SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3iwa'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N49_B_RITB301_2
(PROTEASE)		 3iwa FAD-DEPENDENT
PYRIDINE
NUCLEOTIDE-DISULPHID
E OXIDOREDUCTASE
(Desulfovibrio
vulgaris) 		6 / 11 GLY A 273
ALA A 274
VAL A 277
ILE A 297
GLY A 306
ILE A 276
 None
 1.31A 1n49B-3iwaA:
undetectable		 1n49B-3iwaA:
13.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N49_D_RITD401_1
(PROTEASE)		 3iwa FAD-DEPENDENT
PYRIDINE
NUCLEOTIDE-DISULPHID
E OXIDOREDUCTASE
(Desulfovibrio
vulgaris) 		6 / 11 GLY A 273
ALA A 274
VAL A 277
ILE A 297
GLY A 306
ILE A 276
 None
 1.31A 1n49C-3iwaA:
undetectable		 1n49C-3iwaA:
13.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FQY_A_ADNA400_1
(MEMBRANE LIPOPROTEIN
TMPC)		 3iwa FAD-DEPENDENT
PYRIDINE
NUCLEOTIDE-DISULPHID
E OXIDOREDUCTASE
(Desulfovibrio
vulgaris) 		5 / 12 ASP A 327
PHE A  21
PHE A 289
VAL A   5
LYS A   3
 None
 1.39A 2fqyA-3iwaA:
5.1		 2fqyA-3iwaA:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IVU_A_ZD6A3015_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET
PRECURSOR)		 3iwa FAD-DEPENDENT
PYRIDINE
NUCLEOTIDE-DISULPHID
E OXIDOREDUCTASE
(Desulfovibrio
vulgaris) 		3 / 3 ALA A 191
GLY A 197
SER A 204
 None
 0.59A 2ivuA-3iwaA:
undetectable		 2ivuA-3iwaA:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNK_A_ROCA401_1
(PROTEASE)		 3iwa FAD-DEPENDENT
PYRIDINE
NUCLEOTIDE-DISULPHID
E OXIDOREDUCTASE
(Desulfovibrio
vulgaris) 		5 / 12 LEU A 211
ALA A 178
ILE A 250
VAL A 218
VAL A 216
 None
 0.75A 2nnkA-3iwaA:
undetectable		 2nnkA-3iwaA:
13.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NPN_A_SAMA4633_0
(PUTATIVE COBALAMIN
SYNTHESIS RELATED
PROTEIN)		 3iwa FAD-DEPENDENT
PYRIDINE
NUCLEOTIDE-DISULPHID
E OXIDOREDUCTASE
(Desulfovibrio
vulgaris) 		5 / 9 GLY A 292
LEU A 120
ALA A 290
LEU A 269
THR A 283
 None
 1.17A 2npnA-3iwaA:
undetectable		 2npnA-3iwaA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_B_SVRB501_2
(PHOSPHOLIPASE A2)		 3iwa FAD-DEPENDENT
PYRIDINE
NUCLEOTIDE-DISULPHID
E OXIDOREDUCTASE
(Desulfovibrio
vulgaris) 		5 / 11 LEU A 269
GLY A 273
SER A 256
PRO A 257
SER A 122
 None
 1.09A 3bjwB-3iwaA:
undetectable		 3bjwB-3iwaA:
13.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_E_SVRE503_1
(PHOSPHOLIPASE A2)		 3iwa FAD-DEPENDENT
PYRIDINE
NUCLEOTIDE-DISULPHID
E OXIDOREDUCTASE
(Desulfovibrio
vulgaris) 		5 / 11 LEU A 269
GLY A 273
SER A 256
PRO A 257
SER A 122
 None
 1.22A 3bjwE-3iwaA:
undetectable		 3bjwE-3iwaA:
13.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_H_SVRH504_3
(PHOSPHOLIPASE A2)		 3iwa FAD-DEPENDENT
PYRIDINE
NUCLEOTIDE-DISULPHID
E OXIDOREDUCTASE
(Desulfovibrio
vulgaris) 		5 / 11 LEU A 269
GLY A 273
SER A 256
PRO A 257
SER A 122
 None
 1.12A 3bjwH-3iwaA:
undetectable		 3bjwH-3iwaA:
13.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DAT_A_MTXA201_1
(DIHYDROFOLATE
REDUCTASE)		 3iwa FAD-DEPENDENT
PYRIDINE
NUCLEOTIDE-DISULPHID
E OXIDOREDUCTASE
(Desulfovibrio
vulgaris) 		5 / 12 ALA A 265
LEU A 261
LEU A 116
ILE A 100
LEU A 111
 None
 1.17A 3datA-3iwaA:
undetectable		 3datA-3iwaA:
17.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DCJ_A_THHA401_0
(PROBABLE
5'-PHOSPHORIBOSYLGLY
CINAMIDE
FORMYLTRANSFERASE
PURN)		 3iwa FAD-DEPENDENT
PYRIDINE
NUCLEOTIDE-DISULPHID
E OXIDOREDUCTASE
(Desulfovibrio
vulgaris) 		5 / 12 ILE A 194
LEU A 207
LEU A 343
PRO A 309
VAL A 341
 None
 1.19A 3dcjA-3iwaA:
3.6
3dcjB-3iwaA:
4.1		 3dcjA-3iwaA:
20.21
3dcjB-3iwaA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E00_A_9CRA7223_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 3iwa FAD-DEPENDENT
PYRIDINE
NUCLEOTIDE-DISULPHID
E OXIDOREDUCTASE
(Desulfovibrio
vulgaris) 		5 / 12 ALA A  17
ALA A  18
VAL A 277
ILE A 275
CYH A 294
 None
 0.94A 3e00A-3iwaA:
undetectable		 3e00A-3iwaA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_H_SAMH300_0
(PUTATIVE RRNA
METHYLASE)		 3iwa FAD-DEPENDENT
PYRIDINE
NUCLEOTIDE-DISULPHID
E OXIDOREDUCTASE
(Desulfovibrio
vulgaris) 		5 / 12 GLY A 453
ASN A 454
ASN A 458
ILE A 401
GLY A 400
 None
 1.16A 3eeyH-3iwaA:
2.0		 3eeyH-3iwaA:
18.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_I_SAMI300_0
(PUTATIVE RRNA
METHYLASE)		 3iwa FAD-DEPENDENT
PYRIDINE
NUCLEOTIDE-DISULPHID
E OXIDOREDUCTASE
(Desulfovibrio
vulgaris) 		5 / 12 GLY A 453
ASN A 454
ASN A 458
ILE A 401
GLY A 400
 None
 1.18A 3eeyI-3iwaA:
2.3		 3eeyI-3iwaA:
18.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EL5_B_1UNB201_1
(PROTEASE)		 3iwa FAD-DEPENDENT
PYRIDINE
NUCLEOTIDE-DISULPHID
E OXIDOREDUCTASE
(Desulfovibrio
vulgaris) 		5 / 10 VAL A 218
ILE A 194
GLY A 167
ILE A 169
THR A 185
 None
 1.07A 3el5A-3iwaA:
undetectable		 3el5A-3iwaA:
13.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FAL_A_REAA501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 3iwa FAD-DEPENDENT
PYRIDINE
NUCLEOTIDE-DISULPHID
E OXIDOREDUCTASE
(Desulfovibrio
vulgaris) 		5 / 10 ALA A  17
ALA A  18
VAL A 277
ILE A 275
CYH A 294
 None
 0.73A 3falA-3iwaA:
undetectable		 3falA-3iwaA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FAL_A_REAA501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 3iwa FAD-DEPENDENT
PYRIDINE
NUCLEOTIDE-DISULPHID
E OXIDOREDUCTASE
(Desulfovibrio
vulgaris) 		5 / 10 ILE A 321
ALA A  17
ALA A  18
VAL A 277
ILE A 275
 None
 1.06A 3falA-3iwaA:
undetectable		 3falA-3iwaA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H0A_A_9RAA500_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 3iwa FAD-DEPENDENT
PYRIDINE
NUCLEOTIDE-DISULPHID
E OXIDOREDUCTASE
(Desulfovibrio
vulgaris) 		5 / 12 ALA A  17
ALA A  18
VAL A 277
ILE A 275
CYH A 294
 None
 0.99A 3h0aA-3iwaA:
undetectable		 3h0aA-3iwaA:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JW5_B_TOPB208_1
(DIHYDROFOLATE
REDUCTASE)		 3iwa FAD-DEPENDENT
PYRIDINE
NUCLEOTIDE-DISULPHID
E OXIDOREDUCTASE
(Desulfovibrio
vulgaris) 		5 / 10 ALA A 265
LEU A 261
LEU A 116
ILE A 100
LEU A 111
 None
 1.13A 3jw5B-3iwaA:
undetectable		 3jw5B-3iwaA:
18.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LN1_A_CELA682_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3iwa FAD-DEPENDENT
PYRIDINE
NUCLEOTIDE-DISULPHID
E OXIDOREDUCTASE
(Desulfovibrio
vulgaris) 		5 / 12 HIS A  96
TYR A 113
GLY A 266
ALA A 265
LEU A 261
 None
 1.03A 3ln1A-3iwaA:
undetectable		 3ln1A-3iwaA:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LN1_B_CELB682_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3iwa FAD-DEPENDENT
PYRIDINE
NUCLEOTIDE-DISULPHID
E OXIDOREDUCTASE
(Desulfovibrio
vulgaris) 		5 / 12 HIS A  96
TYR A 113
GLY A 266
ALA A 265
LEU A 261
 None
 1.03A 3ln1B-3iwaA:
undetectable		 3ln1B-3iwaA:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LN1_C_CELC682_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3iwa FAD-DEPENDENT
PYRIDINE
NUCLEOTIDE-DISULPHID
E OXIDOREDUCTASE
(Desulfovibrio
vulgaris) 		5 / 12 HIS A  96
TYR A 113
GLY A 266
ALA A 265
LEU A 261
 None
 1.03A 3ln1C-3iwaA:
undetectable		 3ln1C-3iwaA:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LN1_D_CELD682_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3iwa FAD-DEPENDENT
PYRIDINE
NUCLEOTIDE-DISULPHID
E OXIDOREDUCTASE
(Desulfovibrio
vulgaris) 		5 / 12 HIS A  96
TYR A 113
GLY A 266
ALA A 265
LEU A 261
 None
 1.04A 3ln1D-3iwaA:
undetectable		 3ln1D-3iwaA:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OZW_A_KKKA413_1
(FLAVOHEMOGLOBIN)		 3iwa FAD-DEPENDENT
PYRIDINE
NUCLEOTIDE-DISULPHID
E OXIDOREDUCTASE
(Desulfovibrio
vulgaris) 		4 / 8 GLN A 150
ALA A 252
LEU A 251
LEU A 227
 None
 0.88A 3ozwA-3iwaA:
3.0		 3ozwA-3iwaA:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RAE_F_LFXF101_1
(DNA TOPOISOMERASE 4
SUBUNIT A
DNA TOPOISOMERASE 4
SUBUNIT B)		 3iwa FAD-DEPENDENT
PYRIDINE
NUCLEOTIDE-DISULPHID
E OXIDOREDUCTASE
(Desulfovibrio
vulgaris) 		3 / 4 SER A 312
GLY A 352
GLU A 361
 None
 0.64A 3raeA-3iwaA:
undetectable
3raeC-3iwaA:
undetectable		 3raeA-3iwaA:
24.36
3raeC-3iwaA:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUD_D_SUED1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 3iwa FAD-DEPENDENT
PYRIDINE
NUCLEOTIDE-DISULPHID
E OXIDOREDUCTASE
(Desulfovibrio
vulgaris) 		5 / 12 GLN A 402
GLY A 400
VAL A 428
ALA A 419
ALA A 417
 None
 0.93A 3sudD-3iwaA:
undetectable		 3sudD-3iwaA:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EQ4_B_SALB601_1
(4-SUBSTITUTED
BENZOATES-GLUTAMATE
LIGASE GH3.12)		 3iwa FAD-DEPENDENT
PYRIDINE
NUCLEOTIDE-DISULPHID
E OXIDOREDUCTASE
(Desulfovibrio
vulgaris) 		4 / 8 THR A 259
ILE A 275
VAL A 277
GLY A 292
 None
 0.89A 4eq4B-3iwaA:
undetectable		 4eq4B-3iwaA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HAJ_A_DXCA75_0
(PPCA)		 3iwa FAD-DEPENDENT
PYRIDINE
NUCLEOTIDE-DISULPHID
E OXIDOREDUCTASE
(Desulfovibrio
vulgaris) 		4 / 7 ILE A 194
LEU A 171
LYS A 213
GLY A 346
 None
 0.84A 4hajA-3iwaA:
undetectable		 4hajA-3iwaA:
9.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JUO_F_LFXF101_1
(DNA TOPOISOMERASE 4
SUBUNIT A
DNA TOPOISOMERASE 4
SUBUNIT B
E-SITE DNA)		 3iwa FAD-DEPENDENT
PYRIDINE
NUCLEOTIDE-DISULPHID
E OXIDOREDUCTASE
(Desulfovibrio
vulgaris) 		3 / 4 SER A 312
GLY A 352
GLU A 361
 None
 0.61A 4juoA-3iwaA:
undetectable
4juoC-3iwaA:
undetectable		 4juoA-3iwaA:
24.36
4juoC-3iwaA:
23.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L6V_1_PQN12001_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
FUSION PROTEIN OF
PHOTOSYSTEM I
SUBUNIT III AND
SUBUNIT IX)		 3iwa FAD-DEPENDENT
PYRIDINE
NUCLEOTIDE-DISULPHID
E OXIDOREDUCTASE
(Desulfovibrio
vulgaris) 		5 / 11 GLY A 311
ALA A  12
LEU A  13
GLY A 292
ALA A  28
 None
 1.14A 4l6v1-3iwaA:
undetectable
4l6v6-3iwaA:
undetectable		 4l6v1-3iwaA:
21.29
4l6v6-3iwaA:
13.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UCI_A_SAMA2409_0
(RNA-DIRECTED RNA
POLYMERASE L)		 3iwa FAD-DEPENDENT
PYRIDINE
NUCLEOTIDE-DISULPHID
E OXIDOREDUCTASE
(Desulfovibrio
vulgaris) 		6 / 12 GLY A  14
GLY A 318
GLY A 322
ASN A 324
ALA A  10
ALA A 119
 None
 1.22A 4uciA-3iwaA:
undetectable		 4uciA-3iwaA:
23.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UCI_B_SAMB2409_0
(RNA-DIRECTED RNA
POLYMERASE L)		 3iwa FAD-DEPENDENT
PYRIDINE
NUCLEOTIDE-DISULPHID
E OXIDOREDUCTASE
(Desulfovibrio
vulgaris) 		6 / 12 GLY A  14
GLY A 318
GLY A 322
ASN A 324
ALA A  10
ALA A 119
 None
 1.22A 4uciB-3iwaA:
undetectable		 4uciB-3iwaA:
23.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UCK_A_SAMA2409_0
(RNA-DIRECTED RNA
POLYMERASE L)		 3iwa FAD-DEPENDENT
PYRIDINE
NUCLEOTIDE-DISULPHID
E OXIDOREDUCTASE
(Desulfovibrio
vulgaris) 		6 / 12 GLY A  14
GLY A 318
GLY A 322
ASN A 324
ALA A  10
ALA A 119
 None
 1.21A 4uckA-3iwaA:
undetectable		 4uckA-3iwaA:
23.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BW4_B_SAMB301_0
(16S RRNA
(ADENINE(1408)-N(1))
-METHYLTRANSFERASE)		 3iwa FAD-DEPENDENT
PYRIDINE
NUCLEOTIDE-DISULPHID
E OXIDOREDUCTASE
(Desulfovibrio
vulgaris) 		5 / 12 GLY A 403
ALA A 351
ALA A 340
LEU A 411
ALA A 452
 None
 0.89A 5bw4B-3iwaA:
undetectable		 5bw4B-3iwaA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKQ_A_JMSA602_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3iwa FAD-DEPENDENT
PYRIDINE
NUCLEOTIDE-DISULPHID
E OXIDOREDUCTASE
(Desulfovibrio
vulgaris) 		3 / 3 VAL A 175
SER A 347
MET A 206
 None
 0.93A 5ikqA-3iwaA:
undetectable		 5ikqA-3iwaA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JW1_A_CELA602_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3iwa FAD-DEPENDENT
PYRIDINE
NUCLEOTIDE-DISULPHID
E OXIDOREDUCTASE
(Desulfovibrio
vulgaris) 		5 / 12 HIS A  96
TYR A 113
GLY A 266
ALA A 265
LEU A 261
 None
 1.05A 5jw1A-3iwaA:
undetectable		 5jw1A-3iwaA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JW1_B_CELB602_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3iwa FAD-DEPENDENT
PYRIDINE
NUCLEOTIDE-DISULPHID
E OXIDOREDUCTASE
(Desulfovibrio
vulgaris) 		5 / 12 HIS A  96
TYR A 113
GLY A 266
ALA A 265
LEU A 261
 None
 1.02A 5jw1B-3iwaA:
undetectable		 5jw1B-3iwaA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KIR_B_RCXB601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3iwa FAD-DEPENDENT
PYRIDINE
NUCLEOTIDE-DISULPHID
E OXIDOREDUCTASE
(Desulfovibrio
vulgaris) 		5 / 12 HIS A  96
TYR A 113
GLY A 266
ALA A 265
LEU A 261
 None
 1.05A 5kirB-3iwaA:
undetectable		 5kirB-3iwaA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KVA_B_SAMB301_0
(CAFFEOYL-COA
O-METHYLTRANSFERASE)		 3iwa FAD-DEPENDENT
PYRIDINE
NUCLEOTIDE-DISULPHID
E OXIDOREDUCTASE
(Desulfovibrio
vulgaris) 		5 / 12 THR A  31
GLY A  14
ILE A 321
ALA A 314
ALA A 119
 None
 1.10A 5kvaB-3iwaA:
3.7		 5kvaB-3iwaA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VCY_A_DB8A401_2
(MEMBRANE-ASSOCIATED
TYROSINE- AND
THREONINE-SPECIFIC
CDC2-INHIBITORY
KINASE)		 3iwa FAD-DEPENDENT
PYRIDINE
NUCLEOTIDE-DISULPHID
E OXIDOREDUCTASE
(Desulfovibrio
vulgaris) 		4 / 4 VAL A 368
LEU A 387
ASN A 458
ASP A 457
 None
 1.31A 5vcyA-3iwaA:
undetectable		 5vcyA-3iwaA:
24.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B58_A_ACTA607_0
(FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT)		 3iwa FAD-DEPENDENT
PYRIDINE
NUCLEOTIDE-DISULPHID
E OXIDOREDUCTASE
(Desulfovibrio
vulgaris) 		4 / 4 GLY A 322
ARG A 282
ASN A 324
LEU A 325
 None
 1.30A 6b58A-3iwaA:
12.3		 6b58A-3iwaA:
23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HU9_N_PCFN606_0
(CYTOCHROME B)		 3iwa FAD-DEPENDENT
PYRIDINE
NUCLEOTIDE-DISULPHID
E OXIDOREDUCTASE
(Desulfovibrio
vulgaris) 		5 / 12 ALA A  17
THR A 331
PHE A 289
VAL A 117
VAL A   6
 None
 1.38A 6hu9N-3iwaA:
undetectable		 6hu9N-3iwaA:
23.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6J20_A_GBQA1201_1
(SUBSTANCE-P
RECEPTOR,ENDOLYSIN)		 3iwa FAD-DEPENDENT
PYRIDINE
NUCLEOTIDE-DISULPHID
E OXIDOREDUCTASE
(Desulfovibrio
vulgaris) 		4 / 7 ILE A   8
GLN A  35
GLU A 101
VAL A  98
 None
 1.18A 6j20A-3iwaA:
undetectable		 6j20A-3iwaA:
21.56