(HEMOLYTIC LECTIN
CEL-III)		 3iuu PUTATIVE
METALLOPEPTIDASE
(Chelativorans
sp.
BNC1) 		4 / 5 VAL A 303
GLY A 307
TYR A 332
ASP A 310
 None
 1.45A 3w9tD-3iuuA:
undetectable		 3w9tD-3iuuA:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_E_W9TE504_1
(HEMOLYTIC LECTIN
CEL-III)		 3iuu PUTATIVE
METALLOPEPTIDASE
(Chelativorans
sp.
BNC1) 		4 / 5 VAL A 303
GLY A 307
TYR A 332
ASP A 310
 None
 1.44A 3w9tE-3iuuA:
undetectable		 3w9tE-3iuuA:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_F_W9TF504_1
(HEMOLYTIC LECTIN
CEL-III)		 3iuu PUTATIVE
METALLOPEPTIDASE
(Chelativorans
sp.
BNC1) 		4 / 5 VAL A 303
GLY A 307
TYR A 332
ASP A 310
 None
 1.44A 3w9tF-3iuuA:
undetectable		 3w9tF-3iuuA:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_G_W9TG504_1
(HEMOLYTIC LECTIN
CEL-III)		 3iuu PUTATIVE
METALLOPEPTIDASE
(Chelativorans
sp.
BNC1) 		4 / 5 VAL A 303
GLY A 307
TYR A 332
ASP A 310
 None
 1.44A 3w9tG-3iuuA:
undetectable		 3w9tG-3iuuA:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A6E_A_SAMA1349_1
(HYDROXYINDOLE
O-METHYLTRANSFERASE)		 3iuu PUTATIVE
METALLOPEPTIDASE
(Chelativorans
sp.
BNC1) 		3 / 3 TYR A 332
ASP A  27
ASP A 391
 None
 0.68A 4a6eA-3iuuA:
2.9		 4a6eA-3iuuA:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HTF_A_SAMA301_0
(S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE)		 3iuu PUTATIVE
METALLOPEPTIDASE
(Chelativorans
sp.
BNC1) 		5 / 12 GLY A  15
GLY A  72
GLY A  73
ALA A 106
VAL A 238
 None
 0.92A 4htfA-3iuuA:
3.3		 4htfA-3iuuA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HTF_B_SAMB301_0
(S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE)		 3iuu PUTATIVE
METALLOPEPTIDASE
(Chelativorans
sp.
BNC1) 		5 / 12 GLY A  15
GLY A  72
GLY A  73
ALA A 106
VAL A 238
 None
 1.01A 4htfB-3iuuA:
3.2		 4htfB-3iuuA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J24_A_ESTA600_1
(ESTROGEN RECEPTOR
BETA)		 3iuu PUTATIVE
METALLOPEPTIDASE
(Chelativorans
sp.
BNC1) 		5 / 12 MET A 173
LEU A 176
LEU A 179
ILE A   6
LEU A  57
 None
 1.04A 4j24A-3iuuA:
undetectable		 4j24A-3iuuA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J24_B_ESTB600_1
(ESTROGEN RECEPTOR
BETA)		 3iuu PUTATIVE
METALLOPEPTIDASE
(Chelativorans
sp.
BNC1) 		5 / 12 MET A 173
LEU A 176
LEU A 179
ILE A   6
LEU A  57
 None
 1.06A 4j24B-3iuuA:
undetectable		 4j24B-3iuuA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KRH_B_SAMB900_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE
2)		 3iuu PUTATIVE
METALLOPEPTIDASE
(Chelativorans
sp.
BNC1) 		5 / 12 PHE A 462
GLY A 300
SER A 311
ALA A 411
ILE A  21
 None
 1.10A 4krhB-3iuuA:
2.7		 4krhB-3iuuA:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KRH_B_SAMB900_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE
2)		 3iuu PUTATIVE
METALLOPEPTIDASE
(Chelativorans
sp.
BNC1) 		5 / 12 PHE A 462
GLY A 307
SER A 311
ALA A 411
ILE A  21
 None
 1.09A 4krhB-3iuuA:
2.7		 4krhB-3iuuA:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PGF_B_ADNB502_2
(ADENOSYLHOMOCYSTEINA
SE)		 3iuu PUTATIVE
METALLOPEPTIDASE
(Chelativorans
sp.
BNC1) 		4 / 5 THR A 460
THR A  23
HIS A  13
ASN A 413
 None
 1.15A 4pgfB-3iuuA:
3.9		 4pgfB-3iuuA:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q15_A_HFGA803_1
(PROLINE--TRNA LIGASE)		 3iuu PUTATIVE
METALLOPEPTIDASE
(Chelativorans
sp.
BNC1) 		3 / 3 GLU A  14
THR A 160
HIS A 162
 IMD  A 496 (-3.3A)
None
ZN  A 495 ( 3.3A)
 0.75A 4q15A-3iuuA:
3.8		 4q15A-3iuuA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q15_B_HFGB803_1
(PROLINE--TRNA LIGASE)		 3iuu PUTATIVE
METALLOPEPTIDASE
(Chelativorans
sp.
BNC1) 		3 / 3 GLU A  14
THR A 160
HIS A 162
 IMD  A 496 (-3.3A)
None
ZN  A 495 ( 3.3A)
 0.75A 4q15B-3iuuA:
1.6		 4q15B-3iuuA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UBE_A_2FAA401_1
(ADENOSINE KINASE)		 3iuu PUTATIVE
METALLOPEPTIDASE
(Chelativorans
sp.
BNC1) 		5 / 12 ASP A 310
GLY A 309
ALA A 461
GLN A 466
ASP A 298
 None
 1.17A 4ubeA-3iuuA:
5.3		 4ubeA-3iuuA:
23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XQE_A_AG2A506_1
(HOMOSPERMIDINE
SYNTHASE)		 3iuu PUTATIVE
METALLOPEPTIDASE
(Chelativorans
sp.
BNC1) 		4 / 6 ARG A  92
ARG A 122
VAL A  84
ASP A  85
 None
 1.26A 4xqeA-3iuuA:
3.0		 4xqeA-3iuuA:
24.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XQE_B_AG2B505_1
(HOMOSPERMIDINE
SYNTHASE)		 3iuu PUTATIVE
METALLOPEPTIDASE
(Chelativorans
sp.
BNC1) 		4 / 6 ARG A  92
ARG A 122
VAL A  84
ASP A  85
 None
 1.25A 4xqeB-3iuuA:
2.9		 4xqeB-3iuuA:
24.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YDQ_B_HFGB802_1
(PROLINE--TRNA LIGASE)		 3iuu PUTATIVE
METALLOPEPTIDASE
(Chelativorans
sp.
BNC1) 		3 / 3 GLU A  14
THR A 160
HIS A 162
 IMD  A 496 (-3.3A)
None
ZN  A 495 ( 3.3A)
 0.81A 4ydqB-3iuuA:
1.6		 4ydqB-3iuuA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZVM_B_DM2B303_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 3iuu PUTATIVE
METALLOPEPTIDASE
(Chelativorans
sp.
BNC1) 		5 / 11 VAL A 232
PHE A 462
GLY A 305
GLY A 307
GLU A  14
 None
None
SO4  A 497 ( 4.7A)
None
IMD  A 496 (-3.3A)
 1.31A 4zvmA-3iuuA:
5.4
4zvmB-3iuuA:
5.8		 4zvmA-3iuuA:
20.16
4zvmB-3iuuA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H2U_A_1N1A501_2
(PROTEIN-TYROSINE
KINASE 6)		 3iuu PUTATIVE
METALLOPEPTIDASE
(Chelativorans
sp.
BNC1) 		3 / 3 ILE A  75
MET A 304
ASP A  27
 None
IMD  A 496 ( 4.6A)
None
 0.82A 5h2uA-3iuuA:
undetectable		 5h2uA-3iuuA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KPC_A_SAMA401_0
(PAVINE
N-METHYLTRANSFERASE)		 3iuu PUTATIVE
METALLOPEPTIDASE
(Chelativorans
sp.
BNC1) 		6 / 12 GLY A   9
SER A 134
LEU A 135
ALA A  46
LEU A  47
ALA A  40
 None
 1.47A 5kpcA-3iuuA:
undetectable		 5kpcA-3iuuA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UBB_A_SAMA301_1
(ALPHA N-TERMINAL
PROTEIN
METHYLTRANSFERASE 1B)		 3iuu PUTATIVE
METALLOPEPTIDASE
(Chelativorans
sp.
BNC1) 		4 / 5 GLY A 117
ARG A 122
ASP A 114
GLN A 471
 None
 1.47A 5ubbA-3iuuA:
2.5		 5ubbA-3iuuA:
18.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_A_C2FA3001_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 3iuu PUTATIVE
METALLOPEPTIDASE
(Chelativorans
sp.
BNC1) 		5 / 12 GLU A 210
VAL A 245
LEU A 227
GLY A 212
ILE A 211
 None
 1.10A 5vooA-3iuuA:
3.4		 5vooA-3iuuA:
23.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_B_C2FB702_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 3iuu PUTATIVE
METALLOPEPTIDASE
(Chelativorans
sp.
BNC1) 		5 / 12 GLU A 210
VAL A 245
LEU A 227
GLY A 212
ILE A 211
 None
 1.10A 5vooB-3iuuA:
undetectable		 5vooB-3iuuA:
23.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_C_C2FC702_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 3iuu PUTATIVE
METALLOPEPTIDASE
(Chelativorans
sp.
BNC1) 		5 / 12 GLU A 210
VAL A 245
LEU A 227
GLY A 212
ILE A 211
 None
 1.12A 5vooC-3iuuA:
3.3		 5vooC-3iuuA:
23.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_D_C2FD3001_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 3iuu PUTATIVE
METALLOPEPTIDASE
(Chelativorans
sp.
BNC1) 		5 / 12 GLU A 210
VAL A 245
LEU A 227
GLY A 212
ILE A 211
 None
 1.12A 5vooD-3iuuA:
2.4		 5vooD-3iuuA:
23.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_F_C2FF3001_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 3iuu PUTATIVE
METALLOPEPTIDASE
(Chelativorans
sp.
BNC1) 		5 / 12 GLU A 210
VAL A 245
LEU A 227
GLY A 212
ILE A 211
 None
 1.15A 5vooF-3iuuA:
2.4		 5vooF-3iuuA:
23.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOP_B_C2FB3001_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 3iuu PUTATIVE
METALLOPEPTIDASE
(Chelativorans
sp.
BNC1) 		5 / 12 GLU A 210
VAL A 245
LEU A 227
GLY A 212
ILE A 211
 None
 1.11A 5vopB-3iuuA:
undetectable		 5vopB-3iuuA:
23.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X23_A_LSNA502_2
(CYTOCHROME P450 2C9)		 3iuu PUTATIVE
METALLOPEPTIDASE
(Chelativorans
sp.
BNC1) 		3 / 3 LEU A 123
VAL A  84
ASP A  85
 None
 0.65A 5x23A-3iuuA:
undetectable		 5x23A-3iuuA:
20.26