SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3iv3'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MRG_A_ADNA300_1
(ALPHA-MOMORCHARIN)		 3iv3 TAGATOSE
1,6-DIPHOSPHATE
ALDOLASE 2
(Streptococcus
mutans) 		5 / 9 TYR A 145
ILE A 146
TYR A  91
ILE A 149
GLU A 152
 EDO  A 336 (-4.1A)
None
None
None
None
 1.30A 1mrgA-3iv3A:
undetectable		 1mrgA-3iv3A:
23.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MRJ_A_ADNA300_1
(ALPHA-TRICHOSANTHIN)		 3iv3 TAGATOSE
1,6-DIPHOSPHATE
ALDOLASE 2
(Streptococcus
mutans) 		5 / 8 TYR A 145
ILE A 146
TYR A  91
ILE A 149
GLU A 152
 EDO  A 336 (-4.1A)
None
None
None
None
 1.20A 1mrjA-3iv3A:
undetectable		 1mrjA-3iv3A:
24.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N49_D_RITD401_2
(PROTEASE)		 3iv3 TAGATOSE
1,6-DIPHOSPHATE
ALDOLASE 2
(Streptococcus
mutans) 		4 / 6 ASP A 157
GLY A 200
ILE A 201
ILE A 113
 None
EDO  A 331 ( 3.7A)
None
None
 0.72A 1n49D-3iv3A:
undetectable		 1n49D-3iv3A:
13.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z2B_C_VLBC800_2
(TUBULIN ALPHA CHAIN)		 3iv3 TAGATOSE
1,6-DIPHOSPHATE
ALDOLASE 2
(Streptococcus
mutans) 		4 / 5 PRO A 209
VAL A 187
ASN A 188
VAL A 206
 None
 1.03A 1z2bC-3iv3A:
undetectable		 1z2bC-3iv3A:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJF_B_ADNB2002_1
(235AA LONG
HYPOTHETICAL
BIOTIN--[ACETYL-COA-
CARBOXYLASE] LIGASE)		 3iv3 TAGATOSE
1,6-DIPHOSPHATE
ALDOLASE 2
(Streptococcus
mutans) 		4 / 6 ARG A  29
GLU A  50
PRO A  76
ALA A  78
 None
 1.42A 2ejfB-3iv3A:
undetectable		 2ejfB-3iv3A:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HDN_F_TACF3888_1
(ELONGATION FACTOR
EF-TU)		 3iv3 TAGATOSE
1,6-DIPHOSPHATE
ALDOLASE 2
(Streptococcus
mutans) 		4 / 7 SER A  65
ASP A  16
SER A  66
LEU A   3
 None
 1.01A 2hdnE-3iv3A:
undetectable
2hdnF-3iv3A:
2.2
2hdnH-3iv3A:
2.4		 2hdnE-3iv3A:
9.88
2hdnF-3iv3A:
24.68
2hdnH-3iv3A:
24.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HDN_H_TACH4888_1
(ELONGATION FACTOR
EF-TU)		 3iv3 TAGATOSE
1,6-DIPHOSPHATE
ALDOLASE 2
(Streptococcus
mutans) 		4 / 7 SER A  66
LEU A   3
SER A  65
ASP A  16
 None
 0.98A 2hdnF-3iv3A:
2.2
2hdnG-3iv3A:
undetectable
2hdnH-3iv3A:
2.3		 2hdnF-3iv3A:
24.68
2hdnG-3iv3A:
9.88
2hdnH-3iv3A:
24.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AVP_A_MV2A313_1
(PANTOTHENATE KINASE)		 3iv3 TAGATOSE
1,6-DIPHOSPHATE
ALDOLASE 2
(Streptococcus
mutans) 		4 / 7 VAL A 213
LEU A 256
TYR A 214
ASN A 211
 None
None
None
EDO  A 334 (-3.5A)
 0.98A 3avpA-3iv3A:
undetectable		 3avpA-3iv3A:
23.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DOU_A_SAMA1_1
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE J)		 3iv3 TAGATOSE
1,6-DIPHOSPHATE
ALDOLASE 2
(Streptococcus
mutans) 		3 / 3 ASP A 131
ASP A 135
ASP A 189
 None
 0.78A 3douA-3iv3A:
undetectable		 3douA-3iv3A:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KPD_B_SAMB1000_1
(UNCHARACTERIZED
PROTEIN MJ0100)		 3iv3 TAGATOSE
1,6-DIPHOSPHATE
ALDOLASE 2
(Streptococcus
mutans) 		3 / 3 ASN A 211
ASN A 174
GLU A 207
 EDO  A 334 (-3.5A)
EDO  A 334 (-3.7A)
EDO  A 334 ( 4.9A)
 0.93A 3kpdC-3iv3A:
undetectable		 3kpdC-3iv3A:
17.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DC3_B_2FAB401_2
(ADENOSINE KINASE)		 3iv3 TAGATOSE
1,6-DIPHOSPHATE
ALDOLASE 2
(Streptococcus
mutans) 		4 / 5 LEU A  68
ILE A  21
ALA A 123
PHE A 161
 None
 0.80A 4dc3B-3iv3A:
undetectable		 4dc3B-3iv3A:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_F_SASF805_1
(SEPIAPTERIN
REDUCTASE)		 3iv3 TAGATOSE
1,6-DIPHOSPHATE
ALDOLASE 2
(Streptococcus
mutans) 		5 / 12 LEU A  52
PHE A  26
PRO A  44
ASP A  27
GLY A  30
 None
None
None
EDO  A 335 (-3.2A)
None
 1.29A 4j7xF-3iv3A:
undetectable		 4j7xF-3iv3A:
23.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K7G_B_ACTB902_0
(3-HYDROXYPROLINE
DEHYDRATSE)		 3iv3 TAGATOSE
1,6-DIPHOSPHATE
ALDOLASE 2
(Streptococcus
mutans) 		4 / 7 ASP A  16
SER A  65
TRP A 322
SER A  22
 None
 1.13A 4k7gB-3iv3A:
undetectable		 4k7gB-3iv3A:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LMN_A_EUIA503_1
(DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1)		 3iv3 TAGATOSE
1,6-DIPHOSPHATE
ALDOLASE 2
(Streptococcus
mutans) 		5 / 12 LEU A 204
LEU A 162
ILE A 164
ASN A 139
SER A 195
 None
 0.98A 4lmnA-3iv3A:
undetectable		 4lmnA-3iv3A:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YP2_B_NCAB302_0
(RIBOSOME-INACTIVATIN
G PROTEIN MOMORDIN I)		 3iv3 TAGATOSE
1,6-DIPHOSPHATE
ALDOLASE 2
(Streptococcus
mutans) 		5 / 9 TYR A 145
ILE A 146
TYR A  91
ILE A 149
GLU A 152
 EDO  A 336 (-4.1A)
None
None
None
None
 1.07A 4yp2B-3iv3A:
undetectable		 4yp2B-3iv3A:
24.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CF9_B_NCAB302_0
(RIBOSOME-INACTIVATIN
G PROTEIN MOMORDIN I)		 3iv3 TAGATOSE
1,6-DIPHOSPHATE
ALDOLASE 2
(Streptococcus
mutans) 		5 / 9 TYR A 145
ILE A 146
TYR A  91
ILE A 149
GLU A 152
 EDO  A 336 (-4.1A)
None
None
None
None
 1.07A 5cf9B-3iv3A:
undetectable		 5cf9B-3iv3A:
24.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MUR_B_PFLB407_1
(PROTON-GATED ION
CHANNEL)		 3iv3 TAGATOSE
1,6-DIPHOSPHATE
ALDOLASE 2
(Streptococcus
mutans) 		4 / 7 PRO A 105
TYR A 145
ILE A 149
ILE A 146
 None
EDO  A 336 (-4.1A)
None
None
 0.91A 5murB-3iv3A:
undetectable		 5murB-3iv3A:
12.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N8J_E_DVAE7_0
(GLY-DTY-GLY-DLE-DAL-
DSG-DVA-DAS-DGL-DSN-
DSN-GLY
STREPTAVIDIN)		 3iv3 TAGATOSE
1,6-DIPHOSPHATE
ALDOLASE 2
(Streptococcus
mutans) 		3 / 3 TYR A   8
SER A 327
TRP A 322
 None
 0.97A 5n8jB-3iv3A:
undetectable		 5n8jB-3iv3A:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N8J_O_DVAO7_0
(GLY-DTY-GLY-DLE-DAL-
DSG-DVA-DAS-DGL-DSN-
DSN-GLY
STREPTAVIDIN)		 3iv3 TAGATOSE
1,6-DIPHOSPHATE
ALDOLASE 2
(Streptococcus
mutans) 		3 / 3 TYR A   8
SER A 327
TRP A 322
 None
 0.98A 5n8jA-3iv3A:
undetectable		 5n8jA-3iv3A:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N8J_P_DVAP5_0
(GLY-DTY-GLY-DLE-DAL-
DSG-DVA-DAS-DGL-DSN-
DSN-GLY
STREPTAVIDIN)		 3iv3 TAGATOSE
1,6-DIPHOSPHATE
ALDOLASE 2
(Streptococcus
mutans) 		3 / 3 TYR A   8
SER A 327
TRP A 322
 None
 1.01A 5n8jD-3iv3A:
undetectable		 5n8jD-3iv3A:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UBB_A_SAMA301_0
(ALPHA N-TERMINAL
PROTEIN
METHYLTRANSFERASE 1B)		 3iv3 TAGATOSE
1,6-DIPHOSPHATE
ALDOLASE 2
(Streptococcus
mutans) 		5 / 12 GLY A 273
VAL A 203
LEU A 315
VAL A 274
LEU A 311
 None
None
None
None
EDO  A 338 ( 3.9A)
 1.29A 5ubbA-3iv3A:
undetectable		 5ubbA-3iv3A:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXD_B_ZITB501_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E MPHH)		 3iv3 TAGATOSE
1,6-DIPHOSPHATE
ALDOLASE 2
(Streptococcus
mutans) 		5 / 12 LEU A 256
VAL A 252
PHE A 263
PHE A 234
ALA A 233
 None
None
None
None
EDO  A 339 ( 3.7A)
 0.83A 5uxdB-3iv3A:
undetectable		 5uxdB-3iv3A:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YW0_A_ACTA411_0
(UNCHARACTERIZED
PROTEIN KDOO)		 3iv3 TAGATOSE
1,6-DIPHOSPHATE
ALDOLASE 2
(Streptococcus
mutans) 		3 / 3 LYS A 293
LEU A  55
ARG A 297
 None
 0.89A 5yw0A-3iv3A:
undetectable		 5yw0A-3iv3A:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z3J_A_NCAA302_0
(ABRIN A-CHAIN)		 3iv3 TAGATOSE
1,6-DIPHOSPHATE
ALDOLASE 2
(Streptococcus
mutans) 		4 / 6 TYR A 145
TYR A  91
ILE A 149
GLU A 152
 EDO  A 336 (-4.1A)
None
None
None
 1.00A 5z3jA-3iv3A:
undetectable		 5z3jA-3iv3A:
24.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BXM_A_SAMA402_0
(DIPHTHAMIDE
BIOSYNTHESIS ENZYME
DPH2)		 3iv3 TAGATOSE
1,6-DIPHOSPHATE
ALDOLASE 2
(Streptococcus
mutans) 		5 / 12 GLY A  30
SER A 284
LEU A  55
VAL A  56
ASP A  70
 None
 1.15A 6bxmA-3iv3A:
undetectable		 6bxmA-3iv3A:
22.99