SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3iwg'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SG9_B_SAMB302_1
(HEMK PROTEIN)		 3iwg ACETYLTRANSFERASE,
GNAT FAMILY
(Colwellia
psychrerythraea) 		3 / 3 ASP A 112
PHE A 268
ASN A 105
 None
 0.75A 1sg9B-3iwgA:
undetectable		 1sg9B-3iwgA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1X70_B_715B801_2
(DIPEPTIDYL PEPTIDASE
IV)		 3iwg ACETYLTRANSFERASE,
GNAT FAMILY
(Colwellia
psychrerythraea) 		3 / 3 PHE A 270
TYR A 106
TYR A  66
 None
 0.67A 1x70B-3iwgA:
undetectable		 1x70B-3iwgA:
17.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LMY_A_CP6A562_1
(BETA-HEXOSAMINIDASE
SUBUNIT BETA)		 3iwg ACETYLTRANSFERASE,
GNAT FAMILY
(Colwellia
psychrerythraea) 		5 / 12 ARG A 195
ASP A 206
ASP A  29
LEU A 166
GLU A 193
 None
 0.99A 3lmyA-3iwgA:
undetectable		 3lmyA-3iwgA:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LTW_A_HLZA300_1
(ARYLAMINE
N-ACETYLTRANSFERASE
NAT)		 3iwg ACETYLTRANSFERASE,
GNAT FAMILY
(Colwellia
psychrerythraea) 		4 / 6 TYR A  66
CYH A  55
VAL A  94
PHE A  80
 None
 0.97A 3ltwA-3iwgA:
undetectable		 3ltwA-3iwgA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VT7_A_VDXA500_2
(VITAMIN D3 RECEPTOR)		 3iwg ACETYLTRANSFERASE,
GNAT FAMILY
(Colwellia
psychrerythraea) 		4 / 4 LEU A  16
ILE A  83
TYR A 106
TYR A  46
 None
 1.45A 3vt7A-3iwgA:
undetectable		 3vt7A-3iwgA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A6E_A_SAMA1349_0
(HYDROXYINDOLE
O-METHYLTRANSFERASE)		 3iwg ACETYLTRANSFERASE,
GNAT FAMILY
(Colwellia
psychrerythraea) 		5 / 12 GLY A 181
GLY A 192
ILE A 138
VAL A 224
ALA A 143
 None
None
CL  A 603 (-4.3A)
None
None
 1.17A 4a6eA-3iwgA:
undetectable		 4a6eA-3iwgA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WNW_B_RTZB602_2
(CYTOCHROME P450 2D6)		 3iwg ACETYLTRANSFERASE,
GNAT FAMILY
(Colwellia
psychrerythraea) 		3 / 3 GLU A 244
ILE A 210
ALA A 249
 None
None
SO4  A 501 ( 4.2A)
 0.64A 4wnwB-3iwgA:
undetectable		 4wnwB-3iwgA:
18.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZO1_X_T3X500_1
(THYROID HORMONE
RECEPTOR BETA)		 3iwg ACETYLTRANSFERASE,
GNAT FAMILY
(Colwellia
psychrerythraea) 		5 / 12 ILE A 254
ALA A 250
MET A 209
ASN A 247
PHE A 259
 None
 1.35A 4zo1X-3iwgA:
undetectable		 4zo1X-3iwgA:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AYF_A_C7HA402_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 3iwg ACETYLTRANSFERASE,
GNAT FAMILY
(Colwellia
psychrerythraea) 		4 / 5 TYR A 169
GLY A 208
TYR A 170
GLY A 181
 None
 1.04A 5ayfA-3iwgA:
undetectable		 5ayfA-3iwgA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESH_A_1YNA602_2
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 3iwg ACETYLTRANSFERASE,
GNAT FAMILY
(Colwellia
psychrerythraea) 		4 / 5 TYR A 200
LEU A  10
PRO A  38
LEU A  16
 None
 1.45A 5eshA-3iwgA:
undetectable		 5eshA-3iwgA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OF1_A_SALA301_1
(SPORE
COAT-ASSOCIATED
PROTEIN N)		 3iwg ACETYLTRANSFERASE,
GNAT FAMILY
(Colwellia
psychrerythraea) 		4 / 5 ALA A  97
VAL A  57
PHE A 270
ILE A  91
 None
 1.04A 5of1A-3iwgA:
undetectable		 5of1A-3iwgA:
15.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OF1_B_SALB301_1
(SPORE
COAT-ASSOCIATED
PROTEIN N)		 3iwg ACETYLTRANSFERASE,
GNAT FAMILY
(Colwellia
psychrerythraea) 		4 / 5 ALA A  97
VAL A  57
PHE A 270
ILE A  91
 None
 1.05A 5of1B-3iwgA:
undetectable		 5of1B-3iwgA:
15.87