SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3ivu'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EI6_C_PPFC413_1
(PHOSPHONOACETATE
HYDROLASE)		 3ivu HOMOCITRATE
SYNTHASE,
MITOCHONDRIAL
(Schizosaccharomy
ces
pombe) 		4 / 8 ASP A 220
PHE A  35
THR A 245
HIS A 246
 None
 0.92A 1ei6C-3ivuA:
undetectable		 1ei6C-3ivuA:
23.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NT2_A_SAMA301_1
(FIBRILLARIN-LIKE
PRE-RRNA PROCESSING
PROTEIN)		 3ivu HOMOCITRATE
SYNTHASE,
MITOCHONDRIAL
(Schizosaccharomy
ces
pombe) 		3 / 3 THR A 249
GLU A 291
ASP A 396
 None
 0.82A 1nt2A-3ivuA:
undetectable		 1nt2A-3ivuA:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XMU_B_ROFB102_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		 3ivu HOMOCITRATE
SYNTHASE,
MITOCHONDRIAL
(Schizosaccharomy
ces
pombe) 		4 / 5 ASN A 235
THR A 202
GLN A 205
PHE A 170
 None
 1.41A 1xmuB-3ivuA:
undetectable		 1xmuB-3ivuA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W1B_A_DXCA2034_0
(ACRIFLAVIN
RESISTANCE PROTEIN B)		 3ivu HOMOCITRATE
SYNTHASE,
MITOCHONDRIAL
(Schizosaccharomy
ces
pombe) 		3 / 3 PHE A  53
SER A 250
LEU A 252
 None
 0.82A 2w1bA-3ivuA:
undetectable		 2w1bA-3ivuA:
17.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ARU_A_PNXA607_1
(CHITINASE A)		 3ivu HOMOCITRATE
SYNTHASE,
MITOCHONDRIAL
(Schizosaccharomy
ces
pombe) 		4 / 8 VAL A 346
GLY A 349
GLY A 319
ALA A 318
 None
 0.75A 3aruA-3ivuA:
6.8		 3aruA-3ivuA:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_Q_TRPQ1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 3ivu HOMOCITRATE
SYNTHASE,
MITOCHONDRIAL
(Schizosaccharomy
ces
pombe) 		4 / 8 GLN A  47
ILE A 251
VAL A 294
VAL A 298
 AKG  A1000 ( 4.9A)
None
None
None
 0.77A 3fi0Q-3ivuA:
undetectable		 3fi0Q-3ivuA:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JB2_A_SAMA1101_1
(STRUCTURAL PROTEIN
VP3)		 3ivu HOMOCITRATE
SYNTHASE,
MITOCHONDRIAL
(Schizosaccharomy
ces
pombe) 		3 / 3 GLU A 161
ASP A 123
ASP A 220
 None
 0.60A 3jb2A-3ivuA:
undetectable		 3jb2A-3ivuA:
18.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JWQ_B_VIAB901_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
CATALYTIC DOMAIN,
CONE CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
SUBUNIT ALPHA
CHIMERA)		 3ivu HOMOCITRATE
SYNTHASE,
MITOCHONDRIAL
(Schizosaccharomy
ces
pombe) 		5 / 11 ASN A 227
LEU A 266
ALA A 242
VAL A 206
THR A 249
 None
 1.49A 3jwqB-3ivuA:
undetectable
3jwqC-3ivuA:
undetectable		 3jwqB-3ivuA:
20.59
3jwqC-3ivuA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3S_E_9PLE1_1
(CYTOCHROME P450 2A13)		 3ivu HOMOCITRATE
SYNTHASE,
MITOCHONDRIAL
(Schizosaccharomy
ces
pombe) 		4 / 8 PHE A  35
ALA A 244
ALA A 236
THR A 261
 None
 1.02A 3t3sE-3ivuA:
undetectable		 3t3sE-3ivuA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TWP_A_SALA404_1
(ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE)		 3ivu HOMOCITRATE
SYNTHASE,
MITOCHONDRIAL
(Schizosaccharomy
ces
pombe) 		4 / 7 ASN A 227
ALA A 232
ARG A 269
ALA A 265
 None
 0.98A 3twpA-3ivuA:
undetectable		 3twpA-3ivuA:
23.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TWP_B_SALB404_1
(ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE)		 3ivu HOMOCITRATE
SYNTHASE,
MITOCHONDRIAL
(Schizosaccharomy
ces
pombe) 		4 / 7 ASN A 227
ALA A 232
ARG A 269
ALA A 265
 None
 0.84A 3twpB-3ivuA:
undetectable		 3twpB-3ivuA:
23.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TWP_C_SALC404_1
(ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE)		 3ivu HOMOCITRATE
SYNTHASE,
MITOCHONDRIAL
(Schizosaccharomy
ces
pombe) 		4 / 7 ASN A 227
ALA A 232
ARG A 269
ALA A 265
 None
 0.79A 3twpC-3ivuA:
undetectable		 3twpC-3ivuA:
23.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A83_A_DXCA1160_0
(MAJOR POLLEN
ALLERGEN BET V 1-A)		 3ivu HOMOCITRATE
SYNTHASE,
MITOCHONDRIAL
(Schizosaccharomy
ces
pombe) 		5 / 12 PHE A  52
LEU A  65
ILE A 251
GLN A  60
ALA A 297
 None
 1.35A 4a83A-3ivuA:
undetectable		 4a83A-3ivuA:
17.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AC9_C_DXCC1478_0
(MJ0495-LIKE PROTEIN)		 3ivu HOMOCITRATE
SYNTHASE,
MITOCHONDRIAL
(Schizosaccharomy
ces
pombe) 		4 / 7 SER A 166
GLY A 127
THR A 128
THR A 197
 None
None
None
AKG  A1000 (-2.9A)
 0.65A 4ac9C-3ivuA:
3.6		 4ac9C-3ivuA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACA_C_DXCC1478_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 3ivu HOMOCITRATE
SYNTHASE,
MITOCHONDRIAL
(Schizosaccharomy
ces
pombe) 		4 / 7 SER A 166
GLY A 127
THR A 128
THR A 197
 None
None
None
AKG  A1000 (-2.9A)
 0.63A 4acaC-3ivuA:
3.5		 4acaC-3ivuA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GH8_B_MTXB201_1
(DIHYDROFOLATE
REDUCTASE)		 3ivu HOMOCITRATE
SYNTHASE,
MITOCHONDRIAL
(Schizosaccharomy
ces
pombe) 		5 / 12 ALA A  49
SER A 250
ILE A 260
PRO A 262
ASN A 227
 None
 1.08A 4gh8B-3ivuA:
undetectable		 4gh8B-3ivuA:
17.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N09_B_ADNB401_2
(ADENOSINE KINASE)		 3ivu HOMOCITRATE
SYNTHASE,
MITOCHONDRIAL
(Schizosaccharomy
ces
pombe) 		4 / 5 LEU A 290
LEU A 252
LEU A  65
ASN A 306
 None
 0.92A 4n09B-3ivuA:
2.6		 4n09B-3ivuA:
23.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X3U_B_SVRB102_1
(CHROMOBOX PROTEIN
HOMOLOG 7)		 3ivu HOMOCITRATE
SYNTHASE,
MITOCHONDRIAL
(Schizosaccharomy
ces
pombe) 		3 / 3 LYS A 156
ARG A 191
VAL A 192
 None
 0.66A 4x3uA-3ivuA:
undetectable
4x3uB-3ivuA:
undetectable		 4x3uA-3ivuA:
10.40
4x3uB-3ivuA:
10.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XQG_A_AG2A505_1
(HOMOSPERMIDINE
SYNTHASE)		 3ivu HOMOCITRATE
SYNTHASE,
MITOCHONDRIAL
(Schizosaccharomy
ces
pombe) 		4 / 8 ARG A 388
ARG A 397
ASP A 393
ASP A 394
 None
 1.04A 4xqgA-3ivuA:
undetectable		 4xqgA-3ivuA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XQG_B_AG2B505_1
(HOMOSPERMIDINE
SYNTHASE)		 3ivu HOMOCITRATE
SYNTHASE,
MITOCHONDRIAL
(Schizosaccharomy
ces
pombe) 		4 / 8 ARG A 388
ARG A 397
ASP A 393
ASP A 394
 None
 1.06A 4xqgB-3ivuA:
undetectable		 4xqgB-3ivuA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTG_F_LFXF101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		 3ivu HOMOCITRATE
SYNTHASE,
MITOCHONDRIAL
(Schizosaccharomy
ces
pombe) 		5 / 7 ALA A 236
ASP A 228
ARG A 257
GLY A 255
GLU A 256
 None
 1.42A 5btgA-3ivuA:
undetectable
5btgC-3ivuA:
undetectable
5btgD-3ivuA:
undetectable		 5btgA-3ivuA:
24.29
5btgC-3ivuA:
24.29
5btgD-3ivuA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D4U_D_SAMD301_0
(UNCHARACTERIZED
PROTEIN MJ0489)		 3ivu HOMOCITRATE
SYNTHASE,
MITOCHONDRIAL
(Schizosaccharomy
ces
pombe) 		6 / 12 LEU A 101
ILE A 260
HIS A 224
THR A  41
GLY A  45
ILE A 254
 None
None
CO  A 500 ( 3.3A)
None
None
None
 1.49A 5d4uD-3ivuA:
undetectable		 5d4uD-3ivuA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ECK_A_ILEA601_0
(JASMONIC ACID-AMIDO
SYNTHETASE JAR1)		 3ivu HOMOCITRATE
SYNTHASE,
MITOCHONDRIAL
(Schizosaccharomy
ces
pombe) 		4 / 6 ALA A 148
THR A 149
VAL A 151
VAL A 184
 None
 1.03A 5eckA-3ivuA:
undetectable		 5eckA-3ivuA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ECK_D_ILED601_0
(JASMONIC ACID-AMIDO
SYNTHETASE JAR1)		 3ivu HOMOCITRATE
SYNTHASE,
MITOCHONDRIAL
(Schizosaccharomy
ces
pombe) 		4 / 6 ALA A 148
THR A 149
VAL A 151
VAL A 184
 None
 1.01A 5eckD-3ivuA:
undetectable		 5eckD-3ivuA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIE_C_P06C801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 3ivu HOMOCITRATE
SYNTHASE,
MITOCHONDRIAL
(Schizosaccharomy
ces
pombe) 		4 / 7 ILE A 233
VAL A 298
ILE A 251
PHE A  48
 None
 0.95A 5hieC-3ivuA:
undetectable		 5hieC-3ivuA:
18.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5PBE_A_TYLA2001_1
(BROMODOMAIN ADJACENT
TO ZINC FINGER
DOMAIN PROTEIN 2B)		 3ivu HOMOCITRATE
SYNTHASE,
MITOCHONDRIAL
(Schizosaccharomy
ces
pombe) 		4 / 6 VAL A 192
VAL A 217
TYR A 181
ILE A 210
 None
 0.88A 5pbeA-3ivuA:
undetectable		 5pbeA-3ivuA:
15.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X23_A_LSNA502_2
(CYTOCHROME P450 2C9)		 3ivu HOMOCITRATE
SYNTHASE,
MITOCHONDRIAL
(Schizosaccharomy
ces
pombe) 		3 / 3 LEU A 377
VAL A 395
ASP A 396
 None
 0.56A 5x23A-3ivuA:
undetectable		 5x23A-3ivuA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H7U_A_FVTA501_0
(PEPTIDE ABC
TRANSPORTER PERMEASE)		 3ivu HOMOCITRATE
SYNTHASE,
MITOCHONDRIAL
(Schizosaccharomy
ces
pombe) 		4 / 6 ASN A 306
PRO A 303
ILE A 302
GLU A 291
 None
 1.06A 6h7uA-3ivuA:
undetectable		 6h7uA-3ivuA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H7U_A_FVTA501_0
(PEPTIDE ABC
TRANSPORTER PERMEASE)		 3ivu HOMOCITRATE
SYNTHASE,
MITOCHONDRIAL
(Schizosaccharomy
ces
pombe) 		4 / 6 VAL A 300
PRO A 303
ILE A 302
GLU A 291
 None
 1.11A 6h7uA-3ivuA:
undetectable		 6h7uA-3ivuA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HZP_A_FVTA501_0
(PEPTIDE ABC
TRANSPORTER PERMEASE)		 3ivu HOMOCITRATE
SYNTHASE,
MITOCHONDRIAL
(Schizosaccharomy
ces
pombe) 		5 / 8 VAL A 300
ASN A 306
PRO A 303
ILE A 302
GLU A 291
 None
 1.16A 6hzpA-3ivuA:
undetectable		 6hzpA-3ivuA:
21.62