SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3iwt'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DHI_B_MTXB361_1
(DIHYDROFOLATE
REDUCTASE)		 3iwt 178AA LONG
HYPOTHETICAL
MOLYBDENUM COFACTOR
BIOSYNTHESIS PROTEIN
B
(Sulfurisphaera
tokodaii) 		5 / 11 ILE A  21
LEU A  70
ILE A 142
LEU A  77
ILE A  85
 None
 1.05A 1dhiB-3iwtA:
undetectable		 1dhiB-3iwtA:
23.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQT_A_ACTA1866_0
(FPRA)		 3iwt 178AA LONG
HYPOTHETICAL
MOLYBDENUM COFACTOR
BIOSYNTHESIS PROTEIN
B
(Sulfurisphaera
tokodaii) 		4 / 4 ARG A 177
LEU A  16
ASN A  17
VAL A 173
 None
 1.28A 1lqtA-3iwtA:
1.1		 1lqtA-3iwtA:
18.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQT_B_ACTB1875_0
(FPRA)		 3iwt 178AA LONG
HYPOTHETICAL
MOLYBDENUM COFACTOR
BIOSYNTHESIS PROTEIN
B
(Sulfurisphaera
tokodaii) 		4 / 4 ARG A 177
LEU A  16
ASN A  17
VAL A 173
 None
 1.27A 1lqtB-3iwtA:
1.0		 1lqtB-3iwtA:
18.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQU_A_ACTA1423_0
(FPRA)		 3iwt 178AA LONG
HYPOTHETICAL
MOLYBDENUM COFACTOR
BIOSYNTHESIS PROTEIN
B
(Sulfurisphaera
tokodaii) 		4 / 4 ARG A 177
LEU A  16
ASN A  17
VAL A 173
 None
 1.28A 1lquA-3iwtA:
5.4		 1lquA-3iwtA:
18.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQU_B_ACTB1432_0
(FPRA)		 3iwt 178AA LONG
HYPOTHETICAL
MOLYBDENUM COFACTOR
BIOSYNTHESIS PROTEIN
B
(Sulfurisphaera
tokodaii) 		4 / 4 ARG A 177
LEU A  16
ASN A  17
VAL A 173
 None
 1.27A 1lquB-3iwtA:
5.0		 1lquB-3iwtA:
18.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_G_BEZG513_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 3iwt 178AA LONG
HYPOTHETICAL
MOLYBDENUM COFACTOR
BIOSYNTHESIS PROTEIN
B
(Sulfurisphaera
tokodaii) 		4 / 5 ARG A  27
ILE A  44
PRO A 154
GLU A  40
 None
 1.46A 1oniG-3iwtA:
0.9
1oniH-3iwtA:
0.9		 1oniG-3iwtA:
22.70
1oniH-3iwtA:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RB2_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 3iwt 178AA LONG
HYPOTHETICAL
MOLYBDENUM COFACTOR
BIOSYNTHESIS PROTEIN
B
(Sulfurisphaera
tokodaii) 		5 / 12 ILE A  21
LEU A  70
ILE A 142
LEU A  77
ILE A  85
 None
 1.00A 1rb2A-3iwtA:
undetectable		 1rb2A-3iwtA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RD7_B_FOLB361_0
(DIHYDROFOLATE
REDUCTASE)		 3iwt 178AA LONG
HYPOTHETICAL
MOLYBDENUM COFACTOR
BIOSYNTHESIS PROTEIN
B
(Sulfurisphaera
tokodaii) 		5 / 12 ILE A  21
LEU A  70
ILE A 142
LEU A  77
ILE A  85
 None
 1.04A 1rd7B-3iwtA:
undetectable		 1rd7B-3iwtA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SDU_B_MK1B902_1
(PROTEASE RETROPEPSIN)		 3iwt 178AA LONG
HYPOTHETICAL
MOLYBDENUM COFACTOR
BIOSYNTHESIS PROTEIN
B
(Sulfurisphaera
tokodaii) 		5 / 11 LEU A 161
ILE A 111
GLY A 140
ILE A  85
ILE A 165
 None
 1.00A 1sduA-3iwtA:
undetectable		 1sduA-3iwtA:
23.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A1M_B_CAMB2422_0
(CYTOCHROME P450-CAM)		 3iwt 178AA LONG
HYPOTHETICAL
MOLYBDENUM COFACTOR
BIOSYNTHESIS PROTEIN
B
(Sulfurisphaera
tokodaii) 		4 / 8 PHE A  73
THR A 102
GLY A  90
ILE A  21
 None
 0.79A 2a1mB-3iwtA:
undetectable		 2a1mB-3iwtA:
18.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A1O_B_CAMB2422_0
(CYTOCHROME P450-CAM)		 3iwt 178AA LONG
HYPOTHETICAL
MOLYBDENUM COFACTOR
BIOSYNTHESIS PROTEIN
B
(Sulfurisphaera
tokodaii) 		5 / 9 PHE A  73
THR A 102
GLY A  90
VAL A  62
ILE A  21
 None
 1.02A 2a1oB-3iwtA:
undetectable		 2a1oB-3iwtA:
18.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJ1_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 3iwt 178AA LONG
HYPOTHETICAL
MOLYBDENUM COFACTOR
BIOSYNTHESIS PROTEIN
B
(Sulfurisphaera
tokodaii) 		5 / 12 ILE A  21
LEU A  70
ILE A 142
LEU A  77
ILE A  85
 None
 0.96A 4ej1A-3iwtA:
undetectable		 4ej1A-3iwtA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJJ_C_NCTC501_1
(CYTOCHROME P450 2A6)		 3iwt 178AA LONG
HYPOTHETICAL
MOLYBDENUM COFACTOR
BIOSYNTHESIS PROTEIN
B
(Sulfurisphaera
tokodaii) 		4 / 5 PHE A  73
ILE A  23
GLY A  89
THR A  91
 None
 1.02A 4ejjC-3iwtA:
undetectable		 4ejjC-3iwtA:
17.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I13_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 3iwt 178AA LONG
HYPOTHETICAL
MOLYBDENUM COFACTOR
BIOSYNTHESIS PROTEIN
B
(Sulfurisphaera
tokodaii) 		5 / 12 ILE A  21
LEU A  70
ILE A 142
LEU A  77
ILE A  85
 None
 0.93A 4i13A-3iwtA:
undetectable		 4i13A-3iwtA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P3R_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 3iwt 178AA LONG
HYPOTHETICAL
MOLYBDENUM COFACTOR
BIOSYNTHESIS PROTEIN
B
(Sulfurisphaera
tokodaii) 		5 / 12 ILE A  21
LEU A  70
ILE A 142
LEU A  77
ILE A  85
 None
 1.00A 4p3rA-3iwtA:
undetectable		 4p3rA-3iwtA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X5G_B_FOLB201_0
(DIHYDROFOLATE
REDUCTASE)		 3iwt 178AA LONG
HYPOTHETICAL
MOLYBDENUM COFACTOR
BIOSYNTHESIS PROTEIN
B
(Sulfurisphaera
tokodaii) 		5 / 12 ILE A  21
LEU A  70
ILE A 142
LEU A  77
ILE A  85
 None
 1.03A 4x5gB-3iwtA:
undetectable		 4x5gB-3iwtA:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X5I_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 3iwt 178AA LONG
HYPOTHETICAL
MOLYBDENUM COFACTOR
BIOSYNTHESIS PROTEIN
B
(Sulfurisphaera
tokodaii) 		5 / 12 ILE A  21
LEU A  70
ILE A 142
LEU A  77
ILE A  85
 None
 0.90A 4x5iA-3iwtA:
undetectable		 4x5iA-3iwtA:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HNZ_B_TA1B902_1
(TUBULIN BETA-2B
CHAIN)		 3iwt 178AA LONG
HYPOTHETICAL
MOLYBDENUM COFACTOR
BIOSYNTHESIS PROTEIN
B
(Sulfurisphaera
tokodaii) 		5 / 12 VAL A  62
LEU A 106
ALA A  72
SER A  60
ARG A 104
 None
 1.35A 5hnzB-3iwtA:
undetectable		 5hnzB-3iwtA:
17.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DLZ_A_CYZA1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 3iwt 178AA LONG
HYPOTHETICAL
MOLYBDENUM COFACTOR
BIOSYNTHESIS PROTEIN
B
(Sulfurisphaera
tokodaii) 		5 / 10 PRO A 154
LEU A 150
ASP A  64
ILE A  45
GLY A  42
 None
 1.35A 6dlzA-3iwtA:
5.7
6dlzD-3iwtA:
6.3		 6dlzA-3iwtA:
18.23
6dlzD-3iwtA:
18.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DLZ_C_CYZC1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 3iwt 178AA LONG
HYPOTHETICAL
MOLYBDENUM COFACTOR
BIOSYNTHESIS PROTEIN
B
(Sulfurisphaera
tokodaii) 		5 / 10 ILE A  45
GLY A  42
PRO A 154
LEU A 150
ASP A  64
 None
 1.35A 6dlzB-3iwtA:
6.3
6dlzC-3iwtA:
5.7		 6dlzB-3iwtA:
18.23
6dlzC-3iwtA:
18.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DM1_A_CYZA1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 3iwt 178AA LONG
HYPOTHETICAL
MOLYBDENUM COFACTOR
BIOSYNTHESIS PROTEIN
B
(Sulfurisphaera
tokodaii) 		5 / 10 PRO A 154
LEU A 150
ASP A  64
ILE A  45
GLY A  42
 None
 1.36A 6dm1A-3iwtA:
6.4
6dm1D-3iwtA:
6.3		 6dm1A-3iwtA:
18.23
6dm1D-3iwtA:
18.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DM1_C_CYZC1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 3iwt 178AA LONG
HYPOTHETICAL
MOLYBDENUM COFACTOR
BIOSYNTHESIS PROTEIN
B
(Sulfurisphaera
tokodaii) 		5 / 10 ILE A  45
GLY A  42
PRO A 154
LEU A 150
ASP A  64
 None
 1.36A 6dm1B-3iwtA:
6.3
6dm1C-3iwtA:
6.4		 6dm1B-3iwtA:
18.23
6dm1C-3iwtA:
18.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EBZ_A_DAHA123_0
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE,
BETA SUBUNIT)		 3iwt 178AA LONG
HYPOTHETICAL
MOLYBDENUM COFACTOR
BIOSYNTHESIS PROTEIN
B
(Sulfurisphaera
tokodaii) 		5 / 11 LEU A 149
GLY A  92
PHE A  73
ILE A  69
ILE A  23
 None
 1.03A 6ebzA-3iwtA:
undetectable		 6ebzA-3iwtA:
17.78