SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3iv0'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CLA_A_CLMA221_0
(TYPE III
CHLORAMPHENICOL
ACETYLTRANSFERASE)		 3iv0 SUSD HOMOLOG
(Bacteroides
thetaiotaomicron) 		5 / 10 PHE A  55
ALA A  58
PHE A  65
ALA A 120
VAL A 187
 None
 0.92A 1claA-3iv0A:
undetectable		 1claA-3iv0A:
18.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CMC_A_SAMA105_0
(MET REPRESSOR)		 3iv0 SUSD HOMOLOG
(Bacteroides
thetaiotaomicron) 		5 / 10 ALA A 147
PHE A 145
LEU A 140
LEU A 208
PRO A 209
 None
 1.29A 1cmcA-3iv0A:
undetectable
1cmcB-3iv0A:
undetectable		 1cmcA-3iv0A:
13.02
1cmcB-3iv0A:
13.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTI_C_CCSC47_0
(GLUTATHIONE
S-TRANSFERASE)		 3iv0 SUSD HOMOLOG
(Bacteroides
thetaiotaomicron) 		4 / 6 THR A 101
LEU A  98
GLY A  96
TYR A  89
 None
 0.96A 1gtiC-3iv0A:
2.9		 1gtiC-3iv0A:
16.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HK2_A_T44A3004_1
(SERUM ALBUMIN)		 3iv0 SUSD HOMOLOG
(Bacteroides
thetaiotaomicron) 		4 / 7 ALA A 397
GLU A 398
LEU A 394
VAL A 417
 None
 0.95A 1hk2A-3iv0A:
undetectable		 1hk2A-3iv0A:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HTT_B_HISB450_0
(HISTIDYL-TRNA
SYNTHETASE)		 3iv0 SUSD HOMOLOG
(Bacteroides
thetaiotaomicron) 		5 / 12 GLU A 261
LEU A 393
TYR A 389
TYR A 267
GLY A 225
 None
 1.31A 1httB-3iv0A:
undetectable		 1httB-3iv0A:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HTT_C_HISC450_0
(HISTIDYL-TRNA
SYNTHETASE)		 3iv0 SUSD HOMOLOG
(Bacteroides
thetaiotaomicron) 		5 / 12 GLU A 261
LEU A 393
TYR A 389
TYR A 267
GLY A 225
 None
 1.26A 1httC-3iv0A:
undetectable		 1httC-3iv0A:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KNY_A_KANA558_1
(KANAMYCIN
NUCLEOTIDYLTRANSFERA
SE)		 3iv0 SUSD HOMOLOG
(Bacteroides
thetaiotaomicron) 		4 / 7 SER A 283
GLU A 285
GLU A 448
GLU A 444
 None
 1.17A 1knyA-3iv0A:
undetectable
1knyB-3iv0A:
undetectable		 1knyA-3iv0A:
17.90
1knyB-3iv0A:
17.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJQ_I_SAMI199_0
(METHIONINE REPRESSOR)		 3iv0 SUSD HOMOLOG
(Bacteroides
thetaiotaomicron) 		5 / 11 LEU A 140
LEU A 208
PRO A 209
ALA A 147
PHE A 145
 None
 1.35A 1mjqI-3iv0A:
undetectable
1mjqJ-3iv0A:
undetectable		 1mjqI-3iv0A:
13.02
1mjqJ-3iv0A:
13.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBI_C_SAMC2293_0
(GLYCINE
N-METHYLTRANSFERASE)		 3iv0 SUSD HOMOLOG
(Bacteroides
thetaiotaomicron) 		5 / 12 TYR A 267
GLY A 286
ALA A 392
SER A 226
TYR A 212
 None
 1.25A 1nbiC-3iv0A:
undetectable		 1nbiC-3iv0A:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBI_D_SAMD3293_0
(GLYCINE
N-METHYLTRANSFERASE)		 3iv0 SUSD HOMOLOG
(Bacteroides
thetaiotaomicron) 		5 / 12 TYR A 267
GLY A 286
ALA A 392
SER A 226
TYR A 212
 None
 1.26A 1nbiD-3iv0A:
undetectable		 1nbiD-3iv0A:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V54_C_CHDC3271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE III
CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART)		 3iv0 SUSD HOMOLOG
(Bacteroides
thetaiotaomicron) 		4 / 8 LEU A 230
PHE A 151
LEU A 155
PHE A 159
 None
 0.89A 1v54C-3iv0A:
1.9
1v54J-3iv0A:
undetectable		 1v54C-3iv0A:
20.57
1v54J-3iv0A:
8.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V54_P_CHDP4271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE III
CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART)		 3iv0 SUSD HOMOLOG
(Bacteroides
thetaiotaomicron) 		4 / 8 LEU A 230
PHE A 151
LEU A 155
PHE A 159
 None
 0.93A 1v54P-3iv0A:
1.8
1v54W-3iv0A:
undetectable		 1v54P-3iv0A:
20.57
1v54W-3iv0A:
8.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XDK_A_9CRA500_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 3iv0 SUSD HOMOLOG
(Bacteroides
thetaiotaomicron) 		5 / 12 ILE A 121
ALA A 124
ASN A 172
ALA A 149
VAL A 167
 None
 1.11A 1xdkA-3iv0A:
undetectable		 1xdkA-3iv0A:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XZX_X_T3X500_2
(THYROID HORMONE
RECEPTOR BETA-1)		 3iv0 SUSD HOMOLOG
(Bacteroides
thetaiotaomicron) 		3 / 3 PHE A 366
ARG A  56
ASN A 383
 None
 0.72A 1xzxX-3iv0A:
undetectable		 1xzxX-3iv0A:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DG4_A_RAPA501_1
(FK506-BINDING
PROTEIN 1A)		 3iv0 SUSD HOMOLOG
(Bacteroides
thetaiotaomicron) 		5 / 11 PHE A  55
VAL A 386
PHE A 288
ILE A 234
PHE A 151
 None
None
None
CSO  A 191 ( 4.8A)
None
 1.11A 2dg4A-3iv0A:
undetectable		 2dg4A-3iv0A:
12.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DYR_C_CHDC271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 3)		 3iv0 SUSD HOMOLOG
(Bacteroides
thetaiotaomicron) 		4 / 8 LEU A 230
PHE A 151
LEU A 155
PHE A 159
 None
 0.89A 2dyrC-3iv0A:
undetectable
2dyrJ-3iv0A:
undetectable		 2dyrC-3iv0A:
20.57
2dyrJ-3iv0A:
8.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DYR_P_CHDP1271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 3)		 3iv0 SUSD HOMOLOG
(Bacteroides
thetaiotaomicron) 		4 / 8 LEU A 230
PHE A 151
LEU A 155
PHE A 159
 None
 0.92A 2dyrP-3iv0A:
undetectable
2dyrW-3iv0A:
undetectable		 2dyrP-3iv0A:
20.57
2dyrW-3iv0A:
8.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIK_C_CHDC271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 3)		 3iv0 SUSD HOMOLOG
(Bacteroides
thetaiotaomicron) 		4 / 7 LEU A 230
PHE A 151
LEU A 155
PHE A 159
 None
 0.95A 2eikC-3iv0A:
1.9
2eikJ-3iv0A:
undetectable		 2eikC-3iv0A:
20.57
2eikJ-3iv0A:
8.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIM_W_CHDW1271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 3)		 3iv0 SUSD HOMOLOG
(Bacteroides
thetaiotaomicron) 		4 / 7 LEU A 230
PHE A 151
LEU A 155
PHE A 159
 None
 0.95A 2eimP-3iv0A:
1.9
2eimW-3iv0A:
undetectable		 2eimP-3iv0A:
20.57
2eimW-3iv0A:
8.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HC4_A_VDXA525_1
(VITAMIN D RECEPTOR)		 3iv0 SUSD HOMOLOG
(Bacteroides
thetaiotaomicron) 		5 / 12 TYR A 328
PHE A 438
LEU A 455
VAL A 461
CYH A 442
 None
 1.40A 2hc4A-3iv0A:
undetectable		 2hc4A-3iv0A:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OD9_A_NCAA3721_0
(NAD-DEPENDENT
DEACETYLASE HST2)		 3iv0 SUSD HOMOLOG
(Bacteroides
thetaiotaomicron) 		3 / 3 PHE A 151
PHE A 288
PHE A 387
 None
 0.79A 2od9A-3iv0A:
undetectable		 2od9A-3iv0A:
18.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQG_A_NCAA3721_0
(NAD-DEPENDENT
DEACETYLASE HST2)		 3iv0 SUSD HOMOLOG
(Bacteroides
thetaiotaomicron) 		3 / 3 PHE A 151
PHE A 288
PHE A 387
 None
 0.79A 2qqgA-3iv0A:
undetectable		 2qqgA-3iv0A:
18.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZTH_A_SAMA305_1
(CATECHOL
O-METHYLTRANSFERASE)		 3iv0 SUSD HOMOLOG
(Bacteroides
thetaiotaomicron) 		3 / 3 SER A 211
GLU A 289
ASP A 284
 None
 0.68A 2zthA-3iv0A:
undetectable		 2zthA-3iv0A:
17.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A7E_A_SAMA216_1
(CATECHOL
O-METHYLTRANSFERASE)		 3iv0 SUSD HOMOLOG
(Bacteroides
thetaiotaomicron) 		4 / 6 GLY A 286
SER A 211
GLU A 289
ASP A 284
 None
 0.81A 3a7eA-3iv0A:
undetectable		 3a7eA-3iv0A:
16.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABK_P_CHDP1271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 3iv0 SUSD HOMOLOG
(Bacteroides
thetaiotaomicron) 		4 / 6 LEU A 230
PHE A 151
LEU A 155
PHE A 159
 None
 1.02A 3abkP-3iv0A:
1.8
3abkW-3iv0A:
undetectable		 3abkP-3iv0A:
20.57
3abkW-3iv0A:
8.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG4_C_CHDC271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 3iv0 SUSD HOMOLOG
(Bacteroides
thetaiotaomicron) 		4 / 8 LEU A 230
PHE A 151
LEU A 155
PHE A 159
 None
 0.88A 3ag4C-3iv0A:
1.8
3ag4J-3iv0A:
undetectable		 3ag4C-3iv0A:
20.57
3ag4J-3iv0A:
8.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG4_P_CHDP1271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 3iv0 SUSD HOMOLOG
(Bacteroides
thetaiotaomicron) 		4 / 7 LEU A 230
PHE A 151
LEU A 155
PHE A 159
 None
 0.86A 3ag4P-3iv0A:
1.8
3ag4W-3iv0A:
undetectable		 3ag4P-3iv0A:
20.57
3ag4W-3iv0A:
8.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ASN_C_CHDC271_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1)		 3iv0 SUSD HOMOLOG
(Bacteroides
thetaiotaomicron) 		4 / 7 LEU A 230
PHE A 151
LEU A 155
PHE A 159
 None
 0.92A 3asnC-3iv0A:
undetectable
3asnJ-3iv0A:
undetectable		 3asnC-3iv0A:
20.57
3asnJ-3iv0A:
8.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ASN_P_CHDP1271_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1)		 3iv0 SUSD HOMOLOG
(Bacteroides
thetaiotaomicron) 		4 / 7 LEU A 230
PHE A 151
LEU A 155
PHE A 159
 None
 0.95A 3asnP-3iv0A:
2.0
3asnW-3iv0A:
undetectable		 3asnP-3iv0A:
20.57
3asnW-3iv0A:
8.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ASO_P_CHDP1271_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1)		 3iv0 SUSD HOMOLOG
(Bacteroides
thetaiotaomicron) 		4 / 7 LEU A 230
PHE A 151
LEU A 155
PHE A 159
 None
 0.92A 3asoP-3iv0A:
1.9
3asoW-3iv0A:
undetectable		 3asoP-3iv0A:
20.57
3asoW-3iv0A:
8.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BWM_A_SAMA301_1
(CATECHOL
O-METHYLTRANSFERASE)		 3iv0 SUSD HOMOLOG
(Bacteroides
thetaiotaomicron) 		3 / 3 SER A 211
GLU A 289
ASP A 284
 None
 0.77A 3bwmA-3iv0A:
undetectable		 3bwmA-3iv0A:
16.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BWY_A_SAMA301_1
(COMT PROTEIN)		 3iv0 SUSD HOMOLOG
(Bacteroides
thetaiotaomicron) 		3 / 3 SER A 211
GLU A 289
ASP A 284
 None
 0.71A 3bwyA-3iv0A:
undetectable		 3bwyA-3iv0A:
16.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K37_B_BCZB468_1
(NEURAMINIDASE)		 3iv0 SUSD HOMOLOG
(Bacteroides
thetaiotaomicron) 		3 / 3 ARG A 341
GLU A 343
TYR A 351
 None
 0.76A 3k37B-3iv0A:
undetectable		 3k37B-3iv0A:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEE_D_30BD500_2
(GENOME POLYPROTEIN)		 3iv0 SUSD HOMOLOG
(Bacteroides
thetaiotaomicron) 		4 / 4 PHE A 387
TYR A 453
VAL A 417
LEU A 393
 None
 1.43A 3keeD-3iv0A:
undetectable		 3keeD-3iv0A:
17.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MJR_D_AC2D601_1
(DEOXYCYTIDINE KINASE)		 3iv0 SUSD HOMOLOG
(Bacteroides
thetaiotaomicron) 		4 / 8 GLU A 440
ARG A 341
ARG A 443
ASP A 339
 None
 1.18A 3mjrD-3iv0A:
undetectable		 3mjrD-3iv0A:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8X_A_NIMA701_2
(PROSTAGLANDIN G/H
SYNTHASE 1)		 3iv0 SUSD HOMOLOG
(Bacteroides
thetaiotaomicron) 		3 / 3 VAL A 277
SER A 283
LEU A 270
 None
 0.70A 3n8xA-3iv0A:
undetectable		 3n8xA-3iv0A:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3Z_C_9PLC501_1
(CYTOCHROME P450 2E1)		 3iv0 SUSD HOMOLOG
(Bacteroides
thetaiotaomicron) 		4 / 5 PHE A 151
PHE A 387
ALA A 229
LEU A 195
 None
None
None
CSO  A 191 ( 3.5A)
 1.06A 3t3zC-3iv0A:
undetectable		 3t3zC-3iv0A:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VW1_D_CVID301_1
(PUTATIVE REGULATORY
PROTEIN)		 3iv0 SUSD HOMOLOG
(Bacteroides
thetaiotaomicron) 		3 / 3 TYR A  52
MET A 231
LEU A 198
 None
EDO  A   4 (-4.8A)
None
 0.94A 3vw1D-3iv0A:
0.2		 3vw1D-3iv0A:
18.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WG7_C_CHDC305_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3iv0 SUSD HOMOLOG
(Bacteroides
thetaiotaomicron) 		4 / 6 LEU A 230
PHE A 151
LEU A 155
PHE A 159
 None
 0.89A 3wg7C-3iv0A:
1.8
3wg7J-3iv0A:
undetectable		 3wg7C-3iv0A:
20.57
3wg7J-3iv0A:
8.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3X2Q_C_CHDC304_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3iv0 SUSD HOMOLOG
(Bacteroides
thetaiotaomicron) 		4 / 7 LEU A 230
PHE A 151
LEU A 155
PHE A 159
 None
 0.92A 3x2qC-3iv0A:
1.8
3x2qJ-3iv0A:
undetectable		 3x2qC-3iv0A:
20.57
3x2qJ-3iv0A:
8.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AZT_A_SAMA1472_1
(METHYLTRANSFERASE
WBDD)		 3iv0 SUSD HOMOLOG
(Bacteroides
thetaiotaomicron) 		3 / 3 GLN A  62
ASP A 115
GLN A 113
 None
 0.89A 4aztA-3iv0A:
undetectable		 4aztA-3iv0A:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B7N_A_ZMRA601_2
(NEURAMINIDASE)		 3iv0 SUSD HOMOLOG
(Bacteroides
thetaiotaomicron) 		3 / 3 ARG A 162
ARG A 457
TRP A 237
 None
 1.27A 4b7nA-3iv0A:
undetectable		 4b7nA-3iv0A:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPZ_F_ZMRF1470_2
(NEURAMINIDASE)		 3iv0 SUSD HOMOLOG
(Bacteroides
thetaiotaomicron) 		3 / 3 ARG A 162
ARG A 457
TRP A 237
 None
 1.27A 4cpzF-3iv0A:
undetectable		 4cpzF-3iv0A:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPZ_G_ZMRG1471_2
(NEURAMINIDASE)		 3iv0 SUSD HOMOLOG
(Bacteroides
thetaiotaomicron) 		3 / 3 ARG A 162
ARG A 457
TRP A 237
 None
 1.23A 4cpzG-3iv0A:
undetectable		 4cpzG-3iv0A:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F8Y_C_VK3C202_1
(NADPH QUINONE
OXIDOREDUCTASE)		 3iv0 SUSD HOMOLOG
(Bacteroides
thetaiotaomicron) 		4 / 7 TYR A  68
TYR A  86
LEU A  90
TYR A 324
 None
 1.18A 4f8yC-3iv0A:
undetectable
4f8yD-3iv0A:
undetectable		 4f8yC-3iv0A:
16.01
4f8yD-3iv0A:
16.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FFW_A_715A801_2
(DIPEPTIDYL PEPTIDASE
4)		 3iv0 SUSD HOMOLOG
(Bacteroides
thetaiotaomicron) 		3 / 3 PHE A 322
TYR A 451
TYR A 324
 None
 1.03A 4ffwA-3iv0A:
undetectable		 4ffwA-3iv0A:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYS_B_VIBB501_1
(THIAMINE
PYRIDINYLASE I)		 3iv0 SUSD HOMOLOG
(Bacteroides
thetaiotaomicron) 		5 / 11 ILE A 150
THR A 182
TYR A 157
ASP A 194
LEU A 128
 None
None
CSO  A 191 ( 4.6A)
CSO  A 191 ( 4.8A)
None
 1.47A 4kysB-3iv0A:
0.0		 4kysB-3iv0A:
23.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PCL_B_SAMB301_1
(O-METHYLTRANSFERASE
FAMILY PROTEIN)		 3iv0 SUSD HOMOLOG
(Bacteroides
thetaiotaomicron) 		4 / 4 SER A 211
GLU A 289
GLU A 448
ASP A 284
 None
 0.96A 4pclB-3iv0A:
0.0		 4pclB-3iv0A:
17.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XUD_A_SAMA303_1
(CATECHOL
O-METHYLTRANSFERASE)		 3iv0 SUSD HOMOLOG
(Bacteroides
thetaiotaomicron) 		3 / 3 SER A 211
GLU A 289
ASP A 284
 None
 0.70A 4xudA-3iv0A:
undetectable		 4xudA-3iv0A:
16.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XUE_A_SAMA303_1
(CATECHOL
O-METHYLTRANSFERASE)		 3iv0 SUSD HOMOLOG
(Bacteroides
thetaiotaomicron) 		4 / 5 GLY A 286
SER A 211
GLU A 289
ASP A 284
 None
 0.93A 4xueA-3iv0A:
undetectable		 4xueA-3iv0A:
16.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1A_C_CHDC304_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3iv0 SUSD HOMOLOG
(Bacteroides
thetaiotaomicron) 		4 / 7 LEU A 230
PHE A 151
LEU A 155
PHE A 159
 None
 0.93A 5b1aC-3iv0A:
1.8
5b1aJ-3iv0A:
undetectable		 5b1aC-3iv0A:
20.57
5b1aJ-3iv0A:
8.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1A_P_CHDP305_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3iv0 SUSD HOMOLOG
(Bacteroides
thetaiotaomicron) 		4 / 7 LEU A 230
PHE A 151
LEU A 155
PHE A 159
 None
 0.95A 5b1aP-3iv0A:
1.8
5b1aW-3iv0A:
undetectable		 5b1aP-3iv0A:
20.57
5b1aW-3iv0A:
8.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1B_P_CHDP306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3iv0 SUSD HOMOLOG
(Bacteroides
thetaiotaomicron) 		4 / 7 LEU A 230
PHE A 151
LEU A 155
PHE A 159
 None
 0.78A 5b1bP-3iv0A:
1.9
5b1bW-3iv0A:
undetectable		 5b1bP-3iv0A:
20.57
5b1bW-3iv0A:
8.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BMV_C_VLBC507_1
(TUBULIN BETA CHAIN
TUBULIN ALPHA-1B
CHAIN)		 3iv0 SUSD HOMOLOG
(Bacteroides
thetaiotaomicron) 		4 / 6 ASP A 105
TYR A  89
TYR A  68
LEU A  90
 None
 1.25A 5bmvB-3iv0A:
1.5		 5bmvB-3iv0A:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DQF_A_CZEA613_1
(SERUM ALBUMIN)		 3iv0 SUSD HOMOLOG
(Bacteroides
thetaiotaomicron) 		5 / 9 ALA A 392
LEU A 256
GLY A 257
LEU A 260
LEU A 287
 None
EDO  A   4 ( 4.3A)
None
None
None
 0.69A 5dqfA-3iv0A:
undetectable		 5dqfA-3iv0A:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IMS_B_ACTB713_0
(ACETOLACTATE
SYNTHASE CATALYTIC
SUBUNIT,
MITOCHONDRIAL)		 3iv0 SUSD HOMOLOG
(Bacteroides
thetaiotaomicron) 		3 / 3 GLY A 447
GLN A 384
LYS A 365
 None
 0.89A 5imsB-3iv0A:
undetectable		 5imsB-3iv0A:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IY5_C_CHDC307_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3iv0 SUSD HOMOLOG
(Bacteroides
thetaiotaomicron) 		4 / 7 LEU A 230
PHE A 151
LEU A 155
PHE A 159
 None
 0.95A 5iy5C-3iv0A:
1.9
5iy5J-3iv0A:
undetectable		 5iy5C-3iv0A:
20.58
5iy5J-3iv0A:
8.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N5D_B_SAMB303_1
(METHYLTRANSFERASE)		 3iv0 SUSD HOMOLOG
(Bacteroides
thetaiotaomicron) 		4 / 7 GLY A 286
SER A 211
GLU A 289
ASP A 284
 None
 0.99A 5n5dB-3iv0A:
undetectable		 5n5dB-3iv0A:
18.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V5Z_A_1YNA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 3iv0 SUSD HOMOLOG
(Bacteroides
thetaiotaomicron) 		5 / 12 PHE A 322
ILE A  77
PHE A 306
PHE A 346
PHE A 333
 None
 1.19A 5v5zA-3iv0A:
undetectable		 5v5zA-3iv0A:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VCG_A_08YA602_1
(CYTOCHROME P450 3A4)		 3iv0 SUSD HOMOLOG
(Bacteroides
thetaiotaomicron) 		5 / 12 ASP A 308
PHE A 279
SER A 283
ILE A 278
ALA A 291
 None
 1.26A 5vcgA-3iv0A:
undetectable		 5vcgA-3iv0A:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X19_C_CHDC304_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3iv0 SUSD HOMOLOG
(Bacteroides
thetaiotaomicron) 		4 / 5 LEU A 230
PHE A 151
LEU A 155
PHE A 159
 None
 0.95A 5x19C-3iv0A:
undetectable
5x19J-3iv0A:
undetectable		 5x19C-3iv0A:
20.57
5x19J-3iv0A:
8.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1F_P_CHDP304_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3iv0 SUSD HOMOLOG
(Bacteroides
thetaiotaomicron) 		4 / 7 LEU A 230
PHE A 151
LEU A 155
PHE A 159
 None
 0.85A 5x1fP-3iv0A:
1.9
5x1fW-3iv0A:
undetectable		 5x1fP-3iv0A:
20.57
5x1fW-3iv0A:
8.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z84_C_CHDC307_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3iv0 SUSD HOMOLOG
(Bacteroides
thetaiotaomicron) 		4 / 7 LEU A 230
PHE A 151
LEU A 155
PHE A 159
 None
 0.77A 5z84C-3iv0A:
1.9
5z84J-3iv0A:
undetectable		 5z84C-3iv0A:
20.57
5z84J-3iv0A:
8.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z85_C_CHDC306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3iv0 SUSD HOMOLOG
(Bacteroides
thetaiotaomicron) 		4 / 7 LEU A 230
PHE A 151
LEU A 155
PHE A 159
 None
 0.76A 5z85C-3iv0A:
1.9
5z85J-3iv0A:
undetectable		 5z85C-3iv0A:
20.57
5z85J-3iv0A:
8.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCO_C_CHDC306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3iv0 SUSD HOMOLOG
(Bacteroides
thetaiotaomicron) 		4 / 7 LEU A 230
PHE A 151
LEU A 155
PHE A 159
 None
 0.73A 5zcoC-3iv0A:
1.9
5zcoJ-3iv0A:
undetectable		 5zcoC-3iv0A:
20.57
5zcoJ-3iv0A:
8.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCQ_C_CHDC306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3iv0 SUSD HOMOLOG
(Bacteroides
thetaiotaomicron) 		4 / 7 LEU A 230
PHE A 151
LEU A 155
PHE A 159
 None
 0.77A 5zcqC-3iv0A:
undetectable
5zcqJ-3iv0A:
undetectable		 5zcqC-3iv0A:
20.57
5zcqJ-3iv0A:
8.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCQ_P_CHDP306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3iv0 SUSD HOMOLOG
(Bacteroides
thetaiotaomicron) 		4 / 7 LEU A 230
PHE A 151
LEU A 155
PHE A 159
 None
 0.78A 5zcqP-3iv0A:
1.9
5zcqW-3iv0A:
undetectable		 5zcqP-3iv0A:
20.57
5zcqW-3iv0A:
8.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BAA_E_GBME2001_2
(ATP-BINDING CASSETTE
SUB-FAMILY C MEMBER
8)		 3iv0 SUSD HOMOLOG
(Bacteroides
thetaiotaomicron) 		3 / 3 LEU A 195
THR A 171
ASN A 125
 CSO  A 191 ( 3.5A)
None
None
 0.72A 6baaE-3iv0A:
undetectable		 6baaE-3iv0A:
15.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BAA_F_GBMF2001_2
(ATP-BINDING CASSETTE
SUB-FAMILY C MEMBER
8)		 3iv0 SUSD HOMOLOG
(Bacteroides
thetaiotaomicron) 		3 / 3 LEU A 195
THR A 171
ASN A 125
 CSO  A 191 ( 3.5A)
None
None
 0.73A 6baaF-3iv0A:
0.0		 6baaF-3iv0A:
15.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BAA_G_GBMG2001_2
(ATP-BINDING CASSETTE
SUB-FAMILY C MEMBER
8)		 3iv0 SUSD HOMOLOG
(Bacteroides
thetaiotaomicron) 		3 / 3 LEU A 195
THR A 171
ASN A 125
 CSO  A 191 ( 3.5A)
None
None
 0.73A 6baaG-3iv0A:
0.6		 6baaG-3iv0A:
15.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BAA_H_GBMH2001_2
(ATP-BINDING CASSETTE
SUB-FAMILY C MEMBER
8)		 3iv0 SUSD HOMOLOG
(Bacteroides
thetaiotaomicron) 		3 / 3 LEU A 195
THR A 171
ASN A 125
 CSO  A 191 ( 3.5A)
None
None
 0.73A 6baaH-3iv0A:
0.0		 6baaH-3iv0A:
15.28