SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3iuz'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJG_B_ADNB1502_1
(235AA LONG
HYPOTHETICAL
BIOTIN--[ACETYL-COA-
CARBOXYLASE] LIGASE)
3iuz PUTATIVE GLYOXALASE
SUPERFAMILY PROTEIN

(Cupriavidus
pinatubonensis)
4 / 7 ARG A 307
GLU A 136
PRO A 135
ALA A 130
None
1.47A 2ejgB-3iuzA:
undetectable
2ejgB-3iuzA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNH_A_9CRA501_1
(CYTOCHROME P450 2C8)
3iuz PUTATIVE GLYOXALASE
SUPERFAMILY PROTEIN

(Cupriavidus
pinatubonensis)
5 / 11 GLY A  30
ALA A   6
THR A  18
VAL A  27
PRO A  28
None
0.92A 2nnhA-3iuzA:
undetectable
2nnhA-3iuzA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A50_C_VD3C2001_1
(VITAMIN D
HYDROXYLASE)
3iuz PUTATIVE GLYOXALASE
SUPERFAMILY PROTEIN

(Cupriavidus
pinatubonensis)
5 / 11 THR A  40
ILE A 138
LEU A   8
LEU A  31
ILE A   5
None
1.31A 3a50C-3iuzA:
undetectable
3a50C-3iuzA:
24.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K13_A_THHA642_0
(5-METHYLTETRAHYDROFO
LATE-HOMOCYSTEINE
METHYLTRANSFERASE)
3iuz PUTATIVE GLYOXALASE
SUPERFAMILY PROTEIN

(Cupriavidus
pinatubonensis)
5 / 12 GLY A  98
GLY A 232
ASN A 233
PHE A 102
ILE A 228
MLY  A  88 ( 3.8A)
None
None
None
None
1.25A 3k13A-3iuzA:
undetectable
3k13A-3iuzA:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PS9_A_SAMA670_1
(TRNA
5-METHYLAMINOMETHYL-
2-THIOURIDINE
BIOSYNTHESIS
BIFUNCTIONAL PROTEIN
MNMC)
3iuz PUTATIVE GLYOXALASE
SUPERFAMILY PROTEIN

(Cupriavidus
pinatubonensis)
4 / 6 THR A 188
LEU A 187
GLU A  36
ASP A 184
PGE  A 344 ( 4.9A)
None
None
PGE  A 344 ( 3.9A)
1.04A 3ps9A-3iuzA:
undetectable
3ps9A-3iuzA:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q1E_C_T44C128_1
(5-HYDROXYISOURATE
HYDROLASE)
3iuz PUTATIVE GLYOXALASE
SUPERFAMILY PROTEIN

(Cupriavidus
pinatubonensis)
4 / 6 PRO A 108
LEU A 106
LEU A 195
LEU A 199
P6G  A 340 ( 4.8A)
None
None
None
1.07A 3q1eA-3iuzA:
undetectable
3q1eC-3iuzA:
undetectable
3q1eA-3iuzA:
19.16
3q1eC-3iuzA:
19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ECK_A_FOLA703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)
3iuz PUTATIVE GLYOXALASE
SUPERFAMILY PROTEIN

(Cupriavidus
pinatubonensis)
5 / 12 ALA A 101
LEU A 170
PHE A 203
LEU A  48
VAL A  51
None
1.05A 4eckA-3iuzA:
undetectable
4eckA-3iuzA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGL_D_CLQD303_0
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])
3iuz PUTATIVE GLYOXALASE
SUPERFAMILY PROTEIN

(Cupriavidus
pinatubonensis)
4 / 7 GLY A  63
PHE A  53
ILE A  56
PHE A  79
None
0.82A 4fglC-3iuzA:
undetectable
4fglC-3iuzA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GBO_A_CUA301_0
(E7)
3iuz PUTATIVE GLYOXALASE
SUPERFAMILY PROTEIN

(Cupriavidus
pinatubonensis)
4 / 5 HIS A  81
ALA A  83
HIS A 237
GLN A 273
None
1.37A 4gboA-3iuzA:
undetectable
4gboA-3iuzA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QOG_B_ML1B302_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])
3iuz PUTATIVE GLYOXALASE
SUPERFAMILY PROTEIN

(Cupriavidus
pinatubonensis)
4 / 6 GLY A  63
PHE A  53
ILE A  56
PHE A  79
None
0.75A 4qogA-3iuzA:
undetectable
4qogB-3iuzA:
undetectable
4qogA-3iuzA:
21.68
4qogB-3iuzA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ND7_B_TA1B601_2
(TUBULIN BETA-2B
CHAIN)
3iuz PUTATIVE GLYOXALASE
SUPERFAMILY PROTEIN

(Cupriavidus
pinatubonensis)
3 / 3 THR A 217
PRO A 148
ARG A 150
None
MLY  A  88 ( 4.6A)
None
0.76A 5nd7B-3iuzA:
undetectable
5nd7B-3iuzA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UIZ_A_CUA301_0
(AA10A)
3iuz PUTATIVE GLYOXALASE
SUPERFAMILY PROTEIN

(Cupriavidus
pinatubonensis)
4 / 5 HIS A  81
ALA A  83
HIS A 237
GLN A 273
None
1.37A 5uizA-3iuzA:
undetectable
5uizA-3iuzA:
21.53