SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3iwp'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QKU_B_ESTB600_1
(ESTRADIOL RECEPTOR)		 3iwp COPPER HOMEOSTASIS
PROTEIN CUTC HOMOLOG
(Homo
sapiens) 		5 / 10 ALA A 147
LEU A 119
LEU A  90
MET A  99
ILE A  96
 None
 1.44A 1qkuB-3iwpA:
undetectable		 1qkuB-3iwpA:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QKU_C_ESTC600_1
(ESTRADIOL RECEPTOR)		 3iwp COPPER HOMEOSTASIS
PROTEIN CUTC HOMOLOG
(Homo
sapiens) 		5 / 10 ALA A 147
LEU A 119
LEU A  90
MET A  99
ILE A  96
 None
 1.44A 1qkuC-3iwpA:
undetectable		 1qkuC-3iwpA:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S8F_B_BEZB1503_0
(RAS-RELATED PROTEIN
RAB-9A)		 3iwp COPPER HOMEOSTASIS
PROTEIN CUTC HOMOLOG
(Homo
sapiens) 		4 / 6 VAL A 142
THR A 143
GLU A  50
LEU A 114
 None
 1.07A 1s8fB-3iwpA:
undetectable		 1s8fB-3iwpA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XF1_A_ACTA1107_0
(C5A PEPTIDASE)		 3iwp COPPER HOMEOSTASIS
PROTEIN CUTC HOMOLOG
(Homo
sapiens) 		4 / 5 LEU A 119
GLY A 123
HIS A 124
ILE A 125
 None
 0.87A 1xf1A-3iwpA:
undetectable		 1xf1A-3iwpA:
16.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2H77_A_T3A1_1
(THRA PROTEIN)		 3iwp COPPER HOMEOSTASIS
PROTEIN CUTC HOMOLOG
(Homo
sapiens) 		5 / 12 ILE A 189
ALA A 178
LEU A 182
LEU A 213
ILE A 204
 None
 1.06A 2h77A-3iwpA:
undetectable		 2h77A-3iwpA:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2H79_A_T3A1_1
(THRA PROTEIN)		 3iwp COPPER HOMEOSTASIS
PROTEIN CUTC HOMOLOG
(Homo
sapiens) 		5 / 12 ILE A 189
ALA A 178
LEU A 182
LEU A 213
ILE A 204
 None
 1.07A 2h79A-3iwpA:
undetectable		 2h79A-3iwpA:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_L_ASDL1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 3iwp COPPER HOMEOSTASIS
PROTEIN CUTC HOMOLOG
(Homo
sapiens) 		4 / 7 LEU A 264
ALA A 268
PHE A  26
PHE A 221
 None
 1.09A 2vcvL-3iwpA:
undetectable		 2vcvL-3iwpA:
23.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ROD_D_NCAD302_0
(NICOTINAMIDE
N-METHYLTRANSFERASE)		 3iwp COPPER HOMEOSTASIS
PROTEIN CUTC HOMOLOG
(Homo
sapiens) 		4 / 7 LEU A  90
ASP A 126
ALA A 118
TYR A  91
 None
 1.15A 3rodD-3iwpA:
undetectable		 3rodD-3iwpA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EYR_B_RITB301_2
(HIV-1 PROTEASE)		 3iwp COPPER HOMEOSTASIS
PROTEIN CUTC HOMOLOG
(Homo
sapiens) 		4 / 8 GLY A 110
ALA A 111
ASP A 112
THR A  61
 None
 0.77A 4eyrB-3iwpA:
undetectable		 4eyrB-3iwpA:
15.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KOU_A_C04A207_1
(UNCHARACTERIZED
PROTEIN)		 3iwp COPPER HOMEOSTASIS
PROTEIN CUTC HOMOLOG
(Homo
sapiens) 		3 / 3 GLY A 113
GLU A 167
THR A 143
 None
 0.54A 4kouA-3iwpA:
undetectable		 4kouA-3iwpA:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X80_B_SALB203_1
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		 3iwp COPPER HOMEOSTASIS
PROTEIN CUTC HOMOLOG
(Homo
sapiens) 		4 / 6 GLY A 110
TYR A 109
LEU A 140
VAL A  80
 None
 0.94A 5x80A-3iwpA:
undetectable
5x80B-3iwpA:
undetectable		 5x80A-3iwpA:
23.53
5x80B-3iwpA:
23.53