SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3iv7'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DDR_B_MTXB200_1
(DIHYDROFOLATE
REDUCTASE)		 3iv7 ALCOHOL
DEHYDROGENASE IV
(Corynebacterium
glutamicum) 		5 / 12 ILE A 106
ALA A  81
ILE A  73
LEU A 132
THR A  84
 None
 1.15A 1ddrB-3iv7A:
2.1		 1ddrB-3iv7A:
18.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DDS_A_MTXA201_1
(DIHYDROFOLATE
REDUCTASE)		 3iv7 ALCOHOL
DEHYDROGENASE IV
(Corynebacterium
glutamicum) 		5 / 12 ILE A 106
ALA A  81
ILE A  73
LEU A 132
THR A  84
 None
 1.13A 1ddsA-3iv7A:
2.4		 1ddsA-3iv7A:
18.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DDS_B_MTXB201_1
(DIHYDROFOLATE
REDUCTASE)		 3iv7 ALCOHOL
DEHYDROGENASE IV
(Corynebacterium
glutamicum) 		5 / 12 ILE A 106
ALA A  81
ILE A  73
LEU A 132
THR A  84
 None
 1.12A 1ddsB-3iv7A:
2.3		 1ddsB-3iv7A:
18.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JOL_A_FFOA161_0
(DIHYDROFOLATE
REDUCTASE)		 3iv7 ALCOHOL
DEHYDROGENASE IV
(Corynebacterium
glutamicum) 		5 / 12 ILE A 106
ALA A  81
ILE A  73
LEU A 132
THR A  84
 None
 1.12A 1jolA-3iv7A:
2.4		 1jolA-3iv7A:
18.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JOL_B_FFOB361_0
(DIHYDROFOLATE
REDUCTASE)		 3iv7 ALCOHOL
DEHYDROGENASE IV
(Corynebacterium
glutamicum) 		5 / 12 ILE A 106
ALA A  81
ILE A  73
LEU A 132
THR A  84
 None
 1.12A 1jolB-3iv7A:
2.2		 1jolB-3iv7A:
18.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S9P_A_DESA459_1
(ESTROGEN-RELATED
RECEPTOR GAMMA)		 3iv7 ALCOHOL
DEHYDROGENASE IV
(Corynebacterium
glutamicum) 		5 / 12 LEU A 341
LEU A 344
ALA A 347
ARG A 298
LEU A 247
 None
 1.12A 1s9pA-3iv7A:
undetectable		 1s9pA-3iv7A:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TKQ_B_DVAB6_0
(GRAMICIDIN A)		 3iv7 ALCOHOL
DEHYDROGENASE IV
(Corynebacterium
glutamicum) 		3 / 3 ALA A 111
VAL A 146
TRP A 130
 None
 0.90A 1tkqB-3iv7A:
undetectable		 1tkqB-3iv7A:
5.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XIU_A_9CRA201_1
(RXR-LIKE PROTEIN)		 3iv7 ALCOHOL
DEHYDROGENASE IV
(Corynebacterium
glutamicum) 		5 / 12 ALA A 347
ALA A 348
LEU A 357
CYH A 244
LEU A 247
 None
 1.02A 1xiuA-3iv7A:
undetectable		 1xiuA-3iv7A:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZZA_B_FOLB164_0
(DIHYDROFOLATE
REDUCTASE)		 3iv7 ALCOHOL
DEHYDROGENASE IV
(Corynebacterium
glutamicum) 		5 / 11 ILE A 106
ALA A  81
ILE A  73
LEU A 132
THR A  84
 None
 1.32A 2zzaB-3iv7A:
undetectable		 2zzaB-3iv7A:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A51_B_VDYB6178_1
(VITAMIN D
HYDROXYLASE)		 3iv7 ALCOHOL
DEHYDROGENASE IV
(Corynebacterium
glutamicum) 		5 / 12 PRO A 354
LEU A 357
THR A 324
VAL A 328
LEU A 239
 None
 1.31A 3a51B-3iv7A:
undetectable		 3a51B-3iv7A:
24.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ARU_A_PNXA607_1
(CHITINASE A)		 3iv7 ALCOHOL
DEHYDROGENASE IV
(Corynebacterium
glutamicum) 		4 / 8 VAL A  54
GLY A  95
GLY A  44
ALA A  43
 None
 0.76A 3aruA-3iv7A:
undetectable		 3aruA-3iv7A:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QL0_A_FOLA160_0
(DIHYDROFOLATE
REDUCTASE)		 3iv7 ALCOHOL
DEHYDROGENASE IV
(Corynebacterium
glutamicum) 		5 / 12 ILE A 106
ALA A  81
ILE A  73
LEU A 132
THR A  84
 None
 1.20A 3ql0A-3iv7A:
2.2		 3ql0A-3iv7A:
18.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D33_B_ACTB860_0
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 3iv7 ALCOHOL
DEHYDROGENASE IV
(Corynebacterium
glutamicum) 		4 / 5 GLY A 101
ILE A 100
VAL A 146
SER A 124
 None
 1.05A 4d33B-3iv7A:
undetectable		 4d33B-3iv7A:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D39_B_ACTB860_0
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 3iv7 ALCOHOL
DEHYDROGENASE IV
(Corynebacterium
glutamicum) 		4 / 6 GLY A 101
ILE A 100
VAL A 146
SER A 124
 None
 1.06A 4d39B-3iv7A:
undetectable		 4d39B-3iv7A:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G24_A_ACAA1004_1
(PENTATRICOPEPTIDE
REPEAT-CONTAINING
PROTEIN AT2G32230,
MITOCHONDRIAL)		 3iv7 ALCOHOL
DEHYDROGENASE IV
(Corynebacterium
glutamicum) 		4 / 6 ALA A 271
ASN A 270
LEU A 267
VAL A 266
 None
 1.01A 4g24A-3iv7A:
undetectable		 4g24A-3iv7A:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LVC_B_ADNB501_2
(S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE
(SAHASE))		 3iv7 ALCOHOL
DEHYDROGENASE IV
(Corynebacterium
glutamicum) 		4 / 5 THR A 261
THR A 246
LEU A 341
LEU A 344
 None
 0.90A 4lvcB-3iv7A:
3.0		 4lvcB-3iv7A:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QI9_C_MTXC201_1
(DIHYDROFOLATE
REDUCTASE)		 3iv7 ALCOHOL
DEHYDROGENASE IV
(Corynebacterium
glutamicum) 		5 / 11 ILE A 106
ALA A  81
ILE A  73
LEU A 132
THR A  84
 None
 1.17A 4qi9C-3iv7A:
2.6		 4qi9C-3iv7A:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QLE_B_FOLB201_0
(DIHYDROFOLATE
REDUCTASE)		 3iv7 ALCOHOL
DEHYDROGENASE IV
(Corynebacterium
glutamicum) 		5 / 11 ILE A 106
ALA A  81
ILE A  73
LEU A 132
THR A  84
 None
 1.13A 4qleB-3iv7A:
2.1		 4qleB-3iv7A:
18.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QLF_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 3iv7 ALCOHOL
DEHYDROGENASE IV
(Corynebacterium
glutamicum) 		5 / 11 ILE A 106
ALA A  81
ILE A  73
LEU A 132
THR A  84
 None
 1.17A 4qlfA-3iv7A:
2.2		 4qlfA-3iv7A:
18.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QLG_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 3iv7 ALCOHOL
DEHYDROGENASE IV
(Corynebacterium
glutamicum) 		5 / 12 ILE A 106
ALA A  81
ILE A  73
LEU A 132
THR A  84
 None
 1.18A 4qlgA-3iv7A:
undetectable		 4qlgA-3iv7A:
18.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QLG_B_FOLB201_0
(DIHYDROFOLATE
REDUCTASE)		 3iv7 ALCOHOL
DEHYDROGENASE IV
(Corynebacterium
glutamicum) 		5 / 12 ILE A 106
ALA A  81
ILE A  73
LEU A 132
THR A  84
 None
 1.13A 4qlgB-3iv7A:
2.1		 4qlgB-3iv7A:
18.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XI3_B_29SB601_2
(ESTROGEN RECEPTOR)		 3iv7 ALCOHOL
DEHYDROGENASE IV
(Corynebacterium
glutamicum) 		4 / 5 LEU A 181
GLU A 278
LEU A 174
HIS A 241
 EDO  A 364 ( 4.3A)
None
None
None
 1.30A 4xi3B-3iv7A:
undetectable		 4xi3B-3iv7A:
18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_P_BEZP801_1
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 3iv7 ALCOHOL
DEHYDROGENASE IV
(Corynebacterium
glutamicum) 		4 / 6 SER A 234
ALA A 235
HIS A   9
LEU A 193
 None
 1.17A 5dzkB-3iv7A:
undetectable
5dzkP-3iv7A:
undetectable		 5dzkB-3iv7A:
21.41
5dzkP-3iv7A:
2.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_R_BEZR801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 3iv7 ALCOHOL
DEHYDROGENASE IV
(Corynebacterium
glutamicum) 		4 / 7 SER A 234
ALA A 235
HIS A   9
LEU A 193
 None
 1.02A 5dzkD-3iv7A:
undetectable
5dzkR-3iv7A:
undetectable		 5dzkD-3iv7A:
21.41
5dzkR-3iv7A:
2.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E4D_B_BEZB202_0
(HYDROXYNITRILE LYASE)		 3iv7 ALCOHOL
DEHYDROGENASE IV
(Corynebacterium
glutamicum) 		4 / 7 THR A 324
LEU A 253
VAL A 262
THR A 258
 None
 0.92A 5e4dA-3iv7A:
undetectable
5e4dB-3iv7A:
undetectable		 5e4dA-3iv7A:
20.80
5e4dB-3iv7A:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E8Q_B_FOLB201_0
(DIHYDROFOLATE
REDUCTASE)		 3iv7 ALCOHOL
DEHYDROGENASE IV
(Corynebacterium
glutamicum) 		5 / 12 ILE A 106
ALA A  81
ILE A  73
LEU A 132
THR A  84
 None
 1.09A 5e8qB-3iv7A:
2.3		 5e8qB-3iv7A:
18.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EAJ_B_FOLB201_0
(DIHYDROFOLATE
REDUCTASE)		 3iv7 ALCOHOL
DEHYDROGENASE IV
(Corynebacterium
glutamicum) 		5 / 12 ILE A 106
ALA A  81
ILE A  73
LEU A 132
THR A  84
 None
 1.11A 5eajB-3iv7A:
2.3		 5eajB-3iv7A:
18.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HI6_A_MTXA201_1
(DIHYDROFOLATE
REDUCTASE)		 3iv7 ALCOHOL
DEHYDROGENASE IV
(Corynebacterium
glutamicum) 		5 / 12 ILE A 106
ALA A  81
ILE A  73
LEU A 132
THR A  84
 None
 1.11A 5hi6A-3iv7A:
2.1		 5hi6A-3iv7A:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HI6_B_MTXB201_1
(DIHYDROFOLATE
REDUCTASE)		 3iv7 ALCOHOL
DEHYDROGENASE IV
(Corynebacterium
glutamicum) 		5 / 12 ILE A 106
ALA A  81
ILE A  73
LEU A 132
THR A  84
 None
 1.11A 5hi6B-3iv7A:
2.1		 5hi6B-3iv7A:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGV_A_ZITA404_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 3iv7 ALCOHOL
DEHYDROGENASE IV
(Corynebacterium
glutamicum) 		5 / 12 ILE A 100
GLY A  96
GLU A 149
ALA A 229
ILE A 152
 None
 1.19A 5igvA-3iv7A:
undetectable		 5igvA-3iv7A:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JGL_A_SAMA301_0
(UBIE/COQ5 FAMILY
METHYLTRANSFERASE,
PUTATIVE)		 3iv7 ALCOHOL
DEHYDROGENASE IV
(Corynebacterium
glutamicum) 		5 / 12 ALA A 225
SER A 124
ALA A 221
GLY A 170
SER A 169
 None
 1.48A 5jglA-3iv7A:
undetectable		 5jglA-3iv7A:
24.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JS5_A_ASCA202_0
(CYTOCHROME C')		 3iv7 ALCOHOL
DEHYDROGENASE IV
(Corynebacterium
glutamicum) 		3 / 3 CYH A 244
LYS A 242
HIS A 245
 None
 0.97A 5js5A-3iv7A:
2.3		 5js5A-3iv7A:
16.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N5D_A_SAMA306_0
(METHYLTRANSFERASE)		 3iv7 ALCOHOL
DEHYDROGENASE IV
(Corynebacterium
glutamicum) 		5 / 12 GLY A 173
TYR A 226
ARG A 298
ALA A 260
ALA A 175
 None
 1.15A 5n5dA-3iv7A:
2.7		 5n5dA-3iv7A:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TWJ_B_SAMB201_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE H)		 3iv7 ALCOHOL
DEHYDROGENASE IV
(Corynebacterium
glutamicum) 		5 / 10 ILE A 198
GLY A 197
GLY A 224
LEU A 263
LEU A 171
 None
 1.16A 5twjB-3iv7A:
undetectable		 5twjB-3iv7A:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UJX_B_FOLB201_0
(DIHYDROFOLATE
REDUCTASE)		 3iv7 ALCOHOL
DEHYDROGENASE IV
(Corynebacterium
glutamicum) 		5 / 12 ILE A 106
ALA A  81
ILE A  73
LEU A 132
THR A  84
 None
 1.09A 5ujxB-3iv7A:
2.3		 5ujxB-3iv7A:
18.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXD_A_ZITA501_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E MPHH)		 3iv7 ALCOHOL
DEHYDROGENASE IV
(Corynebacterium
glutamicum) 		4 / 7 TYR A 153
PHE A  18
ALA A 200
GLY A 204
 None
 1.07A 5uxdA-3iv7A:
undetectable		 5uxdA-3iv7A:
24.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X23_A_LSNA504_1
(CYTOCHROME P450 2C9)		 3iv7 ALCOHOL
DEHYDROGENASE IV
(Corynebacterium
glutamicum) 		4 / 8 ILE A 178
PHE A 285
ASN A 202
PRO A 304
 None
 0.93A 5x23A-3iv7A:
undetectable		 5x23A-3iv7A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XXI_A_LSNA503_1
(CYTOCHROME P450 2C9)		 3iv7 ALCOHOL
DEHYDROGENASE IV
(Corynebacterium
glutamicum) 		5 / 12 ILE A 178
PHE A 285
ASN A 202
PRO A 304
LEU A 263
 None
 1.06A 5xxiA-3iv7A:
undetectable		 5xxiA-3iv7A:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BRD_A_RFPA502_1
(RIFAMPIN
MONOOXYGENASE)		 3iv7 ALCOHOL
DEHYDROGENASE IV
(Corynebacterium
glutamicum) 		5 / 12 HIS A  70
LEU A 307
PHE A 312
THR A 250
GLY A 249
 None
 1.37A 6brdA-3iv7A:
undetectable		 6brdA-3iv7A:
17.15