SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3iuy'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QVT_A_PRLA311_0
(TRANSCRIPTIONAL
REGULATOR QACR)		 3iuy PROBABLE
ATP-DEPENDENT RNA
HELICASE DDX53
(Homo
sapiens) 		4 / 8 LEU A 266
THR A 380
ILE A 291
TYR A 239
 None
 1.04A 1qvtA-3iuyA:
undetectable		 1qvtA-3iuyA:
18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QVU_A_PRLA196_0
(TRANSCRIPTIONAL
REGULATOR QACR)		 3iuy PROBABLE
ATP-DEPENDENT RNA
HELICASE DDX53
(Homo
sapiens) 		4 / 6 LEU A 266
THR A 380
TYR A 381
TYR A 239
 None
 1.15A 1qvuA-3iuyA:
undetectable		 1qvuA-3iuyA:
18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CLA_A_CLMA221_0
(TYPE III
CHLORAMPHENICOL
ACETYLTRANSFERASE)		 3iuy PROBABLE
ATP-DEPENDENT RNA
HELICASE DDX53
(Homo
sapiens) 		5 / 9 ALA A 235
PHE A 236
LEU A 271
VAL A 413
ILE A 264
 None
 1.47A 3claA-3iuyA:
undetectable		 3claA-3iuyA:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D91_A_REMA350_2
(RENIN)		 3iuy PROBABLE
ATP-DEPENDENT RNA
HELICASE DDX53
(Homo
sapiens) 		4 / 5 TYR A 285
ALA A 387
ALA A 275
TYR A 438
 None
 1.22A 3d91A-3iuyA:
undetectable		 3d91A-3iuyA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FRQ_B_ERYB195_0
(REPRESSOR PROTEIN
MPHR(A))		 3iuy PROBABLE
ATP-DEPENDENT RNA
HELICASE DDX53
(Homo
sapiens) 		5 / 12 LEU A 426
LEU A 286
ILE A 399
VAL A 321
ILE A 357
 None
 1.03A 3frqB-3iuyA:
undetectable		 3frqB-3iuyA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HBB_D_TMQD614_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3iuy PROBABLE
ATP-DEPENDENT RNA
HELICASE DDX53
(Homo
sapiens) 		5 / 10 ALA A 275
MET A 212
ILE A 264
PRO A 263
ILE A 436
 None
 1.24A 3hbbD-3iuyA:
undetectable		 3hbbD-3iuyA:
17.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MB5_A_SAMA301_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 3iuy PROBABLE
ATP-DEPENDENT RNA
HELICASE DDX53
(Homo
sapiens) 		5 / 12 VAL A 355
GLY A 307
ARG A 407
ILE A 402
LEU A 376
 None
 1.03A 3mb5A-3iuyA:
3.6		 3mb5A-3iuyA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UVV_A_T3A501_1
(THYROID HORMONE
RECEPTOR ALPHA)		 3iuy PROBABLE
ATP-DEPENDENT RNA
HELICASE DDX53
(Homo
sapiens) 		5 / 12 ILE A 399
ALA A 360
LEU A 311
LEU A 376
ILE A 358
 None
 0.89A 3uvvA-3iuyA:
undetectable		 3uvvA-3iuyA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_A_ACTA504_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 3iuy PROBABLE
ATP-DEPENDENT RNA
HELICASE DDX53
(Homo
sapiens) 		3 / 3 THR A 312
VAL A 310
GLU A 386
 None
 0.68A 3v4tA-3iuyA:
1.2
3v4tD-3iuyA:
1.1		 3v4tA-3iuyA:
20.10
3v4tD-3iuyA:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AFG_C_QMRC1214_1
(CAPITELLA TELETA
ACHBP)		 3iuy PROBABLE
ATP-DEPENDENT RNA
HELICASE DDX53
(Homo
sapiens) 		4 / 8 VAL A 273
CYH A 214
ILE A 257
ILE A 264
 None
 0.98A 4afgD-3iuyA:
undetectable
4afgE-3iuyA:
undetectable		 4afgD-3iuyA:
22.93
4afgE-3iuyA:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E0F_A_RBFA301_2
(RIBOFLAVIN SYNTHASE
SUBUNIT ALPHA)		 3iuy PROBABLE
ATP-DEPENDENT RNA
HELICASE DDX53
(Homo
sapiens) 		3 / 3 LYS A 281
THR A 282
ILE A 359
 None
AMP  A 160 (-3.5A)
None
 0.93A 4e0fB-3iuyA:
undetectable		 4e0fB-3iuyA:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM4_B_8PRB603_2
(TRANSPORTER)		 3iuy PROBABLE
ATP-DEPENDENT RNA
HELICASE DDX53
(Homo
sapiens) 		3 / 3 SER A 416
MET A 414
ASP A 215
 None
 0.91A 4mm4B-3iuyA:
undetectable		 4mm4B-3iuyA:
17.69